| THE
UNIVERSITY OF HONG KONG |
DEPARTMENT OF ANATOMY
| Researcher : Agrawal KR |
| List of Research Outputs |
| Lucas P.W., Prinz J.F., Agrawal K.R. and Bruce I.C., Food texture & its effects o ingestion, mastication & swallowing, Journal of Texture Studies. 2004, 35: 159-170. |
| Researcher : Chai H |
| List of Research Outputs |
| Wu W., Chai H., Zhang J., Gu H., Xie Y.Y. and Zhou L., Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats, Journal of Neirotrauma. 2004, 21(8): 1050-1058. |
| Wu W., Li L., Yick L.W., Chai H., Xie Y., Yang Y., Prevette D.M. and Oppenheim R.W., GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats, Journal of Neurotrauma. 2003, 20 No. 6: 603-612. |
| Xie Y., Yao Z., Chai H., Wong W.M. and Wu W., Expression and role of low-affinity nerve growth factor receptor (p75) in spinal motor neurons of aged rats following axonal injury, Developmental Neuroscience. 2003, 25: 65-71. |
| Zhang J., Chai H. and Wu W., survival and regeneration of motoneurons in adult rats by delayed reimplantation of ventral root following spinal root avulsion, Chinese Journal of Clinical Anatomy. 2003, 21: 362-364. |
| Researcher : Chan SYM |
| List of Research Outputs |
| Chan S.Y.M., Yick L.W., So K.F., Oppenheim R.W. and Wu W., Early release of mitochondrial cytochrome c and the subsequent activation of caspase-3 are involved in the apoptotic death of neonatal motoneurons after injury, Hong Koong Medical Journal. 2003, 9 Supplement: 72. |
| Cheung Z.H.Y., Chan S.Y.M., Siu F.K.W., Yip H.K.F., Wu W., Leung M.C.P. and So K.F., Regulation of caspase activation in axotomized retinal ganglion cells, Molecular and Cellular Neuroscience. 2004, 25: 383-393. |
| Researcher : Chang RCC |
| Project Title: | Influence of double-stranded RNA-dependent protein kinase (PKR) on stress kinases (p38 and JNK) in neurons upon b-amyloid peptide toxicity |
| Investigator(s): | Dr. Chang R.C.C., Prof. Hugon J. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 10/2002 |
| Completion Date: | 09/2003 |
| Abstract: |
| To understand and examine whether activation of different kinases occur at different time points in order to know whether one is at upstream of the others; to elucidate whether knockout of PKR affects activation of stress kinase in neurons exposed to Ab peptide (1-42); to further prove whether PKR is at upstream of the stress kinases, inhibition of these stress kinases should not have any effects on PKR-eIF2a pathway; there are increasing lines of evidence showing that different kinases can form complex to control each others. This set of experiment is to examine whether PKR interacts with these stress kinases. |
| Project Title: | Caspase-3 as an upstream signaling molecule for translational control in neuronal apoptosis: implications of b-amyloid peptides-induced neuronal apoptosis |
| Investigator(s): | Dr. Chang R.C.C., Dr. Chung S.K., Prof. Hugon J. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To identify the modes and the underlying mechanisms of activation for PKR-eIF2a pathway in neurons, which are relevant to Ab peptides toxicity. |
| Project Title: | Molecular Signaling of Neuronal Death in Alzheimer's Disease |
| Investigator(s): | Dr. Chang R.C.C., Prof. Hugon J. |
| Department: | Anatomy |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme |
| Start Date: | 01/2004 |
| Abstract: |
| To elucidate the molecular signaling pathways leading to neuronal death in Ab peptide neurotoxicity and neurodegeneration in Alzheimer's disease. |
| Project Title: | Roles of tumor necrosis factor receptor (TNFR1) and Fas in modulating double-stranded RNA-dependent protein kinase (PKR) in neurons upon b-amyloid peptide toxicity and in Alzheimer's disease |
| Investigator(s): | Dr. Chang R.C.C. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 02/2004 |
| Abstract: |
| To examine whether there is any difference for the signaling of TRADD, TRAF2 and RIP1. There are some lines of evidence showing that TRAF2 and RIP1 exert different downstream signaling pathways althrough they both contain the death domain. |
| List of Research Outputs |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in beta-amyloid peptide (Ab)-induced neuronal death, Journal of Neurochemistry. 2004, 88 Suppl. 1: 20 No. C7-4. |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in neuronal death, Proceeding of 2nd Frontiers in Medical Sciences. 2003, 69. |
| Chang R.C.C., Ji J., Chiu K. and So K.F., Participation of microglia/macrophages prevents retinal ganglion cell-loss in rats with laser-induced chronic ocular hypertension, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 132 No. P13-28. |
| Chang R.C.C., Suen K.C., Yu M.S., So K.F. and Hugon J., Upstream signaling of PKR in beta-amyloid peptide neurotoxicity, Society for Neuroscience. 2003, Program Number 210.16. |
| Leung S.K.Y., Yu M.S., Yuen W.H., Che C.M., Fang J. and Chang R.C.C., Extracts from chinese medicinal herb lycium barbarum (gou-qi-zi) as potential neuroprotective agents, Society for Neuroscience. 2003. |
| Lin K.F., Chang R.C.C., Suen K.C., So K.F. and Hugon J., Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity, European Journal of Neuroscience. 2004, 19: 2047-2055. |
| Lin K.F., Suen K.C., Hugon J., So K.F. and Chang R.C.C., Roles of calcium/calmodulin kinase-II attenuates beta-amyloid peptide-mediated neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Activation of the PKR-eIF2a pathway is mediated by caspase-3 activation, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Involvement of PKR in mediating the activation of caspases in b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-18. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., PERK might not be involved in b-amyloid peptide-induced and endoplasmic reticulum stress in neurons, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-19. |
| Suen K.C., Lin K.F., Hugon J., So K.F. and Chang R.C.C., Reducing calcium-mediated endoplasmic reticulum stress could attenuate beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S19. |
| Suen K.C., Lin K.F., Elyaman W., So K.F., Chang R.C.C. and Hugon J., Reduction of calcium release from the endoplasmic reticulum could not provide partial neuroprotection against beta-amyloid peptide toxicity, Journal of Neurochemistry. 2003, 87: 1413-1426. |
| Suen K.C., Hugon J., So K.F. and Chang R.C.C., Reduction of intracellular calcium increase provides partial protection against b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-20. |
| Suen K.C., Yu M.S., So K.F., Chang R.C.C. and Hugon J., Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in b-amyloid peptide neurotoxicity, The Journal of Biological Chemistry. 2003, 278 No. 50: 49819-49827. |
| Wong H.I., Chang R.C.C., Wang X., Feng H., Li H.M., Wong Y.C. and Tsao G.S.W., Functional study of EBV encoded RNA in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Yeung S.C., Chang R.C.C. and Yip H.K.F., Role of ciliary neurotrophic factor (CNTF) family growth factors in the survival and neurite outgrowth of retinal ganglion cells, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 176 No. P17-19. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Absence of endoplasmic reticulum stress in early apoptosis in beta-amyloid peptide neurotoxicity, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, No. A-05. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Lack of early activation of endoplasmic reticulum stress in beta-amyloid neurotoxicity, Journal of Neurochemistry. 2004, 88 Suppl. 1: 52 No. P21-16. |
| Yu M.S., Yuen W.H., So K.F. and Chang R.C.C., Neuroprotective effects of extracts from anti-aging chinese medicine Lycium Barbarum (Gou-Qi-Zi), Journal of Neurochemistry. 2004, 88 Suppl. 1: 69 No.P26-21. |
| Yu M.S., Lin K.F., Fang J., Yuen W.H., So K.F. and Chang R.C.C., Potential significance of polysaccharides from nerium indicum in neuroprotection, Society for Neuroscience. 2003, Program Number 98.5. |
| Researcher : Chau RMW |
| Project Title: | Molecular structure and function of prions (PRNs) |
| Investigator(s): | Dr. Chau R.M.W., Prof. Fung P.C.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Biotech Company (Growthfactor, Hong Kong) |
| Start Date: | 07/2000 |
| Abstract: |
| To study bioinformatics and computational approaches in determining the molecular structural homology and the functional homology of the PRNs in relationship to the Mad Cow Disease. |
| Project Title: | Molecular structure and function of aquaporins (AQPs) |
| Investigator(s): | Dr. Chau R.M.W., Prof. Fung P.C.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Department of Medicine |
| Start Date: | 01/2001 |
| Abstract: |
| To study bioinformatics and computational approaches in determining the molecular structural homology and the functional homology of the AQPs in relationship to their superfamily of gene members. |
| List of Research Outputs |
| Tai A.Y.P. and Chau R.M.W., Bioinformatics data mining and modelling on the molecular interactions between S-adenosylmethionine decarboxylase and its substrate, International Union/American Society Biochemistry and Molecular Biology 2004, Boston, June 2004. |
| Tse D.M.L., Yee B.M.Y. and Chau R.M.W., Computer generated superstructures of scrapie fibril, International Union/American Society Biochemistry and Molecular Biology 2004, Boston, June 2004. |
| Researcher : Chen B |
| List of Research Outputs |
| Chen B., Tay D.K.C., Diao Y., Xiao Y., Yu E. and So K.F., Expression of nicotinamide adenine dinucleotide phosphate-diaphorase positive neurons in the developing retina of the golden hamster without normal light stimulations, The 4th Congress of Asian-Oceanic Glaucoma Society, Hong Kong, October 1-4, 2003. 181 no. P-B-6. |
| Researcher : Chen H |
| List of Research Outputs |
| Chen H., A study of male accessory sex glands in protecting the genomic integrity of sperm in the golden hamster (Mesocricetus Auratus). 2004, 1-228. |
| Chen H., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Fate of sperm ejaculated from male Syrian hamster with all accessory sex glands removed during fertilization, Reproduction Abstract Series. 2003, no. 30: 40-41 O81. |
| Chen H., Chow P.H., Cheng S.K., Cheung A., Cheng L.Y.L. and O W.S., Male genital tract antioxidant enzymes: their source, funciton in the female, and ability to preserve sperm DNA integrity in the golden hamster, Journal of Andrology. 2003, 24 No. 5: 704-711. |
| Researcher : Cheung ALM |
| Project Title: | Methylation profiling in esophageal squamous cell carcinoma |
| Investigator(s): | Dr. Cheung A.L.M., Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To study the frequencies of promoter hypermethylation of selected genes in esophageal squamous cell carcinoma; to investigate the relationship between aberrant methylation and expression of these selected genes in esophageal cancer cell lines; to determine the role of promoter hypermethylation-associated gene silencing in the pathogenesis of esophageal squamous cell carcinoma. |
| Project Title: | Chromosomal aberrations and telomere changes in human ovarian surface epithelial cells during cell immortalization - a FISH/SKY study |
| Investigator(s): | Dr. Cheung A.L.M., Dr. Guan X.Y., Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2002 |
| Abstract: |
| To study chromosomal aberrations in human ovarian surface epithelial (HOSE) cells during the immortalization process, and to correlate them with changes in telomere sizes. |
| Project Title: | Telomere erosion and initiation of chromosomal instability in human cells undergoing immortalization |
| Investigator(s): | Dr. Cheung A.L.M., Dr. Guan X.Y., Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2003 |
| Abstract: |
| To obtain telomere length profiles for indivdual chromosomes and to characterize dynamic telomere shortening in pre-crisis cells; to determine if the chromosomes with shorter telomeres or faster telomere shortening are more frequently involved in the formation of chromosome aberrations during immortalization. |
| Project Title: | Telomere erosion and initiation of chromosomal instability in human cells undergoing immortalization |
| Investigator(s): | Dr. Cheung A.L.M., Dr. Guan X.Y., Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 09/2003 |
| Abstract: |
| To obtain telomere length profiles for indivdual chromosomes and to characterize dynamic telomere shortening in pre-crisis cells; to determine if the chromosomes with shorter telomeres or faster telomere shortening are more frequently involved in the formation of chromosome aberrations during immortalization. |
| Project Title: | Allelic loss in esophageal precancerous and cancerous lesions: study of a high-risk population in China |
| Investigator(s): | Dr. Cheung A.L.M., Prof. Tsao G.S.W., Prof. Wang L.D. |
| Department: | Anatomy |
| Source(s) of Funding: | Leung Kau Kui Research and Teaching Endowment Fund |
| Start Date: | 11/2003 |
| Abstract: |
| To study and compare the LOH profiles in precancerous and cancerous esophageal lesions; to identify chromosomal regions with frequent allelic loss. |
| List of Research Outputs |
| Chen H., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Fate of sperm ejaculated from male Syrian hamster with all accessory sex glands removed during fertilization, Reproduction Abstract Series. 2003, no. 30: 40-41 O81. |
| Chen H., Chow P.H., Cheng S.K., Cheung A., Cheng L.Y.L. and O W.S., Male genital tract antioxidant enzymes: their source, funciton in the female, and ability to preserve sperm DNA integrity in the golden hamster, Journal of Andrology. 2003, 24 No. 5: 704-711. |
| Cheung A., Si H., Tsao G.S.W., An J.Y., Wang L.D. and Poon C.S.P., Allelic loss in esophageal precancerous and cancerous lesions from a high risk area in China, Proceeding of the American Association for Cancer Research. 2004, 45: 173-174 No. 751. |
| Deng W., Tsao G.S.W., Guan X.Y. and Cheung A., The significance of dynamic dysfunction of critically short telomeres in directing the evolution of chromosomal structural instability in human cells undergoing immortalization, Proceedings of the American Association for Cancer Research. 2004, 45: 613-614 No. 2658. |
| Si H., Tsao G.S.W., Poon S.P., Wang L.D., Wong Y.C. and Cheung A., Human papillomavirus (HPV) infection and allelic loss in esophageal squamous cell carcinoma, Proceedings of the American Association for Cancer Research, July 2003. 22 2nd Edition: 1025 No. R5146. |
| Wang X., Tsao G.S.W., Wong Y.C. and Cheung A., Induction of senescent-like growth arrest as a new target in anticancer treatment, Current Cancer Drug Targets. 2003, 3: 153-160. |
| Wang X., Jin D.Y., Wong Y.C., Cheung A., Chun A.S.C., Lo K.F., Liu Y. and Tsao G.S.W., Significance of MAD2 expression in mitotic checkpoint control and cellular sensitivity in nasopharyngeal carcinoma cells, Hong Kong Medical Journal. 2003, 9: 57. |
| Zhuang Z., Wang L.D., Tsao G.S.W., Cheung A., Feng H., Yang T., Qin Y.R., Wang C.D., Chen Z.Z. and Liu B., Cyclooxygenase-2 expression in esophageal cancer cells and induction by mitomycin C (in Chinese), Zhonghua Nei Ke Za Zhi. 2003, 42(10): 701-704. |
| Researcher : Cheung HW |
| List of Research Outputs |
| Cheung H.W., Ling M.T., Tsao G.S.W., Wong Y.C. and Wang X., Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal cacinoma cells, Carcinogenesis. 2004, 25 no. 5: 881-887. |
| Wang X., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Oncogene. 2004, 23: 474-482. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Proceedings of the American Association for Cancer Research. 2004, 45: 142. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, abHLH protein, in the development of acquired taxol resistance in human cancer cells, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-04. |
| Researcher : Cheung MPL |
| List of Research Outputs |
| Chen H., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Fate of sperm ejaculated from male Syrian hamster with all accessory sex glands removed during fertilization, Reproduction Abstract Series. 2003, no. 30: 40-41 O81. |
| Researcher : Cheung ZHY |
| List of Research Outputs |
| Cheung Z.H.Y., Chan S.Y.M., Siu F.K.W., Yip H.K.F., Wu W., Leung M.C.P. and So K.F., Regulation of caspase activation in axotomized retinal ganglion cells, Molecular and Cellular Neuroscience. 2004, 25: 383-393. |
| Researcher : Chiu K |
| List of Research Outputs |
| Chang R.C.C., Ji J., Chiu K. and So K.F., Participation of microglia/macrophages prevents retinal ganglion cell-loss in rats with laser-induced chronic ocular hypertension, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 132 No. P13-28. |
| Researcher : Deng W |
| List of Research Outputs |
| Deng W., Tsao G.S.W., Guan X.Y. and Cheung A., The significance of dynamic dysfunction of critically short telomeres in directing the evolution of chromosomal structural instability in human cells undergoing immortalization, Proceedings of the American Association for Cancer Research. 2004, 45: 613-614 No. 2658. |
| Researcher : Elyaman W |
| List of Research Outputs |
| Ji J., Elyaman W., Yip H.K.F., Lee V.W.H., Yick L.W., Hugon J. and So K.F., CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway, European Journal of Neuroscience. 2004, 19: 265-272. |
| Suen K.C., Lin K.F., Elyaman W., So K.F., Chang R.C.C. and Hugon J., Reduction of calcium release from the endoplasmic reticulum could not provide partial neuroprotection against beta-amyloid peptide toxicity, Journal of Neurochemistry. 2003, 87: 1413-1426. |
| Researcher : Feng H |
| List of Research Outputs |
| Cheung A.N.Y., Xue W., Chan D.Y., Feng H., Chiu P.M., Tsao G.S.W. and Ngan H.Y.S., Promoter hypermethylation of multiple genes in hydatiform mole choriocarcinoma, Proceedings of the American Association for Cancer Research. 2004, 45: 1149 Abstract No. 4974. |
| Feng H., Xue W., Cheung A.N.Y., Wang Y.L. and Tsao G.S.W., Differentially expressed genes between ormal placenta and choriocarcinoma, Proceedings of the American Society for Cell Biology, 43rd Annual Meeting. 2003, Abstract No. 2774. |
| Feng H., Cheung A.N.Y., Xue W., Wang Y., Wang X., Fu S., Wang Q., Ngan H.Y.S. and Tsao G.S.W., Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma, Gynecologic Oncology. 2004, 94: 375-382. |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Wang Q., Tsao G.S.W., Fu S.B., Xue W.C., Meng X.N., Feng H., Wong Y.C. and Wang X., Overexpression of Id1 in gastric adenocarcinoma:Implication for a novel diagnostic marker, Anticancer Research. 2004, 24: 881-886. |
| Wong H.I., Chang R.C.C., Wang X., Feng H., Li H.M., Wong Y.C. and Tsao G.S.W., Functional study of EBV encoded RNA in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Xue W., Feng H., Tsao G.S.W., Chan Y.K., Ngan H.Y.S., Chiu P.M., Maccalman C.D. and Cheung A.N.Y., Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases, International Journal of Gynecological Cancer. 2003, 13(6): 879-888. |
| Zhuang Z., Wang L.D., Tsao G.S.W., Cheung A., Feng H., Yang T., Qin Y.R., Wang C.D., Chen Z.Z. and Liu B., Cyclooxygenase-2 expression in esophageal cancer cells and induction by mitomycin C (in Chinese), Zhonghua Nei Ke Za Zhi. 2003, 42(10): 701-704. |
| Researcher : Gu H |
| List of Research Outputs |
| Wu W., Chai H., Zhang J., Gu H., Xie Y.Y. and Zhou L., Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats, Journal of Neirotrauma. 2004, 21(8): 1050-1058. |
| Researcher : Ho MCT |
| List of Research Outputs |
| Ho M.C.T., Lau T.Y.H., Jin Y., Lu H.B., Liong E.C., Leung K.M. and Tipoe G.L., Overexpression of iNOS and down-regulation of BMPs-2, 4 and 7 in retinoic acid induced cleft palate formation, Histology and Histopathology. 2004, 19: 95-104. |
| Researcher : Hugon J |
| List of Research Outputs |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in beta-amyloid peptide (Ab)-induced neuronal death, Journal of Neurochemistry. 2004, 88 Suppl. 1: 20 No. C7-4. |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in neuronal death, Proceeding of 2nd Frontiers in Medical Sciences. 2003, 69. |
| Chang R.C.C., Suen K.C., Yu M.S., So K.F. and Hugon J., Upstream signaling of PKR in beta-amyloid peptide neurotoxicity, Society for Neuroscience. 2003, Program Number 210.16. |
| Ji J., Elyaman W., Yip H.K.F., Lee V.W.H., Yick L.W., Hugon J. and So K.F., CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway, European Journal of Neuroscience. 2004, 19: 265-272. |
| Lin K.F., Chang R.C.C., Suen K.C., So K.F. and Hugon J., Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity, European Journal of Neuroscience. 2004, 19: 2047-2055. |
| Lin K.F., Suen K.C., Hugon J., So K.F. and Chang R.C.C., Roles of calcium/calmodulin kinase-II attenuates beta-amyloid peptide-mediated neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Activation of the PKR-eIF2a pathway is mediated by caspase-3 activation, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Involvement of PKR in mediating the activation of caspases in b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-18. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., PERK might not be involved in b-amyloid peptide-induced and endoplasmic reticulum stress in neurons, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-19. |
| Suen K.C., Lin K.F., Hugon J., So K.F. and Chang R.C.C., Reducing calcium-mediated endoplasmic reticulum stress could attenuate beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S19. |
| Suen K.C., Lin K.F., Elyaman W., So K.F., Chang R.C.C. and Hugon J., Reduction of calcium release from the endoplasmic reticulum could not provide partial neuroprotection against beta-amyloid peptide toxicity, Journal of Neurochemistry. 2003, 87: 1413-1426. |
| Suen K.C., Hugon J., So K.F. and Chang R.C.C., Reduction of intracellular calcium increase provides partial protection against b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-20. |
| Suen K.C., Yu M.S., So K.F., Chang R.C.C. and Hugon J., Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in b-amyloid peptide neurotoxicity, The Journal of Biological Chemistry. 2003, 278 No. 50: 49819-49827. |
| Researcher : Ji J |
| List of Research Outputs |
| Chang R.C.C., Ji J., Chiu K. and So K.F., Participation of microglia/macrophages prevents retinal ganglion cell-loss in rats with laser-induced chronic ocular hypertension, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 132 No. P13-28. |
| Ji J., Elyaman W., Yip H.K.F., Lee V.W.H., Yick L.W., Hugon J. and So K.F., CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway, European Journal of Neuroscience. 2004, 19: 265-272. |
| Researcher : Kwok NS |
| List of Research Outputs |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Absence of endoplasmic reticulum stress in early apoptosis in beta-amyloid peptide neurotoxicity, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, No. A-05. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Lack of early activation of endoplasmic reticulum stress in beta-amyloid neurotoxicity, Journal of Neurochemistry. 2004, 88 Suppl. 1: 52 No. P21-16. |
| Researcher : Lai C |
| List of Research Outputs |
| Lai C., Neuroprotective effect of Ginkgo biloba extract on retinal ganglion cells in a rat glaucoma model. 2004, 1-102. |
| Researcher : Lau WM |
| List of Research Outputs |
| Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Hong Kong Society of Neuroscience Annual Meeting Abstract. 2003. |
| Lau W.M., Li S., Tsao G.S.W., Wong A.O.L. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in goldfish (Carassius auratus) retina, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Lau W.M., Tsao G.S.W., Wong A.O.L. and Yip H.K.F., Induction of retinal telomerase activity during optic nerve regeneration after optic nerve cut, Journal of Neurochemistry. 2003, 87(S1): 144-151. |
| Researcher : Lee DTW |
| List of Research Outputs |
| Ling M.T., Wang X., Lee D.T.W., Tam P.C., Tsao G.S.W. and Wong Y.C., Id-1 expression induces androgen-independent prostate cancer call growth through activation of epidermal growth factor receptor (EGF-R), Carcinogenesis. 2004, 25 No. 4: 517-525. |
| Wang X., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Oncogene. 2004, 23: 474-482. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Proceedings of the American Association for Cancer Research. 2004, 45: 142. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, abHLH protein, in the development of acquired taxol resistance in human cancer cells, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-04. |
| Researcher : Lee VWH |
| List of Research Outputs |
| Ji J., Elyaman W., Yip H.K.F., Lee V.W.H., Yick L.W., Hugon J. and So K.F., CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway, European Journal of Neuroscience. 2004, 19: 265-272. |
| Mok K.H., Cheung R.W.L., Wong B.K.H., Yip K.K. and Lee V.W.H., Effectiveness of no-rub contact lens cleaning on protein removal: a pilot study, Optometry and Vision Science. 2004, 81 no. 6: 468-470. |
| Mok K.H., Lee V.W.H. and So K.F., Increasing scans per examination improves the reproducibility on retinal nerve fiber layer measurements by optical coherence tomography, Optometry and Vision Science. 2004, 81 no. 4: 267-270. |
| Mok K.H., Lee V.W.H. and So K.F., Pattern loss of retinal nerve fiber with glaucoma progression, The 4th Congress of Asian-Oceanic Glaucoma Society, Hong Kong, October 1-4, 2003. 202 no. P-G-17. |
| Mok K.H., Lee V.W.H. and So K.F., Retinal nerve fiber loss in high- and normal-tension glaucoma by optical coherence tomography, Optometry and Vision Science. 2004, 81 no. 5: 369-372. |
| Researcher : Leung KM |
| List of Research Outputs |
| Ho M.C.T., Lau T.Y.H., Jin Y., Lu H.B., Liong E.C., Leung K.M. and Tipoe G.L., Overexpression of iNOS and down-regulation of BMPs-2, 4 and 7 in retinoic acid induced cleft palate formation, Histology and Histopathology. 2004, 19: 95-104. |
| Researcher : Leung TM |
| List of Research Outputs |
| Tipoe G.L., Leung T.M., Liong E.C., So H., Leung K.M., Tom W.M., Fan S.T. and Nanji A.A., Nitric oxide in an acute liver injury model (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004. |
| Researcher : Li HM |
| List of Research Outputs |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Li H.M. and Tsao G.S.W., Imortalization of normal human nasopharyngeal epithelial cells, Proceedings of The American Society for cell Biology, 43rd Annual Meeting. 2003, Abstract No. 2774. |
| Lo K.F., Huang D.P., Lo K.W., Chui Y.L., Li H.M., Pang J.C.S. and Tsao G.S.W., phenotypic alterations induced by the Hong Kong-prevalent epstein-barr virus-encoded LMP1 variant (2117-LMP1) in hasopharyngeal epithelial cells, International Journal of Cancer. 2004, 109: 919-925. |
| Tsao G.S.W., Lo K.F., Liu Y. and Li H.M., Functional study of LMP1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2003, 44 2nd Edition: 993 no. 4978. |
| Tsao G.S.W., Li H.M., Wang X. and Wong Y.C., Functional study of expression of the Epstein Barr virus encoded LMP1 protein in nasopharyngeal epithelial cells, Hong Kong Medical Journal. 2003, 9: 17. |
| Tsao G.S.W., Li H.M., Man C.W.Y., Yip Y.L., Young L.S. and Huang D.P., The role of immortalizatiion and transformation of nasopharyngeal epithelials, Proceedings of EBV Symposium 2004. 124. |
| Wong H.I., Chang R.C.C., Wang X., Feng H., Li H.M., Wong Y.C. and Tsao G.S.W., Functional study of EBV encoded RNA in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Researcher : Li S |
| List of Research Outputs |
| Lau W.M., Li S., Tsao G.S.W., Wong A.O.L. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in goldfish (Carassius auratus) retina, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Differential expression of glutamate decarboxylase isoforms in the horizontal cells of human and rat retinas, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Expression of glutamate decarboxylase isoforms in human and rat retinas, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Program No. A-02. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Li F., Yang W.K. and Yip H.K.F., F1k-1, a receptor for vascular endothelial growth factor, is expressed in the neural cells of developmental human retinas, USA Society of Neuroscience Annual Meeting Abstract. 2003. |
| Yip H.K.F., Yeung S.C. and Li S., Expression of Id gene family in the retina during development, Association for Research in vision and Ophthalmology Annual Meeting Abstract. 2004. |
| Yip H.K.F., Li S., Tay D.K.C., Shu Y., Bao X.M., Lui Kau K.W.F., Li F. and Yang W.K., Expression of nitric oxide synthases in the developing human retinas, 6th IBRO World Congress of Neuroscience. 2003. |
| Yip H.K.F., Li S., Shu S., Bao X., So K.F., Lui Kau K.W.F. and Yang W., Neuronal nitric oxide expresses in the retinal ganglion cells and endothelial nitric oxide synthase in the retinal neurons in the developing human retinas, Association for Research in Vision and Ophthalmology Annual Meeting Abstract. 2003. |
| Researcher : Lin KF |
| List of Research Outputs |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in beta-amyloid peptide (Ab)-induced neuronal death, Journal of Neurochemistry. 2004, 88 Suppl. 1: 20 No. C7-4. |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in neuronal death, Proceeding of 2nd Frontiers in Medical Sciences. 2003, 69. |
| Lin K.F., Chang R.C.C., Suen K.C., So K.F. and Hugon J., Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity, European Journal of Neuroscience. 2004, 19: 2047-2055. |
| Lin K.F., Suen K.C., Hugon J., So K.F. and Chang R.C.C., Roles of calcium/calmodulin kinase-II attenuates beta-amyloid peptide-mediated neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Lin K.F., Hugon J., So K.F. and Chang R.C.C., Reducing calcium-mediated endoplasmic reticulum stress could attenuate beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S19. |
| Suen K.C., Lin K.F., Elyaman W., So K.F., Chang R.C.C. and Hugon J., Reduction of calcium release from the endoplasmic reticulum could not provide partial neuroprotection against beta-amyloid peptide toxicity, Journal of Neurochemistry. 2003, 87: 1413-1426. |
| Yu M.S., Lin K.F., Fang J., Yuen W.H., So K.F. and Chang R.C.C., Potential significance of polysaccharides from nerium indicum in neuroprotection, Society for Neuroscience. 2003, Program Number 98.5. |
| Researcher : Ling MT |
| List of Research Outputs |
| Cheung H.W., Ling M.T., Tsao G.S.W., Wong Y.C. and Wang X., Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal cacinoma cells, Carcinogenesis. 2004, 25 no. 5: 881-887. |
| Lee K.W., Man K., Ling M.T., Wang X., Wong Y.C., Lo C.M., Poon R.T.P., Ng I.O.L. and Fan S.T., Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway, Carcinogenesis. 2003, 24(11): 1729-1736. |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Ling M.T., Wang X., Lee D.T.W., Tam P.C., Tsao G.S.W. and Wong Y.C., Id-1 expression induces androgen-independent prostate cancer call growth through activation of epidermal growth factor receptor (EGF-R), Carcinogenesis. 2004, 25 No. 4: 517-525. |
| Ling M.T., Wang X. and Wong Y.C., Id-1 expression promotes cell survival through activation of NF-kB signaling pathway in prostate cancer cells, proceedings of the American Asociation for Cancer Research. 2003, 44: 481. |
| Ling M.T., Wang X. and Wong Y.C., Id1 expression induces androen independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R), 10th Hong Kong International Cancer Congress, Hong Kong, November 19-21, 2003. P2.3. |
| Ling M.T., Wang X. and Wong Y.C., Id1 induced Raf/MEK pathway activation is essential for its protective role against apoptosis i nasopharyngeal carcinoma cells, Proceedings of the American Association for Cancer Research. 2004, 45: 20. |
| Ling M.T., The role of Id-1 in prostate development and carcinogenesis. 2003, 1-190. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Proceedings of the American Association for Cancer Research. 2004, 45: 142. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, abHLH protein, in the development of acquired taxol resistance in human cancer cells, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-04. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth, Proceedings of the American Association for Cancer Research. 2003, 44: 290-291. |
| Wong Y.C., Wang X. and Ling M.T., Id-1 expression and cell survival, Apoptosis. 2004, 9 No. 3: 279-289. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Id1 expression induces androgen independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R), Proceedings of the American Association for Cancer Research. 2004, 45: 1032. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Id1 expression induces androgen independent prostate cancer cell growth, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-03. |
| Wong Y.C., Ling M.T. and Wang X., Id1 is crucial factor regulating the development of prostate cancer, First Northern Lights Summer Conference: The Interface of Cancer and Development, Vancouver, June 16-20, 2004. |
| Wong Y.C., Wang X. and Ling M.T., Prostate development and carcinogenesis, International Review of Cytology. 2003, 227: 65-130. |
| Woo M.F., Ling M.T., Wang X. and Tsao G.S.W., Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer growth, Hong Kong Medical Journal. 2003, 9: 57. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines, Chinese Medical Journal. 2003, 116: 1673-1677. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., The a1-adrenoceptor anatagonist terazosin induces prostate cancer cell death through a p53 and Rb independent pathway, Oncology Reports. 2003, 10: 1555-1560. |
| Researcher : Liu Y |
| List of Research Outputs |
| Lo K.F., Liu Y., Huang D.P., Lo K.W., Wong Y.C. and Tsao G.S.W., Alterations of biological properties and gene expression in nasopharyngeal epithelial cells by Epstein-Barr virus encoded latent membrane protein 1, Proceedings of the American Association for Cancer Research. 2003, 44: 1183. |
| Tsao G.S.W., Lo K.F., Liu Y. and Li H.M., Functional study of LMP1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2003, 44 2nd Edition: 993 no. 4978. |
| Wang X., Jin D.Y., Wong Y.C., Cheung A., Chun A.S.C., Lo K.F., Liu Y. and Tsao G.S.W., Significance of MAD2 expression in mitotic checkpoint control and cellular sensitivity in nasopharyngeal carcinoma cells, Hong Kong Medical Journal. 2003, 9: 57. |
| Researcher : Lo KF |
| List of Research Outputs |
| Lo K.F., Liu Y., Huang D.P., Lo K.W., Wong Y.C. and Tsao G.S.W., Alterations of biological properties and gene expression in nasopharyngeal epithelial cells by Epstein-Barr virus encoded latent membrane protein 1, Proceedings of the American Association for Cancer Research. 2003, 44: 1183. |
| Lo K.F., Huang D.P., Lo K.W., Chui Y.L., Li H.M., Pang J.C.S. and Tsao G.S.W., phenotypic alterations induced by the Hong Kong-prevalent epstein-barr virus-encoded LMP1 variant (2117-LMP1) in hasopharyngeal epithelial cells, International Journal of Cancer. 2004, 109: 919-925. |
| Tsao G.S.W., Lo K.F., Liu Y. and Li H.M., Functional study of LMP1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2003, 44 2nd Edition: 993 no. 4978. |
| Wang X., Jin D.Y., Wong Y.C., Cheung A., Chun A.S.C., Lo K.F., Liu Y. and Tsao G.S.W., Significance of MAD2 expression in mitotic checkpoint control and cellular sensitivity in nasopharyngeal carcinoma cells, Hong Kong Medical Journal. 2003, 9: 57. |
| Researcher : Lu Q |
| List of Research Outputs |
| Lu Q., Cui Q., Yip H.K.F. and So K.F., c-Jun expression in surviving and regenerating retinal ganglion cells: effects of intravitreal neurotrophic supply, Investigative Ophthalmology & Visual Science. 2003, 44 No. 12: 5342-5348. |
| Researcher : Lucas PW |
| Project Title: | Adaptation of the teeth of primates to diet |
| Investigator(s): | Prof. Lucas P.W., Dr. Bruce I.C., Dr. Ungar P., Dr. Yamashita N. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To understand the tooth design of 8 species of primates (two lemur, five monkey and one ape species) with respect to diet. |
| Project Title: | The mechanics of the first bite |
| Investigator(s): | Prof. Lucas P.W., Dr. Corke H. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To place the function of the incisor teeth on a firm mechanical basis. |
| Project Title: | Incisal action and deformation transitions in foods |
| Investigator(s): | Prof. Lucas P.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 02/2004 |
| Abstract: |
| To measure incisal efficiency in individuals and to establish the anatomical and physiological variables that affect this. |
| List of Research Outputs |
| Dominy N.J., Lucas P.W. and Wright S.J., Mechanics and chemistry of rain forest leaves: canopy and understorey compared, Journal of Experimental Botany. 2003, 54 No. 390: 2007-2014. |
| Dominy N.J., Lucas P.W. and Supardi Noor N., Sensory perception of food: a study of fruits, fingers, and fermentation, American Journal of Physical Anthropology. 2004, Supplement 38: 88-89. |
| Dominy N.J. and Lucas P.W., Significance of color, calories, and climate to the visual ecology of Catarrhines, American Journal of Primatology. 2004, 62: 189-207. |
| Lucas P.W., Dental Functional Morphology: How Teeth Work. United Kingdom, Cambridge University Press, 2004, 1-355. |
| Lucas P.W., Osorio D., Yamashita N., Prinz J.F., Dominy N.J. and Darvell B.W., Dietary analysis I: Food physics, In: Joanna M. Setchell and Deborah J. Curtis, Field and Laboratory Methods in Primatology. United Kingdom, Cambridge University Press, 2003, 184-198. |
| Lucas P.W., Corlett R.T., Dominy N.J., Essackjee H.C., Riba-Hernandez P., Stoner K.E. and Yamashita N., Dietary analysis II: Food chemistry, In: Joanna M. Setchell and Deborah J. Curtis, Field and Laboratory Methods in Primatology. United Kingdom, Cambridge University Press, 2003, 199-213. |
| Lucas P.W., Dominy N.J., Riba-Hernandez P., Stoner K.E., Yamashita N., Loria-Calderon E., Petersen-Pereira W., Rojas-Duran Y., Salas-Pena R., Solis-Madrigal S., Osorio D. and Darvell B.W., Evolution and function of routine trichromatic vision in primates, Evolution. 2003, 57(11): 2636-2643. |
| Lucas P.W., Prinz J.F., Agrawal K.R. and Bruce I.C., Food texture & its effects o ingestion, mastication & swallowing, Journal of Texture Studies. 2004, 35: 159-170. |
| Lucas P.W., Plant mechanics and primate dental adaptations: an overview, In: Fred Anapol, Rebecca Z German, Nina G. Jablonski, Shaping Primate Evolution. Cambridge, United Kingdom, Cambridge University Press, 2004, 193-205. |
| Lucas P.W., The size of dentition, American Journal of physical Anthropology. 2004, Supplement 38: 138. |
| Vinyard C.J., Lucas P.W., Valenca-Montenergro M.M., Melo L.C.O., Valle Y.M. and Monteiro da Cruz M.A.O., Where the wild things are: linking lab and field work in studying tree grouging common marmosets (Cal-lithrix jacchus), American Journal of Physical Anthropology. 2004, Supplement 38: 200-201. |
| Researcher : Lui Kau KWF |
| List of Research Outputs |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Differential expression of glutamate decarboxylase isoforms in the horizontal cells of human and rat retinas, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Expression of glutamate decarboxylase isoforms in human and rat retinas, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Program No. A-02. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Li F., Yang W.K. and Yip H.K.F., F1k-1, a receptor for vascular endothelial growth factor, is expressed in the neural cells of developmental human retinas, USA Society of Neuroscience Annual Meeting Abstract. 2003. |
| Yip H.K.F., Li S., Tay D.K.C., Shu Y., Bao X.M., Lui Kau K.W.F., Li F. and Yang W.K., Expression of nitric oxide synthases in the developing human retinas, 6th IBRO World Congress of Neuroscience. 2003. |
| Yip H.K.F., Li S., Shu S., Bao X., So K.F., Lui Kau K.W.F. and Yang W., Neuronal nitric oxide expresses in the retinal ganglion cells and endothelial nitric oxide synthase in the retinal neurons in the developing human retinas, Association for Research in Vision and Ophthalmology Annual Meeting Abstract. 2003. |
| Researcher : Man CWY |
| List of Research Outputs |
| Tsao G.S.W., Li H.M., Man C.W.Y., Yip Y.L., Young L.S. and Huang D.P., The role of immortalizatiion and transformation of nasopharyngeal epithelials, Proceedings of EBV Symposium 2004. 124. |
| Researcher : Mok KH |
| List of Research Outputs |
| Mok K.H., Cheung R.W.L., Wong B.K.H., Yip K.K. and Lee V.W.H., Effectiveness of no-rub contact lens cleaning on protein removal: a pilot study, Optometry and Vision Science. 2004, 81 no. 6: 468-470. |
| Mok K.H., Lee V.W.H. and So K.F., Increasing scans per examination improves the reproducibility on retinal nerve fiber layer measurements by optical coherence tomography, Optometry and Vision Science. 2004, 81 no. 4: 267-270. |
| Mok K.H., Lee V.W.H. and So K.F., Pattern loss of retinal nerve fiber with glaucoma progression, The 4th Congress of Asian-Oceanic Glaucoma Society, Hong Kong, October 1-4, 2003. 202 no. P-G-17. |
| Mok K.H., Lee V.W.H. and So K.F., Retinal nerve fiber loss in high- and normal-tension glaucoma by optical coherence tomography, Optometry and Vision Science. 2004, 81 no. 5: 369-372. |
| Researcher : O WS |
| Project Title: | Assessment of testicular, epididymal and ejaculated human sperm after intraceptoplasmic sperm injection into hamster oocytes |
| Investigator(s): | Dr. O W.S., Dr. Cheng L.Y.L., Dr. Yeung W.S.B. |
| Department: | Anatomy |
| Source(s) of Funding: | Faculty Development Fund for Faculty of Medicine |
| Start Date: | 11/1998 |
| Abstract: |
| To determine the function of testicular, epididymal and ejaculated sperm to activate oocytes after ICSI; to compare the genomic integrity of sperms. |
| Project Title: | Effect of male accessory sex gland secretion on leptin expression - from fertilization to mid-gestation |
| Investigator(s): | Dr. O W.S. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 10/2002 |
| Completion Date: | 09/2003 |
| Abstract: |
| To assess the effect of lack of exposure of sperm to accessory sex gland secretions on fertilization and early embryogenesis; to investigate the effect of deletion of paternal accessory sex glands on the activation of ob gene expression during the morula and blastocyst stage; to study the effect of deletion of paternal accessory sex glands on the expression of ob gene in the placentae and fetuses up to mid-gestation. |
| Project Title: | A novel function the male accessory sex gland secretions on male germ cell development in the testis |
| Investigator(s): | Dr. O W.S. |
| Department: | Anatomy |
| Source(s) of Funding: | Leung Kau Kui Research and Teaching Endowment Fund |
| Start Date: | 11/2003 |
| Abstract: |
| To find out (1) how the removal of male accessory sex glands can affect the male germ cell development in terms of p53 conformation from "wild type" to "mutation" form; (2) to measure the plasma Zn++ levels in plasma; (3) to co-localise by immuno-histochemical and histochemical methods the repair enzyme, RAD51 and Zn++ in the male germ cells in the testis. |
| List of Research Outputs |
| Chan O.C., O W.S., Ferguson-Smith A. and Chow P.H., A potential role for male accessory sex gland secretions on the epigenetic regulation of embryo development in golden hamster, Reproductive BioMedicine Online. 2003, 7 Supplement 1: 16-17 no. O-42. |
| Chen H., Cheung M.P.L., Chow P.H., Cheung A. and O W.S., Fate of sperm ejaculated from male Syrian hamster with all accessory sex glands removed during fertilization, Reproduction Abstract Series. 2003, no. 30: 40-41 O81. |
| Chen H., Chow P.H., Cheng S.K., Cheung A., Cheng L.Y.L. and O W.S., Male genital tract antioxidant enzymes: their source, funciton in the female, and ability to preserve sperm DNA integrity in the golden hamster, Journal of Andrology. 2003, 24 No. 5: 704-711. |
| Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181(2): 339-345. |
| Chow P., Chan O., Ferguson-Smith A. and O W.S., Deletion of paternal ventral prostate gland leads to aberrant methylation of embryonic genome in the golden hamster, Experimental Biology 2004. Abstract no. 65.6. |
| Tse J.Y.M., Wong E.Y.M., Cheung A.N.Y., O W.S., Tam P.C. and Yeung W.S.B., Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility , Biology of Reproduction. 2003, 69: 746-751. |
| Researcher : Si H |
| List of Research Outputs |
| Cheung A., Si H., Tsao G.S.W., An J.Y., Wang L.D. and Poon C.S.P., Allelic loss in esophageal precancerous and cancerous lesions from a high risk area in China, Proceeding of the American Association for Cancer Research. 2004, 45: 173-174 No. 751. |
| Si H., HPV infection and genetic alterations in esophageal squamous cell carcinoma in the Chinese population. 2003, 1-215. |
| Si H., Tsao G.S.W., Poon S.P., Wang L.D., Wong Y.C. and Cheung A., Human papillomavirus (HPV) infection and allelic loss in esophageal squamous cell carcinoma, Proceedings of the American Association for Cancer Research, July 2003. 22 2nd Edition: 1025 No. R5146. |
| Researcher : So KF |
| Project Title: | The role of PKR/EiF2 -a pathway in the pathophysiology of glaucoma |
| Investigator(s): | Prof. So K.F., Prof. Hugon J. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 10/2002 |
| Completion Date: | 09/2003 |
| Abstract: |
| To evaluate the involvement of PKR/EiF2-a pathway in a rat ocular hypertension model; to study the inhibition of both PKR and GSK3b in protection of RGC death in a rat ocular hypertension model; to study the interaction of the PKR/EiF2-a and GSK3b pathways in a) the retina of normal and glaucomatous rats and b) the retina of normal and PKR knockout mice. |
| Project Title: | Molecular signaling of PKR/EiF2-a and GSK3b in the pathophysiology of glaucoma |
| Investigator(s): | Prof. So K.F., Dr. Chang R.C.C., Prof. Hugon J. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To further explore the roles of PKR-eIF2a in neuronal apoptosis of RGCs in experimental glaucoma; to study whether inhibition of PKR-eIF2a and GSK3b pathways affords neuroprotection of RGCs; to investigate how the influence of GSK3b on PKR-eIF2a pathways in the loss of RGCs. |
| Project Title: | The involvement of P13k/Akt pathway in the regulation of the caspases activity of axotomized retinal ganglion cells |
| Investigator(s): | Prof. So K.F. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To elucidate the molecular events contribution to the late onset of detectable axotomized RGC death by examining the kinetics of caspase activation, and the mechanisms implicated in the regulation of caspase activation. |
| List of Research Outputs |
| Chan S.Y.M., Yick L.W., So K.F., Oppenheim R.W. and Wu W., Early release of mitochondrial cytochrome c and the subsequent activation of caspase-3 are involved in the apoptotic death of neonatal motoneurons after injury, Hong Koong Medical Journal. 2003, 9 Supplement: 72. |
| Chang R.C.C., Ji J., Chiu K. and So K.F., Participation of microglia/macrophages prevents retinal ganglion cell-loss in rats with laser-induced chronic ocular hypertension, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 132 No. P13-28. |
| Chang R.C.C., Suen K.C., Yu M.S., So K.F. and Hugon J., Upstream signaling of PKR in beta-amyloid peptide neurotoxicity, Society for Neuroscience. 2003, Program Number 210.16. |
| Chen B., Tay D.K.C., Diao Y., Xiao Y., Yu E. and So K.F., Expression of nicotinamide adenine dinucleotide phosphate-diaphorase positive neurons in the developing retina of the golden hamster without normal light stimulations, The 4th Congress of Asian-Oceanic Glaucoma Society, Hong Kong, October 1-4, 2003. 181 no. P-B-6. |
| Cheung Z.H.Y., Chan S.Y.M., Siu F.K.W., Yip H.K.F., Wu W., Leung M.C.P. and So K.F., Regulation of caspase activation in axotomized retinal ganglion cells, Molecular and Cellular Neuroscience. 2004, 25: 383-393. |
| Cui Q., Cho K.S., So K.F. and Yip H.K.F., Synergistic effect of nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systems, Journal of Neurotrauma. 2004, 21 no. 5: 617-625. |
| Ji J., Elyaman W., Yip H.K.F., Lee V.W.H., Yick L.W., Hugon J. and So K.F., CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway, European Journal of Neuroscience. 2004, 19: 265-272. |
| Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Hong Kong Society of Neuroscience Annual Meeting Abstract. 2003. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Differential expression of glutamate decarboxylase isoforms in the horizontal cells of human and rat retinas, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Expression of glutamate decarboxylase isoforms in human and rat retinas, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Program No. A-02. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Li F., Yang W.K. and Yip H.K.F., F1k-1, a receptor for vascular endothelial growth factor, is expressed in the neural cells of developmental human retinas, USA Society of Neuroscience Annual Meeting Abstract. 2003. |
| Li Y., You S., So K.F., Tong Y. and Ju G., Progress in restoration of injured optic nerve, Chinese Journal of Ophthalmology. 2004, 40(2): 141-144. |
| Lin K.F., Chang R.C.C., Suen K.C., So K.F. and Hugon J., Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity, European Journal of Neuroscience. 2004, 19: 2047-2055. |
| Lin K.F., Suen K.C., Hugon J., So K.F. and Chang R.C.C., Roles of calcium/calmodulin kinase-II attenuates beta-amyloid peptide-mediated neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Liu Y., Bula D., So K.F., Arroyo J.G. and Chen D.H., Prevention of photoreceptor cell degeneration following retinal detachment in BAX-deficient mice, Society for Neuroscience. 2003, Program Number 335.9. |
| Lu Q., Cui Q., Yip H.K.F. and So K.F., c-Jun expression in surviving and regenerating retinal ganglion cells: effects of intravitreal neurotrophic supply, Investigative Ophthalmology & Visual Science. 2003, 44 No. 12: 5342-5348. |
| Mok K.H., Lee V.W.H. and So K.F., Increasing scans per examination improves the reproducibility on retinal nerve fiber layer measurements by optical coherence tomography, Optometry and Vision Science. 2004, 81 no. 4: 267-270. |
| Mok K.H., Lee V.W.H. and So K.F., Pattern loss of retinal nerve fiber with glaucoma progression, The 4th Congress of Asian-Oceanic Glaucoma Society, Hong Kong, October 1-4, 2003. 202 no. P-G-17. |
| Mok K.H., Lee V.W.H. and So K.F., Retinal nerve fiber loss in high- and normal-tension glaucoma by optical coherence tomography, Optometry and Vision Science. 2004, 81 no. 5: 369-372. |
| So K.F., Ciliary neurotrophic factor and optic nerve regeneration, Journal of Neurochemistry. 2004, 88 (Suppl. 1): 13 No. S10-4. |
| So K.F., Ciliary neurotrophic factor promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway, The 4th Congress of Asian-Oceanic Glaucoma Society, Hong Kong, October 1-4, 2003. 112. |
| So K.F., Learning from a rat glaucoma model, international Symposium of Ophthalmology and Visual Science, Beijing, China. 2004, 109-110 no. 040. |
| So K.F., Neuroprotection of retinal ganglion cells in an animal glaucoma model: molecular and ERG studies, The 9th China Symposium of Clinical Visual Physiology, Chengdu, Sichuan, China, June 11-14, 2004. 18. |
| So K.F., Optic nerve regeneration, International symposium of Ophthalmology and Visual Science, Beijing, China. 2004, 100-101 no. 030. |
| So K.F., Regeneration strategies to promote repair of the injured optic nerve, The 3rd Symposium on Neuroscience of Young Scholars Worldwide, Guangzhou, China, June 11-16, 2004. 12-13. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Activation of the PKR-eIF2a pathway is mediated by caspase-3 activation, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Involvement of PKR in mediating the activation of caspases in b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-18. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., PERK might not be involved in b-amyloid peptide-induced and endoplasmic reticulum stress in neurons, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-19. |
| Suen K.C., Lin K.F., Hugon J., So K.F. and Chang R.C.C., Reducing calcium-mediated endoplasmic reticulum stress could attenuate beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S19. |
| Suen K.C., Lin K.F., Elyaman W., So K.F., Chang R.C.C. and Hugon J., Reduction of calcium release from the endoplasmic reticulum could not provide partial neuroprotection against beta-amyloid peptide toxicity, Journal of Neurochemistry. 2003, 87: 1413-1426. |
| Suen K.C., Hugon J., So K.F. and Chang R.C.C., Reduction of intracellular calcium increase provides partial protection against b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-20. |
| Suen K.C., Yu M.S., So K.F., Chang R.C.C. and Hugon J., Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in b-amyloid peptide neurotoxicity, The Journal of Biological Chemistry. 2003, 278 No. 50: 49819-49827. |
| Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the effect of chondroitinase ABC on promoting axonal regeneration of rubrospinal neurons after spinal cord injury, Society for Neuroscience. 2003, Program Number 275.1. |
| Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the effect of chondroitinase ABC on promoting axonal regeneration of rubrospinal neurons after spinal cord injury, The 33 Annual Meeting Of Society For Neuroscience, New Orlean, FL., U.S.A. November 2003. Program No. 275.1. |
| Yip H.K.F., Li S., Shu S., Bao X., So K.F., Lui Kau K.W.F. and Yang W., Neuronal nitric oxide expresses in the retinal ganglion cells and endothelial nitric oxide synthase in the retinal neurons in the developing human retinas, Association for Research in Vision and Ophthalmology Annual Meeting Abstract. 2003. |
| You S., Tay D.K.C., Yip H.K.F. and So K.F., Effects of MK-801 and L-NA on the survival and regeneration of axotomized retinal ganglion cells in adult hamsters, Acta Anatomica Sinica. 2003, 34 No. 5: 453-457. |
| You S. and So K.F., Exploration on the promotion of neuro-regeneration after central nervous system injury, China Prescription Drug. 2004, 2 no.23: 30-33. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Absence of endoplasmic reticulum stress in early apoptosis in beta-amyloid peptide neurotoxicity, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, No. A-05. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Lack of early activation of endoplasmic reticulum stress in beta-amyloid neurotoxicity, Journal of Neurochemistry. 2004, 88 Suppl. 1: 52 No. P21-16. |
| Yu M.S., Yuen W.H., So K.F. and Chang R.C.C., Neuroprotective effects of extracts from anti-aging chinese medicine Lycium Barbarum (Gou-Qi-Zi), Journal of Neurochemistry. 2004, 88 Suppl. 1: 69 No.P26-21. |
| Yu M.S., Lin K.F., Fang J., Yuen W.H., So K.F. and Chang R.C.C., Potential significance of polysaccharides from nerium indicum in neuroprotection, Society for Neuroscience. 2003, Program Number 98.5. |
| Yuan Q., Xie Y., So K.F. and Wu W., Inflammatory response associated with axonal injury to spinal motoneurons in newborn rats, Developmental Neuroscience. 2003, 25: 72-78. |
| Yuan Q.J., So K.F. and Wu W., Lesion-induced expression of nestin in supraoptic and paraventricular nuclei in developing and adult rats following hypothysectomy, Society for Neuroscience. 2003, Program Number 355.12. |
| Yuan Q.J., So K.F. and Wu W., Lesion-induced expression of nestin in supraoptic and paraventricular nuclei in developing and adult rats following hypothysectomy, The 33 annual Meeting of Society for Neuroscience, New Orlean, FL., U.S.A., November 2003. Program No. 255.12. |
| Yuan Q.J., Wu W. and So K.F., The role of nitric oxide on regeneration of paraventricular nucleus and supraoptic nucleus following hypophysectomy, Hong Kong Medical Journal. 2003, 9 Supplement: 84. |
| Researcher : Suen KC |
| List of Research Outputs |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in beta-amyloid peptide (Ab)-induced neuronal death, Journal of Neurochemistry. 2004, 88 Suppl. 1: 20 No. C7-4. |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in neuronal death, Proceeding of 2nd Frontiers in Medical Sciences. 2003, 69. |
| Chang R.C.C., Suen K.C., Yu M.S., So K.F. and Hugon J., Upstream signaling of PKR in beta-amyloid peptide neurotoxicity, Society for Neuroscience. 2003, Program Number 210.16. |
| Lin K.F., Chang R.C.C., Suen K.C., So K.F. and Hugon J., Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity, European Journal of Neuroscience. 2004, 19: 2047-2055. |
| Lin K.F., Suen K.C., Hugon J., So K.F. and Chang R.C.C., Roles of calcium/calmodulin kinase-II attenuates beta-amyloid peptide-mediated neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Activation of the PKR-eIF2a pathway is mediated by caspase-3 activation, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Involvement of PKR in mediating the activation of caspases in b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-18. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., PERK might not be involved in b-amyloid peptide-induced and endoplasmic reticulum stress in neurons, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-19. |
| Suen K.C., Lin K.F., Hugon J., So K.F. and Chang R.C.C., Reducing calcium-mediated endoplasmic reticulum stress could attenuate beta-amyloid peptide neurotoxicity, Neuroscience Letters. 2003, 349 Supplement 1: S19. |
| Suen K.C., Lin K.F., Elyaman W., So K.F., Chang R.C.C. and Hugon J., Reduction of calcium release from the endoplasmic reticulum could not provide partial neuroprotection against beta-amyloid peptide toxicity, Journal of Neurochemistry. 2003, 87: 1413-1426. |
| Suen K.C., Hugon J., So K.F. and Chang R.C.C., Reduction of intracellular calcium increase provides partial protection against b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-20. |
| Suen K.C., Yu M.S., So K.F., Chang R.C.C. and Hugon J., Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in b-amyloid peptide neurotoxicity, The Journal of Biological Chemistry. 2003, 278 No. 50: 49819-49827. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Absence of endoplasmic reticulum stress in early apoptosis in beta-amyloid peptide neurotoxicity, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, No. A-05. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Lack of early activation of endoplasmic reticulum stress in beta-amyloid neurotoxicity, Journal of Neurochemistry. 2004, 88 Suppl. 1: 52 No. P21-16. |
| Researcher : Tay DKC |
| Project Title: | Neurotrophic factors affect axonal regeneration of injured retinocollicular projections in hamsters |
| Investigator(s): | Dr. Tay D.K.C., Prof. So K.F., Dr. Tan M.M.L., Dr. Yip H.K.F. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2001 |
| Abstract: |
| To examine the effect of neurotrophic factors on retinal ganglion cell (RGC) axon regrowth and target re-innervation after distal axotomy in the adult central nervous system (CNS); to determine the efficacy of SC brachial transection in adult hamsters and the relative important of collateral connections on the survival of RGCs following brachial transection; to determine the effect of perineuronal neurotropic factor application on retinocollicular axon regrowth and the target SC re-innervation after brachial lesions; to determine the combined effect of perineuronal neurotropic factor application and denaturation of putative inhibitory molecules on the extent of post-lesion retinocollicular axon growth and target SC re-innervation; to determine whether target SC re-innervation is associated with re-expression of axon-target guidance molecules; to determine whether re-innervation of the target SC can be related to behavioural recovery. |
| Project Title: | The application of self-assembled peptide scaffolds to faciliate axonal regeneration in adult mammalian brain |
| Investigator(s): | Dr. Tay D.K.C. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 01/2003 |
| Completion Date: | 12/2003 |
| Abstract: |
| To assess the application of self-assembled peptide scaffolds (SAPS) at the lesion site for axonal regeneration and to compare it with the implantation of peripheral nerve graft (PNG) following transection of the retinal fibres at the brachium of the superior colliculus. |
| Project Title: | The role of NADPH-d in the amacrine cells of early postnatal and adult hamsters |
| Investigator(s): | Dr. Tay D.K.C. |
| Department: | Anatomy |
| Source(s) of Funding: | Leung Kau Kui Research and Teaching Endowment Fund |
| Start Date: | 11/2003 |
| Abstract: |
| To test the hypothesis that NADPH-d is necessary to mediate visual signals in hamsters and to further investigate the role of NADPH-d in maintaining visual function in adult hamsters. |
| List of Research Outputs |
| Chen B., Tay D.K.C., Diao Y., Xiao Y., Yu E. and So K.F., Expression of nicotinamide adenine dinucleotide phosphate-diaphorase positive neurons in the developing retina of the golden hamster without normal light stimulations, The 4th Congress of Asian-Oceanic Glaucoma Society, Hong Kong, October 1-4, 2003. 181 no. P-B-6. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Differential expression of glutamate decarboxylase isoforms in the horizontal cells of human and rat retinas, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Expression of glutamate decarboxylase isoforms in human and rat retinas, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Program No. A-02. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Li F., Yang W.K. and Yip H.K.F., F1k-1, a receptor for vascular endothelial growth factor, is expressed in the neural cells of developmental human retinas, USA Society of Neuroscience Annual Meeting Abstract. 2003. |
| Peng Y., Yang P., Guo Y., Ng S.M., Liu J., Fung P.C.W., Tay D.K.C., Ge J., He M.L., Kung H. and Lin M.C., Catalase and peroxiredoxin 5 protect xenopus embryos against alcohol-induced ocular anomalies, Investigative Ophthalmology & Visual Science. 2004, 45 No. 1: 23-29. |
| Yip H.K.F., Li S., Tay D.K.C., Shu Y., Bao X.M., Lui Kau K.W.F., Li F. and Yang W.K., Expression of nitric oxide synthases in the developing human retinas, 6th IBRO World Congress of Neuroscience. 2003. |
| You S., Tay D.K.C., Yip H.K.F. and So K.F., Effects of MK-801 and L-NA on the survival and regeneration of axotomized retinal ganglion cells in adult hamsters, Acta Anatomica Sinica. 2003, 34 No. 5: 453-457. |
| Researcher : Tipoe GL |
| Project Title: | The role of nitric oxide in acute and chronic liver injury |
| Investigator(s): | Dr. Tipoe G.L., Dr. Fung M.L. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To establish the underlying role of NO in acute and chronic liver injury. |
| Project Title: | The functional role of hypoxic inducible factor (HIF)-1 a in chronic liver hypoxia |
| Investigator(s): | Dr. Tipoe G.L., Dr. Fung M.L. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To evaluate whether necroinflammatory changes and oxidative stress exist in chronic liver hypoxia; to determine the hepatic expression of HIF-1a; to assess the expression of downstream genes which carry HRE and regulate vascular and metabolic responses such as iNOS, VEGF, eNOS, ET-1 and glucose transporters (Glut-1, 2 and 3) respectively; to determine the role of other nuclear transcription factors such as nuclear factor k B (NF-kB) and activator protein -1 (AP-1) in chronic liver hypoxia. |
| List of Research Outputs |
| Fung M.L., Tipoe G.L., Liong E.C. and Ip S.F., Alterations in systemic and pulmonary circulation in cyclooxygenase-1-deficient mice in chronic hypoxia, 205th Xiangshan Conference and The Third Symposium on Hypoxia Across Strait: Hypoxia & Health, Wuwei, PRC. 2003. |
| Fung M.L., Tipoe G.L., Liong E.C. and Ip S.F., Elevated systemic pressure and nitric oxide synthesis in cyclooxygenase-1-deficient mice in chronic hypoxia, The Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P11, 2003. Journal of the Hong Kong College of Cardiology, 11(Suppl. 1):A21. 2003. |
| Fung M.L., Tipoe G.L., Tjong Y.W., Chen Y., Ye J.S. and Liong E.C., Molecular regulation and functions of vasoactive factors in the carotid body during chronic hypoxia, The Fourth Symposium on Cardiovascular Science Across Strait, Taipei, Taiwan . 2003. |
| Fung M.L. and Tipoe G.L., Role of HIF-1 in physiological adaptation of the carotid body during chronic hypoxia, In: Jean-Marc Pequignot, Constancio Gonzalez, Colin A. Nurse, Nanduri R. Prabhakar, Yvette Dalmaz, Advances in Experimental Medicine & Biology: Chemoreception. New York, Kluwer Academic/Plenum Publishers, 2003, 536: 593-601. |
| Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341. |
| Ho M.C.T., Lau T.Y.H., Jin Y., Lu H.B., Liong E.C., Leung K.M. and Tipoe G.L., Overexpression of iNOS and down-regulation of BMPs-2, 4 and 7 in retinoic acid induced cleft palate formation, Histology and Histopathology. 2004, 19: 95-104. |
| Lau T.Y.H., Fung M.L., Tom W.M., Nanji A.A. and Tipoe G.L., Hypoxia-inducible factor-1 (HIF-1) in hepatic adaptation to chronic hypoxia, 8th Research Postgraduate Symposium, HKU. 2003. |
| Leung W.C.H., Ooi C.G.C., Mak J.C.W., Leung Y.H., Leung K.M., Lam W.K., Tsang K.W.T. and Tipoe G.L., Animal model of bronchiectasis, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: A-06. |
| Nanji A.A., Jokelainen K., Tipoe G.L., Rahemtulla A., Thomas P. and Dannenberg A.J., Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kB-dependent genes, American Journal of Physiology: GI and Liver Physiology. 2003, 284: G321-G327. |
| Su G.L., Wang S.C., Aminlari A., Tipoe G.L., Steinstraesser L. and Nanji A., Impaired hepatocyte regeneration in toll-like receptor 4 mutant mice., Digestive Diseases and Sciences. 2004, 49(5): 843-849. |
| Tipoe G.L. and Fung M.L., Expression of HIF-1 alpha, VEGF and VEGF receptors in the carotid body of chronically hypoxic rat, Respiratory Physiology and Neurobiology. 2003, 138: 143-154. |
| Tipoe G.L., Leung T.M., Liong E.C., So H., Leung K.M., Tom W.M., Fan S.T. and Nanji A.A., Nitric oxide in an acute liver injury model (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004. |
| Tipoe G.L., Lau Y.H., Fung M.L., Liong E. and Nanji A.A., Vascular adaptive response in chronic liver hypoxia, Hong Kong – Shanghai International Liver Congress. 2004, ABS00102: P85. |
| Tjong Y.W., Chen Y., Liong E.C., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis, Journal of Pineal Research. 2004, 36: 49-57. |
| Tsang K.W.T. and Tipoe G.L., Bronchiectasis: not an orphan disease in the East, Internatiional Journal of Tuberculosis and Lung Disease. 2004, 8(6): 691-702. |
| Tsang K.W.T. and Tipoe G.L., Bronchiectasis: not an orphan disease in the East, International Journal of Tuberculosis and Lung Disease. 2004, Jun; 8(6): 691-702. |
| Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199. |
| Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200. |
| Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P559. |
| Tsang K.W.T., Ho P.L., Tan K.C., Ooi C.G.C., Ho J.C.M., Tipoe G.L., Lam W.K. and Chan M.M.W., Efficacy of 12-month treatment with inhaled corticosteroid in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P3213. |
| Tsang K.W.T., Tipoe G.L., Sun J.Z., Leung Y.H., Ho P.L., Yuen K.Y., Mak J.C.W. and Lam W.K., Helicobacter pylori exotoxin disrupts ciliary beating and ultrastructure of human airway mucosa, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-22: p.201. |
| Wong M.P., Tipoe G.L., Sun J.Z., Mak J.C.W., Ooi C.G.C., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Clinical significance of ciliary abnormalities in bronchiectasis, Annual Scientific Meeting, Hong Kong Thoracic Society & American College of Chest Physicians, 2003. Abstract pp.30. |
| Researcher : Tsao GSW |
| Project Title: | Functional studies of the prevalent LMP1 variant associated with nasopharyngeal carcinoma of Hong Kong |
| Investigator(s): | Prof. Tsao G.S.W., Dr. Huang D.W.S.P., Prof. Young L.S. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2002 |
| Abstract: |
| The project attempts to examine:- i) the functional difference between the prevalent LMP1 variants isolated from NPC patients and healthy subjects; ii) the functional significance of the unique substitution of codon 335 in the prevalent LMP1 isolated from NPC patients in Hong Kong; and iii) if the transmission domain of the HK-LMP1 variants may have different ability in cell signaling. |
| Project Title: | Malignant transformation of normal esophageal epithelial cells by defined genetic elements |
| Investigator(s): | Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2002 |
| Abstract: |
| To define the genetic alterations required for malignant transformation of human esophageal epithelial cells. |
| Project Title: | Functional analysis of expression of EBV encoded RNAs (EBERs) in nasopharyngeal epithelial cells |
| Investigator(s): | Prof. Tsao G.S.W., Dr. Chang R.C.C., Dr. Huang D.W.S.P. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2003 |
| Abstract: |
| To determine if expression of high level of EBER would alter the growth properties of nasopharyngeal epithelial cells; to examine alterations of gene expression profile in nasopharyngeal epithelial cells after expression of EBER; to examine if EBER expression may enhance the transformation properties of the EBV encoded oncogene-LMP1 in nasopharyngeal epithelial cells; to examine if EBER expression may induced resistance to TNFa induced apoptosis in nasopharyngeal epithelial cells. |
| Project Title: | Functional analysis of expression of EBV encoded RNAs (EBERs) in nasopharyngeal epithelial cells |
| Investigator(s): | Prof. Tsao G.S.W., Dr. Chang R.C.C., Dr. Huang D.W.S.P. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 09/2003 |
| Abstract: |
| To determine if expression of high level of EBER would alter the growth properties of nasopharyngeal epithelial cells; to examine alterations of gene expression profile in nasopharyngeal epithelial cells after expression of EBER; to examine if EBER expression may enhance the transformation properties of the EBV encoded oncogene-LMP1 in nasopharyngeal epithelial cells; to examine if EBER expression may induced resistance to TNFa induced apoptosis in nasopharyngeal epithelial cells. |
| Project Title: | Mechanism of induction of Id1 expression by the EBV encoded LMP1 in nasopharyngeal epithelia cells |
| Investigator(s): | Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To examine the cell signalling mechanism involved in the induction of ID1 expression by LMP1 and its functional significance. |
| List of Research Outputs |
| Cheung A., Si H., Tsao G.S.W., An J.Y., Wang L.D. and Poon C.S.P., Allelic loss in esophageal precancerous and cancerous lesions from a high risk area in China, Proceeding of the American Association for Cancer Research. 2004, 45: 173-174 No. 751. |
| Cheung A.N.Y., Khoo U.S., Lai C.Y.L., Chan Y.K., Xue W., Cheng D.K.L., Chiu P.M., Tsao G.S.W. and Ngan H.Y.S., Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis, Cancer. 2004, 100(7): 1411-1417. |
| Cheung A.N.Y., Xue W., Chan D.Y., Feng H., Chiu P.M., Tsao G.S.W. and Ngan H.Y.S., Promoter hypermethylation of multiple genes in hydatiform mole choriocarcinoma, Proceedings of the American Association for Cancer Research. 2004, 45: 1149 Abstract No. 4974. |
| Cheung H.W., Ling M.T., Tsao G.S.W., Wong Y.C. and Wang X., Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal cacinoma cells, Carcinogenesis. 2004, 25 no. 5: 881-887. |
| Deng W., Tsao G.S.W., Guan X.Y. and Cheung A., The significance of dynamic dysfunction of critically short telomeres in directing the evolution of chromosomal structural instability in human cells undergoing immortalization, Proceedings of the American Association for Cancer Research. 2004, 45: 613-614 No. 2658. |
| Feng H., Xue W., Cheung A.N.Y., Wang Y.L. and Tsao G.S.W., Differentially expressed genes between ormal placenta and choriocarcinoma, Proceedings of the American Society for Cell Biology, 43rd Annual Meeting. 2003, Abstract No. 2774. |
| Feng H., Cheung A.N.Y., Xue W., Wang Y., Wang X., Fu S., Wang Q., Ngan H.Y.S. and Tsao G.S.W., Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma, Gynecologic Oncology. 2004, 94: 375-382. |
| Jin Y., Zhang H., Tsao G.S.W., Jin C., Lv M., Strombeck B., Wiegant J., Wan T.S.K., Yuen P.W. and Kwong Y.L., Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20, Gynecologic Oncology. 2004, 92: 183-191. |
| Lai C.Y.L., Chan Y.K., Khoo U.S., Ngan H.Y.S., Xue W., Chiu P.M., Tsao G.S.W. and Cheung A.N.Y., Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization, Modern Pathology. 2004, 17: 40-48. |
| Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Hong Kong Society of Neuroscience Annual Meeting Abstract. 2003. |
| Lau W.M., Li S., Tsao G.S.W., Wong A.O.L. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in goldfish (Carassius auratus) retina, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Lau W.M., Tsao G.S.W., Wong A.O.L. and Yip H.K.F., Induction of retinal telomerase activity during optic nerve regeneration after optic nerve cut, Journal of Neurochemistry. 2003, 87(S1): 144-151. |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Li H.M. and Tsao G.S.W., Imortalization of normal human nasopharyngeal epithelial cells, Proceedings of The American Society for cell Biology, 43rd Annual Meeting. 2003, Abstract No. 2774. |
| Li Y.R., Wang L.D., Guan X.Y., Tsao G.S.W., Sham J.S.T., Fan Z., Yang C.S., Zheng S. and Kwong D.L.W., Comparative genomic hybridization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from Linzhou, Henan, a high-incidenc area of esophageal cancer, Proceedings of the American Association for Cancer Research. 2003, 44: 897 no. 4520. |
| Ling M.T., Wang X., Lee D.T.W., Tam P.C., Tsao G.S.W. and Wong Y.C., Id-1 expression induces androgen-independent prostate cancer call growth through activation of epidermal growth factor receptor (EGF-R), Carcinogenesis. 2004, 25 No. 4: 517-525. |
| Lo K.F., Liu Y., Huang D.P., Lo K.W., Wong Y.C. and Tsao G.S.W., Alterations of biological properties and gene expression in nasopharyngeal epithelial cells by Epstein-Barr virus encoded latent membrane protein 1, Proceedings of the American Association for Cancer Research. 2003, 44: 1183. |
| Lo K.F., Huang D.P., Lo K.W., Chui Y.L., Li H.M., Pang J.C.S. and Tsao G.S.W., phenotypic alterations induced by the Hong Kong-prevalent epstein-barr virus-encoded LMP1 variant (2117-LMP1) in hasopharyngeal epithelial cells, International Journal of Cancer. 2004, 109: 919-925. |
| Pang R.T.K., Poon T.C.W., Chan C.M.L., Tsao G.S.W., Huang D.P. and Chan A.T.C., Comparative proteomic study of an immortalized normal nasopharyngeal epithelial cell and an Esptein-Barr virus positive nasopharyngeal cell line using isotope-coded affinity tags and mass spectrometry, Proceedings of the American Association for Cancer Research. 2003, 44 2nd Edition: 1261-1262 No. 6319. |
| Qiu G.H., Tan L.K., Loh K.S., Lim C.Y., Srivastava G., Tsai S.T., Tsao G.S.W. and Tao Q., The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma, Oncogene. 2004, 1-14. |
| Shen Z.Y., Xu L.Y., Li E.M., Cai W.J., Shen J., Chen M.H., Cen S., Tsao G.S.W. and Zeng Y., The multistage process of carcinogenesis in human esophageal epithelial induced by human papillomavirus, Oncology Reports. 2004, 11(3): 647-654. |
| Si H., Tsao G.S.W., Poon S.P., Wang L.D., Wong Y.C. and Cheung A., Human papillomavirus (HPV) infection and allelic loss in esophageal squamous cell carcinoma, Proceedings of the American Association for Cancer Research, July 2003. 22 2nd Edition: 1025 No. R5146. |
| Tsao G.S.W., Lo K.F., Liu Y. and Li H.M., Functional study of LMP1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2003, 44 2nd Edition: 993 no. 4978. |
| Tsao G.S.W., Li H.M., Wang X. and Wong Y.C., Functional study of expression of the Epstein Barr virus encoded LMP1 protein in nasopharyngeal epithelial cells, Hong Kong Medical Journal. 2003, 9: 17. |
| Tsao G.S.W., Li H.M., Man C.W.Y., Yip Y.L., Young L.S. and Huang D.P., The role of immortalizatiion and transformation of nasopharyngeal epithelials, Proceedings of EBV Symposium 2004. 124. |
| Wang Q., Tsao G.S.W., Fu S.B., Xue W.C., Meng X.N., Feng H., Wong Y.C. and Wang X., Overexpression of Id1 in gastric adenocarcinoma:Implication for a novel diagnostic marker, Anticancer Research. 2004, 24: 881-886. |
| Wang X., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Oncogene. 2004, 23: 474-482. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Proceedings of the American Association for Cancer Research. 2004, 45: 142. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, abHLH protein, in the development of acquired taxol resistance in human cancer cells, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-04. |
| Wang X., Tsao G.S.W., Wong Y.C. and Cheung A., Induction of senescent-like growth arrest as a new target in anticancer treatment, Current Cancer Drug Targets. 2003, 3: 153-160. |
| Wang X., Jin D.Y., Wong Y.C., Cheung A., Chun A.S.C., Lo K.F., Liu Y. and Tsao G.S.W., Significance of MAD2 expression in mitotic checkpoint control and cellular sensitivity in nasopharyngeal carcinoma cells, Hong Kong Medical Journal. 2003, 9: 57. |
| Wong H.I., Chang R.C.C., Wang X., Feng H., Li H.M., Wong Y.C. and Tsao G.S.W., Functional study of EBV encoded RNA in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Wong T.S., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Wei W.I., Kwong Y.L. and Yuen P.W., Promoter Hypermethylation Of High-in-normal 1 Gene In Primary Nasopharyngeal Carcinoma, Clinical Cancer Research. 2003, 9: 3042-3046. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth, Proceedings of the American Association for Cancer Research. 2003, 44: 290-291. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Id1 expression induces androgen independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R), Proceedings of the American Association for Cancer Research. 2004, 45: 1032. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Id1 expression induces androgen independent prostate cancer cell growth, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-03. |
| Woo M.F., Ling M.T., Wang X. and Tsao G.S.W., Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer growth, Hong Kong Medical Journal. 2003, 9: 57. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines, Chinese Medical Journal. 2003, 116: 1673-1677. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., The a1-adrenoceptor anatagonist terazosin induces prostate cancer cell death through a p53 and Rb independent pathway, Oncology Reports. 2003, 10: 1555-1560. |
| Xue W., Feng H., Tsao G.S.W., Chan Y.K., Ngan H.Y.S., Chiu P.M., Maccalman C.D. and Cheung A.N.Y., Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases, International Journal of Gynecological Cancer. 2003, 13(6): 879-888. |
| Xue W., Khoo U.S., Ngan H.Y.S., Chan Y.K., Chiu P.M., Tsao G.S.W. and Cheung A.N.Y., Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: correlation with Ki67, PCNA and clinicopathological parameters, Histopathology. 2003, 43: 485-490. |
| Xue W., Khoo U.S., Ngan H.Y.S., Chan Y.K., Ip P.P.C., Tsao G.S.W. and Cheung A.N.Y., c-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions, International Journal of Gynecological Pathology. 2004, 23(2): 145-150. |
| Zhang H., Tsao G.S.W., Jin C., Stromback B., Yuen P.W., Kwong Y.L. and Jin Y., Sequential Cytogenetic and Molecular Cytogenetic Characterization of an SV40T Immortalized Nasopharyngeal Cell Line transformed by Epstein-Barr virus latent membrane protein-1 gene, Cancer Genetics and Cytogenetics . 2004, 150: 144-52. |
| Zhuang Z., Wang L.D., Tsao G.S.W., Cheung A., Feng H., Yang T., Qin Y.R., Wang C.D., Chen Z.Z. and Liu B., Cyclooxygenase-2 expression in esophageal cancer cells and induction by mitomycin C (in Chinese), Zhonghua Nei Ke Za Zhi. 2003, 42(10): 701-704. |
| Researcher : Wang Q |
| List of Research Outputs |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Wang Q., Tsao G.S.W., Fu S.B., Xue W.C., Meng X.N., Feng H., Wong Y.C. and Wang X., Overexpression of Id1 in gastric adenocarcinoma:Implication for a novel diagnostic marker, Anticancer Research. 2004, 24: 881-886. |
| Researcher : Wang X |
| Project Title: | Significance of Twist gene expression to chemodrug resistance in nasopharyngeal carcinoma cells |
| Investigator(s): | Dr. Wang X.H., Prof. Tsao G.S.W., Prof. Wong Y.C. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 01/2003 |
| Completion Date: | 12/2003 |
| Abstract: |
| To confirm that Twist is responsible for cellular resistance to taxol in HNE1-T3 cells; to determine Twist expression in additional NPC cell lines and examine its association with taxol resistance; to investigate if Twist expression is specific to taxol resistance by testing additional anticancer drugs on HNE1-T3 cells. |
| Project Title: | Downregulation of MAD2 expression and its significance in chemodrug sensitization in nasopharyngeal carcinoma cells |
| Investigator(s): | Dr. Wang X.H., Dr. Jin D.Y., Dr. Nicholls J.M., Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2003 |
| Abstract: |
| To confirm that MAD2 expression is downregulated in clinical samples of NPC; to determine the mechanism by which MAD2 is downregulated in NPC; to establish whether upregulation of MAD2 expression can sensitize NPC cells to chemotherapy. |
| Project Title: | Downregulation of MAD2 expression and its significance in chemodrug sensitization in nasopharyngeal carcinoma cells |
| Investigator(s): | Dr. Wang X.H., Dr. Jin D.Y., Dr. Nicholls J.M., Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 09/2003 |
| Abstract: |
| To confirm that MAD2 expression is downregulated in clinical samples of NPC; to determine the mechanism by which MAD2 is downregulated in NPC; to establish whether upregulation of MAD2 expression can sensitize NPC cells to chemotherapy. |
| Project Title: | The role fo MAD2 in overcoming cisplatin resistance in testicular germ cell tumors |
| Investigator(s): | Dr. Wang X.H., Dr. Jin D.Y. |
| Department: | Anatomy |
| Source(s) of Funding: | Lance Armstrong Foundation |
| Start Date: | 10/2003 |
| Abstract: |
| To investigate the association between decreased MAD2 protein expression and cisplatin resistance in TGCT cells; to study if exogenous expression of the MAD2 gene in TGCT cells can lead to chemosensitization to cisplatin in TGCT cells; to demonstrate that downregulation of MAD2 results in resistance ot cisplatin in TGCT cells; to characterize the role of MAD2 in cisplatin-induced cell death inTGCT cells; to identify binding partners of MAD2 in response to cisplatin-induced DNA damage. |
| Project Title: | The role of Id-1 in chemodrug resistance in nasopharyngeal carcinoma cells |
| Investigator(s): | Dr. Wang X.H., Prof. Wong Y.C. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 02/2004 |
| Abstract: |
| To study if ectopic Id-1 expression could lead to resistance to chemodrugs, 5-FU, taxol and cisplatin; to examine if the protective role of Id-1 is through inhibition of chemodrug-induced apoptosis; to investigate if MAPK and NFkB pathways are involved in the Id-1 induced chemo-protection in NPC cells. |
| List of Research Outputs |
| Cheung H.W., Ling M.T., Tsao G.S.W., Wong Y.C. and Wang X., Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal cacinoma cells, Carcinogenesis. 2004, 25 no. 5: 881-887. |
| Feng H., Cheung A.N.Y., Xue W., Wang Y., Wang X., Fu S., Wang Q., Ngan H.Y.S. and Tsao G.S.W., Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma, Gynecologic Oncology. 2004, 94: 375-382. |
| Lee K.W., Man K., Ling M.T., Wang X., Wong Y.C., Lo C.M., Poon R.T.P., Ng I.O.L. and Fan S.T., Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway, Carcinogenesis. 2003, 24(11): 1729-1736. |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Ling M.T., Wang X., Lee D.T.W., Tam P.C., Tsao G.S.W. and Wong Y.C., Id-1 expression induces androgen-independent prostate cancer call growth through activation of epidermal growth factor receptor (EGF-R), Carcinogenesis. 2004, 25 No. 4: 517-525. |
| Ling M.T., Wang X. and Wong Y.C., Id-1 expression promotes cell survival through activation of NF-kB signaling pathway in prostate cancer cells, proceedings of the American Asociation for Cancer Research. 2003, 44: 481. |
| Ling M.T., Wang X. and Wong Y.C., Id1 expression induces androen independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R), 10th Hong Kong International Cancer Congress, Hong Kong, November 19-21, 2003. P2.3. |
| Ling M.T., Wang X. and Wong Y.C., Id1 induced Raf/MEK pathway activation is essential for its protective role against apoptosis i nasopharyngeal carcinoma cells, Proceedings of the American Association for Cancer Research. 2004, 45: 20. |
| Tsao G.S.W., Li H.M., Wang X. and Wong Y.C., Functional study of expression of the Epstein Barr virus encoded LMP1 protein in nasopharyngeal epithelial cells, Hong Kong Medical Journal. 2003, 9: 17. |
| Wang Q., Tsao G.S.W., Fu S.B., Xue W.C., Meng X.N., Feng H., Wong Y.C. and Wang X., Overexpression of Id1 in gastric adenocarcinoma:Implication for a novel diagnostic marker, Anticancer Research. 2004, 24: 881-886. |
| Wang X., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Oncogene. 2004, 23: 474-482. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Proceedings of the American Association for Cancer Research. 2004, 45: 142. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, abHLH protein, in the development of acquired taxol resistance in human cancer cells, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-04. |
| Wang X., Tsao G.S.W., Wong Y.C. and Cheung A., Induction of senescent-like growth arrest as a new target in anticancer treatment, Current Cancer Drug Targets. 2003, 3: 153-160. |
| Wang X., Jin D.Y., Wong Y.C., Cheung A., Chun A.S.C., Lo K.F., Liu Y. and Tsao G.S.W., Significance of MAD2 expression in mitotic checkpoint control and cellular sensitivity in nasopharyngeal carcinoma cells, Hong Kong Medical Journal. 2003, 9: 57. |
| Wong H.I., Chang R.C.C., Wang X., Feng H., Li H.M., Wong Y.C. and Tsao G.S.W., Functional study of EBV encoded RNA in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth, Proceedings of the American Association for Cancer Research. 2003, 44: 290-291. |
| Wong Y.C., Wang X. and Ling M.T., Id-1 expression and cell survival, Apoptosis. 2004, 9 No. 3: 279-289. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Id1 expression induces androgen independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R), Proceedings of the American Association for Cancer Research. 2004, 45: 1032. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Id1 expression induces androgen independent prostate cancer cell growth, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-03. |
| Wong Y.C., Ling M.T. and Wang X., Id1 is crucial factor regulating the development of prostate cancer, First Northern Lights Summer Conference: The Interface of Cancer and Development, Vancouver, June 16-20, 2004. |
| Wong Y.C., Wang X. and Ling M.T., Prostate development and carcinogenesis, International Review of Cytology. 2003, 227: 65-130. |
| Woo M.F., Ling M.T., Wang X. and Tsao G.S.W., Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer growth, Hong Kong Medical Journal. 2003, 9: 57. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines, Chinese Medical Journal. 2003, 116: 1673-1677. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., The a1-adrenoceptor anatagonist terazosin induces prostate cancer cell death through a p53 and Rb independent pathway, Oncology Reports. 2003, 10: 1555-1560. |
| Researcher : Wong BKH |
| List of Research Outputs |
| Mok K.H., Cheung R.W.L., Wong B.K.H., Yip K.K. and Lee V.W.H., Effectiveness of no-rub contact lens cleaning on protein removal: a pilot study, Optometry and Vision Science. 2004, 81 no. 6: 468-470. |
| Researcher : Wong HL |
| List of Research Outputs |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Researcher : Wong WM |
| List of Research Outputs |
| Xie Y., Yao Z., Chai H., Wong W.M. and Wu W., Expression and role of low-affinity nerve growth factor receptor (p75) in spinal motor neurons of aged rats following axonal injury, Developmental Neuroscience. 2003, 25: 65-71. |
| Researcher : Wong YC |
| Project Title: | Role of IGF-1 and VEGF in sex hormone induced prostate carcinogenesis |
| Investigator(s): | Prof. Wong Y.C., Dr. Cheung A.L.M., Dr. Sheng H.P. |
| Department: | Anatomy |
| Source(s) of Funding: | Medical Faculty Research Grant Fund |
| Start Date: | 11/1998 |
| Abstract: |
| To further examine the role of IGF-1 system and to confirm by in situ hybridization (ISH) the existence of mRNA for IGF-1 and its receptors in dysplastic and carcinoma cells; to establish the expression pattern of VEGF and its receptors during initiation, and progression to carcinoma and to establish whether an autocrine loop exists in this rat prostate cancer by ISH. |
| Project Title: | The role of androgens in breast carcinogenesis |
| Investigator(s): | Prof. Wong Y.C., Dr. Ke Y.Q., Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 10/2000 |
| Completion Date: | 09/2003 |
| Abstract: |
| To establish the mechanism of androgen actions by examining several factors involved in the cross talk between the epithelium and stroma during the process of mammary carcinogenesis; to further refine and characterize these factors at protein and mRNA levels; to examine changes in expression patterns of several oncogenes and tumour suppressor genes as well as the role of apoptosis in hormonal carcinogenesis; and finally to examine the genes affected during the early process of hormonal carcinogenesis. |
| Project Title: | The role of Id-1 gene in prostate carcinogenesis and its relationship to invasiveness of prostate cancer |
| Investigator(s): | Prof. Wong Y.C., Dr. Tam P.C., Prof. Tsao G.S.W. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 10/2001 |
| Abstract: |
| To compare the status of Id-1 in normal human prostate and prostate carcinoma using immunohistochemical and in situ hybridization approaches and to correlate the levels of expression of Id-1 to the histopathological phenotypes and its relationship to prognosis of prostate cancer; to examine the expression levls of Id-1 of normal prostate cell and several lines of prostate cancer cells (i.e. DU-145, PC-3 and LNCaP) in vitro and its regulation by serum and sex hormones; to examine the relationship of Id-1 expression to the invasiveness of prostate cancer by transfecting the Id-1 gene to cancer cell line (i.e. LNCap) or normal lines which are not constitutively expressing Id-1 protein. |
| Project Title: | Identification and evaluation of specific marker proteins for benign prostatic hyperplasia |
| Investigator(s): | Prof. Wong Y.C., Dr. Tam P.C. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2002 |
| Completion Date: | 10/2003 |
| Abstract: |
| To identify and characterize new specific proteins in expressed prostatic secretion of BPH by 2-D gel electrophoresis followed by mass spectrometry and mass sequencing; to examine the sources of these differentially expressed proteins including the iPSP94, 1wSPA and a-sl-casein and to evaluate the value of these proteins as a markers of GPH; to examine whether smilar markers are present in serum and to examine the potential of these proteins as markers for BPH. |
| Project Title: | The Beijing, Hong Kong and UK Collaborative Study on the Molecular Genetic Basis of Differential Susceptibility of Prostate Cancer Between Chinese and Caucasian |
| Investigator(s): | Prof. Wong Y.C., Prof. Foster C.S., Dr. Ho K.M.T., Dr. Ke Y.Q., Prof. Na Y.Q., Dr. Wang X.H., Dr. Xin D.Q. |
| Department: | Anatomy |
| Source(s) of Funding: | HKU Foundation Seed Grant |
| Start Date: | 07/2003 |
| Abstract: |
| To investigate molecular mechanisms responsible for racial differences in prostate cancer incidence. |
| Project Title: | Id-1 activation of NF-kB and its role in development of androgen-independent prostate cancer |
| Investigator(s): | Prof. Wong Y.C., Prof. Tsao G.S.W., Dr. Wang X.H. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2003 |
| Abstract: |
| To investigate the correlation between the over-expression of Id-1 and activation of NF-kB in prostate cancer progression; to examine the sensitivity of LNCaP-Id-1 clones towards TNF-a induced apoptosis; to explore the effect of inhibition of Id-1 expression by antisense Id-1 oligonucleotide on TNFa induced apoptosis; to study the role of Id-1 gene in development of AI prostate cancer in vivo; to investigate the effect of Id-1 gene silencing on growth of prostate cancer using RNA interference on human prostate cancer xenograft, CWR22. |
| Project Title: | Id-1 activation of NF-kB and its role in development of androgen-independent prostate cancer |
| Investigator(s): | Prof. Wong Y.C., Prof. Tsao G.S.W., Dr. Wang X.H. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 09/2003 |
| Abstract: |
| To investigate the correlation between the over-expression of Id-1 and activation of NF-kB in prostate cancer progression; to examine the sensitivity of LNCaP-Id-1 clones towards TNF-a induced apoptosis; to explore the effect of inhibition of Id-1 expression by antisense Id-1 oligonucleotide on TNFa induced apoptosis; to study the role of Id-1 gene in development of AI prostate cancer in vivo; to investigate the effect of Id-1 gene silencing on growth of prostate cancer using RNA interference on human prostate cancer xenograft, CWR22. |
| Project Title: | Identification and evaluation of specific marker proteins from secretions of benign prostatic hyperplasia (BPH) |
| Investigator(s): | Prof. Wong Y.C., Prof. Na Y.Q., Dr. Tam P.C., Dr. Wang X.H., Dr. Xin D.Q., Dr. Xu K.X. |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China |
| Start Date: | 12/2003 |
| Abstract: |
| To confirm and characterize these proteins in the secretion of BPH by 2-D gel electrophoresis followed by mass spectrometry and mass sequencing; to examine the sources of these differetially expressed proteins including the PSP61, lwPSA and protein X, and to investigate the value of these proteins as markers of BPH; to examine whether these proteins are present in serum and to examine the potential of using these proteins as markers in clinical diagnosis of PBPH; to assess correlation of the levels of these newly identified proteins to PSA levels in prostate cancer and BPH patient and to examine their association with PSA. |
| List of Research Outputs |
| Cheung H.W., Ling M.T., Tsao G.S.W., Wong Y.C. and Wang X., Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal cacinoma cells, Carcinogenesis. 2004, 25 no. 5: 881-887. |
| Lee K.W., Man K., Ling M.T., Wang X., Wong Y.C., Lo C.M., Poon R.T.P., Ng I.O.L. and Fan S.T., Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway, Carcinogenesis. 2003, 24(11): 1729-1736. |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Ling M.T., Wang X., Lee D.T.W., Tam P.C., Tsao G.S.W. and Wong Y.C., Id-1 expression induces androgen-independent prostate cancer call growth through activation of epidermal growth factor receptor (EGF-R), Carcinogenesis. 2004, 25 No. 4: 517-525. |
| Ling M.T., Wang X. and Wong Y.C., Id-1 expression promotes cell survival through activation of NF-kB signaling pathway in prostate cancer cells, proceedings of the American Asociation for Cancer Research. 2003, 44: 481. |
| Ling M.T., Wang X. and Wong Y.C., Id1 expression induces androen independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R), 10th Hong Kong International Cancer Congress, Hong Kong, November 19-21, 2003. P2.3. |
| Ling M.T., Wang X. and Wong Y.C., Id1 induced Raf/MEK pathway activation is essential for its protective role against apoptosis i nasopharyngeal carcinoma cells, Proceedings of the American Association for Cancer Research. 2004, 45: 20. |
| Lo K.F., Liu Y., Huang D.P., Lo K.W., Wong Y.C. and Tsao G.S.W., Alterations of biological properties and gene expression in nasopharyngeal epithelial cells by Epstein-Barr virus encoded latent membrane protein 1, Proceedings of the American Association for Cancer Research. 2003, 44: 1183. |
| Si H., Tsao G.S.W., Poon S.P., Wang L.D., Wong Y.C. and Cheung A., Human papillomavirus (HPV) infection and allelic loss in esophageal squamous cell carcinoma, Proceedings of the American Association for Cancer Research, July 2003. 22 2nd Edition: 1025 No. R5146. |
| Thota A., Karajgika M., Duan W., Gabril M.Y., Chan F.L., Wong Y.C., Sakai H., Chin J.L., Moussa M. and Xuan J.W., Mouse PSP94 expression is prostate tissue-specific as demonstrated by a comparison of multiple antibodies against recombinant proteins, Journal of Cellular Biochemistry. 2003, 88: 999-1011. |
| Tsao G.S.W., Li H.M., Wang X. and Wong Y.C., Functional study of expression of the Epstein Barr virus encoded LMP1 protein in nasopharyngeal epithelial cells, Hong Kong Medical Journal. 2003, 9: 17. |
| Wang Q., Tsao G.S.W., Fu S.B., Xue W.C., Meng X.N., Feng H., Wong Y.C. and Wang X., Overexpression of Id1 in gastric adenocarcinoma:Implication for a novel diagnostic marker, Anticancer Research. 2004, 24: 881-886. |
| Wang X., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Oncogene. 2004, 23: 474-482. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells, Proceedings of the American Association for Cancer Research. 2004, 45: 142. |
| Wang X., Ling M.T., Guan X.Y., Tsao G.S.W., Cheung H.W., Lee D.T.W. and Wong Y.C., Identification of a novel function of TWIST, abHLH protein, in the development of acquired taxol resistance in human cancer cells, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-04. |
| Wang X., Tsao G.S.W., Wong Y.C. and Cheung A., Induction of senescent-like growth arrest as a new target in anticancer treatment, Current Cancer Drug Targets. 2003, 3: 153-160. |
| Wang X., Jin D.Y., Wong Y.C., Cheung A., Chun A.S.C., Lo K.F., Liu Y. and Tsao G.S.W., Significance of MAD2 expression in mitotic checkpoint control and cellular sensitivity in nasopharyngeal carcinoma cells, Hong Kong Medical Journal. 2003, 9: 57. |
| Wong H.I., Chang R.C.C., Wang X., Feng H., Li H.M., Wong Y.C. and Tsao G.S.W., Functional study of EBV encoded RNA in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth, Proceedings of the American Association for Cancer Research. 2003, 44: 290-291. |
| Wong Y.C., Wang X. and Ling M.T., Id-1 expression and cell survival, Apoptosis. 2004, 9 No. 3: 279-289. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Id1 expression induces androgen independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R), Proceedings of the American Association for Cancer Research. 2004, 45: 1032. |
| Wong Y.C., Ling M.T., Wang X. and Tsao G.S.W., Id1 expression induces androgen independent prostate cancer cell growth, 9th Medical Research Conference, The University of Hong Kong, February 7-8, 2004. PA-03. |
| Wong Y.C., Ling M.T. and Wang X., Id1 is crucial factor regulating the development of prostate cancer, First Northern Lights Summer Conference: The Interface of Cancer and Development, Vancouver, June 16-20, 2004. |
| Wong Y.C., Wang X. and Ling M.T., Prostate development and carcinogenesis, International Review of Cytology. 2003, 227: 65-130. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines, Chinese Medical Journal. 2003, 116: 1673-1677. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., The a1-adrenoceptor anatagonist terazosin induces prostate cancer cell death through a p53 and Rb independent pathway, Oncology Reports. 2003, 10: 1555-1560. |
| Researcher : Woo MF |
| List of Research Outputs |
| Woo M.F., Ling M.T., Wang X. and Tsao G.S.W., Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer growth, Hong Kong Medical Journal. 2003, 9: 57. |
| Researcher : Wu W |
| Project Title: | Effect of delayed transplantation of a peripheral nerve (PN) graft on motoneuron survival and regeneration after spinal root avulsion |
| Investigator(s): | Dr. Wu W.T. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 07/1998 |
| Abstract: |
| To hypothesize whether a delayed implantation of PN graft can prevent the dealth of motoneurons and enhance their regeneration. The study will also determine the best post-injury time for PN graft transplantation. |
| Project Title: | Effect of delayed transplantation of a peripheral nerve (PN) graft on motoneuron survival and regeneration after spinal root avulsion |
| Investigator(s): | Dr. Wu W.T. |
| Department: | Anatomy |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 07/1998 |
| Abstract: |
| To hypothesize whether a delayed implantation of PN graft can prevent the dealth of motoneurons and enhance their regeneration. The study will also determine the best post-injury time for PN graft transplantation. |
| Project Title: | The role of neuronal nitric oxide synthase in motoneuron degeneration |
| Investigator(s): | Dr. Wu W.T. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To determine the role of injury-induced nNOS in adult spinal motoneurons following root avulsion injury. |
| Project Title: | Effects of chondroitinase ABC and lithium chloride on neuronal survival and regneration after spinal cord injury |
| Investigator(s): | Dr. Wu W.T., Prof. So K.F., Dr. Yick L.W. |
| Department: | Anatomy |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 11/2003 |
| Abstract: |
| To study the effects of chondroitinase ABC and lithium chloride on neuronal survival and regneration after spinal cord injury. |
| Project Title: | Axonal regeneration of CNS neurons after spinal cord injury |
| Investigator(s): | Dr. Wu W.T. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 02/2004 |
| Abstract: |
| To examine the effects of lithium chloride (LiC1) and chondroitinase ABC (ChABC) on promoting the survival and regeneration of neurons in the severed Clarke's nucleus (CN) and red nucleus (RN) after spinal cord injury; to investigate how LiC1 and ChABC enhances the axonal regeneration of the severed CN and RN neurons, focusing on both the intracellular signaling and extracellular matrix molecules. |
| List of Research Outputs |
| Chan S.Y.M., Yick L.W., So K.F., Oppenheim R.W. and Wu W., Early release of mitochondrial cytochrome c and the subsequent activation of caspase-3 are involved in the apoptotic death of neonatal motoneurons after injury, Hong Koong Medical Journal. 2003, 9 Supplement: 72. |
| Cheung Z.H.Y., Chan S.Y.M., Siu F.K.W., Yip H.K.F., Wu W., Leung M.C.P. and So K.F., Regulation of caspase activation in axotomized retinal ganglion cells, Molecular and Cellular Neuroscience. 2004, 25: 383-393. |
| Gu H.Y., Hong C., Zhang J.Y., Yao Z.B., Zhou L.H., Bruce I.C. and Wu W., Survival, regeneration & functional recovery of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion, European Journal of Neuroscience . 2004, 19: 2123-2131. |
| Li F.L., Zhou L., Yuan Q.J., He H.W., Yao Z.B. and Wu W., Influence of ginkgo biloba extract on NOS expression and survival of C7 motoneurons following brachial root avulsion, Chinese Journal of Pathophysiology. 2003, 19: 1231-1233. |
| Li F.L., Zhou L., Yuan Q.J., Liu F.L., Yao Z.B. and Wu W., The effect of IA9901 and EG6761 complex on motoneurons following root avulsion (in Chinese), Anatomical Research . 2003, 25: 163-165. |
| Wu W., Chai H., Zhang J., Gu H., Xie Y.Y. and Zhou L., Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats, Journal of Neirotrauma. 2004, 21(8): 1050-1058. |
| Wu W., Li L., Yick L.W., Chai H., Xie Y., Yang Y., Prevette D.M. and Oppenheim R.W., GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats, Journal of Neurotrauma. 2003, 20 No. 6: 603-612. |
| Wu W. and Yuan Q.J., Potential role of nitric oxide synthase (NOS) in regeneration of neurohypophyseal system after axotomy, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong, February 8-9, 2004. |
| Xie Y., Yao Z., Chai H., Wong W.M. and Wu W., Expression and role of low-affinity nerve growth factor receptor (p75) in spinal motor neurons of aged rats following axonal injury, Developmental Neuroscience. 2003, 25: 65-71. |
| Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the effect of chondroitinase ABC on promoting axonal regeneration of rubrospinal neurons after spinal cord injury, Society for Neuroscience. 2003, Program Number 275.1. |
| Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the effect of chondroitinase ABC on promoting axonal regeneration of rubrospinal neurons after spinal cord injury, The 33 Annual Meeting Of Society For Neuroscience, New Orlean, FL., U.S.A. November 2003. Program No. 275.1. |
| Yuan Q., Xie Y., So K.F. and Wu W., Inflammatory response associated with axonal injury to spinal motoneurons in newborn rats, Developmental Neuroscience. 2003, 25: 72-78. |
| Yuan Q.J., So K.F. and Wu W., Lesion-induced expression of nestin in supraoptic and paraventricular nuclei in developing and adult rats following hypothysectomy, Society for Neuroscience. 2003, Program Number 355.12. |
| Yuan Q.J., So K.F. and Wu W., Lesion-induced expression of nestin in supraoptic and paraventricular nuclei in developing and adult rats following hypothysectomy, The 33 annual Meeting of Society for Neuroscience, New Orlean, FL., U.S.A., November 2003. Program No. 255.12. |
| Yuan Q.J., Wu W. and So K.F., The role of nitric oxide on regeneration of paraventricular nucleus and supraoptic nucleus following hypophysectomy, Hong Kong Medical Journal. 2003, 9 Supplement: 84. |
| Zhang J., Chai H. and Wu W., survival and regeneration of motoneurons in adult rats by delayed reimplantation of ventral root following spinal root avulsion, Chinese Journal of Clinical Anatomy. 2003, 21: 362-364. |
| Zhang X., Ng A.H.L., Tanner J.A., Wu W., Jenkins N.A. and Huang J., Highly Restricted Expression of Cre Recombinase in Cerebellar Purkinje Cells, Genesis: The Journal of Genetics and Development. 2004, V40: 45-51. |
| Zhang X.M., Ng H.L., Tanner J.A., Wu W., Copeland N.G., Jenkins N.A. and Huang J.D., Highly restricted expression of Cre recombinase in cerebellar Purkinje cells, Genesis. 2004, 40: 45-51. |
| Zhou L. and Wu W., Antisense oligodeoxynucleotide (ODN)against neuronal NOS down-regulated the De Novo expression of NOS and decreased the survival of adult spinal motoneurons following root avulsion, The 33 Annual Meeting of Society for Neuroscience, New Orlean, FL., U.S.A.. 2003, Program No. 602.1. |
| Researcher : Xie Y |
| List of Research Outputs |
| Wu W., Li L., Yick L.W., Chai H., Xie Y., Yang Y., Prevette D.M. and Oppenheim R.W., GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats, Journal of Neurotrauma. 2003, 20 No. 6: 603-612. |
| Xie Y., Yao Z., Chai H., Wong W.M. and Wu W., Expression and role of low-affinity nerve growth factor receptor (p75) in spinal motor neurons of aged rats following axonal injury, Developmental Neuroscience. 2003, 25: 65-71. |
| Yuan Q., Xie Y., So K.F. and Wu W., Inflammatory response associated with axonal injury to spinal motoneurons in newborn rats, Developmental Neuroscience. 2003, 25: 72-78. |
| Researcher : Xu K |
| List of Research Outputs |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines, Chinese Medical Journal. 2003, 116: 1673-1677. |
| Xu K., Wang X., Ling M.T., Tsao G.S.W. and Wong Y.C., The a1-adrenoceptor anatagonist terazosin induces prostate cancer cell death through a p53 and Rb independent pathway, Oncology Reports. 2003, 10: 1555-1560. |
| Researcher : Yang Y |
| List of Research Outputs |
| Wu W., Li L., Yick L.W., Chai H., Xie Y., Yang Y., Prevette D.M. and Oppenheim R.W., GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats, Journal of Neurotrauma. 2003, 20 No. 6: 603-612. |
| Researcher : Yeung SC |
| List of Research Outputs |
| Yeung S.C., Chang R.C.C. and Yip H.K.F., Role of ciliary neurotrophic factor (CNTF) family growth factors in the survival and neurite outgrowth of retinal ganglion cells, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 176 No. P17-19. |
| Yip H.K.F., Yeung S.C. and Li S., Expression of Id gene family in the retina during development, Association for Research in vision and Ophthalmology Annual Meeting Abstract. 2004. |
| Researcher : Yick LW |
| List of Research Outputs |
| Chan S.Y.M., Yick L.W., So K.F., Oppenheim R.W. and Wu W., Early release of mitochondrial cytochrome c and the subsequent activation of caspase-3 are involved in the apoptotic death of neonatal motoneurons after injury, Hong Koong Medical Journal. 2003, 9 Supplement: 72. |
| Ji J., Elyaman W., Yip H.K.F., Lee V.W.H., Yick L.W., Hugon J. and So K.F., CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway, European Journal of Neuroscience. 2004, 19: 265-272. |
| Wu W., Li L., Yick L.W., Chai H., Xie Y., Yang Y., Prevette D.M. and Oppenheim R.W., GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats, Journal of Neurotrauma. 2003, 20 No. 6: 603-612. |
| Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the effect of chondroitinase ABC on promoting axonal regeneration of rubrospinal neurons after spinal cord injury, Society for Neuroscience. 2003, Program Number 275.1. |
| Yick L.W., So K.F., Cheung P.T. and Wu W., Lithium chloride reinforces the effect of chondroitinase ABC on promoting axonal regeneration of rubrospinal neurons after spinal cord injury, The 33 Annual Meeting Of Society For Neuroscience, New Orlean, FL., U.S.A. November 2003. Program No. 275.1. |
| Researcher : Yip HKF |
| Project Title: | The role of microglia in the survival of retinal ganglion cells (RGCs) following transient retinal ishemia |
| Investigator(s): | Dr. Yip H.K.F., Dr. Chang R.C.C. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2002 |
| Abstract: |
| To study the effects of: (1) Ischemia on the survival of RGCs and microglial response; (2) Neurotrophic factors (CNTF, BDNF, and bFGF) and cytokines (TGF-g, IL-4, IL-10, TNF-g, CSF-1, and IFN-/LPS) on the survival of RGCs and microglial response after transient retinal ischemia; (3) Neurotrophic factors and cytokines on the microglia from ischemic retina in vitro. |
| Project Title: | Expression of basic Helix-Loop-Helix transcription factors in the retinal ganglion cells after axonal injury |
| Investigator(s): | Dr. Yip H.K.F., Prof. Tsao G.S.W., Dr. Wang X.H. |
| Department: | Anatomy |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To examine (1) the changes in the expression of several HLH transcription factors that function as negative regulators of neurogenesis and axonal outgrowth induced by axonal injury; and (2) the expression of these negative HLH transcription factors and the vulnerability of neurons to apoptosis. |
| List of Research Outputs |
| Cheung Z.H.Y., Chan S.Y.M., Siu F.K.W., Yip H.K.F., Wu W., Leung M.C.P. and So K.F., Regulation of caspase activation in axotomized retinal ganglion cells, Molecular and Cellular Neuroscience. 2004, 25: 383-393. |
| Cui Q., Cho K.S., So K.F. and Yip H.K.F., Synergistic effect of nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systems, Journal of Neurotrauma. 2004, 21 no. 5: 617-625. |
| Ji J., Elyaman W., Yip H.K.F., Lee V.W.H., Yick L.W., Hugon J. and So K.F., CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway, European Journal of Neuroscience. 2004, 19: 265-272. |
| Lau W.M., Tsao G.S.W., So K.F. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in adult rat retina, Hong Kong Society of Neuroscience Annual Meeting Abstract. 2003. |
| Lau W.M., Li S., Tsao G.S.W., Wong A.O.L. and Yip H.K.F., Expression of telomerase activity and telomeric catalytic subunit in goldfish (Carassius auratus) retina, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Lau W.M., Tsao G.S.W., Wong A.O.L. and Yip H.K.F., Induction of retinal telomerase activity during optic nerve regeneration after optic nerve cut, Journal of Neurochemistry. 2003, 87(S1): 144-151. |
| Leung T.W.C., Cheung H.W., Bhatia I., Yip H.K.F., Sham M.H. and Cheung P.T., Characterization of a novel X-linked nuclear protein down-regulated in neonatal mouse hypoxic-ischemic encephalopathy, HID1, Journal of Neurochemistry. UK, Blackwell Publishing Ltd, 2003, 87 Suppl.: 143-143. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Differential expression of glutamate decarboxylase isoforms in the horizontal cells of human and rat retinas, Journal of Neurochemistry. 2004, 88(S1): 30-32. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Wu Y.M., Yang W.K. and Yip H.K.F., Expression of glutamate decarboxylase isoforms in human and rat retinas, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Program No. A-02. |
| Li S., Shu S.Y., Bao X.M., So K.F., Tay D.K.C., Lui Kau K.W.F., Li F., Yang W.K. and Yip H.K.F., F1k-1, a receptor for vascular endothelial growth factor, is expressed in the neural cells of developmental human retinas, USA Society of Neuroscience Annual Meeting Abstract. 2003. |
| Lu Q., Cui Q., Yip H.K.F. and So K.F., c-Jun expression in surviving and regenerating retinal ganglion cells: effects of intravitreal neurotrophic supply, Investigative Ophthalmology & Visual Science. 2003, 44 No. 12: 5342-5348. |
| Yeung S.C., Chang R.C.C. and Yip H.K.F., Role of ciliary neurotrophic factor (CNTF) family growth factors in the survival and neurite outgrowth of retinal ganglion cells, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 176 No. P17-19. |
| Yip H.K.F., Yeung S.C. and Li S., Expression of Id gene family in the retina during development, Association for Research in vision and Ophthalmology Annual Meeting Abstract. 2004. |
| Yip H.K.F., Li S., Tay D.K.C., Shu Y., Bao X.M., Lui Kau K.W.F., Li F. and Yang W.K., Expression of nitric oxide synthases in the developing human retinas, 6th IBRO World Congress of Neuroscience. 2003. |
| Yip H.K.F., Li S., Shu S., Bao X., So K.F., Lui Kau K.W.F. and Yang W., Neuronal nitric oxide expresses in the retinal ganglion cells and endothelial nitric oxide synthase in the retinal neurons in the developing human retinas, Association for Research in Vision and Ophthalmology Annual Meeting Abstract. 2003. |
| You S., Tay D.K.C., Yip H.K.F. and So K.F., Effects of MK-801 and L-NA on the survival and regeneration of axotomized retinal ganglion cells in adult hamsters, Acta Anatomica Sinica. 2003, 34 No. 5: 453-457. |
| Researcher : Yip YL |
| List of Research Outputs |
| Tsao G.S.W., Li H.M., Man C.W.Y., Yip Y.L., Young L.S. and Huang D.P., The role of immortalizatiion and transformation of nasopharyngeal epithelials, Proceedings of EBV Symposium 2004. 124. |
| Researcher : You S |
| List of Research Outputs |
| Li Y., You S., So K.F., Tong Y. and Ju G., Progress in restoration of injured optic nerve, Chinese Journal of Ophthalmology. 2004, 40(2): 141-144. |
| You S., Tay D.K.C., Yip H.K.F. and So K.F., Effects of MK-801 and L-NA on the survival and regeneration of axotomized retinal ganglion cells in adult hamsters, Acta Anatomica Sinica. 2003, 34 No. 5: 453-457. |
| You S. and So K.F., Exploration on the promotion of neuro-regeneration after central nervous system injury, China Prescription Drug. 2004, 2 no.23: 30-33. |
| Researcher : Yu MS |
| List of Research Outputs |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in beta-amyloid peptide (Ab)-induced neuronal death, Journal of Neurochemistry. 2004, 88 Suppl. 1: 20 No. C7-4. |
| Chang R.C.C., Suen K.C., Yu M.S., Lin K.F. and Hugon J., Molecular signaling of double-stranded RNA-dependent protein kinase (PKR) in neuronal death, Proceeding of 2nd Frontiers in Medical Sciences. 2003, 69. |
| Chang R.C.C., Suen K.C., Yu M.S., So K.F. and Hugon J., Upstream signaling of PKR in beta-amyloid peptide neurotoxicity, Society for Neuroscience. 2003, Program Number 210.16. |
| Leung S.K.Y., Yu M.S., Yuen W.H., Che C.M., Fang J. and Chang R.C.C., Extracts from chinese medicinal herb lycium barbarum (gou-qi-zi) as potential neuroprotective agents, Society for Neuroscience. 2003. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Activation of the PKR-eIF2a pathway is mediated by caspase-3 activation, Neuroscience Letters. 2003, 349 Supplement 1: S20. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., Involvement of PKR in mediating the activation of caspases in b-amyloid peptide neurotoxicity, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-18. |
| Suen K.C., Yu M.S., Hugon J., So K.F. and Chang R.C.C., PERK might not be involved in b-amyloid peptide-induced and endoplasmic reticulum stress in neurons, Journal of Neurochemistry. 2003, 87 (Suppl. 1): 96 No. P09-19. |
| Suen K.C., Yu M.S., So K.F., Chang R.C.C. and Hugon J., Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in b-amyloid peptide neurotoxicity, The Journal of Biological Chemistry. 2003, 278 No. 50: 49819-49827. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Absence of endoplasmic reticulum stress in early apoptosis in beta-amyloid peptide neurotoxicity, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, No. A-05. |
| Yu M.S., Suen K.C., Kwok N.S., So K.F. and Chang R.C.C., Lack of early activation of endoplasmic reticulum stress in beta-amyloid neurotoxicity, Journal of Neurochemistry. 2004, 88 Suppl. 1: 52 No. P21-16. |
| Yu M.S., Yuen W.H., So K.F. and Chang R.C.C., Neuroprotective effects of extracts from anti-aging chinese medicine Lycium Barbarum (Gou-Qi-Zi), Journal of Neurochemistry. 2004, 88 Suppl. 1: 69 No.P26-21. |
| Yu M.S., Lin K.F., Fang J., Yuen W.H., So K.F. and Chang R.C.C., Potential significance of polysaccharides from nerium indicum in neuroprotection, Society for Neuroscience. 2003, Program Number 98.5. |
| Researcher : Yuan Q |
| List of Research Outputs |
| Yuan Q., Xie Y., So K.F. and Wu W., Inflammatory response associated with axonal injury to spinal motoneurons in newborn rats, Developmental Neuroscience. 2003, 25: 72-78. |
| Researcher : Yuan QJ |
| List of Research Outputs |
| Li F.L., Zhou L., Yuan Q.J., He H.W., Yao Z.B. and Wu W., Influence of ginkgo biloba extract on NOS expression and survival of C7 motoneurons following brachial root avulsion, Chinese Journal of Pathophysiology. 2003, 19: 1231-1233. |
| Li F.L., Zhou L., Yuan Q.J., Liu F.L., Yao Z.B. and Wu W., The effect of IA9901 and EG6761 complex on motoneurons following root avulsion (in Chinese), Anatomical Research . 2003, 25: 163-165. |
| Wu W. and Yuan Q.J., Potential role of nitric oxide synthase (NOS) in regeneration of neurohypophyseal system after axotomy, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong, February 8-9, 2004. |
| Yuan Q.J., So K.F. and Wu W., Lesion-induced expression of nestin in supraoptic and paraventricular nuclei in developing and adult rats following hypothysectomy, Society for Neuroscience. 2003, Program Number 355.12. |
| Yuan Q.J., So K.F. and Wu W., Lesion-induced expression of nestin in supraoptic and paraventricular nuclei in developing and adult rats following hypothysectomy, The 33 annual Meeting of Society for Neuroscience, New Orlean, FL., U.S.A., November 2003. Program No. 255.12. |
| Yuan Q.J., Wu W. and So K.F., The role of nitric oxide on regeneration of paraventricular nucleus and supraoptic nucleus following hypophysectomy, Hong Kong Medical Journal. 2003, 9 Supplement: 84. |
| Researcher : Zhang J |
| List of Research Outputs |
| Wu W., Chai H., Zhang J., Gu H., Xie Y.Y. and Zhou L., Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats, Journal of Neirotrauma. 2004, 21(8): 1050-1058. |
| Zhang J., Chai H. and Wu W., survival and regeneration of motoneurons in adult rats by delayed reimplantation of ventral root following spinal root avulsion, Chinese Journal of Clinical Anatomy. 2003, 21: 362-364. |
| Researcher : Zhou L |
| List of Research Outputs |
| Li F.L., Zhou L., Yuan Q.J., He H.W., Yao Z.B. and Wu W., Influence of ginkgo biloba extract on NOS expression and survival of C7 motoneurons following brachial root avulsion, Chinese Journal of Pathophysiology. 2003, 19: 1231-1233. |
| Li F.L., Zhou L., Yuan Q.J., Liu F.L., Yao Z.B. and Wu W., The effect of IA9901 and EG6761 complex on motoneurons following root avulsion (in Chinese), Anatomical Research . 2003, 25: 163-165. |
| Wu W., Chai H., Zhang J., Gu H., Xie Y.Y. and Zhou L., Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats, Journal of Neirotrauma. 2004, 21(8): 1050-1058. |
| Zhou L. and Wu W., Antisense oligodeoxynucleotide (ODN)against neuronal NOS down-regulated the De Novo expression of NOS and decreased the survival of adult spinal motoneurons following root avulsion, The 33 Annual Meeting of Society for Neuroscience, New Orlean, FL., U.S.A.. 2003, Program No. 602.1. |
| Researcher : Zhuang Z |
| List of Research Outputs |
| Li H.M., Zhuang Z., Wang Q., Pang J.C.S., Wang X., Wong H.L., Feng H., Jin D., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Oncogene. 2004, 1-7. |
| Li H.M., Zhuang Z., Wang Q., Wang X., Wong H.L., Feng H., Jin D.Y., Ling M.T., Wong Y.C., Eliopoulos A.G., Young L.S., Huang D.P. and Tsao G.S.W., Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells, Proceedings of the American Association for Cancer Research. 2004, 45: 61. |
| Zhuang Z., Wang L.D., Tsao G.S.W., Cheung A., Feng H., Yang T., Qin Y.R., Wang C.D., Chen Z.Z. and Liu B., Cyclooxygenase-2 expression in esophageal cancer cells and induction by mitomycin C (in Chinese), Zhonghua Nei Ke Za Zhi. 2003, 42(10): 701-704. |