Dept of Surgery

THE UNIVERSITY OF HONG KONG
Research and Scholarship 2004

DEPARTMENT OF SURGERY

Researcher : Au DKK

Project Title:	Electrical tinnitus suppression in hearing-impaired patients
Investigator(s):	Dr. Au D.K.K., Dr. Ho W.K.
Department:	Surgery
Source(s) of Funding:	Run Run Shaw Research and Teaching Endowment Fund
Start Date:	11/2003

Abstract:

To evaluate the effectiveness of electrical tinnitus suppression in patients with sensorineural hearing loss; to compare the effectiveness of high versus low electrical stimulation rate in tinnitus suppression.

List of Research Outputs

Au D.K.K., Auditory processing disorder, 284th Dr. Luis E. Guerrero Memorial Lecture, University of Santa Tomas, Manila, Philippine, 26 November 2003. 2003.

Au D.K.K., Co-opt member of the Deafness Medical Commitee (27 May 2003 - 26 May 2006), Occupational Deafness Compensation Board, Hong Kong. 2004.

Au D.K.K., Cochlear implants (Invited Speaker), Guangdong Provincial Rehabilitation Centre for the Disabled Persons, PR China, 4 June 2004. 2004.

Au D.K.K., Chow C.K., Hui Y. and Wei W.I., Cognitive abilities of patients with cochlear implant in the discrimination of tone stimuli with minimal contrast, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003. 102.

Au D.K.K., Diagnoses, management and new trends in audioloy for pediatric patients (Invited Speaker), Philippine Pediatric Society, Philippines, 27 November 2003. 2003.

Au D.K.K., Hui Y., Tsang A.W.C. and Wei W.I., ENT management of a child with CHARGE association, Asian Journal of Surgery. 2004, 27(2): 141-143.

Au D.K.K., Effects of stimulation rates on Cantonese lexical tone perception by cochlear implant users in Hong Kong, Clinical Otolaryngology. 2003, 28(6): 533-538.

Au D.K.K., Guest Speaker, Workshop on "Choice of Suitable Hearing Assistive Device", Workshop for Applicants of the Occupational Deafness Compensation Board, Hong Kong, 3 September. 2003.

Au D.K.K., Guest Speaker, Workshop on "Choice of Suitable Hearing Assistive Devices" , Workshop for Applicants of the Occupational Deafness Compensation Board, Hong Kong, 16 July. 2003.

Au D.K.K., Guest Speaker, Workshop on "Occupational Deafness and Hearing Aid Fitting", Interview by RTHK Channel 2, Hong Kong, 16 July. 2003.

Au D.K.K., Hearing aids and cochlear implants (Invited Lecture), The Hong Kong College of Otorhinolaryngologists, Hong Kong, 7 February 2004. 2004.

Au D.K.K., Invited Speaker, Audiology and rehabilitation of hearing loss, The Tenth Certificate Course in Ear, Nose and Throat Diseases for Nurses, ENT. 2003.

Au D.K.K., Moderator, New advance technology for the deaf, Hong Kong Society for the Deaf 2004, 29 May. 2004.

Au D.K.K., Noise-induced hearing loss, Interview by Ming Pao, 5 April. 2004.

Au D.K.K., Views on hearing assistive device, Invitation by Legislative Council Bills Committee on Occupational Deafness (Compensation) (Amendment) Bill, 27 January. 2003.

Au D.K.K., 認識老年聽力衰退及溝通技巧, 港九敬老福利會, 二＋三週年紀念特?, 2004, 39.

Au D.K.K., Hui Y., Jin H. and Wei W.I., 香港失聰兒童早期人工耳蝸植入後的聽覺和言語康復, 中國長沙湖南中華耳鼻喉科雜誌創?50周年紀念暨全國人工耳蝸專題學術會議上宣讀, 2003年9月13-16日, 2003.

Chow C.K., Hui Y., Au D.K.K., LAM W.W.M. and Wong Y.K., Management of bilateral cochlear fistula in cochlear implantation, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004.

Chow C.K., Hui Y. and Au D.K.K., Minimally invasive surgery for different types of cochlear implant, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003.

Chu K., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Short electrode insertion in cochlear implants: the performance on speech perception, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003. 99.

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Narrative abilities in children with cochlear implants, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004. 181.

金 ..., Hui Y., Au D.K.K. and Wei W.I., Effects of stimulation rate on Cantonese tone perception performance for cochlear implant users, 刺激速率對廣東話人工耳蝸使用者聲調認知能力的影響, Chinese Scientific Journal of Hearing and Speech Rehabilitation. 2004, 4: 7-9.

金 ..., Au D.K.K., Hui Y. and Wei W.I., 噪聲環境下刺激速率對廣東語聲調認知能力的影響, 中國長沙湖中華耳鼻咽喉科雜誌創?50週年紀念暨全國人工耳蝸專題學術會議, 2003年9日13-16日, 2003.

Researcher : Cao B

List of Research Outputs

Ren Y., Cao B., Li W., Chan G.C.F., Woude G.F.V. and Tam P.K.H., Hepatocyte growth factor enhances angiogenesis and tumor cell migration in human neuroblastoma, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004. 33.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Zhao P., Huang X., Vande Woude G. and Wong J., Hepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A101-A102.

Researcher : Chan A

List of Research Outputs

Chang H.W., Chan A., Kwong D.L.W., Wei W.I., Sham J.S.T. and Yuen P.W., Detection of hypermethylated RIZ1 gene in primary tumor, mouth, and throat rinising fluid, nasopharyngeal swab, and peripheral blood of nasopharyngeal carcinoma patient, Clinical Cancer Research . 2003, 9: 1033-1038.

Chang H.W., Chan A., Kwong D.L.W., Wei W.I., Sham J.S.T. and Yuen P.W., Evaluation of hypermethylated tumor suppressor genes as tumor marker in mouth and throat rinsing fluid, nasopharyngeal swab, peripheral blood of naospharyngeal carcinoma patients, International Journal of Cancer. 2003, 105(6): 851-855.

Researcher : Chan ACY

List of Research Outputs

Chan A.C.Y. and Liu C.L., The role of endoscopic ultrasonography in the management of cystic lesions of the pancreas, Hong Kong Medical Journal. 2003, 9(6): 441-445.

Researcher : Chan HM

List of Research Outputs

Ren Y., Chen Y.X., Li W., Jiang G., Liu Q., Chan H.M. and Tam P.K.H., Expression and function of macrophage migration inhibitory factor in human neuroblastoma, 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, 27-31 March 2004.

Ren Y., Li Z., Chan H.M., Lin C.L., Lui V.C.H., Bacher M. and Tam P.K.H., N-MYC induction stimulated by macrophage migration inhibitory factor through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Ren Y., Chan H.M., Li Z., Lin C.L., Nicholls J.M., Chan G.C.F., Lee P.Y., Lui V.C.H., Bacher M. and Tam P.K.H., Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma, Oncogene. UK, Nature Publishing Group, 2004, 23: 4146-4154.

Ren Y., He Q.Y., Fan J.Q., Li Z., Zhou Y., Chan H.M., Bacher M., Haab B., Chiu J.F., Vande Woude G. and Tam P.K.H., cDNA microarray and proteomic analysis of differential gene and protein expression in human neuroblastoma cells induced by macrophage migration inhibitory factor, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Researcher : Chan JKY

List of Research Outputs

Lo C.Y., Wat N.M.S., Lam K.Y., Tiu S.C., Chan J.K.Y. and Lam K.S.L., Multiple endocrine neoplasia type 2 in Chinese families, Clinical Endocrinology. 2003, 58: 528.

Wong I.H.N., Chan J.K.Y., Wong J.S.W. and Tam P.K.H., Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May, 2004. 43.

Researcher : Chan KL

List of Research Outputs

Chan K.L., Fellow (1996 - present), American College of Surgeons. 2004.

Chan K.L., HA's Expert Panel in Surgery Specialty (2003 - 2006), Hospital Authority. 2004.

Chan K.L., Ng S.P., Chan K.W., Wo Y.H. and Tam P.K.H., Pathogenesis of neonatal necrotizing enterocolitis: a study of the role of intraluminal pressure, age and bacterial concentration, Pediatric Surgery International. 2003, 19(8): 573-577.

Chan K.L., Hui T.W.C. and Tam P.K.H., Prospective randomized, single-blinded comparison of laparoscopic versus open repair of pediatric inguinal hernia, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Chan K.L. and Tam P.K.H., Technical refinements in laparoscopic repair of childhood inguinal hernias, Surgical Endoscopy. 2004, 18(6): 957-960.

Chan K.L., 胎兒外科, 中華醫學會第六次全國小兒外科學術會議,中國長沙, 2003年11月25-30日, 2004.

Liu C.L., Saing H., Fan S.T., Lo C.M., Chan K.L., Tam P.K.H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Ng I.O.L., Chan K.L., Shek T.W.H., Lee M.F., Fong D.Y.T., Lo C.M. and Fan S.T., High frequency of chimerism in transplanted livers (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ng I.O.L., Chan K.L., Shek T.W.H., Lee J.M., Fong D.Y.T., Lo C.M. and Fan S.T., High frequency of chimerism in transplanted livers, Hepatology. 2003, 38(4): 989-998.

Ooi C.G.C., Khong P.L., Chan G.C.F., Chan K.N., Chan K.L., Lam W.W.M., Ng I.O.L. and Ha S.Y., Magnetic resonance screening of iron status in transfusion-dependent b-thalassaemia patients, British Journal of Haematology. Blackwell Publishing Ltd, 2004, 124: 385-390.

Wong K.K.Y., Chan K.L., Saing H., Fan S.T. and Tam P.K.H., The management of biliary atresia in the era of liver transplantation, Hong Kong Journal of Paediatrics. 2003, 8: 322-326.

Researcher : Chan MS

List of Research Outputs

Ho J.W.C., Ho M.Y., Chan C.L.W., Yuen S.T., Chan M.S. and Siu H.Y.V., Psychological profile of hereditary colorectal cancer genetic screening test recipients in Hong Kong: results of the first 88 participants (Abstracts & Proceedings), Familial Cancer 2003: Research and Practice, Couran Cove, Australia, 3-6 September 2003.

Researcher : Chan VSF

List of Research Outputs

Chung P.Y., Chen Y., Chan V.S.F., Tam P.K.H. and Lin C.L., Dendritic cells: sentinels against pathogens, Histology and Histopathology. 2004, 19(1): 317-324.

Researcher : Chang HW

List of Research Outputs

Chang H.W., Chan A., Kwong D.L.W., Wei W.I., Sham J.S.T. and Yuen P.W., Detection of hypermethylated RIZ1 gene in primary tumor, mouth, and throat rinising fluid, nasopharyngeal swab, and peripheral blood of nasopharyngeal carcinoma patient, Clinical Cancer Research . 2003, 9: 1033-1038.

Chang H.W., Chan A., Kwong D.L.W., Wei W.I., Sham J.S.T. and Yuen P.W., Evaluation of hypermethylated tumor suppressor genes as tumor marker in mouth and throat rinsing fluid, nasopharyngeal swab, peripheral blood of naospharyngeal carcinoma patients, International Journal of Cancer. 2003, 105(6): 851-855.

Chang H.W., Ling G.S., Wei W.I. and Yuen P.W., Smoking and drinking can induce p15 hypermethylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma , Cancer. 2004, 101: 125-132.

Researcher : Chen BLS

List of Research Outputs

Garcia-Barcelo M.M., Sham M.H., Lui V.C.H., Chen B.L.S., Song Y., Lee W.S., Yung S.K., Romeo G. and Tam P.K.H., Chinese patients with sporadic Hirschsprung’s disease are predominantly represented by a single RET haplotype. , Journal of Medical Genetics. 2003, 40(11): e122.

Garcia-Barcelo M.M., Sham M.H., Lee W.S., Lui V.C.H., Chen B.L.S., Wong K.K.Y., Wong J.S.W. and Tam P.K.H., Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease, Clinical Chemistry. 2004, 50(1): 93-100.

Researcher : Chen Y (Chen Yongxiong)

List of Research Outputs

Chen Y., Lui V.C.H. and Tam P.K.H., Resident macrophages are key players in ischeamia reperfusion injury in gut, 50th Annual International Congress of the British Association of Paediatric Surgeons, Estorial, Portugal, 15-18 July 2003.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Researcher : Chen Y (Chen Yan)

List of Research Outputs

Chung P.Y., Chen Y., Chan V.S.F., Tam P.K.H. and Lin C.L., Dendritic cells: sentinels against pathogens, Histology and Histopathology. 2004, 19(1): 317-324.

Researcher : Cheng LC

List of Research Outputs

Cheng L.C. and Chiu S.W., A simple method of treating seromas involving modified Blalock-Taussig shunts, Cardiology Young. 2003, 13(5): 479-480.

Ng J.Y.Y., Tam S.F., Man D.W.K., Cheng L.C. and Chiu S.W., Gender difference in self-esteem of Hong Kong Chinese with cardiac diseases, International Journal of Rehabilitation Research. 2003, 26(1): 67-70.

Researcher : Cheng SWK

Project Title:	Risks of stroke in patients with irradiation-induced and non-irradiation induced carotid stenosis: a case-control, clinical and haemodynamic study
Investigator(s):	Prof. Cheng S.W.K., Dr. Ting A.C.W.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001
Completion Date:	10/2003

Abstract:

To determine if irradiation-induced carotid stenosis would pursue a more aggressive progression in terms of atherosclerotic disease by serial ultrasonography; to test the behaviour of irradiation-induced carotid stenosis and the actual production of stroke; to attempt risk stratification to identify patients with rapid disease progression or the occurrence of stroke.

Project Title:	The role of COX-2 and its metabolites in the pathogenesis of abdominal aortic aneurysm (AAA)
Investigator(s):	Prof. Cheng S.W.K., Dr. Cheuk L.Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To investigate the functional expression of the inducible COX-2 and its metabolites that may contribute to the apoptotic response involved in the pathogenesis of abdominal aortic aneurysm (AAA).

Project Title:	Molecular profiling of cellular receptors and their specific ligands in abdominal aortic aneurysms and in relation to pathogenesis
Investigator(s):	Prof. Cheng S.W.K., Dr. Cheuk L.Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To investigate the molecular change of a series of cellular receptors and their specific ligands in aneurysmal VSMCs, and study the mechanisms underlining the altered expression pattern.

Project Title:	Endovascular program for treating thoracic aortic dissections
Investigator(s):	Prof. Cheng S.W.K., Dr. Ting A.C.W.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	04/2004

Abstract:

To initiate medical services for the poor and sick in the field of endovascular treatment of aortic dissections and provide equipment for such services.

List of Research Outputs

Cheng S.W.K., Ting A.C.W., Ho P. and Wong Wu L.H., Accelerated progression of carotid stenosis in patients with previous external neck irradiation, Journal of Vascular Surgery. 2004, 39 (2): 409-415.

Cheng S.W.K., Accelerated progression of carotid stenosis in patients with previous external neck irradiation, The XVII Annual Meeting of the European Society for Vascular Surgery, Dublin, Ireland, 5-7 September 2003.

Cheng S.W.K., Ting A.C.W. and Ho P., Angioplasty and primary stenting of high-grade, long-segment superficial femoral artery disease: is it worthwhile?, Annals of Vascular Surgery. 2003, 17(4): 430-437.

Cheng S.W.K., Chairman (1999 - present), Hospital Authority Working Group in Vascular Surgery, Hong Kong. 2004.

Cheng S.W.K., Chairman, CME and CPD Subcommittee (2004 - present), The College of Surgeons of Hong Kong. 2004.

Cheng S.W.K., Chairman, Scientific Subcommittee (2004 - present), The College of Surgeons of Hong Kong. 2004.

Cheng S.W.K., College Tutor (1997 - present), The Royal College of Surgeons of Edinburgh. 2004.

Cheng S.W.K., Consultant (1999 - present), Guangzhou Society of Vascular Surgery. 2004.

Cheng S.W.K., Council Member (2004 - 2007), The College of Surgeons of Hong Kong. 2004.

Cheng S.W.K., Council Member, Advisory Board, Asian Vascular Society. 2003.

Cheng S.W.K., Course Director, Advanced Trauma Life Support Course, American College of Surgeons (Hong Kong Chapter). 2004.

Cheng S.W.K., Course Instructor, Advanced Trauma Life Support Course (1997 - present), American College of Surgeons (Hong Kong Chapter). 2004.

Cheng S.W.K., Critical limb ischemia in Hong Kong (Invited Lecture), The 32nd Annual Meeting of the Japanese Society for Vascular Surgery, Shinjuku, Tokyo, Japan, 12-14 May 2004.

Cheng S.W.K., Critical limb ischemia in Hong Kong (Invited Plenary Lecture), The 7th National Congress of the Chinese Society of Vascular Surgery, Guangzhou, China, 13-16 May 2004.

Cheng S.W.K., Distinguished Fellow (2003 - present), Society for Vascular Surgery. 2004.

Cheng S.W.K., Editor (2002 - present), Annals of the College of Surgeons of Hong Kong. 2004.

Cheng S.W.K., Editor-in-Chief (2002 - present), Asian Journal of Surgery. 2004.

Cheng S.W.K., Editor, American College of Surgeons. 2004.

Cheng S.W.K., Endovascular aortic stent graft: current developments (Invited Lecture), 10th Anniversary: New Challenges in Health Care, Hong Kong Academy of Medicine, Hong Kong, 28-30 November 2004. 2003.

Cheng S.W.K., Endovascular aortic stent graft: five year on (Invited Lecture), The Hong Kong Surgical Forum, Hong Kong, 5 July 2003.

Cheng S.W.K., Endovascular aortic stent grafting: current developments (Invited Lecture), The 2004 Spring Scientific Meeting of the Taiwan Society of Cardiology, Taipei, Taiwan, 8 May 2004.

Cheng S.W.K., Endovascular aortic stent grafts for abdominal aortic aneurysm (Invited Lecture), International Union of Angiology - Asian Chapter Congress, Hong Kong, 25-26 November 2003.

Cheng S.W.K., Endovascular intervention of abdominal aortic aneurysm (Invited Lecture), The 33rd Annual Convention of the Taiwan Society of Cardiology, Taipei, Taiwan, 9-10 August 2003.

Cheng S.W.K., Endovascular treatment of abdominal aortic aneurysm (Prestige Lecture), Department of Cardiovascular Surgery, National Taiwan University Hospital, Taipei, Taiwan, 11-13 August 2003.

Cheng S.W.K., Epidemiology of venous diseases in Hong Kong (Invited Plenary Lecture), The Chinese Venous Forum, Guangzhou, China, 28-30 November 2003.

Cheng S.W.K., Faculty Instructor for Vascular Surgery (1996 - present), Advanced Surgical Skills Course, The Royal College of Surgeons of England. 2004.

Cheng S.W.K., Faculty Instructor for Vascular Surgery (1997 - present), Intercollegiate Basic Surgical Skills Course, The Royal College of Surgeons of Edinburgh. 2004.

Cheng S.W.K., Fellow (1988 - present), Hong Kong Surgical Society. 2004.

Cheng S.W.K., Fellow (1995 - present), American College of Surgeons. 2004.

Cheng S.W.K., Honorary Consultant, Department of Surgery (July 1997 - present), Queen Mary Hospital. 2004.

Cheng S.W.K., Honorary Member (2000- present), Hospital Authority e-Knowledge Gateway Surgery Editorial Panel. 2004.

Cheng S.W.K., Honorary Senior Consultant in Vascular Surgery (March 2000 - present), Department of Surgery, Tung Wah Hospital. 2004.

Cheng S.W.K., Instructor (1993 - present), Advanced Course in Surgery for FRCS Examination. 2004.

Cheng S.W.K., Invited Faculty for Vascular Surgery (1998 - present), The Royal College of Surgeons of Edinburgh/College of Surgeons of Hong Kong Basic Surgical Course. 2004.

Cheng S.W.K., Member (1995 - present), Training Sub-committee, Co-ordinating Committee in Surgery, Hospital Authority. 2004.

Cheng S.W.K., Member (1996 - present), Externship Subcomittee, The Licentiate Committee, Medical Council of Hong Kong. 2004.

Cheng S.W.K., Member (1996 - present), Royal Australasian College of Surgeons, Board of General Surgery, Hong Kong Regional Subcommittee. 2004.

Cheng S.W.K., Member (1998 - present), Accreditation Committee, Hong Kong Intercollegiate Board of Surgical Colleges. 2004.

Cheng S.W.K., Member (1998 - present), Training Subcommittee, College of Surgeons of Hong Kong, General Surgery Board. 2004.

Cheng S.W.K., Member (1999 - present), Ad Hoc Committee on Carotid Endovascular Stenting in the Management of Extracranial Carotid Artery Stenosis, Hong Kong Academy of Medicine. 2004.

Cheng S.W.K., Member (1999 - present), Hospital Authority Working Group in Vascular Surgery, Hong Kong. 2004.

Cheng S.W.K., Member (2000 - present), Examination Subcommittee, The Licentiate Committee, Medical Council of Hong Kong. 2004.

Cheng S.W.K., Member (2000 - present), Hospital Authority Commission on Stroke Service, Hong Kong. 2004.

Cheng S.W.K., Member (2001 - present), European Society for Vascular Surgery. 2004.

Cheng S.W.K., Member (2001 - present), Hospital Authority Expert Panel in Surgery, Hong Kong. 2004.

Cheng S.W.K., Member (2002 - present), Hospital Authority Specialty Group in General Surgery. 2003.

Cheng S.W.K., Member (2002 - present), Society for Vascular Surgery (SVS). 2004.

Cheng S.W.K., Member (2003 - present), Hospital Authority Central Committee on Surgical Training. 2004.

Cheng S.W.K., Member (2003 - present), Western Vascular Society (WVS). 2004.

Cheng S.W.K., Member of Editorial Board (1996 - present), Chinese Journal of Vascular Surgery. 2004.

Cheng S.W.K., Member, Advisory Board (2003 - present), International Union of Angiology. 2004.

Cheng S.W.K., Member, Board of Governors (2003 - present), American College of Surgeons. 2004.

Cheng S.W.K., Member, Editorial Board (2002 - present), Cutting Edge, The College of Surgeons of Hong Kong Newsletter. 2004.

Cheng S.W.K., Member, Education and Examination Subcommittee (2004 - present), The College of Surgeons of Hong Kong. 2004.

Cheng S.W.K., Member, Executive Board (1996 - present), Chinese Society of Vascular Surgery. 2004.

Cheng S.W.K., Metallic stents: where do we stand? (Invited Lecture), 10th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 2-3 August 2003.

Cheng S.W.K., Popliteal antrapment syndrome in Hong Kong and China (Invited Lecture), The 5th Meeting of the Popliteal Vascular Entrapment Forum, Shinjuku, Tokyo, Japan, 13 May 2004.

Cheng S.W.K., Program Director (2002 - present), Basic Surgical Training, Hong Kong West Cluster, Hong Kong. 2003.

Cheng S.W.K., Program Director (2002 - present), Higher Surgical Training Committee, College of Surgeons of Hong Kong. 2003.

Cheng S.W.K., Regional Faculty, Advanced Trauma Life Support Course (1997 - present), American College of Surgeons . 2004.

Cheng S.W.K., Reviewer (1992 - present), European Journal of Vascular Surgery. 2004.

Cheng S.W.K., Reviewer (1999 - present), Cardiologia - Peripheral Vascular Diseases Section. 2004.

Cheng S.W.K., Reviewer (2000 - present), Asian Journal of Surgery. 2004.

Cheng S.W.K., Reviewer (2000 - present), The British Journal of Surgery. 2004.

Cheng S.W.K., Reviewer (2001 - present), Asian Cardiovascular and Thoracic Annals. 2004.

Cheng S.W.K., Reviewer (2002 - present), Ethnicity and Disease. 2003.

Cheng S.W.K., Reviewer (2002-2003), Circulation. 2004.

Cheng S.W.K., Reviewer (2004 - present), Cardiovascular Ultrasound. 2004.

Cheng S.W.K., Reviewer (2004 - present), Stroke. 2004.

Cheng S.W.K., Vascular injuries of the extremities (Invited Speaker), 14th Biennial Congress of the Asian Surgical Association, Kota Kinabalu, Malaysia, 4-6 December 2003.

Cheng S.W.K., Visiting Professor (March 2004 - February 2006), Department of Surgery, Anaesthetics and Intensive Care, Imperial College of Science, Technology and Medicine, London. 2004.

Cheuk L.Y. and Cheng S.W.K., Differential expression of integrin alpha 5 beta 1 in human abdominal aortic aneursym and healthy aortic tissues and its significance in pathogenesis, Journal of Surgical Research. 2004, 118(2): 176-182.

Cheuk L.Y., Cheung G.C.Y. and Cheng S.W.K., Epidemiology of venous thromboembolism in a Chinese population, British Journal of Surgery. 2004, 91(4): 424-428.

Ho P., Law W.L., Tung P.H.M., Poon J.T.C., Ting A.C.W. and Cheng S.W.K., Laparoscopic transperitoneal clipping of the inferior mesenteric artery for the management of type II endoleak after endovascular repair of an aneurysm (Case report), Surgical Endoscopy. 2004, 18(5): 870.

Patil N.G., Cheng S.W.K. and Wong J., Surgical competence, World Journal of Surgery. 2003, 27(8): 943-947.

Ting A.C.W., Cheng S.W.K., Yeung K.M., Cheng P.W., Lui W.M., Ho P. and Tso H.W.K., Carotid stenting for radiation-induced extracranial carotid artery occlusive disease: efficacy and midterm outcomes, Journal of Endovascular Therapy. 2004, 11(1): 53-59.

Ting A.C.W., Au Yeung K.M., Cheng P.W., Lui W.M., Ho P., Poon J.T.C., Tso W.K. and Cheng S.W.K., Carotid stenting for radiation-induced extracranial carotid artery occlusive disease: long-term results, 17th International Congress on Endovascular Interventions (Arizona Heart Institute), The Phoenician, Scottsdale, Arizona, U.S.A., 8-12 February 2004.

Ting A.C.W., Cheng S.W.K., Ho P., Wu L.L.H. and Cheung G.C.Y., Clinical outcomes and changes in venous hemodynamics after subfascial endoscopic perforating vein surgery, International Union of Angiology - Asian Chapter Congress, Hong Kong, 25-26 November 2003.

Ting A.C.W., Cheng S.W.K., Ho P., Wu L.L. and Cheung G.C.Y., Clinical outcomes and changes in venous hemodynamics after subfascial endoscopic perforating vein surgery, Surgical Endoscopy. 2003, 17(8): 1314-1318.

Ting A.C.W., Cheng S.W.K., Ho P. and Poon J.T.C., Endovascular repair for multiple Salmonella mycotic aneurysms of the thoracic aorta presenting with Cardiovocal syndrome, European Journal of Cardiothoracic Surgery. 2004, 26(1): 221-224.

Ting A.C.W., Cheng S.W.K., Ho P., Poon J.T.C. and Tsu J.H.L., Surgical treatment of infected aneurysms of the thoracic and abdominal aorta, International Union of Angiology - Asian Chapter Congress, Hong Kong, 25-26 November 2003.

Researcher : Cheuk LY

List of Research Outputs

Cheuk L.Y. and Cheng S.W.K., Differential expression of integrin alpha 5 beta 1 in human abdominal aortic aneursym and healthy aortic tissues and its significance in pathogenesis, Journal of Surgical Research. 2004, 118(2): 176-182.

Cheuk L.Y., Cheung G.C.Y. and Cheng S.W.K., Epidemiology of venous thromboembolism in a Chinese population, British Journal of Surgery. 2004, 91(4): 424-428.

Researcher : Cheung CKY

List of Research Outputs

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Hepatitis B virus (HBV)-specific immune response after liver transplantation for chronic hepatitis B (Abstract), Liver Transplantation. 2004, 10(6): C42.

Luo Y., Cheung C.K.Y. and Lo C.M., Hepatitis B virus-specific immune response after liver transplantation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus (HBV)-specific lymphocytes in human liver allografts from HBV immune donors (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Researcher : Cheung ST

Project Title:	Characterization of the granulin/epithelin precursor gene in liver cancer
Investigator(s):	Dr. Cheung S.T., Prof. Fan S.T., Prof. Ng I.O.L.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2003

Abstract:

To characterize the role of the granulin/epithelin precursor (GEP) gene in the development and progression of liver cancer: 1) to examine the abnormalities of the GEP gene in normal, diseased and tumor specimens of the liver; 2) to understand the clinical and pathological significance of the GEP gene: to study the growth and proliferation function of the GEP gene in liver cancer; to identify the GEP regulated genes/pathways in liver cancer.

Project Title:	Characterization of the granulin/epithelin precursor gene in liver cancer
Investigator(s):	Dr. Cheung S.T., Prof. Fan S.T., Prof. Ng I.O.L.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	09/2003

Abstract:

Project Title:	Genes associated with liver cancer invasion
Investigator(s):	Dr. Cheung S.T., Prof. Fan S.T.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To study the proliferation and invasion potential of the membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP14) gene in human liver cancer cell lines; to identify the MMP14 regulated genes/pathways.

List of Research Outputs

Chan S.C., Cheung S.T., Leung S.Y., Liu C.L., Fan S.T. and Lo C.M., De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report, Liver Transplantation. 2004, 10(2): 320-323.

Cheung S.T. and Fan S.T., Compositions and methods for the prognosis and therapy of liver cancer, United States Provisional Patent No. 60/500,844, 4 September 2003. 2003.

Cheung S.T., Chen X., Fong D.Y.T., Leung K.L., Ip Y.C., Ng I.O.L., So S. and Fan S.T., Delineation of prognostic biomarkers from the global gene expression profile of liver cancer (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Cheung S.T., Chen X., Leung K.L., So S., Ng I.O.L. and Fan S.T., Different gene expression profiles in cirrhotic livers from cancer patients compared to non-cancer patients (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 2500.

Cheung S.T., Chen X., Leung K.L., So S., Ng I.O.L. and Fan S.T., Different gene expression profiles in cirrhotic livers from cancer patients compared to non-cancer patients (Abstract), The 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July 2003.

Cheung S.T., Wong S.Y. and Fan S.T., GEP as a novel therapeutic target for liver cancer: identification using cDNA microarray approach (Poster Presentation), The International Society for Cancer Gene Therapy 2004 Singapore Conference, Singapore, 20-22 February 2004.

Cheung S.T. and Fan S.T., Granulin-epithelin precursor overexpression as a target for diagnosis, prognosis, and treatment of hepatocellular carcinoma, United States Non-Provisional Patent No. 10/836,390, 29 April 2004. 2004.

Cheung S.T., Identification of novel prognostic genes in liver cancer (Invited Lecture), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Cheung S.T., Chen X., Fong D.Y.K., Leung K.L., Ip Y.C., Ng I.O.L. and Fan S.T., Novel prognostic markers for hepatocellular carcinoma (Poster Presentation), The Spanish National Cancer Centre 2004 Symposium on the Molecular Taxonomy of Cancer, Madrid, Spain, 3-6 February 2004.

Cheung S.T., Chen X., Fong D.Y.K., Leung K.L., Ip Y.C., Ng I.O.L., So S. and Fan S.T., Novel prognostic markers for liver cancer (Abstract), Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003.

Cheung S.T., Poster Competition Award, The Spanish National Cancer Centre 2004 Symposium on the Molecular Taxonomy of Cancer, Madrid, Spain, 3-6 February 2004. 2004.

Cheung S.T., Poster Prize Award, The International Society for Cancer Gene Therapy 2004 Singapore Conference, Singapore, 20-22 February 2004. 2004.

Ho J.C.Y., Cheung S.T. and Fan S.T., Down regulation of CYP2E1 is associated with poor prognosis of hepatocellular carcinoma (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Ho J.C.Y., Cheung S.T. and Fan S.T., Down regulation of CYP2E1 is associated with poor prognosis of hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ho J.C.Y., Cheung S.T. and Fan S.T., Up-regulation of glycosylphatidylinositols anchor attachment protein (GAA1) is associated with poor prognosis of hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 5275.

Ho J.C.Y., Cheung S.T. and Fan S.T., Up-regulation of glycosylphatidylinositols anchor attachment protein (GAA1) is associated with poor prognosis of hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Ip Y.C., Cheung S.T. and Fan S.T., Genes associated with venous invasion in hepatocelluar carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 344.

Ip Y.C., Cheung S.T. and Fan S.T., Genes associated with venous invasion in hepatocellular carcinoma (Abstract), Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July. 2003, 44: 344.

Ip Y.C., Cheung S.T. and Fan S.T., MMP14 enhances tumor growth and invasion in hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 1826.

Ip Y.C., Cheung S.T. and Fan S.T., MMP14 enhances tumor growth and invasion in hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Increased expression of SPARC and SPARC-like 1 in relation to tumor angiogenesis in hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 3256.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Increased expression of SPARC and SPARC-like 1 in relation to tumor angiogenesis in hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Relationship between expression of SPARC and SPARC-like 1 and tumor angiogenesis in hepatocellular carcinoma (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Lo C.M., Cheung S.T., Ng I.O.L., Liu C.L., Lai C.L. and Fan S.T., Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin, Liver Transplantation. 2004, 10(4): 557-563.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Poon R.T.P., Chung K.K., Cheung S.T., Lau C., Tong C.S.W., Leung K.L., Yu W.C., Tuszynski G.P. and Fan S.T., Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 Pt1): 4150-4157.

Wong S.Y., Cheung S.T. and Fan S.T., Expression of granulin/epithelin precursor (GEP) in hepatocellular carcinoma associated with growth and invasion competency (Abstract), Proceedings of The 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July 2003. 44: 1302.

Wong S.Y., Cheung S.T. and Fan S.T., Expression of granulin/epithelin precursor (GEP) in hepatocellular carcinoma associated with growth and invasion competency (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 1302.

Researcher : Cheung WH

List of Research Outputs

Cheung W.H., Zheng S.L., Yu W.Y., Zhou G.C. and Che C.M., Ruthenium porphyrin catalyzed intramolecular carbenoid CH insertion stereoselective synthesis of cis-disubstituted oxygen and nitrogen heterocycles, Organic Letters. 2003, 5(14): 2535-2538.

Researcher : Chiu SW

List of Research Outputs

Chan K.L., Ip P., Chiu S.W. and Cheung Y.F., Peritoneal Dialysis After Surgery for Congenital Heart Disease in Infants and Young Children, The Annals of Thoracic Surgery. 2003, 76: 1443-1449.

Cheng L.C. and Chiu S.W., A simple method of treating seromas involving modified Blalock-Taussig shunts, Cardiology Young. 2003, 13(5): 479-480.

Du X., Gao Z., Lau C.P., Chiu S.W., Tse H.F., Baumgarten C.M. and Li G.R., Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases, Journal of General Physiology. 2004, 123: 427-39.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., A novel ionic mechanism of verapamil in human atrial myocytes, Biophysical Journal/48th Biophysical Society, Baltimore, MD, USA. 2004, 86: 719.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., Effects of Verapamil on Transient Outward and Ultra-rapid Delayed Rectifier Potassium Current in Human Atrial Myocytes , Journal of the Hong Kong College of Cardiology/The 7th Annual Meeting, Institute of Cardiovascular Science and Medicine. 2003, 11 (suppl 1): A14.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., Inhibition of ultra-rapid delayed rectifier K+ current by verapamil in human atrial myocytes, Journal of Molecular and Cellular Cardiology . 2004, 36: 257-263.

Ng J.Y.Y., Tam S.F., Man D.W.K., Cheng L.C. and Chiu S.W., Gender difference in self-esteem of Hong Kong Chinese with cardiac diseases, International Journal of Rehabilitation Research. 2003, 26(1): 67-70.

Researcher : Chow CK

List of Research Outputs

Au D.K.K., Chow C.K., Hui Y. and Wei W.I., Cognitive abilities of patients with cochlear implant in the discrimination of tone stimuli with minimal contrast, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003. 102.

Chow C.K., Hui Y., Au D.K.K., LAM W.W.M. and Wong Y.K., Management of bilateral cochlear fistula in cochlear implantation, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004.

Chow C.K., Hui Y. and Au D.K.K., Minimally invasive surgery for different types of cochlear implant, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003.

Chu K., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Short electrode insertion in cochlear implants: the performance on speech perception, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003. 99.

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Narrative abilities in children with cochlear implants, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004. 181.

Researcher : Chow LWC

Project Title:	In-vitro chemosensitivity testing for breast cancer using histoculture drug response assay (HDRA)
Investigator(s):	Dr. Chow L.W.C.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	07/1996

Abstract:

To optimize the chemotherapy regimen for individual breast cancer patients to produce an improved tumour response and patients survival.

Project Title:	The prediction of persistent drainage, seroma formation and wound necrosis after mastectomy
Investigator(s):	Dr. Chow L.W.C.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	07/1998

Abstract:

To determine whether matrix metalloproteinases account for the delay in wound healing and persistent collection of fluid after mastectomy and axillary dissection.

Project Title:	Role of selectin in the postoperative recovery after mastectomy for breast cancer
Investigator(s):	Dr. Chow L.W.C.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	07/1999

Abstract:

To determine whether selectin is responsible for the acute inflammatory response and postoperative recovery after surgical trauma from mastectomy for breast cancer.

Project Title:	Methylation changes during the longitudinal follow-up of breast cancer patients
Investigator(s):	Dr. Chow L.W.C., Dr. Wong I.H.N.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002
Completion Date:	09/2003

Abstract:

To determine the status of methylation of COX-2 in patients with breast cancer and the relationship of such methylation with cancer progression; to quantify the methylation changes in COX-2 for monitoring cancer progression and the response to treatment during the longitudinal follow-up of breast cancer patients.

Project Title:	Radioguided surgery and breast cancer management courses and seminars
Investigator(s):	Dr. Chow L.W.C., Dr. Kwong A.
Department:	Surgery
Source(s) of Funding:	Professional Services Development Assistance Scheme - Business Services Promotion Unit
Start Date:	03/2003

Abstract:

To host a series of workshops and seminars, once every three months for a period of two years, on the radio guided sentinel node biopsy procedure. Other breast cancer management information and techniques will also be presented.

List of Research Outputs

Chow L.W.C., Board Member (April 2004), Pfizer Global Oncology Board on Celebrex. 2004.

Chow L.W.C., Board Member (October 2002 - present), Breast Cancer Advisory Panel, Japan. 2004.

Chow L.W.C., Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer: preliminary report, First Asia Pacific Oncology Summit, Hanoi, China, October 2003.

Chow L.W.C., Wong J.L.N. and Toi M., Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer: preliminary report, Journal of Steroid Biochemical Molecular Biology. 2003, 86(3-5): 443-447.

Chow L.W.C. and Kwong A., Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer, San Antonio Breast Cancer Symposium, San Antonio,U.S.A., December 2003.

Chow L.W.C., Chairman of Organizing Committee and Speaker, Key Advances in the Treatment of Breast Cancer, Hong Kong, 25 February. 2004.

Chow L.W.C., Chairman of Session and Organizing Committee, First Investigator Assembly on Neoadjuvant Trial (N-001) on Breast Cancer, Tokyo, Japan, December. 2003.

Chow L.W.C., Chairman, A new era in breast cancer therapy, First Asia Pacific Oncology Summit, Hanoi, China, October. 2003.

Chow L.W.C., Chairman, Country specific issues with femara in treatment of breast cancer, Femara Advisory Board Meeting, Shanghai, China, September. 2003.

Chow L.W.C., Chairman, Molecular Oncology, 10th Hong Kong International Cancer Congress, Hong Kong, November. 2003.

Chow L.W.C., Clinical management of women with BRCA1 or BRCA2, Asian Breast Cancer Conference, Taipei, Taiwan, February 2004.

Chow L.W.C., Corresponding Editor, Chinese Medical Journal. 2004.

Chow L.W.C., Director, Hung Chao Hong Integrated Centre for Breast Diseases, Department of Surgery, Tung Wah Hospital, Hong Kong. 2004.

Chow L.W.C., Executive Director (December 2002 - present), Organisation for Oncology and Translational Research. 2004.

Chow L.W.C., Executive Member, Asian Breast Cancer Society. 2004.

Chow L.W.C. and Lam C.K., Feasibility of sentinel lymph node biopsy in patient with breast cancer after neoadjuvant chemotherapy, 第七屆全國乳腺癌學術會議, China, September 2003.

Chow L.W.C., Guest Editor, Breast Cancer Symposium, Asian Journal of Surgery. 2004.

Chow L.W.C., Guest Editor, October Issue, Symposium on Sentinel Lymph Node Biopsy, Asian Journal of Surgery. 2004.

Chow L.W.C., Zhu L. and Loo T.Y., HER-2/NEU expression in breast cancer patients: pre- and postexposure to neoadjuvant endocrine therapy, 10th Hong Kong International Cancer Congress, Hong Kong, November 2003.

Chow L.W.C., Honorary Consultant (July 1996 - present), Department of Surgery, Queen Mary Hospital, Hong Kong. 2004.

Chow L.W.C., Honorary Consultant (July 1996 - present), Department of Surgery, Tung Wah Hospital, Hong Kong. 2004.

Chow L.W.C., Honorary Secretary, Hong Kong Association for Integration of Chinese-Western Medicine. 2004.

Chow L.W.C., Member of Editorial Board (February 2004 - present), The Chinese Journal of Surgical Oncology. 2004.

Chow L.W.C., Member of Editorial Board, British Medical Journal (Chinese). 2004.

Chow L.W.C., Member of Editorial Board, Chinese Journal of Surgical Therapy. 2004.

Chow L.W.C., Member of Editorial Board, Update in Breast Cancer Therapy. 2004.

Chow L.W.C., Member, Task Group on Breast Cancer Management, Hospital Authority. 2004.

Chow L.W.C., Neoadjuvant hormonal therapy, Key Advances in the Treatment of Breast Cancer, Hong Kong, February 2004.

Chow L.W.C., Neoadjuvant therapy for breast cancer, Inaugural Stanford-Hong Kong Oncology Teleconference and Seminar - Update in Breast Cancer Investigation and Treatment, Hong Kong, April 2004.

Chow L.W.C., Toi M. and Takebayashi Y., Neoadjuvant use of 5-fluoroue/racil, epirubicin and cyclophosphamide with and without celecoxib for locally advanced breast cancer: a phase II study correlating response to celecoxib with high levels of COX-2 gene expression in the tumor, 40th Annual Meeting, American Society of Clinical Oncology, New Orleans, June 2004.

Chow L.W.C., Phase II study on an "all-oral" regimen of capecitabine idarubicin and cyclophamide in metastatic breast cancer - possibility and efficacy, 2nd Roche Asia Oncology Forum, Taipei, October 2003.

Chow L.W.C. and Lau G., Preoperative chemotherapy for breast cancer based on chemosensitivity assay, Asian Breast Cancer Conference, Taipei, Taiwan, February 2004.

Chow L.W.C., Prospective pilot study of the preoperative use of cyclooxygenase-2 inhibitor (celecoxib) and 5-fluorouracil/epirubicin/cyclophosphamide (FEC) for the treatment of locally advanced breast cancer, San Antonio Breast Cancer Symposium, San Antonio, U.S.A., December 2003.

Chow L.W.C., Loo T.Y., Sham J.S.T. and Cheung M.N.B., Radix bupleuri containing compound (KY88 Liver-Livo) induces apoptosis and production of interleukin-4 and tumor necrosis factor-a in liver cancer cells in-vitro, American Journal of Chinese Medicine. 2004, 32(2): 185-193.

Chow L.W.C., Reviewer, Annals of Hong Kong College of Surgeons. 2004.

Chow L.W.C., Reviewer, Asian Journal of Surgery. 2004.

Chow L.W.C., Reviewer, Clinical Cancer Research. 2004.

Chow L.W.C., Reviewer, Hong Kong Medical Journal. 2004.

Chow L.W.C., Reviewer, International Immunopharmacology. 2004.

Chow L.W.C., Reviewer, Journal Biologia, Bratislava. 2004.

Chow L.W.C., Reviewer, Journal of Clinical Chemistry. 2004.

Chow L.W.C., Reviewer, Journal of Pharmacology and Experimental Therapeutics. 2004.

Chow L.W.C., Stereotatic breast biopsy with vacuum assisted minimally invasive biopsy technology, First Mammotome Asia Pacific Summit Meeting, Shanghai, China, November 2003.

Chow L.W.C., Loo W.T.Y., Yuen K.Y. and Cheng C., The study of cytokine dynamics at the operation site after mastectomy, Wound Repair and Regeneration. 2003, 11(5): 326-330.

Chow L.W.C., To screen or not to screen: The evidences, 10th Hong Kong International Cancer Congress, Hong Kong, November 2003.

Chow L.W.C., Vice-President (Asia-Africa), Senological International Society. 2004.

Chow L.W.C., Vice-President, Hong Kong Day Surgery Association. 2004.

Chow L.W.C., Visiting Professor (April 2004 - March 2005), Tohoku University, Faculty of Medicine, Sendai, Japan. 2004.

Hu X., Wong I.H.N. and Chow L.W.C., Tumor-derived aberrant methylation in plasma of invasive ductal breast cancer patients: clinical implications, Oncology Reports. 2003, 10(6): 1811-1815.

Kwong A.K., Cheng C.W., Yeung D., Lam C.K. and Chow L.W.C., 1st Prize Award for Poster, The correlation of tumor markers CEA and CA15.3 with the extent of breast cancer using 18-flouro-2-deoxy-D-glucose positron emission tomography (18FDG-PET) , Annual Congress, Asian Surgical Association, Kota Kinabalu, December 2003. 2003.

Law M., Cheng K.C., Wu P.M.C., Ho W.Y. and Chow L.W.C., Patient effective dose from sentinel lymph node lymphoscintigraphy in breast cancer: a study using a female humanoid phantom and thermoluminescent dosemeters, The British Journal of Radiology. 2003, 76(911): 818-823.

Law M., Chow L.W.C., Lam C.K., Kwong A. and Yiu C.C.P., Radiation safety issues for radioguided surgery, Seminars in Oncology. 2004, 31: 298-303.

Law M., Chow L.W.C., Kwong A. and Lam C.K., Sentinel lymph node technique for breast cancer: radiation safety issues, Seminer Oncology. 2004, 31(3): 298-303.

Researcher : Chu ACY

List of Research Outputs

Wang Y., Luk J.M.C., Ikeda K., Man K., Chu A.C.Y., Kaneda K. and Fan S.T., Regulatory role of vHL/HIF-1a in hypoxia-induced VEGF production in hepatic stellate cells, Biochemical and Biophysical Research Communications. 2004, 317(2): 358-362.

Yang Z., Ho D.W.Y., Chu A.C.Y., Wang Y. and Fan S.T., Linking inflammation to acute rejection in small-for-size allografts: the potential role of early macrophage activation, American Journal of Transplantation. 2004, 4(2): 196-209.

Researcher : Chu KM

Project Title:	Inhibition of growth factors expression in gastric adenocarcinoma by small interfering RNAs
Investigator(s):	Dr. Chu K.M., Dr. Ko S., Dr. Leung S.Y., Dr. Yuen S.T.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To investigate: (1) does RNAi model exist in gastric cancer cell lines?; (2) can gene specific siRNA duplexes elicit gene suppression?; (3) can in vitro results be applied to in vivo model?

Project Title:	The role of Id proteins in gastric cancer
Investigator(s):	Dr. Chu K.M., Dr. Ko S.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To investigate the expression levels of mRNA and proteins of Id proteins such as Id1, Id2 and Id3 in gastric cancer.

List of Research Outputs

Chan A.S.W., Tsui W.Y., Chen X., Chu K.M., Chan T.L., Chan A.S.Y., Li R., So S., Yuen S.T. and Leung S.Y., Down-regulation of ID4 by promoter hypermethylation in gastric adenocarcinoma, Proceedings of the International Conference on Applied Genomics, 9th European Society for Analytical Cellular Pathology meeting and 16th International Society for Diagnostic Quantitative Pathology meeting, Netherlands, 2003.

Chan A.S.W., Tsui W.Y., Chen X., Chu K.M., Chan T.L., Chan A.S.Y., Li R., So S., Yuen S.T. and Leung S.Y., Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma, Oncogene. 2003, 22(44): 6946-6953.

Chan A.S.W., Chu K.M., Yuen S.T. and Leung S.Y., High-throughput quantification of hMLH1 promoter methylation using PyrosequencingTM technology , Proceedings of the 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, USA, March 2004.

Chen X., Leung S.Y., Yuen S.T., Chu K.M., Ji J., Li R., Chan A.S.Y., Law S.Y.K., Troyanskaya O.G., Wong J., So S., Botstein D. and Brown P.O., Variation in gene expression patterns in human gastric cancers, Molecular Biology of the Cell. 2003, 14(8): 3208-3215.

Chen Y.W., Liang A.C.T., Au W.Y., Chu K.M., Wong K.Y., Hu X., Lu L., Tang J.C.O., Chan K.W., Beh S.L., Kwong Y.L., Liang R.H.S. and Srivastava G., Multiple BCL6 translocation partners in individual cases of gastric lymphoma, Blood. 2003, 102: 1931-1932.

Chu K.M., "Gastrointestinal diseases", Core Module 14 "Biological Basis of Common Health Problems", Master of Medical Science, The University of Hong Kong, Hong Kong, 18 March 2004. 2004.

Chu K.M., "Upper Gastrointestinal Surgery: Common UGI disorders and surgeries", Lecture for Diploma in Surgical Nursing, School of Professional and Continuing Education (SPACE), The University of Hong Kong, Hong Kong, 2 April 2004. 2004.

Chu K.M., Patil N.G., Saing H. and Wong J., A level grades and undergraduate academic performance in Hong Kong, British Medical Journal. 2003, (online).

Chu K.M., Kwok K.F., Law S.Y.K. and Wong K.H., A prospective evaluation of catheter probe EUS for the detection of ascites in patients with gastric carcinoma, Gastrointestinal Endoscopy. 2004, 59(4): 471-474.

Chu K.M., Associate Member, Hereditary Gastrointestinal Cancer Registry, Hong Kong. 2004.

Chu K.M., Chairman, Session on "Gastrointestinal surgery II", Hong Kong Surgical Forum, Hong Kong, 9-11 January 2004. 2004.

Chu K.M., Chairman, Session on "Stenting in aerodigestive tract", Hong Kong Surgical Forum, Hong Kong, 5 July 2003. 2003.

Chu K.M., Chairman, Symposium on "Gastric cancer", The 10th Hong Kong International Cancer Congress, Hong Kong, 19-21 November 2003. 2003.

Chu K.M., Endosonographic features of gastric adenomyoma: a type of ectopic pancreas-response (Author Reply), Endoscopy. 2003, 35(7): 623.

Chu K.M., Expert Reviewer (July 2000 - present), UICC Fellowships Programme, International Union Against Cancer (UICC), Geneva, Switzerland. 2004.

Chu K.M., External Advisor/Reviewer (September 1999 - present), Quality Education Fund Projects, Quality Education Fund (QEF), Hong Kong. 2004.

Chu K.M., External referee for the appointment of Associate Professor at the Department of Surgery, National University of Singapore. 2003.

Chu K.M., Fellow (1998 - present), American College of Surgeons. 2004.

Chu K.M., Patil N.G., Saing H. and Wong J., Female gender is associated with better undergraduate academic performance, British Medical Journal. 2004, (online).

Chu K.M., From A-level to MBBS, Hong Kong Surgical Forum, Hong Kong, 9-11 January 2004.

Chu K.M., Honorary Consultant (January 1999 - present), Department of Surgery, Queen Mary Hospital, Hong Kong. 2004.

Chu K.M., Honorary Consultant in Gastrointestinal Surgery (March 1999 - present), Tung Wah Hospital, Hong Kong. 2004.

Chu K.M., Invited Reviewer (1997 - present), Asian Journal of Surgery . 2004.

Chu K.M., Invited Reviewer (1999 - present), Annals of the College of Surgeons of Hong Kong. 2004.

Chu K.M., Invited Reviewer, British Journal of Cancer. 2003.

Chu K.M., Invited Reviewer, Digestive and Liver Disease. 2004.

Chu K.M., Invited referee (1998, 1999, 2004), Journal of Gastroenterology and Hepatology . 2004.

Chu K.M., Invited referee (1999-2004), Digestive Surgery. 2004.

Chu K.M., Invited referee (2002, 2004), Hong Kong Medical Journal . 2004.

Chu K.M., Invited referee (2002, 2004), Surgery. 2004.

Chu K.M., Member of Editorial Board (2000 - present), Annals of Cancer Research and Therapy . 2004.

Chu K.M., Member of Editorial Board (2003 - present), Cancer Therapy. 2004.

Chu K.M., Regional Faculty (January 1996 - present), Advanced Trauma Life Support Course, American College of Surgeons. 2004.

Chu K.M., Review and prospect of surgical treatment for gastric cancer in Hong Kong, The 76th Annual Meeting of Japanese Gastric Cancer Association, Yonago, Japan, 4-6 March 2004.

Jin Y., Jin C., Law S.Y.K., Chu K.M., Zhang H., Stromback B., Yuen P.W. and Kwong Y.L., Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas, Cancer Genetics Cytogenetics. 2004, 148(1): 21-28.

Ko S., Chu K.M., Luk J.M.C., Wong W.Y., Leung S.Y., Yuen S.T. and Wong J., Expression of CDX2 and LI-cadherin in intestinal metaplasia and adenocarcinoma of the stomach, 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Ko S., Chu K.M., Luk J.M.C., Wong B.W.Y., Yuen S.T., Leung S.Y.L. and Wong J., Over-expression of LI-cadherin in gastric cancer is associated with lymph node metastasis, Biochemical and Biophysical Research Communications. 2004, 319(2): 562-568.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Law S.Y.K., Kwong D.L.W., Kwok K...F., Wong K...H., Chu K.M., Sham J.S.T. and Wong J., Improvement in treatment results and long-term survival of patients with esophageal cancer: impact of chemoradiation and change in treatment strategy, Annals of Surgery. 2003, 238(3): 339-348.

Law S.Y.K., Boey J...P., Kwok K...F., Wong K...H., Chu K.M. and Wong J., Pleural drainage after transthoracic esophagectomy: experience with a vacuum system, Diseases of the Esophagus. 2004, 17(1): 81-86.

Law W.L., Yong J.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendectomy (Abstract), Journal of Society of Laparoendoscopic Surgery. 2003, 7: S59.

Murthy S.C., Law S.Y.K., Whooley B.P., Alexandrou A., Chu K.M. and Wong J., Atrial fibrillation after esophagectomy is a marker for postoperative morbidity and mortality, The Journal of Thoracic and Cardiovascular Surgery. 2003, 126(4): 1162-1167.

Shin V.Y., Liu E.S.L., Ye Y.N., Koo M.W.L., Chu K.M. and Cho C.H., A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells, Toxicology and Applied Pharmacology. 2004, 195(1): 103-112.

Wong K.H. and Chu K.M., Retrograde jejunojejunogastric intussusception, Gastrointestinal Endoscopy. 2004, 59(4): 544.

Yong J.L., Law W.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendicectomy, The 12th International Congress and Endo Expo 2003, SLS Annual Meeting, The Society of Laparoendoscopic Surgeons, Las Vegas, Nevada, U.S.A., 22-25 September 2003.

Zhao W., Chan T.L., Chu K.M., Chan A.S.Y., Stratton M.R., Yuen S.T. and Leung S.Y., Mutations of BRAF and KRAS in gastric cancer and their association with microsatellite instability, International Journal of Cancer. 2004, 108(1): 167-169.

Researcher : Chu KMY

List of Research Outputs

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Narrative abilities in children with cochlear implants, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004. 181.

Researcher : Chu KW

List of Research Outputs

Chan S.Y., Law W.L. and Chu K.W., Gastrointestinal stromal tumour presenting as incarcerated inguinal hernia (Case report), Australian and New Zealand Journal of Surgery. 2004, 74(5): 391-392.

Choi H.K., Law W.L. and Chu K.W., The value of gastrografin in adhesive small bowel obstruction after unsuccessful conservative treatment: a prospective evaluation, Annual Meeting of the American Society of Colon and Rectal Surgeons, Dallas, Texas, U.S.A., 8-13 May 2004.

Chu K.W., Fellow (1993 - present), American College of Surgeons. 2004.

Chu K.W., Laparoscopic colorectal surgery: technique, indications and limitations, Hong Kong Colorectal Symposium, 9-10 October 2003.

Chu K.W., Laparoscopic low anterior resection, TME (Live surgery), Hong Kong Colorectal Symposium, 9-10 October 2003.

Chu K.W., Open low anterior resection, TME (Live surgery), Hong Kong Colorectal Symposium, 9-10 October 2003.

Chu K.W., Total mesorectal excision for rectal cancer: results and overcoming complications, Hong Kong Colorectal Symposium, 9-10 October 2003.

Ho P., Law W.L., Choy C., Chan G.S. and Chu K.W., Granulomatous appendicitis progressing to Crohn's disease with bleeding complication, Australian and New Zealand Journal of Surgery. 2003, 73(7): 554-556.

Law W.L., Choi H.K., Chu K.W., Ho J.W.C. and Wong L.Y.C., Bowel preparation for colonoscopy: a randomized controlled trial comparing polyethylene glycol solution, one dose and two doses of oral sodium phosphate solution, Asian Journal of Surgery. 2004, 27(2): 120-124.

Law W.L., Choi H.K. and Chu K.W., Comparison of stenting with emergency surgery as palliative treatment for obstructing primary left-sided colorectal cancer, British Journal of Surgery. 2003, 90(11): 1429-1433.

Law W.L., Choi H.K., Lee Y.M. and Chu K.W., Laparoscopic colectomy for obstructing sigmoid cancer with prior insertion of an expandable metallic stent, Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 2004, 14(1): 29-32.

Law W.L., Chan W.F., Lee Y.M. and Chu K.W., Non-curative surgery for colorectal cancer: critical appraisal of outcomes , International Journal of Colorectal Disease. 2004, 19(3): 197-202.

Law W.L., Choi H.K., Lee Y.M. and Chu K.W., Palliation for advanced malignant colorectal obstruction by self-expanding metallic stents: prospective evaluation of outcomes, Diseases of the Colon & Rectum. 2004, 47(1): 39-43.

Law W.L. and Chu K.W., Scirrhous colonic metastasis from ductal carcinoma of the breast - report of a case, Diseases of the Colon & Rectum. 2003, 46(10): 1424-1427.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Researcher : Chu SSM

List of Research Outputs

Chu S.S.M., Member, Institutional Review Board, University of Hong Kong/Hospital Authority Hong Kong West Cluster. 2004.

Ho K.L., Chu S.S.M. and Tam P.C., Reduction of strangulated urethral prolapse using local anaesthesia with hyaluronidase, Journal of Urology. 2003, 169: 288.

Researcher : Chung KK

List of Research Outputs

Chung K.K., Significance of thrombospondin 1 (THBS 1) in hepatocellular carcinoma, Thesis, Master of Philosophy, The University of Hong Kong. 2003.

Poon R.T.P., Chung K.K., Cheung S.T., Lau C., Tong C.S.W., Leung K.L., Yu W.C., Tuszynski G.P. and Fan S.T., Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 Pt1): 4150-4157.

Researcher : Chung PY

List of Research Outputs

Chung P.Y., Chen Y., Chan V.S.F., Tam P.K.H. and Lin C.L., Dendritic cells: sentinels against pathogens, Histology and Histopathology. 2004, 19(1): 317-324.

Researcher : Darzi A

List of Research Outputs

Bann S., Kwok K.F., Lo C.Y., Darzi A. and Wong J., Objective assessment of technical skills of surgical trainees in Hong Kong , British Journal of Surgery. 2003, 90: 1294-1299.

Researcher : Fan ST

Project Title:	Liver transplantation in Hong Kong
Investigator(s):	Prof. Fan S.T.
Department:	Surgery
Source(s) of Funding:	Oriental Press Charitable Fund Association
Start Date:	07/1995

Abstract:

To evaluate the outcome of liver transplantation in Hong Kong.

Project Title:	Right-sided hepatectomy for hepatocellular carcinoma by anterior approach - a prospective randomized trial
Investigator(s):	Prof. Fan S.T.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2000

Abstract:

To carry out a prospective randomised trial on patients operated by anterior approach and conventional approach, and compare which is the better practice in liver surgery.

Project Title:	S.K. Yee Medical Foundation Fellowship in hepatobiliary surgery
Investigator(s):	Prof. Fan S.T.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	11/2000

Abstract:

To train surgeons from less developed cities in China to acquire the technique and knowledge in dealing with complex hepatobiliary problems so as to benefit patients who cannot afford the cost of receiving treatment in cities like Beijing, Shanghai and Guangzhou.

Project Title:	Novel strategy to prevent small-for-size graft failure during liver transplantation
Investigator(s):	Prof. Fan S.T., Dr. Man K.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2002

Abstract:

The project aims at identifying the effect of a new nitric oxide donor FK 409 on hepatic sinusoids and to optimize the dosage and injection timing or route. The study will monitor the portal hemodynamics and intragraft genes expression at the early phase after reperfusion in a rat liver transplantation using different graft sizes.

Project Title:	Clinical significance of metastasis genes in liver cancer
Investigator(s):	Prof. Fan S.T., Dr. Cheung S.T.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003
Completion Date:	12/2003

Abstract:

To study the expression abnormalities of metastasis genes in human liver samples.

Project Title:	Rescue of marginal liver graft from ischemia-reperfusion injury by FTY720 combined with gene therapy using Egr-1 dominant negative mutant and A20
Investigator(s):	Prof. Fan S.T., Dr. Man K., Dr. Xu R.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To investigate the effectiveness of combined drug (FTY 720) and gene therapies (using a novel viral vectors) in improving the long-term function of marginal grafts in liver transplantation.

Project Title:	Clinical and genetic study of novel genes associated with early recurrence in hepatocellular carcinoma
Investigator(s):	Prof. Fan S.T., Dr. Cheung S.T.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To study the expression and structural abnormalities of the novel prognostic markers in human liver samples.

Project Title:	Differential proteomic analysis of biomarkers for primary and recurrent hepatocellular carcinoma
Investigator(s):	Prof. Fan S.T., Prof. Leng X.S., Dr. Luk J.M.C., Dr. Peng J.R.
Department:	Surgery
Source(s) of Funding:	National Natural Science Foundation of China
Start Date:	12/2003

Abstract:

To identify potential biomarkers for HCC in liver tissues by proteomic analysis; to detect HCC-specific protein biomarkers in serum by ProteinChip; to predict proteomic analysis of HCC patients with high-risk recurrence after surgery.

Project Title:	Differential proteomic analysis of biomarkers for primary and recurrent hepatocellular carcinoma
Investigator(s):	Prof. Fan S.T., Prof. Leng X.S., Dr. Luk J.M.C., Dr. Peng J.R.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	12/2003

Abstract:

List of Research Outputs

Chan C.F., Yau T.O., Jin D., Wong C.M., Fan S.T. and Ng I.O.L., Evaluation of nuclear factor-kB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 pt. 1): 4140-4149.

Chan S.C., Cheung S.T., Leung S.Y., Liu C.L., Fan S.T. and Lo C.M., De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report, Liver Transplantation. 2004, 10(2): 320-323.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Abstract), Liver Transplantation. 2004, 10(6): C15.

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Poster Presentation), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Prospective study on donor quality of life before and after right lobe adult-to-adult live donor liver transplantation (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004 . 2004.

Chan S.C., Lo C.M., Liu C.L., Wong Y., Fan S.T. and Wong J., Tailoring donor hepatectomy per segment 4 venous drainage in right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(6): 755-762.

Chan W.F., Lo C.Y., Lo C.M. and Fan S.T., Laparoscopic resection of a pancreatic polypeptidoma with a solitary liver metastasis, Surgical Endoscopy. 2004, 18(3): 554-556.

Chen D.W., Poon R.T.P., Liu C.L., Fan S.T. and Wong J., Immediate and long-term outcomes of hepatectomy for hepatolithiasis, Surgery. 2004, 135(4): 386-393.

Cheung S.T. and Fan S.T., Compositions and methods for the prognosis and therapy of liver cancer, United States Provisional Patent No. 60/500,844, 4 September 2003. 2003.

Cheung S.T., Chen X., Fong D.Y.T., Leung K.L., Ip Y.C., Ng I.O.L., So S. and Fan S.T., Delineation of prognostic biomarkers from the global gene expression profile of liver cancer (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Cheung S.T., Chen X., Leung K.L., So S., Ng I.O.L. and Fan S.T., Different gene expression profiles in cirrhotic livers from cancer patients compared to non-cancer patients (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 2500.

Cheung S.T., Chen X., Leung K.L., So S., Ng I.O.L. and Fan S.T., Different gene expression profiles in cirrhotic livers from cancer patients compared to non-cancer patients (Abstract), The 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July 2003.

Cheung S.T., Wong S.Y. and Fan S.T., GEP as a novel therapeutic target for liver cancer: identification using cDNA microarray approach (Poster Presentation), The International Society for Cancer Gene Therapy 2004 Singapore Conference, Singapore, 20-22 February 2004.

Cheung S.T. and Fan S.T., Granulin-epithelin precursor overexpression as a target for diagnosis, prognosis, and treatment of hepatocellular carcinoma, United States Non-Provisional Patent No. 10/836,390, 29 April 2004. 2004.

Cheung S.T., Chen X., Fong D.Y.K., Leung K.L., Ip Y.C., Ng I.O.L. and Fan S.T., Novel prognostic markers for hepatocellular carcinoma (Poster Presentation), The Spanish National Cancer Centre 2004 Symposium on the Molecular Taxonomy of Cancer, Madrid, Spain, 3-6 February 2004.

Cheung S.T., Chen X., Fong D.Y.K., Leung K.L., Ip Y.C., Ng I.O.L., So S. and Fan S.T., Novel prognostic markers for liver cancer (Abstract), Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003.

Fan S.T., Artifical liver support (State-of-the-Art Lecture), The 11th U.A.E. Surgical Conference, Abu Dhabi, U.A.E., 6-8 October 2003.

Fan S.T., Associate Editor (June 2002 - present), Liver Transplantation . 2004.

Fan S.T., Biliary complication of liver transplantation (Invited Lecture), The 8th Congress of Asian Society of Transplantation, Kuala Lumpur, Malaysia, 23-27 September 2003.

Fan S.T., Chairman, Session 2 - Hepatobiliary tumours, The 2nd Annual Kuwait Postgraduate Assembly in Surgery, Kuwait, 7-9 December 2003. 2003.

Fan S.T., Chairman, Transplant Centre, Queen Mary Hospital, Hong Kong. 2004.

Fan S.T., Chairperson, Free paper session, The 11th U.A.E. Surgical Conference, Abu Dhabi, U.A.E., 6-8 October 2003. 2003.

Fan S.T., Chairperson, Overview of adult living liver transplantation, The 2nd Japan Society of Hepatology Single Topic Conference "Progress and Future Perspective in Adult Living Donor Liver Transplantation", Shiga, Japan, 13 October 2003. 2003.

Fan S.T., Chairperson, Overview of experience: what's new? And donor complications, 2003 Living Donor Liver Transplantation Symposium, Shiga, Japan, 12 October 2003. 2003.

Fan S.T., Co-chairman, Session 1 - Hepatobiliary tumours, The 2nd Annual Kuwait Postgraduate Assembly in Surgery, Kuwait, 7-9 December 2003. 2003.

Fan S.T., Consultant Surgeon, Queen Mary Hospital and Tung Wah Hospital, Hospital Authority, Hong Kong. 2004.

Fan S.T., Council Member , Hong Kong Society of Transplantation. 2004.

Fan S.T., Council Member, Hong Kong Chapter, American College of Surgeons. 2004.

Fan S.T., Cystic neoplasm of the pancreas (Invited Lecture), The 2nd Annual Kuwait Postgraduate Assembly in Surgery, Kuwait, 7-9 December 2003.

Fan S.T., Deputy Chief of Service, Department of Surgery, Queen Mary Hospital, Hong Kong. 2004.

Fan S.T., Lo C.M., Liu C.L., Yong B.H. and Wong J., Determinants of hospital mortality of adult recipients of right lobe live donor liver transplantation, Annals of Surgery. 2003, 238(6): 864-869.

Fan S.T., Diagnosis and staging of pancreatic and preambulary cancer (Invited Lecture), The 2nd Annual Kuwait Postgraduate Assembly in Surgery, Kuwait, 7-9 December 2003.

Fan S.T., Expert Clinician, Phoenix Alliance, U.S.A.. 2004.

Fan S.T., Fellow (1990 - present), American College of Surgeons. 2004.

Fan S.T., History of adult living donor liver transplantation (Invited Lecture), The 8th Congress of Asian Society of Transplantation, Kuala Lumpur, Malaysia, 23-27 September 2003.

Fan S.T., Honorary Senior Consultant (Hepatobiliary Surgery), Tung Wah Hospital, Hospital Authority, Hong Kong. 2004.

Fan S.T., Impact of portal inflow to small for size (Invited Lecture), The 3rd Asia/Oceania Workshop on Immunosuppression, Prograf Miyazaki Summit, Miyazaki, Japan, 17-19 April 2004.

Fan S.T., Lindsay Tasman Ride - Melbourne's contribution to Hong Kong (Invited Lecture), Annual Scientific Congress, Royal Australiasian College of Surgeons, Melbourne, Australia, 3-6 May 2004.

Fan S.T., Live donor liver transplantation (Invited Lecture), Annual Scientific Congress, Royal Australiasian College of Surgeons, Melbourne, Australia, 3-6 May 2004.

Fan S.T., Live donor liver transplantation: right lobe versus left lobe (Invited Lecture), The 8th Congress of Asian Society of Transplantation, Kuala Lumpur, Malaysia, 23-27 September 2003.

Fan S.T., Liver transplantation in Asia (Presidential Lecture), Hong Kong-Shanghai International Liver Congress, the 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and the 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Fan S.T., Living donor liver transplantation (Abstract), Medical Journal of Malaysia. 2003, 58(Suppl. B): 62.

Fan S.T., Living donor liver transplantation (Plenary Lecture), The 5th Liver Update, Malaysian Liver Foundation, Selangor, Malaysia, 10-13 July 2003.

Fan S.T., Member of Editorial Board (1991 - present), Journal of Gastroenterology and Hepatology. 2004.

Fan S.T., Member of Editorial Board (1995 - present), Hepato-Gastroenterology. 2004.

Fan S.T., Member of Editorial Board (1998 - present), Archives of Surgery. 2004.

Fan S.T., Member of Editorial Board (2001 - present), 中國肝癌雜誌, 2004.

Fan S.T., Member of Editorial Board (December 1998 - present), Nutrition. 2004.

Fan S.T., Member of Editorial Board (December 2002 - present), 中國普外基礎與臨床雜誌, 2004.

Fan S.T., Member of Editorial Board (December 2003 - present), 中華外科治療學雜誌, 2004.

Fan S.T., Member of Editorial Board (December 2003 - present), 移植雜誌, 2004.

Fan S.T., Member of Editorial Board (January 1993 - present), Hong Kong Practitioner. 2004.

Fan S.T., Member of Editorial Board (January 1999 - present), 中華普通外科雜誌, 2004.

Fan S.T., Member of Editorial Board (January 2000 - present), 中華醫學雜誌, 2004.

Fan S.T., Member of Editorial Board (January 2000 - present), Asian Journal of Surgery. 2004.

Fan S.T., Member of Editorial Board (July 1999 - present), HPB. 2004.

Fan S.T., Member of Editorial Board (July 2001 - present), 中國實用外科雜誌, 2004.

Fan S.T., Member of Editorial Board (May 1998 - present), 中華肝膽外科雜誌, 2004.

Fan S.T., Member of Editorial Board (October 1999 - present), Digestive Surgery. 2004.

Fan S.T., Member of Editorial Board (October 2001 - present), Hepatobiliary and Pancreatic Diseases International. 2004.

Fan S.T., Member of Editorial Board, British Journal of Surgery. 2004.

Fan S.T., Member of Editorial Board, Journal of Cancer Research and Clinical Oncology. 2004.

Fan S.T., Member, Subcommittee on Service Development in Surgery, Hospital Authority, Hong Kong. 2004.

Fan S.T., Member-at-large to Executive Committee, International Gastro-Surgical Club. 2004.

Fan S.T., Member, American Association for the Study of Liver Diseases. 2004.

Fan S.T., Member, James IV Association of Surgeons. 2004.

Fan S.T., Moderator, Donor results, The 10th Anniversary of the Adult-to-Adult Living Donor Liver Transplantation Symposium, Tokyo, Japan, 21 February 2004. 2004.

Fan S.T., Moderator, Keynote Lecture - Transplantation and liver decompensation, Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004. 2004.

Fan S.T., Moderator, Symposium - The role of MARS therapy in liver diseases, Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004. 2004.

Fan S.T., National Delegate, International Society of Surgery (ISS) Societe Internationale de Chirurgie (SIC). 2004.

Fan S.T., Non-resectional ablative therapy for liver tumours (Invited Lecture), The 2nd Annual Kuwait Postgraduate Assembly in Surgery, Kuwait, 7-9 December 2003.

Fan S.T., Peer Reviewer, American Journal of Gastroenterology. 2004.

Fan S.T., Peer Reviewer, American Journal of Surgery. 2004.

Fan S.T., Peer Reviewer, Annals of Surgery. 2004.

Fan S.T., Peer Reviewer, Archives of Surgery. 2004.

Fan S.T., Peer Reviewer, Asian Journal of Surgery. 2004.

Fan S.T., Peer Reviewer, British Journal of Surgery. 2004.

Fan S.T., Peer Reviewer, Digestive Surgery. 2004.

Fan S.T., Peer Reviewer, Gut. 2004.

Fan S.T., Peer Reviewer, HBP Surgery. 2004.

Fan S.T., Peer Reviewer, Intensive Care Medicine. 2004.

Fan S.T., Peer Reviewer, Journal of Cancer Research and Clinical Oncology. 2004.

Fan S.T., Peer Reviewer, Journal of Gastroenterology and Hepatology. 2004.

Fan S.T., Peer Reviewer, Journal of Hepato-Biliary-Pancreatic Surgery. 2004.

Fan S.T., Peer Reviewer, Liver Transplantation. 2004.

Fan S.T., Peer Reviewer, Nutrition. 2004.

Fan S.T., Peer Reviewer, Surgery. 2004.

Fan S.T., Peer Reviewer, Transplantation. 2004.

Fan S.T., Reconstruction of the biliary tract: duct-to-duct anastomosis (Invited Lecture), The 3rd International Meeting of Living Donor Liver and Kidney Transplantation, Barcelona, Spain, 16 December 2003.

Fan S.T., Resection of liver metastasis (Invited Lecture), The 2nd Annual Kuwait Postgraduate Assembly in Surgery, Kuwait, 7-9 December 2003.

Fan S.T., Right lobe graft with MHV (Invited Lecture), The 10th Anniversary of the Adult-to-Adult Living Donor Liver Transplantation Symposium, Tokyo, Japan, 21 February 2004.

Fan S.T., Lo C.M., Liu C.L., Wang W.X. and Wong J., Safety and necessity of including the middle hepatic vein in the right lobe graft in adult-to-adult live donor liver transplantation, Annals of Surgery. 2003, 238(1): 137-148.

Fan S.T., Strategies during liver surgery (Invited Lecture), The 6th World Congress of the International Hepato-Pancreato-Biliary Association, Washington, D.C., U.S.A., 4 June 2004.

Fan S.T., The middle hepatic vein, with the graft? Pro (Invited Lecture), The 3rd International Meeting of Living Donor Liver and Kidney Transplantation, Barcelona, Spain, 16 December 2003.

Fan S.T., Treatment of hepatocellular carcinoma (Congress Visitor Lecture), Annual Scientific Congress, Royal Australiasian College of Surgeons, Melbourne, Australia, 3-6 May 2004.

Fan S.T., Treatment of hepatolithiasis (Invited Lecture), Annual Scientific Congress, Royal Australiasian College of Surgeons, Melbourne, Australia, 3-6 May 2004.

Fan S.T., Treatment of liver metastases (State-of-the-Art Lecture), The 11th U.A.E. Surgical Conference, Abu Dhabi, U.A.E., 6-8 October 2003.

Fan S.T., 肝移植進展 (Invited Lecture), 中國人民解放軍全軍肝膽外科研究所第三屆21世紀國際外科研討, 胰外科臨床新進展學習班論文匯編, 2003年12月12-17日, 2003.

Fan S.T., 國際肝移植的最新進展與發展趨勢 (Invited Lecture), 中國上海巿第二醫科大學附屬新華醫院東方科技論壇第36次學術研討會, 2003年11月14日, 2003.

Fan S.T., 右葉活體肝臟移植 (Invited Lecture), 中國南京南京大學醫學院附屬鼓樓醫院, 香港大學-南京大學肝膽外科學術研討會, 2004年3月6日, 2004.

Fan S.T., 肝移植血管異常及術後血管併發症處理 (Invited Lecture), 中國上海交通大學附屬第一人民醫院第五屆國際臨床肝臟移植學習班, 2004年6月14日, 2004.

Fan S.T., 活體肝移植的現狀與進展 (Invited Lecture), 中國杭州浙江大學醫學院附屬第一醫院56週年慶典, 2003年11月22日, 2003.

Fan S.T., 香港肝移植的經驗與發展, 中華肝膽外科雜誌, 2004, 10(5): 295-296.

Ho D.W.Y., Luk J.M.C. and Fan S.T., Proteomic analysis of plasma biomarkers of fulminant hepatic failure in a porcine model (Abstract), Hong Kong - Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Ho J.C.Y., Cheung S.T. and Fan S.T., Down regulation of CYP2E1 is associated with poor prognosis of hepatocellular carcinoma (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Ho J.C.Y., Cheung S.T. and Fan S.T., Down regulation of CYP2E1 is associated with poor prognosis of hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ho J.C.Y., Cheung S.T. and Fan S.T., Up-regulation of glycosylphatidylinositols anchor attachment protein (GAA1) is associated with poor prognosis of hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 5275.

Ho J.C.Y., Cheung S.T. and Fan S.T., Up-regulation of glycosylphatidylinositols anchor attachment protein (GAA1) is associated with poor prognosis of hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Ho J.W.Y., Poon R.T.P., Tong C.S.W. and Fan S.T., Clinical significance of serum vascular cell adhesion molecule-1 levels in patients with hepatocellular carcinoma, World Journal of Gastroenterology. 2004, 10(14): 2014-2018.

Ho J.W.Y., Sun K.W., Zhou L., Poon R.T.P. and Fan S.T., Clinicopathological and prognostic implications of endoglin (CD105) staining in hepatocellular carcinoma and its adjacent liver (Abstract), Hong Kong-Shanghai International Liver Congress, the 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and the 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Ho J.W.Y., Man K., Sun K.W., Zhao Y., Fan S.T. and Poon R.T.P., FTY720, a study of its impact on angiogensis and tumor growth in nude mice bearing hepatocellular carcinoma (Oral Presentation), AACR-NCI-EORTIC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Hwang I.S.S., Luk J.M.C., Tan F. and Fan S.T., Vasoactive role of adrenomedullin in CC14-plus-ethanol-induced hepatic cirrhosis (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Ip Y.C., Cheung S.T. and Fan S.T., Genes associated with venous invasion in hepatocelluar carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 344.

Ip Y.C., Cheung S.T. and Fan S.T., Genes associated with venous invasion in hepatocellular carcinoma (Abstract), Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July. 2003, 44: 344.

Ip Y.C., Cheung S.T. and Fan S.T., MMP14 enhances tumor growth and invasion in hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 1826.

Ip Y.C., Cheung S.T. and Fan S.T., MMP14 enhances tumor growth and invasion in hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Lam C.M., Chan O.O., Ho P., Ng I.O.L., Lo C.M., Liu C.L., Poon R.T.P. and Fan S.T., Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients - implications for screening, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 771-777.

Lam C.M., Ng K.K.C., Poon R.T.P., Ai V.H.G., Yuen J. and Fan S.T., Impact of radiofrequency ablation on the management of patients with hepatocellular carcinoma in a specialized centre, British Journal of Surgery. 2004, 91(3): 334-338.

Lam C.M., Fan S.T., Yuen A.W.C., Law W.L. and Poon K., Validation of POSSUM scoring systems for audit of major hepatectomy, British Journal of Surgery. 2004, 91(4): 450-454.

Lang B.H.H., Poon R.T.P., Fan S.T. and Wong J., Influence of laparoscopy on postoperative recurrence and survival in patients with ruptured hepatocellular carcinoma undergoing hepatic resection, British Journal of Surgery. 2004, 91(4): 444-449.

Lang B.H.H., Poon R.T.P., Fan S.T. and Wong J., Perioperative and long-term outcome of major hepatic resection for small solitary hepatocellular carcinoma in patients with cirrhosis, Archives of Surgery. 2003, 138(11): 1207-1213.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Increased expression of SPARC and SPARC-like 1 in relation to tumor angiogenesis in hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 3256.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Increased expression of SPARC and SPARC-like 1 in relation to tumor angiogenesis in hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Relationship between expression of SPARC and SPARC-like 1 and tumor angiogenesis in hepatocellular carcinoma (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Xu R. and Fan S.T., FTY720 selectively induced human hepatoma cell line apoptosis via Akt dephosphorylation (Abstract) , AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Ng I.O.L., Xu R. and Fan S.T., FTY720 selectively induces human hepatoma cell lines apoptosis via Akt dephosphorylation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Lee K.W., Man K., Ling M.T., Wang X., Wong Y.C., Lo C.M., Poon R.T.P., Ng I.O.L. and Fan S.T., Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16^INK4a/RB pathway, Carcinogenesis. 2003, 24(11): 1729-1736.

Li X.L., Man K., Liu Y.F., Lee K.W., Tsui H.T., Lau C.K., Lo C.M. and Fan S.T., Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation, Transplantation. 2003, 76(1): 44-49.

Li X.L., Man K., Ng T.P., Sun K.W., Lo C.M. and Fan S.T., The dysregulation of P13-Kinase/Akt pathway contributes to the ischemia/reperfusion injury during graft preservation by UW solution (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Liang T.B., Zheng S.S., Xu X. and Fan S.T., 兩種不同方法的大鼠小體積肝移植模型建立的比較, 中華肝膽外科雜誌, 2004, 10(5): 320-322.

Liu C.L., Fan S.T., Lo C.M., Wong Y., Ng I.O.L., Lam C.M., Poon R.T.P. and Wong J., Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases, Annals of Surgery. 2004, 239(2): 194-201.

Liu C.L. and Fan S.T., Anterior approach for right hepatectomy for hilar cholangiocarcinoma, Journal of Hepato-Biliary-Pancreatic Surgery. 2003, 10(4): 292-294.

Liu C.L. and Fan S.T., Extending the graft size limits of live-donor liver transplantation (Invited Commentary), Transplantation. 2003, 76(4): 641-642.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Tso W.K. and Wong J., Hepatic resection for incidentaloma (Poster of Distinction), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Liu C.L., Zhao Y., Lo C.M. and Fan S.T., Hepatic venoplasty in right lobe live donor liver transplantation, Liver Transplantation. 2003, 9(12): 1265-1272.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Tso W.K. and Wong J., Heptic resection for incidentaloma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Liu C.L., Lam B.K.Y., Lo C.M. and Fan S.T., Impact of right-lobe live donor liver transplantation on patients waiting for liver transplantation, Liver Transplantation. 2003, 9(8): 863-869.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Lai C.L. and Wong J., Interleukin-2 receptor antibody (basiliximab) for immunosuppressive induction therapy after liver transplantation: a protocol with early elimination of steroids and reduction of tacrolimus dosage, Liver Transplantation. 2004, 10(6): 728-733.

Liu C.L., Lo C.M., Chan S.C., Fan S.T. and Wong J., Internal hernia of the small bowel after right-lobe live donor liver transplantation, Clinical Transplantation. 2004, 18(2): 211-213.

Liu C.L., Saing H., Fan S.T., Lo C.M., Chan K.L., Tam P.K.H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Liu C.L., Fan S.T., Lo C.M., Tam P.K.H., Saing H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, Liver Transplantation. 2003, 9(11): 1185-1190.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Yong B.H., Lai C.L. and Wong J., Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure, Transplantation. 2003, 76: 1174-1179.

Liu C.L., Chan S.C., Lo C.M., Tso W.K. and Fan S.T., Pseudo pseudocyst after right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(4): 571-572.

Liu C.L., Fan S.T., Lo C.M., Chan S.C. and Wong J., Safety of donor right hepatectomy for live donor liver transplantation without abdominal drainage (Abstract), Liver Transplantation. 2004, 10(6): C30.

Liu C.L., Fan S.T., Lo C.M., Chan S.C. and Wong J., Safety of donor right hepatectomy for live donor liver transplantation without abdominal drainage (Oral Presentation), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Liu C.L., Lo C.M., Chan S.C. and Fan S.T., Safety of duct-to-duct biliary reconstruction in right-lobe live-donor liver transplantation without biliary drainage, Transplantation. 2004, 77(5): 726-732.

Liu C.L., Lo C.M., Chan S.C., Tso W.K. and Fan S.T., The right may not be always right: biliary anatomy contraindicates right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(6): 811-812.

Liu Y., Li Q.Y., Poon R.T.P., Shao W.B., Tong C.S.W. and Fan S.T., Blockage of vascular endothelial growth factor receptor in antitumour effect of hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Liu Y., Poon R.T.P., Feng X., Yu W.C., Luk J.M.C. and Fan S.T., Reduced expression of chemokine receptors on peripheral blood lymphocytes in patients with hepatocellular carcinoma, American Journal of Gastroenterology. 2004, 99(6): 1111-1121.

Lo C.M., Cheung S.T., Ng I.O.L., Liu C.L., Lai C.L. and Fan S.T., Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin, Liver Transplantation. 2004, 10(4): 557-563.

Lo C.M. and Fan S.T., Hepatic venoplasty in right lobe liver graft with middle hepatic vein (Invited Lecture), 2003 Living Donor Liver Transplantation Symposium, Shiga, Japan, 12 October 2003.

Lo C.M. and Fan S.T., Liver transplantation for hepatocellular carcinoma (Leading article), British Journal of Surgery. 2004, 91(2): 131-133.

Lo C.M. and Fan S.T., Overview of experience: The University of Hong Kong (Invited Lecture), 2003 Living Donor Liver Transplantation Symposium, Shiga, Japan, 12 October 2003.

Lo C.M., Fan S.T., Liu C.L., Yong B.H., Wong Y., Ng I.O.L. and Wong J., Safety and outcome of hepatitis B core antibody-positive donors in right-lobe living donor liver transplantation, Liver Transplantation. 2003, 9(8): 827-832.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Lo C.M., Fan S.T., Liu C.L., Chan S.C. and Wong J., The role and limitation of living donor liver transplantation for hepatocellular carcinoma, Liver Transplantation. 2004, 10(3): 440-447.

Lo C.Y., Chan W.F., Lo C.M., Fan S.T. and Tam P.K.H., Surgical treatment of pancreatic insulinomas in the era of laparoscopy, Surgical Endoscopy. 2004, 18(2): 297-302.

Lo O.S.H., Poon R.T.P., Lam C.M. and Fan S.T., Inflammatory pseudotumor of the liver in association with a gastrointestinal stromal tumor: a case report, World Journal of Gastroenterology. 2004, 10(12): 1841-1843.

Luk J.M.C., Lam C.T., Hu M.Y. and Fan S.T., Liver cancer proteomics: identifications of chapersones Hsp70 and GRP78 in hepatocellular carcinoma (Abstract), Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003.

Luk J.M.C., Wong W.Y., Hu M.Y. and Fan S.T., Liver-intestine cadherin: a potential disease marker for hepatocellular carcinoma (Abstract), Hepatology. 2003, 38(4 Suppl.): 515.

Luk J.M.C., Ho D.W.Y., Hu M.Y. and Fan S.T., Poteomic analysis of plasma biomarkers for fulminant hepatic failure in a porcine model (Abstract), Keystone Symposia, Tahoe City, California, U.S.A., 24-29 February 2004.

Luk J.M.C., Lam C.T., Hu M. and Fan S.T., Proteomic identification of chaperones Hsp70 and GRP78 in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Hepatitis B virus (HBV)-specific immune response after liver transplantation for chronic hepatitis B (Abstract), Liver Transplantation. 2004, 10(6): C42.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus (HBV)-specific lymphocytes in human liver allografts from HBV immune donors (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Makuuchi M., Belghiti J., Belli G., Fan S.T., Lau J.W.Y., Ringe B., Strasberg S.M., Vauthey J.N., Yamaoka Y. and Yamasaki S., IHPBA concordant classification of primary liver cancer: working group report, Journal of Hepato-Biliary-Pancreatic Surgery. 2003, 10: 26-30.

Man K., Lo C.M., Ng T.P., Zhao Y., Ho J.W.Y., Sun K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed liver tumor growth and metastasis (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Ng T.P., Lo C.M., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed tumor growth and matastasis (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., Distinct intragraft response pattern in liver transplantation using marginal grafts and cirrhotic recipients (Abstract), The 11th Congress of the European Society for Organ Transplantation, Venice, Italy, 20-24 September 2003.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., FTY attenuates ischemia-reperfusion injury in normal and cirrhotic rat liver by down-regulation of Egr-1 and activation of Akt pathway, Liver transplantation. 2003, 9(6): c-37.

Man K., Ng T.P., Lee K.W., Lo C.M., Sun K.W., Li X.L., Zhao Y., Ho J.W.Y. and Fan S.T., FTY720 attenuates hepatic ischemia-reperfusion injury by Egr-1 down-regulation involving Raf-MEK-Erk pathway and Akt activation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathway (Abstract), Liver Transplantation. 2004, 10(6): C69.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ho J.W.Y., Lee K.W., Zhao Y., Wang X.H., Ng T.P., Sun K.W. and Fan S.T., Marked suppression of tumor growth by FTY720 in rat and mouse liver tumor models (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Man K., Zhao Y., Xu A.M., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus adiponectin combination therapy (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Zhao Y., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus asiponectin combination therapy (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lo C.M., Ho J.W.Y., Zhao Y., Sun K.W., Lee K.W., Li X.L. and Fan S.T., The significance of hepatic ischemia-reperfusion injury on liver tumor development - activation of cell invasion and migration pathways (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Ng I.O.L., Chan K.L., Shek T.W.H., Lee M.F., Fong D.Y.T., Lo C.M. and Fan S.T., High frequency of chimerism in transplanted livers (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ng I.O.L., Chan K.L., Shek T.W.H., Lee J.M., Fong D.Y.T., Lo C.M. and Fan S.T., High frequency of chimerism in transplanted livers, Hepatology. 2003, 38(4): 989-998.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Comparison of systemic responses of radiofrequency ablation, cryotherapy and surgical resection in a porcine liver model (Abstract), Annals of the College of Surgeons of Hong Kong. 2004, 8(Suppl.): A7.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Comparison of systemic responses of radiofrequency ablation, cryotherapy and surgical resection in a porcine liver model (Oral Presentation), The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Fan S.T. and Wong J., Delayed portal vein thrombosis after experimental radiofrequency ablation near the main portal vein, British Journal of Surgery. 2004, 91(5): 632-639.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M., Ng I.O.L. and Fan S.T., Impact of preoperative fine-needle aspiration cytologic examination on clinical outcome in patients with hepatocellular carcinoma in a tertiary referral center, Archives of Surgery. 2004, 139(2): 193-200.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to hepatic radiofrequency ablation in a rat model (Abstract), The 5th Annual Scientific Meeting Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Abstract), Annals of the College of Surgeons of Hong Kong. 2004, 8(Suppl.): A7.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Oral Presentation), The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Law W.L., Seto C.L. and Fan S.T., Radiofrequency ablation as a salvage procedure for ruptured hepatocellular carcinoma, Hepatogastroenterology. 2003, 50(53): 1641-1643.

O'Suilleabhain C.B., Poon R.T.P., Lau C.W. and Fan S.T., Repeated resections of extrahepatic metastases after hepatic resection: an aggressive approach to hepatocellular carcinoma, Hepatogastroenterology. 2004, 51(57): 825-829.

Pang A., Ng I.O.L., Fan S.T. and Kwong Y.L., Clinicopathologic significance of genetic alterations in hepatocellular carcinoma, Cancer Genetics and Cytogenetics. 2003, 146(1): 8-15.

Pang R., Yuen J., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E., PIN1 over-expression and b-catenin gene mutations are distinct oncologic events in human hepatocarcinogenesis (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Poon R.T.P., Fan S.T. and Wong J., Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches (Review), Annals of Surgery. 2003, 238(1): 9-28.

Poon R.T.P., Chung K.K., Cheung S.T., Lau C., Tong C.S.W., Leung K.L., Yu W.C., Tuszynski G.P. and Fan S.T., Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 Pt1): 4150-4157.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J. and Fan S.T., Effectiveness of radiofrequency ablation for hepatocellular carcinoma larger than 3 cm in diameter, Archives of Surgery. 2004, 139(3): 281-287.

Poon R.T.P. and Fan S.T., Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome, Liver Transplantation. 2004, 10(2 Suppl 1): S39-S45.

Poon R.T.P., Lau C.P.Y., Yu W.C., Fan S.T. and Wong J., High serum levels of vascular endothelial growth factor predict poor response to transarterial chemoembolizatin in hepatocellular carcinoma: a prospective study, Oncology Reports. 2004, 11(5): 1077-1084.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database (Oral Presentation), The 124th Annual Meeting of the American Surgical Association, San Francisco, U.S.A., 15-17 April 2004.

Poon R.T.P., Yeung C., Liu C.L., Lam C.M., Yuen W.K., Lo C.M., Tang A. and Fan S.T., Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial, Gut. 2003, 52(12): 1768-1773.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J., Fan S.T. and Wong J., Learning curve for radiofrequency ablation of liver tumors: prospective analysis of initial 100 patients in a tertiary institution, Annals of Surgery. 2004, 239(4): 441-449.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J., Fan S.T. and Wong J., Learning curve for radiofrequency ablation of liver tumours: prospective analysis of initial 100 patients in a teritary institution (Oral Presentation), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Poon R.T.P., Yu W.C., Fan S.T. and Wong J., Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 779-788.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement, World Journal of Surgery. 2004, 28(6): 602-608.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J. and Fan S.T., Radiofrequency ablation for subcapsular hepatocellular carcinoma, Annals of Surgical Oncology. 2004, 11(3): 281-289.

Poon R.T.P. and Fan S.T., Resection prior to liver transplantation for hepatocellular carcinoma: a strategy of optimizing the role of resection and transplantation in cirrhotic patients with preserved liver function (Commentary), Liver Transplantation. 2004, 10(6): 813-815.

Poon R.T.P., Sze P.K., Tang E.W.H. and Fan S.T., Role of serum alpha-fetoprotein monitoring in detection of recurrent hepatocellular carcinoma after curative hepatectomy, Cancer Reviews: Asia-Pacific. 2003, 1: 289-296.

Poon R.T.P., Lau C.P.Y., Ho J.W.Y., Yu W.C., Fan S.T. and Wong J., Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma, Clinical Cancer Research. 2003, 9(14): 5339-5345.

Ren Y., Poon R.T.P., Tsui H.T., Chen W.H., Li Z., Lau C., Yu W.C. and Fan S.T., Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis, Clinical Cancer Research. 2003, 9(16 Pt1): 5996-6001.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Shi J., Zheng D., Man K., Fan S.T. and Xu R., TRAIL: a potential agent for cancer therapy, Current Molecular Medicine. 2003, 3(8): 727-736.

Siu A.F.M., Ng K.M., Ho C.M., Che C.M., Luk J.M.C., Fan S.T. and Tsang C.W., Mass spectrometric proteomic analysis (Abstract), The 8th International Symposium on Applied Bioinorganic Chemistry, 2-5 April 2004, Hong Kong. 2004.

Su Y.C.F., Hu M.Y., Fan S.T. and Luk J.M.C., Generation and characterization of monoclonal antibodies against hepatocellular carcinoma (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Tang T.C.M., Poon R.T.P., Guan X.Y. and Fan S.T., The effect of cyclooxygenase-2 (COX-2) inhibitor, Celecoxib, on xenograft of hepatocellular carcinoma (HCC) in nude mice (Oral Presentation), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Tang T.C.M., Poon R.T.P., Guan X.Y. and Fan S.T., The effects of cyclooxygenase-2, Celecoxib, on xenografts of hepatocellular carcinoma in nude mice (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Tipoe G.L., Leung T.M., Liong E.C., So H., Leung K.M., Tom W.M., Fan S.T. and Nanji A.A., Nitric oxide in an acute liver injury model (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Tsui T.Y., Siu Y.T., Ho D.W.Y., Lau C.K. and Fan S.T., Carbon monoxide, the natural product of HO activity, protects mice from fulminant hepatic failure (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Wang P.P., Wang J.H., Yan Z.P., Hu M.Y., Fan S.T. and Luk J.M.C., Intraportal transplantation of bone marrow stromal cells in cirrhotic liver (Abstract), Hong Kong-Shanghai International Liver Congress, the 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and the 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang W.X. and Fan S.T., Use of Endo-GIA vascular stapler for hepatic resection, Asian Journal of Surgery. 2003, 26(4): 193-196.

Wang X., Luk J.M.C. and Fan S.T., Characterization of LI-cadherin mutation in HCC (Oral Presentation), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang X., Wong W.Y., Leung P.L., Leung P.L., Leung P.L., Fan S.T. and Luk J.M.C., Molecular characterization of LI-cardherin mutations in hepatocellular carcinoma (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang Y., Luk J.M.C., Ikeda K., Man K., Chu A.C.Y., Kaneda K. and Fan S.T., Regulatory role of vHL/HIF-1a in hypoxia-induced VEGF production in hepatic stellate cells, Biochemical and Biophysical Research Communications. 2004, 317(2): 358-362.

Wei W.I., Lam L.K., Ng W.M., Liu C.L., Lo C.M., Fan S.T. and Wong J., Microvascular reconstruction of the hepatic artery in live donor liver transplantation: experience across a decade, Archives of Surgery. 2004, 139(3): 304-307.

Wong B.W., Luk J.M.C., Ng I.O.L., Hu M.Y., Liu K.D. and Fan S.T., Identification of liver-intestine cadherin in hepatocellular carcinoma--a potential disease marker, Biochemical and Biophysical Research Communications. 2003, 311(3): 618-624.

Wong K.K.Y., Chan K.L., Saing H., Fan S.T. and Tam P.K.H., The management of biliary atresia in the era of liver transplantation, Hong Kong Journal of Paediatrics. 2003, 8: 322-326.

Wong S.Y., Cheung S.T. and Fan S.T., Expression of granulin/epithelin precursor (GEP) in hepatocellular carcinoma associated with growth and invasion competency (Abstract), Proceedings of The 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July 2003. 44: 1302.

Wong S.Y., Cheung S.T. and Fan S.T., Expression of granulin/epithelin precursor (GEP) in hepatocellular carcinoma associated with growth and invasion competency (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 1302.

Xu R., Sun X., Tse L.Y., Li H., Chan P.C., Xu S., Xiao W., Kung H., Krissansen G.W. and Fan S.T., Long-term expression of angiostatin suppresses metatatic liver cancer in mice (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Xu R., Cai K., Zheng D.X., Ma H., Xu S. and Fan S.T., Molecular therapeutics of HBV, Current Gene Therapy. 2003, 3 (4): 341-355.

Yang Z., Tsui T.Y., Ho D.W.Y., Tang T.C.M. and Fan S.T., Heme oxygenase-1 potentiates the survival of small-for-size liver graft, Liver Transplantation. 2004, 10(6): 784-793.

Yang Z., Ho D.W.Y., Chu A.C.Y., Wang Y. and Fan S.T., Linking inflammation to acute rejection in small-for-size allografts: the potential role of early macrophage activation, American Journal of Transplantation. 2004, 4(2): 196-209.

Yang Z., Poon R.T.P., To J.Y.T., Ho D.W.Y. and Fan S.T., The potential role of hypoxia inducible factor 1a in tumour progression after hypoxia and chemotherapy in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Yuen M.F., Kato T., Mizokami M., Chan O.O., Yuen J.C.H., Yuan H., Wong D.K.H., Sum S.M., Ng I.O.L., Fan S.T. and Lai C.L., Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations, Journal of Hepatology. 2003, 39(5): 850-855.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Lee K.W., Sun K.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Sun K.W., Dai X.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Zhao Y., Lo C.M., Liu C.L. and Fan S.T., Use of elderly donors (>60 years) for liver transplantation, Asian Journal of Surgery. 2004, 27(2): 114-119.

Zhu L.X., Meng X.L. and Fan S.T., Elasticity of small artery in patient with spontaneous rupture of hepatocellular carcinoma, Hepatology Research. 2004, 29(1): 13-17.

Researcher : Fan YW

List of Research Outputs

Chan G.C.F., Khong P.L., Kwong D.L.W., Chiang A.K.S., Hung K.N., Fan Y.W., Ha S.Y. and Lau Y.L., Outcome and long term neurological complications of childhood medulloblastoma: the QMH experience, Rehabilitation Scientific Conference 2003, Hong Kong West Cluster, Hong Kong, 25 October 2003. 28.

Fan Y.W., President, Hong Kong Neurosurgical Society. 2004.

Leung G.K.K., Chow W.S., Tan K.C.B., Fan Y.W. and Lam K.S.L., Metastatic melanoma of the pituitary gland, Journal of Neurosurgery. 2003, 99(5): 913-915.

Researcher : Fu M

List of Research Outputs

Fu M., Tam P.K.H., Sham M.H. and Lui V.C.H., Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study, Anatomy and Embryology. 2004, 208(1): 33-41.

Fu M., Lui V.C.H., Sham M.H., Cheung A.N.Y. and Tam P.K.H., HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts, Developmental Dynamics. 2003, 228(1): 1-10.

Fu M., Neural crest cell development in the nervous system of normal gut and in Hirschsprung's disease, Thesis, Doctor of Philosophy, The University of Hong Kong. 2004.

Lui V.C.H., Fu M., Sham M.H., Pachnis V. and Tam P.K.H., Sonic hedgehog (SHH) regulates the proliferation, migration and differentiation of enteric neural crest stem cells (NCSCS) in gastrointestinal tract, 4th Hirschsprung Disease and Related Neurocristopathies, Genoa, Italy, 22-24 April 2004.

Researcher : Fung TKJ

List of Research Outputs

Fung T.K.J., Development of anti-HBsAb in patients with chronic hepatitis B after liver transplantation using lamivudine prophylaxis: the possible role of adoptive immunity, Dissertation, Master of Research in Medicine, The University of Hong Kong. 2003.

Researcher : Ganster RW

Project Title:	Sensitization of human neuroblastoma cells to apoptosis by biological and chemical chemotherapeutic agents: combinatorial approaches to cell death through activation of stat1 by interferon and the inhibition of NF-kB
Investigator(s):	Dr. Ganster R.W., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003
Completion Date:	12/2003

Abstract:

To define several distinct mechanisms by which IFNg could potentiate apoptosis by TNF-a: IFNg and Stat 1-dependent activation of caspase 1 and 8 expression, constituitive Stat 1-dependent regulation of caspase 3, and IFNg and Stat1-dependent inhibition of NF-kB transcription activity. Additionally, we show that IFNg priming alters proximal signal transduction events since IFNg priming potentiates the ability of TNF-a and IFNg to stimulate Stat1 DNA binding activity.

Project Title:	Regulation of gene transcription by NF-kB and stats downstream of the ret receptor tyrosine kinase in hirschsprung disease and thyroid cancer
Investigator(s):	Dr. Ganster R.W., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2003

Abstract:

To understand the patho-physiological functions of RET receptor tyrosine kinase in Hirschsprung disease (HD) and in thyroid cancers, specifically; Multiple Endocrine Neuroplasia type 2A and 2B (MEN2A/2B), Medullary Thyroid Carcinoma (MTC), and Papillary Thyroid Carcinoma (PTC).

Project Title:	Regulation of gene transcription by NF-kB and stats downstream of the ret receptor tyrosine kinase in hirschsprung disease and thyroid cancer
Investigator(s):	Dr. Ganster R.W., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	09/2003

Abstract:

List of Research Outputs

Ganster R.W., Lau M.F., Neoh K.H.A. and Tam P.K.H., NF-kB, Stat1, and Stat3 are over-expressed in papillary thyroid carcinoma: identification of molecular switches which dys-regulate gene transcription causing thyroid cancer, 95th Annual Meeting of American Association for Cancer Research, Florida, U.S.A., 27-31 March 2004.

Geller D.A., Guo Z., Ganster R.W. and Shao L.F., Regulation of human inducible nitric oxide synthase gene, 6th World Congress on Trauma, Shock, Inflammation, and Sepsis - Pathophysiology, Immune Consequences, and Therapy, Munich, Germany, March 2004.

Lau M.F., Neoh K.H.A., Tam P.K.H. and Ganster R.W., Regulation of gene transcription by NF-kB and Stats downstream of the Ret receptor tyrosine kinase in thyroid cancer and Hirschsprung's disease, 95th Annual Meeting of American Association for Cancer Research, Florida, U.S.A., 27-31 March 2004.

Researcher : Garcia-Barcelo MM

Project Title:	Role of RET regulatory polymorphisms in Hirschsprung's disease
Investigator(s):	Dr. Garcia-Barcelo M.M., Dr. Ganster R.W., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To identify and functionally test a RET susceptibility locus which may predispose to disease more than 60% of the Chinese HSCR patients and to replicate our findings in an extended sample.

List of Research Outputs

Garcia-Barcelo M.M., Sham M.H., Lui V.C.H., Chen B.L.S., Song Y., Lee W.S., Yung S.K., Romeo G. and Tam P.K.H., Chinese patients with sporadic Hirschsprung’s disease are predominantly represented by a single RET haplotype. , Journal of Medical Genetics. 2003, 40(11): e122.

Garcia-Barcelo M.M., Sham M.H., Lee W.S., Lui V.C.H., Chen B.L.S., Wong K.K.Y., Wong J.S.W. and Tam P.K.H., Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease, Clinical Chemistry. 2004, 50(1): 93-100.

Garcia-Barcelo M.M., Lui V.C.H., Sham M.H. and Tam P.K.H., Is there a role for Hedgehog genes in Hirschsprung's diseases?, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May, 2004.

Garcia-Barcelo M.M., Lee W.S., Sham M.H., Lui V.C.H. and Tam P.K.H., Is there a role for the IHH gene in Hirschsprung's disease?, Neurogastroenterology and Motility. 2003, 15(6): 663-668.

Researcher : Ho DWY

List of Research Outputs

Ho D.W.Y., Luk J.M.C. and Fan S.T., Proteomic analysis of plasma biomarkers of fulminant hepatic failure in a porcine model (Abstract), Hong Kong - Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Luk J.M.C., Ho D.W.Y., Hu M.Y. and Fan S.T., Poteomic analysis of plasma biomarkers for fulminant hepatic failure in a porcine model (Abstract), Keystone Symposia, Tahoe City, California, U.S.A., 24-29 February 2004.

Tsui T.Y., Siu Y.T., Ho D.W.Y., Lau C.K. and Fan S.T., Carbon monoxide, the natural product of HO activity, protects mice from fulminant hepatic failure (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Yang Z., Tsui T.Y., Ho D.W.Y., Tang T.C.M. and Fan S.T., Heme oxygenase-1 potentiates the survival of small-for-size liver graft, Liver Transplantation. 2004, 10(6): 784-793.

Yang Z., Ho D.W.Y., Chu A.C.Y., Wang Y. and Fan S.T., Linking inflammation to acute rejection in small-for-size allografts: the potential role of early macrophage activation, American Journal of Transplantation. 2004, 4(2): 196-209.

Yang Z., Poon R.T.P., To J.Y.T., Ho D.W.Y. and Fan S.T., The potential role of hypoxia inducible factor 1a in tumour progression after hypoxia and chemotherapy in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Ho JCY

List of Research Outputs

Ho J.C.Y., Cheung S.T. and Fan S.T., Down regulation of CYP2E1 is associated with poor prognosis of hepatocellular carcinoma (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Ho J.C.Y., Cheung S.T. and Fan S.T., Down regulation of CYP2E1 is associated with poor prognosis of hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ho J.C.Y., Cheung S.T. and Fan S.T., Up-regulation of glycosylphatidylinositols anchor attachment protein (GAA1) is associated with poor prognosis of hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 5275.

Ho J.C.Y., Cheung S.T. and Fan S.T., Up-regulation of glycosylphatidylinositols anchor attachment protein (GAA1) is associated with poor prognosis of hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Researcher : Ho JWC

Project Title:	The Hereditary Gastrointestinal Cancer Registry - a programme for the people of Hong Kong
Investigator(s):	Dr. Ho J.W.C., Dr. Chung L.P., Ms Kwan K.Y.M., Dr. Yuen S.T.
Department:	Surgery
Source(s) of Funding:	Terry Fox Fellowship granted by the Hong Kong Cancer Fund
Start Date:	06/2000

Abstract:

To achieve colorectal cancer prevention in high risk families through early detection and timely treatment; to raise awareness of hereditary colorectal cancer through education of the public and the health care profession so as to ensure proper referral of these families to our Registry for the delivery of proper preventive service; to establish support services to improve psychosocial well beings of affected individuals and their at-risk family members; to improve the understanding of hereditary colorectal cancer and its management.

List of Research Outputs

Chan T.L., Wong C.W., Chan A.S.W., Guo D., Ho J.W.C., Yuen S.T. and Leung S.Y., BRAF and KRAS mutations in mismatch repair deficient colorectal cancer , Proceedings of the 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, USA, March 2004.

Chan T.L., Chan Y.W., Ho J.W.C., Chan C., Chan A.S.Y., Chan E., Lam P.W.Y., Tse C.W., Lee K.C., Lau C.W., Gwi E., Leung S.Y. and Yuen S.T., MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population, The American Journal of Human Genetics. 2004, 74(5): 1035-1042.

Guo D., Yuen S.T., Ho J.W.C., Chan A.S.Y., Chen X. and Leung S.Y., PLA2G2A expression and its clinical significance in colorectal tumors, Proceedings of the 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, USA, March 2004.

Ho J.W.C., Course Director (1998 - present), Advanced Trauma Life Support Course, American College of Surgeons. 2004.

Ho J.W.C., Course Director (2000 - present), Care of Critically III Surgical Patients Course, The Royal College of Surgeons of England. 2004.

Ho J.W.C., FAP in Hong Kong: genotype, phenotype and clinical management, Hong Kong Colorectal Symposium, 9-10 October 2003.

Ho J.W.C., Fellow (1999 - present), American College of Surgeons. 2004.

Ho J.W.C., Hereditary colorectal cancer screening - role of a regional registry, Annual Scientific Meeting of the Hong Kong Society for Coloproctology, 13 December 2003.

Ho J.W.C., Hereditary colorectal cancer, CancerLink, 15 May 2004.

Ho J.W.C., Ho M.Y., Chan C.L.W., Yuen S.T., Chan M.S. and Siu H.Y.V., Psychological profile of hereditary colorectal cancer genetic screening test recipients in Hong Kong: results of the first 88 participants (Abstracts & Proceedings), Familial Cancer 2003: Research and Practice, Couran Cove, Australia, 3-6 September 2003.

Ho J.W.C., Lam T.H., Tse C.W., Chiu L.K., Lam H.S., Leung P.F., Ng K.C., Ho S.Y., Woo J., Leung S.S. and Yuen S.T., Smoking, drinking and colorectal cancer in Hong Kong Chinese: a case-control study, International Journal of Cancer. 2004, 109(4): 587-597.

Ho J.W.C., Trend and management of FAP and hereditary colorectal cancer in Hong Kong, Annual Scientific Meeting of the Hong Kong Enterostomal Therapists Association, 17 April 2004.

Ho J.W.C., Young colorectal cancer patients in Hong Kong: genetic epidemiology and managemnet implications, Hong Kong Colorectal Symposium, 9-10 October 2003.

Law W.L., Choi H.K., Chu K.W., Ho J.W.C. and Wong L.Y.C., Bowel preparation for colonoscopy: a randomized controlled trial comparing polyethylene glycol solution, one dose and two doses of oral sodium phosphate solution, Asian Journal of Surgery. 2004, 27(2): 120-124.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Researcher : Ho JWY

List of Research Outputs

Ho J.W.Y., Poon R.T.P., Tong C.S.W. and Fan S.T., Clinical significance of serum vascular cell adhesion molecule-1 levels in patients with hepatocellular carcinoma, World Journal of Gastroenterology. 2004, 10(14): 2014-2018.

Ho J.W.Y., Sun K.W., Zhou L., Poon R.T.P. and Fan S.T., Clinicopathological and prognostic implications of endoglin (CD105) staining in hepatocellular carcinoma and its adjacent liver (Abstract), Hong Kong-Shanghai International Liver Congress, the 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and the 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Ho J.W.Y., Man K., Sun K.W., Zhao Y., Fan S.T. and Poon R.T.P., FTY720, a study of its impact on angiogensis and tumor growth in nude mice bearing hepatocellular carcinoma (Oral Presentation), AACR-NCI-EORTIC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Xu R. and Fan S.T., FTY720 selectively induced human hepatoma cell line apoptosis via Akt dephosphorylation (Abstract) , AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Ng I.O.L., Xu R. and Fan S.T., FTY720 selectively induces human hepatoma cell lines apoptosis via Akt dephosphorylation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Lo C.M., Ng T.P., Zhao Y., Ho J.W.Y., Sun K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed liver tumor growth and metastasis (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Ng T.P., Lo C.M., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed tumor growth and matastasis (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lee K.W., Lo C.M., Sun K.W., Li X.L., Zhao Y., Ho J.W.Y. and Fan S.T., FTY720 attenuates hepatic ischemia-reperfusion injury by Egr-1 down-regulation involving Raf-MEK-Erk pathway and Akt activation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathway (Abstract), Liver Transplantation. 2004, 10(6): C69.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ho J.W.Y., Lee K.W., Zhao Y., Wang X.H., Ng T.P., Sun K.W. and Fan S.T., Marked suppression of tumor growth by FTY720 in rat and mouse liver tumor models (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Man K., Ng T.P., Lo C.M., Ho J.W.Y., Zhao Y., Sun K.W., Lee K.W., Li X.L. and Fan S.T., The significance of hepatic ischemia-reperfusion injury on liver tumor development - activation of cell invasion and migration pathways (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Poon R.T.P., Lau C.P.Y., Ho J.W.Y., Yu W.C., Fan S.T. and Wong J., Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma, Clinical Cancer Research. 2003, 9(14): 5339-5345.

Researcher : Ho KMT

List of Research Outputs

Ho K.M.T., Shen J., Fung P.C.W., Lee F.C.W. and Tam P.C., Effect of ischemia-reperfusion on nitric oxide production in the pig-bladder (Abstract), European Urology. 2003, No. 1, Supplements 2: 170.

Researcher : Ho WK

Project Title:	Double blind randomized study to compare the efficacy and tolerability of 4 week's course of azelastine HCL nasal spray with oral loratadine in patients with perenial non-allergic rhimitis
Investigator(s):	Dr. Ho W.K., Prof. Yuen P.W.
Department:	Surgery
Source(s) of Funding:	Asta Medica Ag, Asta Medica China Ltd.
Start Date:	02/1998

Abstract:

To assess the efficacy of a topical antihistamine.

Project Title:	Study of laryngo-pharyngeal reflux as an aetiological factor in patients with globus pharyngeus
Investigator(s):	Dr. Ho W.K., Dr. Lam K.Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To study that LPR in the upper oesophagus/pharynx contributes to the development of Globus pharyngeus and new therapeutic strategy can be introduced.

Project Title:	Middle ear effusion in nasopharyngeal carcinoma: conservative versus aggressive treatment; and fluid analysis for underlying mechanism
Investigator(s):	Dr. Ho W.K., Dr. Au D.K.K.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To test the hypothesis of conservative management of middle ear effusion in NPC is as good as aggressive management with myringotomy and grommet insertion in terms of hearing outcome; to investigate the hypothesis of tumor involvement, inflammatory response, infection play significant roles in underlying mechanism in OME in NPC.

Project Title:	Study of changes in upper airway pressure in patients before and after upper airway surgery for sleep-related breathing disorders: identification of levels of collapse and prediction of surgical response
Investigator(s):	Dr. Ho W.K., Prof. Wei W.I.
Department:	Surgery
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund
Start Date:	11/2003

Abstract:

To evaluate the using of multi-level pressure measurements to correlate with the result of surgical treatment.

List of Research Outputs

Ho W.K., Allergic rhinitis, Health Column, Apple Daily, 9 October 2003. 2003.

Ho W.K., Council Member (2000 - present), Hong Kong Society of Otorhinolaryngology, Head and Neck Surgery. 2004.

Ho W.K., Council Member (March 2002 - present), Hong Kong Society of Sleep Medicine. 2004.

Ho W.K., Course Faculty, 9th Certificate Course in Ear, Nose & Throat Diseases for Nurses, ENT Unit, Department of Surgery, The University of Hong Kong and Tung Wah Hospital, Hong Kong. 2003.

Ho W.K., Course Faculty, ENT Surgery Course for Theatre Nurses, 2003, Skills Development Centre, Department of Surgery, University of Hong Kong Medical Cente, Queen Mary Hospital, Hong Kong. 2003.

Ho W.K., Fellow (2002 - present), American College of Surgeons. 2003.

Ho W.K., International Fellow (2003 - present) , American Academy of Otolaryngology - Head and Neck Surgery. 2003.

Ho W.K., Lasers in ENT surgery (Keynote Lecture), Asian Laser Forum 2003 (New Challenges in Laser Medicine), Hong Kong Surgical Laser Association, Hong Kong, 16 November 2003.

Ho W.K., Wei W.I. and Chung K.F., Managing disturbing snoring with palatal implants - a pilot study, Archives of Otolaryngology, Head and Neck Surgery. 2004, 130: 753-758.

Ho W.K., Member (2002 - 2003), CME Subcommittee, The Hong Kong College of Otorhinolaryngologists. 2003.

Ho W.K., Member (2002 - present), Education Committee, The Hong Kong College of Otorhinolaryngologists. 2004.

Ho W.K., Surgery in the management of nasopharyngeal carcinoma, Tropical Surgery and the Global Academy for Tropical Surgery, World Health Organization, Cairo, Egypt, 1-3 March 2004.

Ho W.K., Yuen P.W., Tang K.C., Wei W.I. and Lam P.K.Y., Time course in the relief of nasal blockage after septal and turbinate surgery - a prospective study, Archives of Otolaryngology, Head and Neck Surgery. 2004, 130(3): 324-328.

Ho W.K., What can we do for snoring? (Invited Lecture), Scientific Meeting, St. Paul's Doctor's Association and the Hong Kong Society of Otorhinolaryngology, Head & Neck Surgery. 2004.

Hui Y., Wong S.Y., Wong L.Y., Ho W.K. and Wei W.I., Year Book of Otolaryngology - Head and Neck Surgery. Mosby, 2004.

Lo S., Ho W.K. and Wei W.I., Outcome of patients with positive Epstein-Barr virus serologic status in the absence of nasopharyngeal carcinoma in Hong Kong, Archives of Otolaryngology, Head and Neck Surgery. 2004, 130(6): 770-772.

Lo S. and Ho W.K., Schwannoma of the larynx - an uncommon cause of vocal cord immobility, Hong Kong Medical Journal. 2004, 10(2): 131-133.

Wei W.I., Ng W.M. and Ho W.K., "How I do it" - Pharyngeal entry through the vallecula, Laryngoscope. 2004, 114(1): 181-183.

Wei W.I. and Ho W.K., Nasopharyngeal carcinoma, In: Kamel R. and Lumley J., Textbook of Tropical Surgery. London, Westminster Publishing Ltd., 2004, 345-348.

Wei W.I. and Ho W.K., Theory & surgery in Traditional Chinese Medicine, In: Kamel R. and Lumley J., Textbook of Tropical Surgery. London, Westminster Publishing Ltd., 2004, 170-175.

Researcher : Hu M

List of Research Outputs

Luk J.M.C., Lam C.T., Hu M. and Fan S.T., Proteomic identification of chaperones Hsp70 and GRP78 in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Hu X

List of Research Outputs

Hu X., Wong I.H.N. and Chow L.W.C., Tumor-derived aberrant methylation in plasma of invasive ductal breast cancer patients: clinical implications, Oncology Reports. 2003, 10(6): 1811-1815.

Researcher : Huang X

List of Research Outputs

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Zhao P., Huang X., Vande Woude G. and Wong J., Hepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A101-A102.

Researcher : Hui Y

List of Research Outputs

Au D.K.K., Chow C.K., Hui Y. and Wei W.I., Cognitive abilities of patients with cochlear implant in the discrimination of tone stimuli with minimal contrast, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003. 102.

Au D.K.K., Hui Y., Tsang A.W.C. and Wei W.I., ENT management of a child with CHARGE association, Asian Journal of Surgery. 2004, 27(2): 141-143.

Au D.K.K., Hui Y., Jin H. and Wei W.I., 香港失聰兒童早期人工耳蝸植入後的聽覺和言語康復, 中國長沙湖南中華耳鼻喉科雜誌創?50周年紀念暨全國人工耳蝸專題學術會議上宣讀, 2003年9月13-16日, 2003.

Chow C.K., Hui Y., Au D.K.K., LAM W.W.M. and Wong Y.K., Management of bilateral cochlear fistula in cochlear implantation, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004.

Chow C.K., Hui Y. and Au D.K.K., Minimally invasive surgery for different types of cochlear implant, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003.

Chow C.K.L., Hui Y. and Wei W.I., Permeatal temporalis fascia graft harvesting for minimally invasive myringoplasty, Laryngoscope. 2004, 114(2): 386-388.

Chu K., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Short electrode insertion in cochlear implants: the performance on speech perception, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003. 99.

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Narrative abilities in children with cochlear implants, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004. 181.

Hui Y., Academic Committee Member (4 May 2002 - present), Institute of Speech and Hearing Research, Peking University, Beijing, PR China. 2004.

Hui Y., Best Presented Paper Award, Surgical management of drooling, Rehabilitation Scientific Conference 2003 Hong Kong West Cluster, Hospital Authority, Hong Kong, 25 October 2003,. 2003.

Hui Y., Cochlear implant surgery - how I do it, "Cochlear Implant" Seminar, 中國西安,西安交通大學第二醫院, 26 May 2004, 2004.

Hui Y., Common ENT problems & hearing impairment in children, Post-registration Certificate Course in Child Health Nursing, Hospital Authority Head Office, 28 October 2003. 2003.

Hui Y., Effects of multichannel cochlear implant for Chinese speaking prelingually hearing impaired profound deafness; the facts for and their impact on the rehabilitation of hearing, speech and performance, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Science, Taipei, Taiwan, 6 December 2003.

Hui Y., Examiner, RCSEd/HKCORL Joint Intercollegiate Higher Specialist Examination, October 2002. 2003.

Hui Y., Examiner, Royal College of Surgeons of Edinburgh/Hong Kong College of Otorhinolaryngologists - Joint Intercollegiate Higher Specialist Examination, October 2003. 2003.

Hui Y., Examiner, Royal College of Surgeons of Edinburgh/Hong Kong College of Otorhinolaryngologists - joint Intercollegiate Higher Specialist Examination, October 2003. 2003.

Hui Y., Fellow (2003 - present), American College of Surgeons. 2004.

Hui Y., Honorary Consultant, The University of Hong Kong Clincial Centre of Teaching and Research in Chinese Medicine, Tung Wah Hospital, Hong Kong. 2004.

Hui Y., Honorary Professor (18 March 2002 - present), ZhengZhou University, Henan, PR China. 2004.

Hui Y., Honorary Secretary (December 2003 - present), Hong Kong Society of Otorhinolaryngology, Head and Neck Surgery. 2003.

Hui Y., Invited Discussant, Pediatric Grand Round, 6th Annual Scientific Meeting, Hong Kong Society of Pediatric Respirology, 26 October 2003. 2003.

Hui Y., Major head inury after cochlear implantation in children, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004.

Hui Y., Measurement of success in cochlear implant , Staff of ENT Department, 中國遼寧、沈陽, 中國醫科大學第一附屬醫院, 26 August 2003, 2003.

Hui Y., Member (March 2004 - present), Hospital Authority Expert Panel. 2004.

Hui Y., Member of Editorial Board (March 2001 - present), 中國耳鼻喉顱底外科雜誌, 2004.

Hui Y., Member of Editorial Board (September 2003 - present), 中國聽力語言康復科學雜誌, 2004.

Hui Y., Pediatric tracheostomy, Staff of Pediatric Department, Kwong Wah Hospital, 4 September 2003. 2003.

Hui Y., Wong Y.K. and Wei W.I., Speech outcomes of prelingually deafened Cantonese-speakers after cochlear implantation, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Science, Taipei, Taiwan, 6 December 2003 . 2003.

Hui Y., To R.W.Y. and Goh W.H.S., Surgical Management of Drooling, Rehabilitation Scientific Conference 2003, Hong Kong West Cluster, Hong Kong, 25 October 2003. 16.

Hui Y., To R. and Goh W.H.S., Surgical management of drooling, New Challenges in Healthcare - 10th Anniversary Conference, Hong Kong, 28-30 November 2003.

Hui Y., Visiting Professor (December 2002 - December 2004), ENT - Head & Neck Hospital, Guanzhou, Guangdong, PR China. 2004.

Hui Y., Wong S.Y., Wong L.Y., Ho W.K. and Wei W.I., Year Book of Otolaryngology - Head and Neck Surgery. Mosby, 2004.

Hui Y., 人工耳蝸植入的經濟學評估, 中國長沙湖南中華耳鼻咽喉科雜誌創?50週年紀念暨全國人工耳蝸專題學術會議, 2003年9月13-16日, 2003.

Hui Y., 委員 (January 2004 - present), 第三屆中國殘疾人康復協會聽力語言康復專業委員會, 2004.

Hui Y., Complications in cochlear implant surgery - prevention and management, "Cochlear Implant" Seminar, 中國西安,西安交通大學第二醫院, 26 May 2004, 2004.

Kong W., Yu L., Hui Y., Yue J., Xiong X., Zhu L. and Duan J., 先天性話前聾中國兒童雙耳人工耳蝸植入療效觀察, 臨床耳鼻咽喉科雜誌, 2003, 17 (10): 577-579.

Lam K.Y., Ng W.M. and Hui Y., ?維喉鏡下氣管食管穿刺朮及PROVOX發音鈕植入之體會, Chinese Journal of Otorhinolaryngology - Skull Base Surgery. 2003, 9(5): 276-277.

Lee S.L. and Hui Y., Recurrent respiratory papillomatosis in a survivor of extreme prematurity, Pediatric Pulmonology. 2004, 38: 352-354.

Ng P.K., Hui Y., Lam B.C.C., Goh W.H.S. and Yeung C.Y., Feasibility of implementing a universal neonatal hearing screening programme using distortiion product otoacoustic emission detection at a university hospital in Hong Kong, Hong Kong Medical Journal. 2004, 10(1): 6-13.

孔 ......, Hui Y., Yue J., Xiong X., Zhu L., 孔祥.泉., 韓萍. and 馬輝., 人工耳蝸植入術前聽神經完整性的評估, Chinese Journal of Otology. 2003, 1 (2): 26-30.

金 ..., Hui Y., Au D.K.K. and Wei W.I., Effects of stimulation rate on Cantonese tone perception performance for cochlear implant users, 刺激速率對廣東話人工耳蝸使用者聲調認知能力的影響, Chinese Scientific Journal of Hearing and Speech Rehabilitation. 2004, 4: 7-9.

金 ..., Au D.K.K., Hui Y. and Wei W.I., 噪聲環境下刺激速率對廣東語聲調認知能力的影響, 中國長沙湖中華耳鼻咽喉科雜誌創?50週年紀念暨全國人工耳蝸專題學術會議, 2003年9日13-16日, 2003.

Researcher : Hung KN

List of Research Outputs

Au W.Y., Hung K.N., Loong F. and Ma S.K., Patients presenting with CNS lesions. Case 3: Sequential myeloproliferative disease and glioblastoma multiforme in a renal transplant recipient, Journal of Clinical Oncology. 2003, 21(21): 4062-4063.

Chan G.C.F., Khong P.L., Kwong D.L.W., Chiang A.K.S., Hung K.N., Fan Y.W., Ha S.Y. and Lau Y.L., Outcome and long term neurological complications of childhood medulloblastoma: the QMH experience, Rehabilitation Scientific Conference 2003, Hong Kong West Cluster, Hong Kong, 25 October 2003. 28.

Lee R., Cheung R.T.F., Hung K.N., Au Yeung K.M., Leong Fung L.L.Y., Chan F.L. and Lee T.Y., Use of CT perfusion to differentiate between brain tumor and cerebral infarction, Cerebrovascular Diseases. 2004, 18: 77-83.

Researcher : Hwang ISS

List of Research Outputs

Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181(2): 339-345.

Hwang I.S.S., Luk J.M.C., Tan F. and Fan S.T., Vasoactive role of adrenomedullin in CC14-plus-ethanol-induced hepatic cirrhosis (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Researcher : Ip YC

List of Research Outputs

Cheung S.T., Chen X., Fong D.Y.T., Leung K.L., Ip Y.C., Ng I.O.L., So S. and Fan S.T., Delineation of prognostic biomarkers from the global gene expression profile of liver cancer (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Cheung S.T., Chen X., Fong D.Y.K., Leung K.L., Ip Y.C., Ng I.O.L. and Fan S.T., Novel prognostic markers for hepatocellular carcinoma (Poster Presentation), The Spanish National Cancer Centre 2004 Symposium on the Molecular Taxonomy of Cancer, Madrid, Spain, 3-6 February 2004.

Cheung S.T., Chen X., Fong D.Y.K., Leung K.L., Ip Y.C., Ng I.O.L., So S. and Fan S.T., Novel prognostic markers for liver cancer (Abstract), Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003.

Ip Y.C., Cheung S.T. and Fan S.T., Genes associated with venous invasion in hepatocelluar carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 344.

Ip Y.C., Cheung S.T. and Fan S.T., Genes associated with venous invasion in hepatocellular carcinoma (Abstract), Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July. 2003, 44: 344.

Ip Y.C., Cheung S.T. and Fan S.T., MMP14 enhances tumor growth and invasion in hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 1826.

Ip Y.C., Cheung S.T. and Fan S.T., MMP14 enhances tumor growth and invasion in hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Researcher : Jiang G

List of Research Outputs

Ren Y., Chen Y.X., Li W., Jiang G., Liu Q., Chan H.M. and Tam P.K.H., Expression and function of macrophage migration inhibitory factor in human neuroblastoma, 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, 27-31 March 2004.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Researcher : Jin H

List of Research Outputs

Au D.K.K., Hui Y., Jin H. and Wei W.I., 香港失聰兒童早期人工耳蝸植入後的聽覺和言語康復, 中國長沙湖南中華耳鼻喉科雜誌創?50周年紀念暨全國人工耳蝸專題學術會議上宣讀, 2003年9月13-16日, 2003.

Jin H., Postoperative strategies to improve the benefit of cochlear implantation in a Cantonese-speaking population, Thesis, Master of Philosophy, The University of Hong Kong. 2004.

Researcher : Ko S

List of Research Outputs

Ko S., Associate Member, American Association for Cancer Research. 2004.

Ko S., Chu K.M., Luk J.M.C., Wong W.Y., Leung S.Y., Yuen S.T. and Wong J., Expression of CDX2 and LI-cadherin in intestinal metaplasia and adenocarcinoma of the stomach, 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Ko S., Chu K.M., Luk J.M.C., Wong B.W.Y., Yuen S.T., Leung S.Y.L. and Wong J., Over-expression of LI-cadherin in gastric cancer is associated with lymph node metastasis, Biochemical and Biophysical Research Communications. 2004, 319(2): 562-568.

Researcher : Kong W

List of Research Outputs

Kong W., Yu L., Hui Y., Yue J., Xiong X., Zhu L. and Duan J., 先天性話前聾中國兒童雙耳人工耳蝸植入療效觀察, 臨床耳鼻咽喉科雜誌, 2003, 17 (10): 577-579.

Researcher : Lam BKY

List of Research Outputs

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Liu C.L., Lam B.K.Y., Lo C.M. and Fan S.T., Impact of right-lobe live donor liver transplantation on patients waiting for liver transplantation, Liver Transplantation. 2003, 9(8): 863-869.

Researcher : Lam CM

List of Research Outputs

Chan O.O., Ng I.O.L., Lam C.M., Shek T.W.H. and Lai C.L., Cholestatic jaundice caused by sequential carbimazole and propylthiouracil treatment for thyrotoxicosis, Hong Kong Medical Journal. 2003, 9(5): 377-380.

Chan O.O., Yuen M.F., Lam C.M., Fong C.Y., Wong B.C.Y. and Lai C.L., Prevalence and Characteristics of Familial Hepatocellular Carcinoma Caused by Chronic Hepatitis B Infection in Hong Kong, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 401-6.

Lam C.M., Comparative surgical audit - the hepatectomy model (Invited Lecture), The Hong Kong Surgical Forum, Hong Kong, 5 July 2003.

Lam C.M., Chan O.O., Ho P., Ng I.O.L., Lo C.M., Liu C.L., Poon R.T.P. and Fan S.T., Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients - implications for screening, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 771-777.

Lam C.M., Ng K.K.C., Poon R.T.P., Ai V.H.G., Yuen J. and Fan S.T., Impact of radiofrequency ablation on the management of patients with hepatocellular carcinoma in a specialized centre, British Journal of Surgery. 2004, 91(3): 334-338.

Lam C.M., Management of recurrent HCC and liver secondary, The New Horizon Club of Hong Kong, 20 March 2004. 2004.

Lam C.M., Fan S.T., Yuen A.W.C., Law W.L. and Poon K., Validation of POSSUM scoring systems for audit of major hepatectomy, British Journal of Surgery. 2004, 91(4): 450-454.

Law W.L., Yong J.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendectomy (Abstract), Journal of Society of Laparoendoscopic Surgery. 2003, 7: S59.

Liu C.L., Fan S.T., Lo C.M., Wong Y., Ng I.O.L., Lam C.M., Poon R.T.P. and Wong J., Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases, Annals of Surgery. 2004, 239(2): 194-201.

Lo O.S.H., Poon R.T.P., Lam C.M. and Fan S.T., Inflammatory pseudotumor of the liver in association with a gastrointestinal stromal tumor: a case report, World Journal of Gastroenterology. 2004, 10(12): 1841-1843.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Comparison of systemic responses of radiofrequency ablation, cryotherapy and surgical resection in a porcine liver model (Abstract), Annals of the College of Surgeons of Hong Kong. 2004, 8(Suppl.): A7.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Comparison of systemic responses of radiofrequency ablation, cryotherapy and surgical resection in a porcine liver model (Oral Presentation), The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Fan S.T. and Wong J., Delayed portal vein thrombosis after experimental radiofrequency ablation near the main portal vein, British Journal of Surgery. 2004, 91(5): 632-639.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M., Ng I.O.L. and Fan S.T., Impact of preoperative fine-needle aspiration cytologic examination on clinical outcome in patients with hepatocellular carcinoma in a tertiary referral center, Archives of Surgery. 2004, 139(2): 193-200.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to hepatic radiofrequency ablation in a rat model (Abstract), The 5th Annual Scientific Meeting Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Abstract), Annals of the College of Surgeons of Hong Kong. 2004, 8(Suppl.): A7.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Oral Presentation), The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Law W.L., Seto C.L. and Fan S.T., Radiofrequency ablation as a salvage procedure for ruptured hepatocellular carcinoma, Hepatogastroenterology. 2003, 50(53): 1641-1643.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J. and Fan S.T., Effectiveness of radiofrequency ablation for hepatocellular carcinoma larger than 3 cm in diameter, Archives of Surgery. 2004, 139(3): 281-287.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database (Oral Presentation), The 124th Annual Meeting of the American Surgical Association, San Francisco, U.S.A., 15-17 April 2004.

Poon R.T.P., Yeung C., Liu C.L., Lam C.M., Yuen W.K., Lo C.M., Tang A. and Fan S.T., Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial, Gut. 2003, 52(12): 1768-1773.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J., Fan S.T. and Wong J., Learning curve for radiofrequency ablation of liver tumors: prospective analysis of initial 100 patients in a tertiary institution, Annals of Surgery. 2004, 239(4): 441-449.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J., Fan S.T. and Wong J., Learning curve for radiofrequency ablation of liver tumours: prospective analysis of initial 100 patients in a teritary institution (Oral Presentation), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement, World Journal of Surgery. 2004, 28(6): 602-608.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J. and Fan S.T., Radiofrequency ablation for subcapsular hepatocellular carcinoma, Annals of Surgical Oncology. 2004, 11(3): 281-289.

Yong J.L., Law W.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendicectomy, The 12th International Congress and Endo Expo 2003, SLS Annual Meeting, The Society of Laparoendoscopic Surgeons, Las Vegas, Nevada, U.S.A., 22-25 September 2003.

Researcher : Lam CT

List of Research Outputs

Luk J.M.C., Lam C.T., Hu M.Y. and Fan S.T., Liver cancer proteomics: identifications of chapersones Hsp70 and GRP78 in hepatocellular carcinoma (Abstract), Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003.

Luk J.M.C., Lam C.T., Hu M. and Fan S.T., Proteomic identification of chaperones Hsp70 and GRP78 in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Lam LK

List of Research Outputs

Chan H.H.L., Lam L.K., Wong S.Y. and Wei W.I., Role of skin cooling in improving patient tolerability of Q-switched Alexandrite (QS Alex) laser in nervus of Ota treatment, Lasers in Surgery and Medicine. 2003, 32: 148-151.

Chan H.H.L., Lam L.K., Wong S.Y., Kono T. and Trendall-Smith N., Use of 1,320 nm Nd:YAG laser for wrinkle reduction and the treatment of atrophic acne scarring in Asians, Lasers in Surgery and Medicine. 2004, 34: 98-103.

Lam L.K., Council Member (1998 - present), Asian Pacific Cranio-Facial Association. 2004.

Lam L.K., Course Director (1997 - present), Advanced Burn Life Support Course, American Burn Association. 2004.

Lam L.K., Foundation Member, Hong Kong Burns Society. 2004.

Lam L.K., Foundation Member, Hong Kong Surgical Laser Association. 2004.

Lam L.K., Honorary Adviser (1996 - present), The New Voice Club for Laryngectomees. 2004.

Lam L.K., Honorary Adviser (1999 - present), Department of Otolaryngology, Tianjin Institute of Otorhinolaryngology, First Central Hospital, Tianjin, China. 2004.

Lam L.K., Honorary Adviser (December 1996 - present), Yin Hong Club (Breast Cancer Voluntary Group), Hong Kong. 2004.

Lam L.K., Honorary Advisor (1993 - present), Hong Kong Association for Cleft Lip and Palate. 2004.

Lam L.K., Member of Editorial Board, Chinese Journal of Burns - (Zhonghua Shaoshang Zazhi), Chinese Medical Association. 2004.

Lam L.K., Professional Advisor (1998 - present), Community Rehabilitation Network, Hong Kong Society for Rehabilitation. 2004.

Law S.Y.K., Lo O.S.H., Wei W.I., Lam L.K., Wong K.H., Kwok K.F. and Wong J., Treating esophageal cancer with synchronous or antecedent head and neck cancers: a more formidable challenge? (Abstract), Diseases of the Esophagus. 2004, 17, Supplement 1: A42-A43.

Wei W.I., Lam L.K., Ng W.M., Liu C.L., Lo C.M., Fan S.T. and Wong J., Microvascular reconstruction of the hepatic artery in live donor liver transplantation: experience across a decade, Archives of Surgery. 2004, 139(3): 304-307.

Wei W.I., Tuen H.H.L., Ng W.M. and Lam L.K., Safe tracheostomy for patients with severe acute respiratory syndrome, The Laryngoscope. 2003, 113(10): 1777-1779.

Wong L.Y., Wei W.I., Lam L.K. and Yuen P.W., Salvage of recurrent head and neck squamous cell carcinoma after primary curative surgery, Head & Neck. 2003, 25(1): 953-959.

Researcher : Lamb JR

List of Research Outputs

Wong K.K.Y., Carpenter M.J., Young L.L., Walker S.J., McKenzie G., Rust A.J., Ward G., Packwood L., Wahl K., Delriviere L., Hoyne G., Gibbs P., Champion B.R., Lamb J.R. and Dallman M.J., Notch ligation by Deltal inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism, The Journal of Clinical Investigation. 2003, 112(11): 1741-1750.

Researcher : Lau CK

List of Research Outputs

Li X.L., Man K., Liu Y.F., Lee K.W., Tsui H.T., Lau C.K., Lo C.M. and Fan S.T., Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation, Transplantation. 2003, 76(1): 44-49.

Tsui T.Y., Siu Y.T., Ho D.W.Y., Lau C.K. and Fan S.T., Carbon monoxide, the natural product of HO activity, protects mice from fulminant hepatic failure (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Lau CPY

List of Research Outputs

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Increased expression of SPARC and SPARC-like 1 in relation to tumor angiogenesis in hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 3256.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Increased expression of SPARC and SPARC-like 1 in relation to tumor angiogenesis in hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Relationship between expression of SPARC and SPARC-like 1 and tumor angiogenesis in hepatocellular carcinoma (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Poon R.T.P., Lau C.P.Y., Yu W.C., Fan S.T. and Wong J., High serum levels of vascular endothelial growth factor predict poor response to transarterial chemoembolizatin in hepatocellular carcinoma: a prospective study, Oncology Reports. 2004, 11(5): 1077-1084.

Poon R.T.P., Lau C.P.Y., Ho J.W.Y., Yu W.C., Fan S.T. and Wong J., Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma, Clinical Cancer Research. 2003, 9(14): 5339-5345.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Researcher : Lau CW

List of Research Outputs

O'Suilleabhain C.B., Poon R.T.P., Lau C.W. and Fan S.T., Repeated resections of extrahepatic metastases after hepatic resection: an aggressive approach to hepatocellular carcinoma, Hepatogastroenterology. 2004, 51(57): 825-829.

Researcher : Lau H

List of Research Outputs

Kwan E., Lau H. and Yuen W.K., Laparoscopic resection of a mesenteric cyst (Case Report), Gastrointestinal Endoscopy. 2004, 59(1): 154-156.

Kwan E., Lau H. and Lee F.C.W., Wilkie's syndrome, Surgery. 2004, 135(2): 225-227.

Lau H. and Patil N.G., A prospective comparison of ambulatory endoscopic totally inguinal hernioplasty vs open mesh hernioplasty, Ambulatory Surgery. 2003, 10(3): 137-141.

Lau H. and Patil N.G., Acute pain after endoscopic totally extraperitoneal (TEP) inguinal hernioplasty: multivariate analysis of predictive factors, Surgical Endoscopy. 2004, 18(1): 92-96.

Lau H. and Patil N.G., Acute pain following endoscopic totally extraperitoneal inguinal hernioplasty: multivariate analysis of predictive factors (Abstract), The Medical Journal of Malaysia. 2003, 58 (Supplement F): S24-3.

Lau H. and Patil N.G., Acute pain following endoscopic totally extraperitoneal inguinal hernioplasty: multivariate analysis of predictive factors, 5th Asia-Pacific Congress of Endoscopic Surgery, Kuala Lumpur, Malaysia, 10-13 September 2003.

Lau H., Ambulatory inguinal hernia repair in Hong Kong SAR, China, Hernia Repair 2004, Annual Scientific Meeting of American Hernia Society, Florida, U.S.A., 25-28 February 2004.

Lau H., Chairperson, Free Paper Symposium (Surgery), New Challenges in Healthcare, 10th Anniversary of Celebration Programme of the Hong Kong Academy of Medicine, Hong Kong, 28 November 2003. 2003.

Lau H., Chairperson, 27th Clinical Meeting of Hong Kong Society of Minimal Access Surgery, Queen Mary Hospital, Hong Kong, 11 March 2004. 2004.

Lau H., Council Member, Hong Kong Association of Day Surgery. 2004.

Lau H., Council Member, Hong Kong Society of Minimal Access Surgery. 2004.

Lau H., Endoscopic totally extraperitoneal inguinal hernioplasty, Asian American Multispecialty Congress of Laparoscopy and Minimally Invasive Surgery, Honolulu, Hawaii, 4-7 February 2004.

Lau H., Guest Editor, Annals of The College of Surgeons of Hong Kong. 2004.

Lau H. and Patil N.G., Impact of previous appendectomy on the outcomes of endoscopic totally extraperitoneal inguinal hernioplasty, Hernia Repair 2004, Annual Scientific Meeting of American Hernia Society, Florida, U.S.A., 25-28 February 2004.

Lau H., Indications and techniques of endoscopic totally extraperitoneal inguinal hernioplasty, 27th Clinical Meeting, Hong Kong Society of Minimal Access Surgery, Hong Kong, 11 March 2004.

Lau H., Inguinal hernia surgery, MetroDaily, 16 January 2004. 2004, 30.

Lau H., Laparoscopic inguinal hernia repair, CME Meeting for Surgeons, St. Teresa's Hospital, Hong Kong, 4 January 2004. 2004.

Lau H., Laparoscopic ventral hernia repair, Asian American Multispecialty Congress of Laparoscopy and Minimally Invasive Surgery, Honolulu, Hawaii, 4-7 February 2004.

Lau H., Management of peritoneal tear during endoscopic extraperitoneal inguinal hernioplasty (Reply Letter), Surgical Endoscopy. 2003, 17: 1336.

Lau H., Lam B. and Patil N.G., Management of postoperative urinary retention: a randomized trial of in-out versus overnight catheterization (Abstract), Annals of The College of Surgeons of Hong Kong. 2004, 8(2): A5.

Lau H., Lam B. and Patil N.G., Management of postoperative urinary retention: a randomized trial of in-out versus overnight catheterization, 11th Annual Scientific Meeting, College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Lau H. and Lam B., Management of postoperative urinary retention: a randomized trial of in-out versus overnight catheterization, Australian and New Zealand Journal of Surgery. 2004, 74: 658-661.

Lau H., Moderator, International Advanced Laparoscopic Surgery Symposium 2004, Hong Kong Society of Minimal Access Surgery, ELSA, Hong Kong, 24-25 June 2004. 2004.

Lau H., Organizing Committee Member and Faculty, Asian American Multispecialty Congress of Laparoscopy and Minimally Invasive Surgery, Honolulu, Hawaii, U.S.A., 4-7 February 2004. 2004.

Lau H., Outpatient endoscopic totally extraperitoneal inguinal hernioplasty, Journal of Laparoendoscopic Surgery and Advanced Surgical Techniques. 2004, 14(2): 93-96.

Lau H., Patients' perception of open and endoscopic extraperitoneal inguinal hernioplasty, Hernia Repair 2004, Annual Scientific Meeting of American Hernia Society, Florida, U.S.A., 25-28 February 2004.

Lau H., Patients' perception of open and endoscopic extraperitoneal inguinal hernioplasty, Surgical Laparoscopic Endoscopic Percutaneous Technology. 2004, 14(4): 219-221.

Lau H., Peritoneal tear leads to leakage of carbon dioxide into the peritoneal cavity (Letter), Surgical Endoscopy. 2004, 18(1): 170.

Lau H., Patil N.G., Yuen W.K. and Lee F.C.W., Prevalence and severity of chronic groin pain after endoscopic totally extraperitoneal inguinal hernioplasty, Surgical Endoscopy. 2003, 17: 1620-1623.

Lau H., Patil N.G. and Yuen W.K., Prevalence and severity of chronic groin pain following endoscopic totally extraperitoneal inguinal hernioplasty, New Challenges in Healthcare, 10th Anniversary of Celebration Programme of the Hong Kong Academy of Medicine, Hong Kong, 28-30 November 2003.

Lau H., Reviewer, Annals of The College of Surgeons of Hong Kong. 2004.

Lau H., Reviewer, Asian Journal of Surgery. 2004.

Lau H., Reviewer, British Medical Journal. 2003.

Lau H., Reviewer, Surgical Endoscopy. 2003.

Lau H. and Patil N.G., Selective non-stapling of mesh during unilateral endoscopic total extraperitoneal inguinal hernioplasty (a case-control study), Archives of Surgery. 2003, 138(12): 1352-1355.

Lau H. and Lee F.C.W., Seroma following endoscopic extraperitoneal inguinal hernioplasty, Surgical Endoscopy. 2003, 17: 1773-1777.

Lau H., Sliding lipoma - an indirect inguinal hernia without a peritoneal sac, Hernia Repair 2004, Annual Scientific Meeting of American Hernia Society, Florida, U.S.A., 25-28 February 2004.

Lau H., Sliding lipoma - an indirect inguinal hernia without a peritoneal sac, Journal of Laparoendoscopic Surgery and Advanced Surgical Techniques. 2004, 14(1): 57-59.

Lau H., Umbilical hernia in adults: laparoscopic vs open repair (Abstract), The Medical Journal of Malaysia. 2003, 58 (Supplement F): S24.

Lau H. and Patil N.G., Umbilical hernia in adults: laparoscopic vs open repair, 5th Asia-Pacific Congress of Endoscopic Surgery, Kuala Lumpur, Malaysia, 10-13 September 2003.

Lau H. and Patil N.G., Umbilical hernia in adults, Surgical Endoscopy. 2003, 17 (12): 2016-2020.

Law W.L., Yong J.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendectomy (Abstract), Journal of Society of Laparoendoscopic Surgery. 2003, 7: S59.

Sit K.Y., Lau H. and Yuen W.K., Laparoscopic resection of accessory spleen (Abstract), Annals of The College of Surgeons of Hong Kong. 2004, 8 Suppl.: S24.

Sit K.Y., Lau H. and Yuen W.K., Laparoscopic resection of accessory spleen, 12th Annual Scientific Meeting of the Hong Kong Society of Minimal Access Surgery jointly with Macao Surgery Association, Macau, 10 January. 2004.

Yong J.L., Law W.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendicectomy, The 12th International Congress and Endo Expo 2003, SLS Annual Meeting, The Society of Laparoendoscopic Surgeons, Las Vegas, Nevada, U.S.A., 22-25 September 2003.

Researcher : Lau MF

List of Research Outputs

Ganster R.W., Lau M.F., Neoh K.H.A. and Tam P.K.H., NF-kB, Stat1, and Stat3 are over-expressed in papillary thyroid carcinoma: identification of molecular switches which dys-regulate gene transcription causing thyroid cancer, 95th Annual Meeting of American Association for Cancer Research, Florida, U.S.A., 27-31 March 2004.

Lau M.F., Neoh K.H.A., Tam P.K.H. and Ganster R.W., Regulation of gene transcription by NF-kB and Stats downstream of the Ret receptor tyrosine kinase in thyroid cancer and Hirschsprung's disease, 95th Annual Meeting of American Association for Cancer Research, Florida, U.S.A., 27-31 March 2004.

Researcher : Law IC

List of Research Outputs

Shiu S.Y.W., Law I.C., Law K.W., Tam P.C., Yip A.W.C. and Ng W.T., Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT₁ receptor subtype, Journal of Pineal Research. 2003, 35: 177-182.

Researcher : Law SYK

List of Research Outputs

Chen X., Leung S.Y., Yuen S.T., Chu K.M., Ji J., Li R., Chan A.S.Y., Law S.Y.K., Troyanskaya O.G., Wong J., So S., Botstein D. and Brown P.O., Variation in gene expression patterns in human gastric cancers, Molecular Biology of the Cell. 2003, 14(8): 3208-3215.

Chu K.M., Kwok K.F., Law S.Y.K. and Wong K.H., A prospective evaluation of catheter probe EUS for the detection of ascites in patients with gastric carcinoma, Gastrointestinal Endoscopy. 2004, 59(4): 471-474.

Jin Y., Jin C., Law S.Y.K., Chu K.M., Zhang H., Stromback B., Yuen P.W. and Kwong Y.L., Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas, Cancer Genetics Cytogenetics. 2004, 148(1): 21-28.

Kwong D.L.W., Lam A., Guan X.Y., Law S.Y.K., Tai A., Wong J. and Sham J.S.T., Chromosomal aberrations in esophageal squamous cell carcinoma among Chinese: gain of 12p predicts poor prognosis after surgery, Human Pathology. 2004, 35(3): 309-316.

Law B.F.F., Srivastava G., Wong K.Y., Chen W.Y.W., Liang A.C.T., Lam K.Y., Law S.Y.K., Wong J. and Tang J.C.O., A novel tumor transforming gene at 7q22, GAESCC1, is frequently amplified and overexpressed in primary esophageal squamous cell carcinomas, Abstract of the Proceedings of the 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, USA, March 2004.

Law S.Y.K. and Wong J., Current status of esophageal cancer treatment in Asia, (Abstract) The 58th Annual Meeting of the Japan Esophageal Society, Tokyo, Japan, June 2004.

Law S.Y.K. and Wong J., Hand-sewn anastomoses (Viewpoint - What's new in esophageal anastomoses?), (Abstract) IX World Congress of the International Society for Diseases of the Esophagus, Madrid, Spain, 27-29 May 2004.

Law S.Y.K., Kwong D.L.W., Kwok K...F., Wong K...H., Chu K.M., Sham J.S.T. and Wong J., Improvement in treatment results and long-term survival of patients with esophageal cancer: impact of chemoradiation and change in treatment strategy, Annals of Surgery. 2003, 238(3): 339-348.

Law S.Y.K., Instructor (1998 - present), Advanced Trauma Life Support Course, American College of Surgeons. 2004.

Law S.Y.K., Instructor (1998 - present), Care of Critically III Surgical Patients Course, The Royal College of Surgeons of England. 2004.

Law S.Y.K., Management of complicated cases of esophageal cancer: current strategies, (Abstract) The 16th Biennial Congress of Association of Thoracic and Cardiovascular Surgeons of Asia, Bangkok, Thailand, 16-19 November 2003.

Law S.Y.K. and Wong J., Neoadjuvant chemotherapy vs. surgery alone in esophageal cancer (Lecture), (Abstract) IX World Congress of the International Society for Diseases of the Esophagus, Madrid, Spain, 27-29 May 2004.

Law S.Y.K., Boey J...P., Kwok K...F., Wong K...H., Chu K.M. and Wong J., Pleural drainage after transthoracic esophagectomy: experience with a vacuum system, Diseases of the Esophagus. 2004, 17(1): 81-86.

Law S.Y.K. and Wong J., Right thoraco-abdominal approaches / Ivor Lewis-McKeown procedures for esophageal resection in resectable and potentially curable tumors (Symposium - Controversies in the treatment of squamous cell carcinoma of the esophagus), (Abstract) IX World Congress of the International Society for Diseases of the Esophagus, Madrid, Spain, 27-29 May 2004.

Law S.Y.K., Strategies to improve surgical results in the treatment of esophageal cancer, Esophagus. 2003, 1(1): 49-55.

Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., Supra-carinal esophageal cancers have worse prognosis compared to more distally located tumors, preoperative chemoradiation results in better survival (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A43.

Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., The need to re-classify stage IVb esophageal cancer: evidence from differential response to chemoradiation therapy (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A42.

Law S.Y.K. and Wong J., Therapeutic options for esophageal cancer, Journal of Gastroenterology and Hepatology. 2004, 19(1): 4-12.

Law S.Y.K., Lo O.S.H., Wei W.I., Lam L.K., Wong K.H., Kwok K.F. and Wong J., Treating esophageal cancer with synchronous or antecedent head and neck cancers: a more formidable challenge? (Abstract), Diseases of the Esophagus. 2004, 17, Supplement 1: A42-A43.

Law W.L., Yong J.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendectomy (Abstract), Journal of Society of Laparoendoscopic Surgery. 2003, 7: S59.

Murthy S.C., Law S.Y.K., Whooley B.P., Alexandrou A., Chu K.M. and Wong J., Atrial fibrillation after esophagectomy is a marker for postoperative morbidity and mortality, The Journal of Thoracic and Cardiovascular Surgery. 2003, 126(4): 1162-1167.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Zhao P., Huang X., Vande Woude G. and Wong J., Hepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A101-A102.

Suen D.T.K., Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., Cervical or intrathoracic oesophageal anastomosis after oesophagectomy for cancer: comparisons in 218 patients using a single-layer, continuous hand-sewn method, (Abstract) The 10th Hong Kong International Cancer Congress, Hong Kong, 19-21 November 2003.

Wong J. and Law S.Y.K., Esophageal cancer surgery: lessons from 1,200 resections, (Abstract) 26th Congress of Pan-Pacific Surgical Association, Honolulu, USA, 14 February 2004.

Wong J. and Law S.Y.K., Surgery for cancer of the oesophagus: The GB Ong legacy, Annals of The College of Surgeons of Hong Kong. 2003, (Supplement 2), 7: B18-B20.

Yong J.L., Law W.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendicectomy, The 12th International Congress and Endo Expo 2003, SLS Annual Meeting, The Society of Laparoendoscopic Surgeons, Las Vegas, Nevada, U.S.A., 22-25 September 2003.

Researcher : Law WL

Project Title:	Self-expanding metallic stents for the poor patients with malignant colorectal obstruction
Investigator(s):	Dr. Law W.L., Dr. Chu K.W.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	04/2004

Abstract:

To provide the insertion of self-expanding metallic stents to the poor patients who cannot afford the devices.

List of Research Outputs

Chan S.Y., Law W.L. and Chu K.W., Gastrointestinal stromal tumour presenting as incarcerated inguinal hernia (Case report), Australian and New Zealand Journal of Surgery. 2004, 74(5): 391-392.

Choi H.K., Law W.L. and Chu K.W., The value of gastrografin in adhesive small bowel obstruction after unsuccessful conservative treatment: a prospective evaluation, Annual Meeting of the American Society of Colon and Rectal Surgeons, Dallas, Texas, U.S.A., 8-13 May 2004.

Ho P., Law W.L., Choy C., Chan G.S. and Chu K.W., Granulomatous appendicitis progressing to Crohn's disease with bleeding complication, Australian and New Zealand Journal of Surgery. 2003, 73(7): 554-556.

Ho P., Law W.L., Tung P.H.M., Poon J.T.C., Ting A.C.W. and Cheng S.W.K., Laparoscopic transperitoneal clipping of the inferior mesenteric artery for the management of type II endoleak after endovascular repair of an aneurysm (Case report), Surgical Endoscopy. 2004, 18(5): 870.

Lam C.M., Fan S.T., Yuen A.W.C., Law W.L. and Poon K., Validation of POSSUM scoring systems for audit of major hepatectomy, British Journal of Surgery. 2004, 91(4): 450-454.

Law W.L., Yong J.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendectomy (Abstract), Journal of Society of Laparoendoscopic Surgery. 2003, 7: S59.

Law W.L., Choi H.K., Chu K.W., Ho J.W.C. and Wong L.Y.C., Bowel preparation for colonoscopy: a randomized controlled trial comparing polyethylene glycol solution, one dose and two doses of oral sodium phosphate solution, Asian Journal of Surgery. 2004, 27(2): 120-124.

Law W.L., Colorectal stenting, Hong Kong Surgical Forum, 5 July 2003.

Law W.L., Choi H.K. and Chu K.W., Comparison of stenting with emergency surgery as palliative treatment for obstructing primary left-sided colorectal cancer, British Journal of Surgery. 2003, 90(11): 1429-1433.

Law W.L., Fellow (1998 - present), American College of Surgeons. 2004.

Law W.L. and Lo C.Y., Fishbone perforation of the small bowel: laparoscopic diagnosis and laparoscopically assisted management (Case report), Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 2003, 13(6): 392-393.

Law W.L., Instructor (1998 - present), Advanced Trauma Life Support Course, American College of Surgeons. 2004.

Law W.L., Choi H.K., Lee Y.M. and Chu K.W., Laparoscopic colectomy for obstructing sigmoid cancer with prior insertion of an expandable metallic stent, Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 2004, 14(1): 29-32.

Law W.L., Laparoscopic right hemicolectomy (Live surgery), Hong Kong Colorectal Symposium, 9-10 October 2003.

Law W.L., Laparoscopic surgey for rectal neoplasm: results, Hong Kong Colorectal Symposium, 9-10 October 2003.

Law W.L., Chan W.F., Lee Y.M. and Chu K.W., Non-curative surgery for colorectal cancer: critical appraisal of outcomes , International Journal of Colorectal Disease. 2004, 19(3): 197-202.

Law W.L., Choi H.K., Lee Y.M. and Chu K.W., Palliation for advanced malignant colorectal obstruction by self-expanding metallic stents: prospective evaluation of outcomes, Diseases of the Colon & Rectum. 2004, 47(1): 39-43.

Law W.L., Panel discussant, Day Care Stapled Haemorrhoidectomy Workshop, 16 June 2004.

Law W.L. and Chu K.W., Scirrhous colonic metastasis from ductal carcinoma of the breast - report of a case, Diseases of the Colon & Rectum. 2003, 46(10): 1424-1427.

Law W.L., Stapled haemorrhoidectomy (Live surgery), Hong Kong Colorectal Symposium, 9-10 October 2003.

Law W.L., Stapled haemorrhoidectomy-PPH: Hong Kong experience, Hong Kong Colorectal Symposium, 9-10 October 2003.

Law W.L., Stenting for colorectal obstruction, Hong Kong Colorectal Symposium, 9-10 October 2003.

Ng K.K.C., Lam C.M., Poon R.T.P., Law W.L., Seto C.L. and Fan S.T., Radiofrequency ablation as a salvage procedure for ruptured hepatocellular carcinoma, Hepatogastroenterology. 2003, 50(53): 1641-1643.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Yong J.L., Law W.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendicectomy, The 12th International Congress and Endo Expo 2003, SLS Annual Meeting, The Society of Laparoendoscopic Surgeons, Las Vegas, Nevada, U.S.A., 22-25 September 2003.

Researcher : Lee EWM

List of Research Outputs

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Lee FCW

List of Research Outputs

Ho K.M.T., Shen J., Fung P.C.W., Lee F.C.W. and Tam P.C., Effect of ischemia-reperfusion on nitric oxide production in the pig-bladder (Abstract), European Urology. 2003, No. 1, Supplements 2: 170.

Kwan E., Lau H. and Lee F.C.W., Wilkie's syndrome, Surgery. 2004, 135(2): 225-227.

Lau H., Patil N.G., Yuen W.K. and Lee F.C.W., Prevalence and severity of chronic groin pain after endoscopic totally extraperitoneal inguinal hernioplasty, Surgical Endoscopy. 2003, 17: 1620-1623.

Lau H. and Lee F.C.W., Seroma following endoscopic extraperitoneal inguinal hernioplasty, Surgical Endoscopy. 2003, 17: 1773-1777.

Lee F.C.W., Council Member, Asian Society of Endourology. 2004.

Lee F.C.W., Council Member, Hong Kong Urological Association. 2004.

Lee F.C.W., Director, Chiang Cheung Chun Fong Surgery Day Centre, Queen Mary Hospital, Hong Kong. 2004.

Lee F.C.W., Fellow (1999 - present), American College of Surgeons. 2004.

Lee F.C.W., Honorary Consultant, The University of Hong Kong Clinical Centre for Teaching and Research in Chinese Medicine, Tung Wah Hospital, Hong Kong. 2004.

Lee F.C.W., Honorary Treasurer, Hong Kong Public Consultant Doctors' Group. 2004.

Lee F.C.W., Member, Hong Kong Society of Health Service Executives. 2004.

Lee F.C.W., Secretary General, Asian Surgical Association . 2004.

Researcher : Lee JM

List of Research Outputs

Ng I.O.L., Chan K.L., Shek T.W.H., Lee J.M., Fong D.Y.T., Lo C.M. and Fan S.T., High frequency of chimerism in transplanted livers, Hepatology. 2003, 38(4): 989-998.

Researcher : Lee KW

List of Research Outputs

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Xu R. and Fan S.T., FTY720 selectively induced human hepatoma cell line apoptosis via Akt dephosphorylation (Abstract) , AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Ng I.O.L., Xu R. and Fan S.T., FTY720 selectively induces human hepatoma cell lines apoptosis via Akt dephosphorylation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Lee K.W., Man K., Ling M.T., Wang X., Wong Y.C., Lo C.M., Poon R.T.P., Ng I.O.L. and Fan S.T., Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16^INK4a/RB pathway, Carcinogenesis. 2003, 24(11): 1729-1736.

Li X.L., Man K., Liu Y.F., Lee K.W., Tsui H.T., Lau C.K., Lo C.M. and Fan S.T., Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation, Transplantation. 2003, 76(1): 44-49.

Man K., Ng T.P., Lo C.M., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed tumor growth and matastasis (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., Distinct intragraft response pattern in liver transplantation using marginal grafts and cirrhotic recipients (Abstract), The 11th Congress of the European Society for Organ Transplantation, Venice, Italy, 20-24 September 2003.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., FTY attenuates ischemia-reperfusion injury in normal and cirrhotic rat liver by down-regulation of Egr-1 and activation of Akt pathway, Liver transplantation. 2003, 9(6): c-37.

Man K., Ng T.P., Lee K.W., Lo C.M., Sun K.W., Li X.L., Zhao Y., Ho J.W.Y. and Fan S.T., FTY720 attenuates hepatic ischemia-reperfusion injury by Egr-1 down-regulation involving Raf-MEK-Erk pathway and Akt activation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathway (Abstract), Liver Transplantation. 2004, 10(6): C69.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ho J.W.Y., Lee K.W., Zhao Y., Wang X.H., Ng T.P., Sun K.W. and Fan S.T., Marked suppression of tumor growth by FTY720 in rat and mouse liver tumor models (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Man K., Zhao Y., Xu A.M., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus adiponectin combination therapy (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Zhao Y., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus asiponectin combination therapy (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lo C.M., Ho J.W.Y., Zhao Y., Sun K.W., Lee K.W., Li X.L. and Fan S.T., The significance of hepatic ischemia-reperfusion injury on liver tumor development - activation of cell invasion and migration pathways (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Pang R., Yuen J., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E., PIN1 over-expression and b-catenin gene mutations are distinct oncologic events in human hepatocarcinogenesis (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Lee K.W., Sun K.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Lee KY

List of Research Outputs

Lee K.Y., Samy E.T., Sham M.H., Tam P.K.H. and Lui V.C.H., 3' Splicing variants of ret receptor tyrosine kinase are differentially expressed in mouse embryos and in adult mice, Biochimica Biophysica Acta-Gene Structure Expression. 2003, 1627: 26-38.

Lee K.Y., Lui V.C.H. and Tam P.K.H., Differential expression of RET isoforms in neural crest derived tissues during development, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Researcher : Lee PY (Lee Ping Yin)

List of Research Outputs

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Zhao P., Huang X., Vande Woude G. and Wong J., Hepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A101-A102.

Researcher : Lee PY (Lee Pui Yue)

List of Research Outputs

Ren Y., Chan H.M., Li Z., Lin C.L., Nicholls J.M., Chan G.C.F., Lee P.Y., Lui V.C.H., Bacher M. and Tam P.K.H., Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma, Oncogene. UK, Nature Publishing Group, 2004, 23: 4146-4154.

Researcher : Lee WS

List of Research Outputs

Garcia-Barcelo M.M., Sham M.H., Lui V.C.H., Chen B.L.S., Song Y., Lee W.S., Yung S.K., Romeo G. and Tam P.K.H., Chinese patients with sporadic Hirschsprung’s disease are predominantly represented by a single RET haplotype. , Journal of Medical Genetics. 2003, 40(11): e122.

Garcia-Barcelo M.M., Sham M.H., Lee W.S., Lui V.C.H., Chen B.L.S., Wong K.K.Y., Wong J.S.W. and Tam P.K.H., Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease, Clinical Chemistry. 2004, 50(1): 93-100.

Garcia-Barcelo M.M., Lee W.S., Sham M.H., Lui V.C.H. and Tam P.K.H., Is there a role for the IHH gene in Hirschsprung's disease?, Neurogastroenterology and Motility. 2003, 15(6): 663-668.

Researcher : Leung KL

List of Research Outputs

Cheung S.T., Chen X., Fong D.Y.T., Leung K.L., Ip Y.C., Ng I.O.L., So S. and Fan S.T., Delineation of prognostic biomarkers from the global gene expression profile of liver cancer (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Cheung S.T., Chen X., Leung K.L., So S., Ng I.O.L. and Fan S.T., Different gene expression profiles in cirrhotic livers from cancer patients compared to non-cancer patients (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 2500.

Cheung S.T., Chen X., Leung K.L., So S., Ng I.O.L. and Fan S.T., Different gene expression profiles in cirrhotic livers from cancer patients compared to non-cancer patients (Abstract), The 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July 2003.

Cheung S.T., Chen X., Fong D.Y.K., Leung K.L., Ip Y.C., Ng I.O.L. and Fan S.T., Novel prognostic markers for hepatocellular carcinoma (Poster Presentation), The Spanish National Cancer Centre 2004 Symposium on the Molecular Taxonomy of Cancer, Madrid, Spain, 3-6 February 2004.

Cheung S.T., Chen X., Fong D.Y.K., Leung K.L., Ip Y.C., Ng I.O.L., So S. and Fan S.T., Novel prognostic markers for liver cancer (Abstract), Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003.

Poon R.T.P., Chung K.K., Cheung S.T., Lau C., Tong C.S.W., Leung K.L., Yu W.C., Tuszynski G.P. and Fan S.T., Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 Pt1): 4150-4157.

Researcher : Leung PL

List of Research Outputs

Wang X., Wong W.Y., Leung P.L., Leung P.L., Leung P.L., Fan S.T. and Luk J.M.C., Molecular characterization of LI-cardherin mutations in hepatocellular carcinoma (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Researcher : Leung SYL

List of Research Outputs

Ko S., Chu K.M., Luk J.M.C., Wong B.W.Y., Yuen S.T., Leung S.Y.L. and Wong J., Over-expression of LI-cadherin in gastric cancer is associated with lymph node metastasis, Biochemical and Biophysical Research Communications. 2004, 319(2): 562-568.

Researcher : Li W

List of Research Outputs

Ren Y., Chen Y.X., Li W., Jiang G., Liu Q., Chan H.M. and Tam P.K.H., Expression and function of macrophage migration inhibitory factor in human neuroblastoma, 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, 27-31 March 2004.

Ren Y., Cao B., Li W., Chan G.C.F., Woude G.F.V. and Tam P.K.H., Hepatocyte growth factor enhances angiogenesis and tumor cell migration in human neuroblastoma, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004. 33.

Researcher : Li X (Li Xianliang)

List of Research Outputs

Li X., Insulin in UW solution exacerbates the ischemia/reperfusion injury in rat liver transplantation, Thesis, Doctor of Philosophy, The University of Hong Kong. 2004.

Researcher : Li X (Li Xiaosong)

List of Research Outputs

Tian L., Li X. and Tam P.K.H., Targeting both acute and chronic rejection: a regimen that ensures hundred percent permanent survival of orthotopic small bowel allograft in rat, Basic Sciences Symposium 2003: Transplantation Immunology in the Real World, Colorado, USA, 14-17 September 2003.

Researcher : Li Z

List of Research Outputs

Ren Y., Poon R.T.P., Tsui H.T., Chen W.H., Li Z., Lau C., Yu W.C. and Fan S.T., Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis, Clinical Cancer Research. 2003, 9(16 Pt1): 5996-6001.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Ren Y., Li Z., Chan H.M., Lin C.L., Lui V.C.H., Bacher M. and Tam P.K.H., N-MYC induction stimulated by macrophage migration inhibitory factor through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Ren Y., Chan H.M., Li Z., Lin C.L., Nicholls J.M., Chan G.C.F., Lee P.Y., Lui V.C.H., Bacher M. and Tam P.K.H., Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma, Oncogene. UK, Nature Publishing Group, 2004, 23: 4146-4154.

Ren Y., He Q.Y., Fan J.Q., Li Z., Zhou Y., Chan H.M., Bacher M., Haab B., Chiu J.F., Vande Woude G. and Tam P.K.H., cDNA microarray and proteomic analysis of differential gene and protein expression in human neuroblastoma cells induced by macrophage migration inhibitory factor, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Researcher : Lin CL

Project Title:	Discovery and clinical evaluation of novel immunogenic peptides for immunotherapy of nasopharyngeal carcinoma
Investigator(s):	Dr. Lin C.L., Dr. Yu W.Y.
Department:	Surgery
Source(s) of Funding:	Innovation and Technology Fund, Innovation and Technology Commission of Hong Kong Government
Start Date:	06/2002

Abstract:

To prepare MAP/polyepitope of the LMP1/LMP2 native peptides; to identify highly immunogenic MAPs of the LMP1/LMP2 native peptides by in vitro immunoassays and in reactivating the CTL lines from asymptomatic carriers or NPC patients; to prepare LMP1/LMP2 templated peptide libraries; to identify highly immunogenic peptides from the synthetic peptide libraries by in vitro immunoassays and in reactivating the CTL lines from asymptomatic carriers or NPC patients; to prepare MAP/polyepitope of the synthetic peptide(s) for amplification of immunogenecity; to identify novel peptide candidates for clinical studies; to formulate studies of immunogenic peptides and MAPs; to pulse the dendritic cells from NPC patents with the lead peptides/MAP, followed by intradonal injection into the patients; to evaluate tumor growth in patients with local recurrence or metastasis.

Project Title:	The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance
Investigator(s):	Dr. Lin C.L., Prof. Austyn J.M., Dr. Xu S.N.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	11/2002

Abstract:

The project attempts to characterize the role of DC-DIGN in the regulation of dendritic cell function, and to evaluate the inhibitory effect of DC-SIGN-modulated DC on T cell responses to primary and recall antigens in vitro and in vivo. This study will provide critical insights into the molecular mechanisms whereby DC-SIGN contributes to immunosuppression or peripheral tolerance, which may allow us to design more effective strategies for antiviral therapies and the induction of transplantation tolerance.

Project Title:	Development of heat shock protein-based cancer vaccine against hepatitis B virus-induced hepatocellular carcinoma
Investigator(s):	Dr. Lin C.L., Dr. Chen Y.X., Prof. Fan S.T., Prof. Tam P.K.H., Dr. Yu W.Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	06/2003

Abstract:

To examine the effect of heat shock protein (hsp) gp96 with hepatitis B virus (HBV)-specific antigen YVNTNMG (YVN) in the induction of peptide-specific cytotoxic T cell immunity in vivo; to conduct a dendritic cell-based immunotherapy trial on patients with unresectable HBV-related hepatocellular carcinoma (HCC); to search and discover novel peptide analogues to enhance the antigenecity of hsp-peptide complex through creation of combinatorial peptide library and phage display method.

Project Title:	The effect of SARS-associated coronavirus Spike protein on immune regulation of SARS
Investigator(s):	Dr. Lin C.L., Dr. Chan V.S.F.
Department:	Surgery
Source(s) of Funding:	SARS Research Fund
Start Date:	07/2003

Abstract:

To delineate the immune regulatory mechanisms in the afferent and efferent phases of immune responses against SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) infection.

Project Title:	Development of DNA and viral vector vaccines against Epstein-Barr virus-positive nasopharyngeal carcinoma
Investigator(s):	Dr. Lin C.L., Prof. Austyn J.M., Dr. Xu X.N.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2003

Abstract:

To design and parpare DNA vaccine encoding EBNA1 and LMP2, and the MVA vaccine encoding the cytokine GM-CSF, the chemokine RANTES, the EBV- specific lytic antigen EBNA-1, and EBV-specific latent antigen LMP2; to identify the efficacy of these vaccines in vitro on their capacity in attracting dendritic cells and also in the induction of EBNA-1 specific CD4+T cell response and LMP2-specific CTL immunity; to verify the efficacy of these vaccines in a mouse NPC and a B cell lymphoma model, including the potency of CD4+ and CTL immunity, and also to test the effect of the dosage, route, and the effect of combinational use of both the DNA and MVA vaccines.

Project Title:	Development of DNA and viral vector vaccines against Epstein-Barr virus-positive nasopharyngeal carcinoma
Investigator(s):	Dr. Lin C.L., Prof. Austyn J.M., Dr. Xu X.N.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	09/2003

Abstract:

List of Research Outputs

Chung P.Y., Chen Y., Chan V.S.F., Tam P.K.H. and Lin C.L., Dendritic cells: sentinels against pathogens, Histology and Histopathology. 2004, 19(1): 317-324.

Lin C.L., Advisor, Committee for Medical Research, Chang Gung University, Taiwan, ROC. 2004.

Lin C.L., Lo W.F., Lee T.H. and Rickinson A.B., Development of highly immunogenic EBV-specific peptides for immunotherapy of EBV(+) nasopharyngeal carcinoma, North-South NPC Workshop, Paris, France, 4-6 December 2003.

Lin C.L., Khong P.L. and Tam P.K.H., Double intestinal atresia in imperforate anus: a diagnostic conundrum for paediatric surgeons, Asian Journal of Surgery. 2004, 27(1): 52-53.

Lin C.L., Wong K.K.Y., Lan L.C.L., Chen C.C. and Tam P.K.H., Earlier appearance and higher incidence of the rectoanal relaxation reflex in patients with imperforate anus repaired with laparoscopically assisted anorectoplasty, Surgical Endoscopy. 2003, 17(10): 1646-1649.

Lin C.L., External Reviewer, Section of Surgical Research, National Science Council, Taiwan, ROC. 2004.

Lin C.L., Reviewer, Asian Journal of Surgery. 2004.

Lin C.L., Reviewer, European Journal of Immunology. 2004.

Lin C.L., Reviewer, Journal Formos Medical Association. 2004.

Lin C.L., Reviewer, Journal of Immunology, Clinical and Experimental Immunology. 2004.

Lin C.L., Reviewer, Journal of Surgical Association R.O.C.. 2004.

Lin C.L., Reviewer, PLoS. 2004.

Lin C.L., Reviewer, Transplantation. 2004.

Ren Y., Li Z., Chan H.M., Lin C.L., Lui V.C.H., Bacher M. and Tam P.K.H., N-MYC induction stimulated by macrophage migration inhibitory factor through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Ren Y., Chan H.M., Li Z., Lin C.L., Nicholls J.M., Chan G.C.F., Lee P.Y., Lui V.C.H., Bacher M. and Tam P.K.H., Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma, Oncogene. UK, Nature Publishing Group, 2004, 23: 4146-4154.

Tsai S.L., Lee T.H., Chien R.N., Liao S.K., Lin C.L., Kuo G.C. and Liaw Y.F., A method to increase tetramer staining efficiency of CD8+ T cells with MHC-peptide complexes: therapeutic applications in monitoring cytotoxic T lymphocyte activity during hepatitis B and C treatment, Journal of Immunological Methods. 2004, 285(1): 71-87.

Tsai S.L., Sheen I.S., Chien R.N., Chu C.M., Huang H.C., Chuang Y.L., Lee T.H., Liao S.K., Lin C.L., Kuo G.C. and Liaw Y.F., Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: tetramer assay and therapeutic implications, Journal of Biomedical Science. 2003, 10(1): 120-135.

Whelan K.T., Lin C.L., Cella M., McMichael A.J., Austyn J.M. and Rowland-Jones S.L., The HIV protease inhibitor indinavir reduces immature dendritic cell transendothelial migration, European Journal of Immunology. 2003, 33(9): 2520-2530.

Wong K.K.Y., Fan A., Lan L., Lin C.L. and Tam P.K.H., Effective antibiotic regime for post-operative acute cholangitis in biliary atresia: an evolving scene, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May, 2004. 46.

Wong K.K.Y., Fan A., Lan L.C.L., Lin C.L. and Tam P.K.H., The impact of computerized prescription on medication incidence rate: experience of a single centre, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Korea, 16-20 May, 2004.

Wong K.K.Y., Lan L., Chan G., Lin C.L. and Tam P.K.H., The use of positron emission tomography in detecting hepatoblastoma recurrence: a cautionary tale, 37th Annual Meeting of the Pacific Association of Pediatric Surgoens, Seoul, Korea, 16-20 May 2004. 31.

Wong S.W., Wong K.K.Y., Lin C.L. and Tam P.K.H., Recent advances on the surgical management of common paediatric gastrointestinal diseases, Hong Kong Journal of Paediatrics. 2004, 9(2): 133-137.

Researcher : Ling GS

List of Research Outputs

Chang H.W., Ling G.S., Wei W.I. and Yuen P.W., Smoking and drinking can induce p15 hypermethylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma , Cancer. 2004, 101: 125-132.

Researcher : Liu CL

Project Title:	Health-related quality of life of donors in live donor liver transplantation
Investigator(s):	Dr. Liu C.L., Prof. Fan S.T.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To determine the HRQL of donors in LDLT. From a utilitarian point of view, these data could be incorporated into the process of balancing the risks and benefits of LDLT; to identify factors which are predictors of good quality of life of donors.

Project Title:	The significance of intra-graft expression profile and ultrastructural features at early phase after liver transplantation-a prospective study of liver transplantation using cadaver and live donors
Investigator(s):	Dr. Liu C.L., Dr. Man K.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To investigate the gene expression profiles of the donor and graft at the early phase after liver transplantation associated with hepatic ultrastructural features in liver transplantation using cadaver and live donors; to study the correlation of graft status, gene expression patterns with early and late clinical outcome functionally and morphologically.

List of Research Outputs

Chan A.C.Y. and Liu C.L., The role of endoscopic ultrasonography in the management of cystic lesions of the pancreas, Hong Kong Medical Journal. 2003, 9(6): 441-445.

Chan S.C., Cheung S.T., Leung S.Y., Liu C.L., Fan S.T. and Lo C.M., De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report, Liver Transplantation. 2004, 10(2): 320-323.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Abstract), Liver Transplantation. 2004, 10(6): C15.

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Poster Presentation), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Prospective study on donor quality of life before and after right lobe adult-to-adult live donor liver transplantation (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004 . 2004.

Chan S.C., Lo C.M., Liu C.L., Wong Y., Fan S.T. and Wong J., Tailoring donor hepatectomy per segment 4 venous drainage in right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(6): 755-762.

Chen D.W., Poon R.T.P., Liu C.L., Fan S.T. and Wong J., Immediate and long-term outcomes of hepatectomy for hepatolithiasis, Surgery. 2004, 135(4): 386-393.

Fan S.T., Lo C.M., Liu C.L., Yong B.H. and Wong J., Determinants of hospital mortality of adult recipients of right lobe live donor liver transplantation, Annals of Surgery. 2003, 238(6): 864-869.

Fan S.T., Lo C.M., Liu C.L., Wang W.X. and Wong J., Safety and necessity of including the middle hepatic vein in the right lobe graft in adult-to-adult live donor liver transplantation, Annals of Surgery. 2003, 238(1): 137-148.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Lam C.M., Chan O.O., Ho P., Ng I.O.L., Lo C.M., Liu C.L., Poon R.T.P. and Fan S.T., Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients - implications for screening, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 771-777.

Liu C.L., Fan S.T., Lo C.M., Wong Y., Ng I.O.L., Lam C.M., Poon R.T.P. and Wong J., Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases, Annals of Surgery. 2004, 239(2): 194-201.

Liu C.L., Adult living related liver transplantation: is the procedure standardized? (Invited Lecture), International Symposium, 20 Years of Liver Transplantation at Cliniques Saint-Luc, Brussels, Belgium, 23 April 2004.

Liu C.L. and Fan S.T., Anterior approach for right hepatectomy for hilar cholangiocarcinoma, Journal of Hepato-Biliary-Pancreatic Surgery. 2003, 10(4): 292-294.

Liu C.L., Common liver cancers and treatment, The Hong Kong Anti-Cancer Society, 27 September 2003. 2003.

Liu C.L., Detection of occult cholelithiasis by endoscopic ultrasonography (Invited Lecture), The 2nd Meeting of Endoscopic Ultrasonography, Guangzhou, China, 6-8 November 2003.

Liu C.L., Evaluation of live liver donors (Invited Lecture), The 8th Congress of Asian Society of Transplantation, Kuala Lumpur, Malaysia, 23-27 September 2003.

Liu C.L. and Fan S.T., Extending the graft size limits of live-donor liver transplantation (Invited Commentary), Transplantation. 2003, 76(4): 641-642.

Liu C.L., Fellow (1999 - present), American College of Surgeons. 2004.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Tso W.K. and Wong J., Hepatic resection for incidentaloma (Poster of Distinction), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Liu C.L., Zhao Y., Lo C.M. and Fan S.T., Hepatic venoplasty in right lobe live donor liver transplantation, Liver Transplantation. 2003, 9(12): 1265-1272.

Liu C.L., Hepatitis B and liver transplantation (Abstract), Medical Journal of Malaysia. 2003, 58 (Suppl. B): 75.

Liu C.L., Hepatitis B and liver transplantation (Invited Lecture), The 5th Liver Update, Malaysian Liver Foundation, Selangor, Malaysia, 10-13 July 2003.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Tso W.K. and Wong J., Heptic resection for incidentaloma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Liu C.L., Lam B.K.Y., Lo C.M. and Fan S.T., Impact of right-lobe live donor liver transplantation on patients waiting for liver transplantation, Liver Transplantation. 2003, 9(8): 863-869.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Lai C.L. and Wong J., Interleukin-2 receptor antibody (basiliximab) for immunosuppressive induction therapy after liver transplantation: a protocol with early elimination of steroids and reduction of tacrolimus dosage, Liver Transplantation. 2004, 10(6): 728-733.

Liu C.L., Interleukin-2 receptor antibody for immunosuppression induction therapy after liver transplantation with early elimination of steroid (Invited Lecture), The 8th Congress of Asian Society of Transplantation, Kuala Lumpur, Malaysia, 23-27 September 2003.

Liu C.L., Lo C.M., Chan S.C., Fan S.T. and Wong J., Internal hernia of the small bowel after right-lobe live donor liver transplantation, Clinical Transplantation. 2004, 18(2): 211-213.

Liu C.L., Saing H., Fan S.T., Lo C.M., Chan K.L., Tam P.K.H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Liu C.L., Fan S.T., Lo C.M., Tam P.K.H., Saing H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, Liver Transplantation. 2003, 9(11): 1185-1190.

Liu C.L., Live donor liver transplantation for high-urgency situations (Invited Lecture), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004 . 2004.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Yong B.H., Lai C.L. and Wong J., Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure, Transplantation. 2003, 76: 1174-1179.

Liu C.L., Live-donor liver transplantation for fulminant hepatic failure (Oral Presentation), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Liu C.L., Liver transplantation, Caritas Medical Centre Doctors' Association, 24 March 2004. 2004.

Liu C.L., Management of carcinoma of pancreas (Invited Lecture), The 10th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 2-3 August 2003.

Liu C.L., Member, Organizing Committee (January 2004), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004. 2004.

Liu C.L., Chan S.C., Lo C.M., Tso W.K. and Fan S.T., Pseudo pseudocyst after right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(4): 571-572.

Liu C.L., Fan S.T., Lo C.M., Chan S.C. and Wong J., Safety of donor right hepatectomy for live donor liver transplantation without abdominal drainage (Abstract), Liver Transplantation. 2004, 10(6): C30.

Liu C.L., Fan S.T., Lo C.M., Chan S.C. and Wong J., Safety of donor right hepatectomy for live donor liver transplantation without abdominal drainage (Oral Presentation), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Liu C.L., Lo C.M., Chan S.C. and Fan S.T., Safety of duct-to-duct biliary reconstruction in right-lobe live-donor liver transplantation without biliary drainage, Transplantation. 2004, 77(5): 726-732.

Liu C.L., Surgical treatment including liver transplantation for hepatocellular carcinoma (Abstract), Medical Journal of Malaysia. 2003, 58 (Suppl. B): 54.

Liu C.L., Surgical treatment including liver transplantation for hepatocellular carcinoma (Invited Lecture), The 5th Liver Update, Malaysian Liver Foundation, Selangor, Malaysia, 10-12 July 2003.

Liu C.L., Lo C.M., Chan S.C., Tso W.K. and Fan S.T., The right may not be always right: biliary anatomy contraindicates right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(6): 811-812.

Liu C.L., The role of endoscopic ultrasonography in the management of pancreatitis (Invited Lecture), The 3rd 21st Century Surgical Symposium, Hepatobiliary Surgery Institute of PLA, PLA General Hospital and Postgraduate Medical College of PLA, Beijing, China, 13-14 December 2003.

Liu C.L., The use of endoscopic ultrasonography in the management of cystic lesions of the pancreas (Invited Lecture), The 2nd Meeting of Endoscopic Ultrasonography, Guangzhou, China, 6-8 November 2003.

Lo C.M., Cheung S.T., Ng I.O.L., Liu C.L., Lai C.L. and Fan S.T., Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin, Liver Transplantation. 2004, 10(4): 557-563.

Lo C.M., Fan S.T., Liu C.L., Yong B.H., Wong Y., Ng I.O.L. and Wong J., Safety and outcome of hepatitis B core antibody-positive donors in right-lobe living donor liver transplantation, Liver Transplantation. 2003, 9(8): 827-832.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Lo C.M., Fan S.T., Liu C.L., Chan S.C. and Wong J., The role and limitation of living donor liver transplantation for hepatocellular carcinoma, Liver Transplantation. 2004, 10(3): 440-447.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M., Ng I.O.L. and Fan S.T., Impact of preoperative fine-needle aspiration cytologic examination on clinical outcome in patients with hepatocellular carcinoma in a tertiary referral center, Archives of Surgery. 2004, 139(2): 193-200.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database (Oral Presentation), The 124th Annual Meeting of the American Surgical Association, San Francisco, U.S.A., 15-17 April 2004.

Poon R.T.P., Yeung C., Liu C.L., Lam C.M., Yuen W.K., Lo C.M., Tang A. and Fan S.T., Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial, Gut. 2003, 52(12): 1768-1773.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement, World Journal of Surgery. 2004, 28(6): 602-608.

Wei W.I., Lam L.K., Ng W.M., Liu C.L., Lo C.M., Fan S.T. and Wong J., Microvascular reconstruction of the hepatic artery in live donor liver transplantation: experience across a decade, Archives of Surgery. 2004, 139(3): 304-307.

Zhao Y., Lo C.M., Liu C.L. and Fan S.T., Use of elderly donors (>60 years) for liver transplantation, Asian Journal of Surgery. 2004, 27(2): 114-119.

Researcher : Liu Y

List of Research Outputs

Liu Y., Li Q.Y., Poon R.T.P., Shao W.B., Tong C.S.W. and Fan S.T., Blockage of vascular endothelial growth factor receptor in antitumour effect of hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Liu Y., Poon R.T.P., Feng X., Yu W.C., Luk J.M.C. and Fan S.T., Reduced expression of chemokine receptors on peripheral blood lymphocytes in patients with hepatocellular carcinoma, American Journal of Gastroenterology. 2004, 99(6): 1111-1121.

Researcher : Lo CM

Project Title:	Hepatitis B virus-specific immune response after liver transplantation for chronic hepatitis B using lamivudine prophylaxis
Investigator(s):	Prof. Lo C.M., Prof. Fan S.T., Dr. Lau G.K.K.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	10/2002

Abstract:

The project attempts to prospectively study the serial changes in HBV-specific immune response after liver transplantation for chronic hepatitis B. This HBV-specific immune response will be correlated with the donor's HBV immune status to clarify the possibility of adoptive immunity transfer through the liver graft.

Project Title:	The effect of FTY720 on hepatic ischemia-reperfusion injury in normal and cirrhotic liver
Investigator(s):	Prof. Lo C.M., Dr. Man K.
Department:	Surgery
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund
Start Date:	11/2003

Abstract:

To study the effect of a novel immunosuppressive drug FTY720 on hepatic ischemia-reperfusion injury in normal and cirrhotic livers by investigation of (1) cell signalling pathways related to acute phase inflammatory responses, cell survival and apoptosis; (2) hepatic ultrastructural features; and (3) liver function.

List of Research Outputs

Chan S.C., Cheung S.T., Leung S.Y., Liu C.L., Fan S.T. and Lo C.M., De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report, Liver Transplantation. 2004, 10(2): 320-323.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Abstract), Liver Transplantation. 2004, 10(6): C15.

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Donor quality of life before and after adult-to-adult live donor liver transplantation (Poster Presentation), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Chan S.C., Liu C.L., Lo C.M. and Fan S.T., Prospective study on donor quality of life before and after right lobe adult-to-adult live donor liver transplantation (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004 . 2004.

Chan S.C., Lo C.M., Liu C.L., Wong Y., Fan S.T. and Wong J., Tailoring donor hepatectomy per segment 4 venous drainage in right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(6): 755-762.

Chan W.F., Lo C.Y., Lo C.M. and Fan S.T., Laparoscopic resection of a pancreatic polypeptidoma with a solitary liver metastasis, Surgical Endoscopy. 2004, 18(3): 554-556.

Cheng V.C., Lo C.M. and Lau G., Current issues and treatment of fulminant hepatic failure including transplantation in Hong Kong and the Far East, Seminars in Liver Disease. 2003, 23(3): 239-250.

Fan S.T., Lo C.M., Liu C.L., Yong B.H. and Wong J., Determinants of hospital mortality of adult recipients of right lobe live donor liver transplantation, Annals of Surgery. 2003, 238(6): 864-869.

Fan S.T., Lo C.M., Liu C.L., Wang W.X. and Wong J., Safety and necessity of including the middle hepatic vein in the right lobe graft in adult-to-adult live donor liver transplantation, Annals of Surgery. 2003, 238(1): 137-148.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Lam C.M., Chan O.O., Ho P., Ng I.O.L., Lo C.M., Liu C.L., Poon R.T.P. and Fan S.T., Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients - implications for screening, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 771-777.

Lee K.W., Man K., Ling M.T., Wang X., Wong Y.C., Lo C.M., Poon R.T.P., Ng I.O.L. and Fan S.T., Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16^INK4a/RB pathway, Carcinogenesis. 2003, 24(11): 1729-1736.

Li X.L., Man K., Liu Y.F., Lee K.W., Tsui H.T., Lau C.K., Lo C.M. and Fan S.T., Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation, Transplantation. 2003, 76(1): 44-49.

Li X.L., Man K., Ng T.P., Sun K.W., Lo C.M. and Fan S.T., The dysregulation of P13-Kinase/Akt pathway contributes to the ischemia/reperfusion injury during graft preservation by UW solution (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Liu C.L., Fan S.T., Lo C.M., Wong Y., Ng I.O.L., Lam C.M., Poon R.T.P. and Wong J., Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases, Annals of Surgery. 2004, 239(2): 194-201.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Tso W.K. and Wong J., Hepatic resection for incidentaloma (Poster of Distinction), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Liu C.L., Zhao Y., Lo C.M. and Fan S.T., Hepatic venoplasty in right lobe live donor liver transplantation, Liver Transplantation. 2003, 9(12): 1265-1272.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Tso W.K. and Wong J., Heptic resection for incidentaloma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Liu C.L., Lam B.K.Y., Lo C.M. and Fan S.T., Impact of right-lobe live donor liver transplantation on patients waiting for liver transplantation, Liver Transplantation. 2003, 9(8): 863-869.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Lai C.L. and Wong J., Interleukin-2 receptor antibody (basiliximab) for immunosuppressive induction therapy after liver transplantation: a protocol with early elimination of steroids and reduction of tacrolimus dosage, Liver Transplantation. 2004, 10(6): 728-733.

Liu C.L., Lo C.M., Chan S.C., Fan S.T. and Wong J., Internal hernia of the small bowel after right-lobe live donor liver transplantation, Clinical Transplantation. 2004, 18(2): 211-213.

Liu C.L., Saing H., Fan S.T., Lo C.M., Chan K.L., Tam P.K.H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Liu C.L., Fan S.T., Lo C.M., Tam P.K.H., Saing H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, Liver Transplantation. 2003, 9(11): 1185-1190.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Yong B.H., Lai C.L. and Wong J., Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure, Transplantation. 2003, 76: 1174-1179.

Liu C.L., Chan S.C., Lo C.M., Tso W.K. and Fan S.T., Pseudo pseudocyst after right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(4): 571-572.

Liu C.L., Fan S.T., Lo C.M., Chan S.C. and Wong J., Safety of donor right hepatectomy for live donor liver transplantation without abdominal drainage (Abstract), Liver Transplantation. 2004, 10(6): C30.

Liu C.L., Fan S.T., Lo C.M., Chan S.C. and Wong J., Safety of donor right hepatectomy for live donor liver transplantation without abdominal drainage (Oral Presentation), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Liu C.L., Lo C.M., Chan S.C. and Fan S.T., Safety of duct-to-duct biliary reconstruction in right-lobe live-donor liver transplantation without biliary drainage, Transplantation. 2004, 77(5): 726-732.

Liu C.L., Lo C.M., Chan S.C., Tso W.K. and Fan S.T., The right may not be always right: biliary anatomy contraindicates right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(6): 811-812.

Lo C.M., Adult-to-adult living donor liver transplantation (Abstract), China International Forum on Hepatobiliary Surgery, Chongqing, China, 14-18 April 2004.

Lo C.M., Adult-to-adult living donor liver transplantation (Invited Lecture), The China International Forum on Hepatobiliary Surgery, Chongqing, China, 14-18 April 2004.

Lo C.M., Associate Director (1994 - Present), Liver Transplant Centre, Queen Mary Hospital. 2004.

Lo C.M., Associate Editor (2001 - present), Digestive Surgery. 2004.

Lo C.M., Croucher Senior Medical Research Fellowship, Croucher Foundation, Hong Kong. 2004.

Lo C.M., Donor right hepatectomy with inclusion of middle hepatic vein (Video Presentation), China International Forum on Hepatobiliary Surgery, Chongqing, China, 14-18 April 2004.

Lo C.M., Donor selection and evaluation (Invited Lecture), The 10th Anniversary of the Adult-to-Adult Living Donor Liver Transplantation Symposium, Tokyo, Japan, 21 February 2004.

Lo C.M., Examiner (2003 - present), MRCS Examination, The College of Surgeons of Hong Kong. 2004.

Lo C.M., Examiner in Surgery, Licensing Examination (1995 - present), The Licentiate Committee of the Medical Council of Hong Kong. 2004.

Lo C.M., Fellow (1996 - present), American College of Surgeons . 2004.

Lo C.M., Cheung S.T., Ng I.O.L., Liu C.L., Lai C.L. and Fan S.T., Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin, Liver Transplantation. 2004, 10(4): 557-563.

Lo C.M., Guest Professor (August 2002 - present), The Peking University Health Science Center, Peking University First Hospital. 2004.

Lo C.M., Hepatic resection in hepatocellular carcinoma (Invited Lecture), The 5th International Surgical Update, Muscat, Sultanate of Oman, 16-18 December 2003.

Lo C.M. and Fan S.T., Hepatic venoplasty in right lobe liver graft with middle hepatic vein (Invited Lecture), 2003 Living Donor Liver Transplantation Symposium, Shiga, Japan, 12 October 2003.

Lo C.M., Hepatitis B in liver transplantation: postoperative propylaxis (Invited Lecture), The 2nd Japan Society of Hepatology Single Topic Conference "Progress and Future Perspective in Adult Living Donor Liver Transplantation", Shiga, Japan, 12-14 October 2003.

Lo C.M., Hepatocellular carcinoma (Invited Lecture), The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong 5-6 June 2004.

Lo C.M., Honorary Consultant (1 July 1998 - present), Hospital Authority, Hong Kong. 2004.

Lo C.M., Honorary Consultant (June 2002 - present), King Faisal Hospital & Research Center, Kingdom of Saudi Arabia. 2004.

Lo C.M., Live donor liver transplantation (Invited Lecture), The 5th International Surgical Update, Muscat, Sultanate of Oman, 16-18 December 2003.

Lo C.M., Liver transplantation and hepatitis B (Invited Lecture), The 10th Anniversary of the Adult-to-Adult Living Donor Liver Transplantation Symposium, Tokyo, Japan, 21 February 2004.

Lo C.M., Liver transplantation and hepatitis B infection (Keynote Lecture), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Lo C.M. and Fan S.T., Liver transplantation for hepatocellular carcinoma (Leading article), British Journal of Surgery. 2004, 91(2): 131-133.

Lo C.M., Liver transplantation for hepatocellular carcinoma, The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Lo C.M., Living donor liver transplantation: lessons learned (Invited Lecture), The 2nd China General Surgery Week, Xiamen, China, 16-20 October 2003.

Lo C.M., Living-related liver transplantation: rule or exception? (Abstract), Journal of Gastroenterology and Hepatology. 2003, 18: A8.

Lo C.M., Living-related transplantation: rule or exception? (Invited Lecture), Digestive Week, The 18th Annual Scientific Meeting of the Gastronenterology Society of Singapore, Singapore, 27-30 September 2003.

Lo C.M., Member of Editorial Board (2002 - present), Hepatobiliary and Pancreatic Diseases International. 2004.

Lo C.M., Member of Editorial Board (2002 - present), Surgery. 2004.

Lo C.M., Member, Institutional Review Board (1 March 2003 - 28 February 2005), The University of Hong Kong/Hospital Authority Hong Kong West Cluster, Hong Kong. 2004.

Lo C.M., Member, Organising Committee (22-25 January 2004), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004 . 2004.

Lo C.M., Member, Program Committee (December 1997 - present), International Society for Digestive Surgery. 2004.

Lo C.M., Member, Scientific Committee (July 1998 - present), Cheng Si Yuan China-International Hepatitis Research Foundation. 2004.

Lo C.M., National Delegate (July 1998 - present), International Society for Digestive Surgery. 2004.

Lo C.M. and Fan S.T., Overview of experience: The University of Hong Kong (Invited Lecture), 2003 Living Donor Liver Transplantation Symposium, Shiga, Japan, 12 October 2003.

Lo C.M., Overview of recipient surgical techniques and complications (Invited Lecture), The 10th Congress of the International Liver Transplantation Society, Kyoto, Japan, 9 June 2004.

Lo C.M., President-Elect (2002 - present), International Society for Digestive Surgery. 2004.

Lo C.M., Reply to "Anti-HBs antibodies produced after liver transplantation: from the donor or the recipient", Hepatology. 2003, 38(1): 272.

Lo C.M., Reviewer, UICC Fellowship Selection Committee (November 1997 - present), International Union Against Cancer. 2004.

Lo C.M., Reviewer, Annals of Surgery. 2004.

Lo C.M., Reviewer, Annals of the College of Surgeons of Hong Kong. 2004.

Lo C.M., Reviewer, Asian Journal of Surgery. 2004.

Lo C.M., Reviewer, British Journal of Surgery. 2004.

Lo C.M., Reviewer, Endoscopy. 2004.

Lo C.M., Reviewer, Hepatology. 2004.

Lo C.M., Reviewer, Hong Kong Medical Journal. 2004.

Lo C.M., Reviewer, Liver Transplantation. 2004.

Lo C.M., Reviewer, Surgery. 2004.

Lo C.M., Fan S.T., Liu C.L., Yong B.H., Wong Y., Ng I.O.L. and Wong J., Safety and outcome of hepatitis B core antibody-positive donors in right-lobe living donor liver transplantation, Liver Transplantation. 2003, 9(8): 827-832.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Lo C.M., Fan S.T., Liu C.L., Chan S.C. and Wong J., The role and limitation of living donor liver transplantation for hepatocellular carcinoma, Liver Transplantation. 2004, 10(3): 440-447.

Lo C.M., Treatment of hepatocellular carcinoma: surgeon's role (Invited Lecture), The 14th Biennial Congress of the Asian Surgical Association, Kota Kinabalu, Sabah, Malaysia, 4-6 December 2003.

Lo C.M., 劈離式肝移植手術技術及供肝的評估 (Invited Lecture), 中國成都第四屆國際臨床肝臟移植學術班,2003年12月9-10日, 2003.

Lo C.Y., Chan W.F., Lo C.M., Fan S.T. and Tam P.K.H., Surgical treatment of pancreatic insulinomas in the era of laparoscopy, Surgical Endoscopy. 2004, 18(2): 297-302.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Hepatitis B virus (HBV)-specific immune response after liver transplantation for chronic hepatitis B (Abstract), Liver Transplantation. 2004, 10(6): C42.

Luo Y., Cheung C.K.Y. and Lo C.M., Hepatitis B virus-specific immune response after liver transplantation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus (HBV)-specific lymphocytes in human liver allografts from HBV immune donors (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Man K., Lo C.M., Ng T.P., Zhao Y., Ho J.W.Y., Sun K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed liver tumor growth and metastasis (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Ng T.P., Lo C.M., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed tumor growth and matastasis (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., Distinct intragraft response pattern in liver transplantation using marginal grafts and cirrhotic recipients (Abstract), The 11th Congress of the European Society for Organ Transplantation, Venice, Italy, 20-24 September 2003.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., FTY attenuates ischemia-reperfusion injury in normal and cirrhotic rat liver by down-regulation of Egr-1 and activation of Akt pathway, Liver transplantation. 2003, 9(6): c-37.

Man K., Ng T.P., Lee K.W., Lo C.M., Sun K.W., Li X.L., Zhao Y., Ho J.W.Y. and Fan S.T., FTY720 attenuates hepatic ischemia-reperfusion injury by Egr-1 down-regulation involving Raf-MEK-Erk pathway and Akt activation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathway (Abstract), Liver Transplantation. 2004, 10(6): C69.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Zhao Y., Xu A.M., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus adiponectin combination therapy (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Zhao Y., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus asiponectin combination therapy (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lo C.M., Ho J.W.Y., Zhao Y., Sun K.W., Lee K.W., Li X.L. and Fan S.T., The significance of hepatic ischemia-reperfusion injury on liver tumor development - activation of cell invasion and migration pathways (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Ng I.O.L., Chan K.L., Shek T.W.H., Lee M.F., Fong D.Y.T., Lo C.M. and Fan S.T., High frequency of chimerism in transplanted livers (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ng I.O.L., Chan K.L., Shek T.W.H., Lee J.M., Fong D.Y.T., Lo C.M. and Fan S.T., High frequency of chimerism in transplanted livers, Hepatology. 2003, 38(4): 989-998.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M., Ng I.O.L. and Fan S.T., Impact of preoperative fine-needle aspiration cytologic examination on clinical outcome in patients with hepatocellular carcinoma in a tertiary referral center, Archives of Surgery. 2004, 139(2): 193-200.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database (Oral Presentation), The 124th Annual Meeting of the American Surgical Association, San Francisco, U.S.A., 15-17 April 2004.

Poon R.T.P., Yeung C., Liu C.L., Lam C.M., Yuen W.K., Lo C.M., Tang A. and Fan S.T., Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial, Gut. 2003, 52(12): 1768-1773.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement, World Journal of Surgery. 2004, 28(6): 602-608.

Wei W.I., Lam L.K., Ng W.M., Liu C.L., Lo C.M., Fan S.T. and Wong J., Microvascular reconstruction of the hepatic artery in live donor liver transplantation: experience across a decade, Archives of Surgery. 2004, 139(3): 304-307.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Lee K.W., Sun K.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Sun K.W., Dai X.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Zhao Y., Lo C.M., Liu C.L. and Fan S.T., Use of elderly donors (>60 years) for liver transplantation, Asian Journal of Surgery. 2004, 27(2): 114-119.

Researcher : Lo CY

Project Title:	The role of cyclooxygenase-2 expression in thyroid malignancy
Investigator(s):	Dr. Lo C.Y., Dr. Luk J.M.C.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002
Completion Date:	09/2003

Abstract:

To identify the expression of cyclooxygenases in thyroid nodules and their potential implications in the diagnosis and behaviour of the tumours.

Project Title:	Expressing patterns of p16 and CDK4 in thyroid carcinoma
Investigator(s):	Dr. Lo C.Y., Prof. Lam K.Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To identify the expression of p16 and CDK4 in thyroid carcinoma.

List of Research Outputs

Bann S., Kwok K.F., Lo C.Y., Darzi A. and Wong J., Objective assessment of technical skills of surgical trainees in Hong Kong , British Journal of Surgery. 2003, 90: 1294-1299.

Chan S.C. and Lo C.Y., Images in clinical medicine: Meckel's diverticulum in action, New England Journal of Medicine. 2004, 350(8): E7.

Chan W.F. and Lo C.Y., Adrenlectomy for phaeochromocytoma in patients with multiple endocrine neoplasia type 2 in modern era (Poster presentation), 10th Congress of the Asian Association of Endocrine Surgeons, Taipei, Taiwan, 2-6 March 2004.

Chan W.F. and Lo C.Y., Applicability of intraoperative parathyroid hormone assay in predicting postoperative hypocalcaemia after parathyroidectomy for primary hyperparathyroidism (Poster presentation), Conference of the International Association of Endocrine Surgeons (IAES), Uppsala, Sweden, 13-17 June 2004.

Chan W.F., Lo C.Y., Lo C.M. and Fan S.T., Laparoscopic resection of a pancreatic polypeptidoma with a solitary liver metastasis, Surgical Endoscopy. 2004, 18(3): 554-556.

Chan W.F. and Lo C.Y., The John Farndon Prize in Poster, Adrenlectomy for phaeochromocytoma in patients with multiple endocrine neoplasia type 2 in modern era, 10th Congress of the Asian Association of Endocrine Surgeons, Taipei, Taiwan, 2 - 6 March 2004. 2004.

Chan W.F., Lo C.Y., Lam K.Y. and Wan K.Y., The clinicopathologic features and outcome of patients with well-differentiated thyroid carcinoma presenting with recurrent laryngeal nerve palsy, Conference of the International Association of Endocrine Surgeons (IAES), Uppsala, Sweden, 13-17 June 2004.

Chan W.F., Lam C.K. and Lo C.Y., The role of fine needle aspiration cytology in management of papillary thyroid carcinoma (Poster presentation), Conference of the International Association of Endocrine Surgeons (IAES), Uppsala, Sweden, 13-17 June 2004.

Chang A., Chan W.F., Lo C.Y. and Lam K.S.L., Multiple endocrine neoplasia type 2B in a Chinese patient, Hong Kong Medical Journal. 2004, 10(3): 206-209.

Ku C.F. and Lo C.Y., Total thyroidectomy as the preferred surgical treatment for Grave's disease, 10th Congress of the Asian Association of Endocrine Surgeons, Taipei, Taiwan, 2-6 March 2004.

Law W.L., Yong J.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendectomy (Abstract), Journal of Society of Laparoendoscopic Surgery. 2003, 7: S59.

Law W.L. and Lo C.Y., Fishbone perforation of the small bowel: laparoscopic diagnosis and laparoscopically assisted management (Case report), Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 2003, 13(6): 392-393.

Lo C.Y., American College of Surgeons International Guest Scholarship, American College of Surgeons. 2004.

Lo C.Y., Approaches to nodules detected in ultrasonography (Invited Lecture), 7th Asia and Oceania Thyroid Association Congress, Singapore, 2-4 December 2003.

Lo C.Y., Coordinator (1999 - present), Surgical Skills Training Program for Residents, Department of Surgery, Queen Mary Hospital, Hong Kong. 2004.

Lo C.Y., Corresponding Member (1998 - present), American Association of Endocrine Surgeons. 2004.

Lo C.Y., Council Member (1996 - present), Asian Association of Endocrine Surgeons. 2004.

Lo C.Y., Course Instructor, Intercollegiate Basic Surgical Skills Course, Princess Margaret Hospital, September. 2003.

Lo C.Y., Departmental representative (2001 - present), Pathology Services Subcommittee, Queen Mary Hospital. 2004.

Lo C.Y., Departmental representative (2004 - present), Coordination of Minimal Access Surgery Training. 2004.

Lo C.Y., Director (1997 - present), The Hong Kong Jockey Club Skills Development Centre, Queen Mary Hospital. 2004.

Lo C.Y., Endocrine surgery in Hong Kong, Australian and New Zealand Journal of Surgery. 2004, 74 (Suppl): A42-A48.

Lo C.Y., Fellow (1998 - present), American College of Surgeons. 2004.

Lo C.Y., Foundation Visitorship, Australasian College of Surgeons. 2004.

Lo C.Y., Honorary Consultant (2002 - present), Department of Surgery, Queen Mary Hospital, Hong Kong. 2004.

Lo C.Y., Honorary Consultant, Junior Police Association, Hong Kong. 2004.

Lo C.Y., Interns Coordinator (1995 - present), Department of Surgery, Queen Mary Hospital. 2004.

Lo C.Y., Laparoscopic adrenalectomy (Invited Lecture), Hong Kong Surgical Forum, Hong Kong, 9-10 January 2004.

Lo C.Y., Localisation and laparoscopic approach to pancreatic neuroendocrine tumours, Australian and New Zealand Journal of Surgery. 2004, 74 (Supplement): A42-48.

Lo C.Y., Member (1996 - present), Clinical Services Subcommittee, Department of Surgery, Queen Mary Hospital. 2004.

Lo C.Y., Member (2002 - present), Continued Education Subcommittee, Hong Kong Medical Association. 2004.

Lo C.Y., Member (2003 - present), Hospital Authority HK West Institution Review Board. 2004.

Lo C.Y., Member (2004 - present), The Task Force for Subspecialty Training in General Surgery, The College of Surgeons of Hong Kong. 2004.

Lo C.Y., Member of Editorial Board (1 February 2002 - present), Asian Journal of Surgery. 2004.

Lo C.Y., Member, International Advisory Board (2002 - present), Chinese Journal of Endocrine Surgery . 2004.

Lo C.Y., Member, Hospital Authority Expert Panel. 2004.

Lo C.Y., Chan W.F. and Luk J.M.C., Minimally invasive endoscopic-assisted parathyroidectomy for primary hyperparathyroidism, Surgical Endoscopy. 2003, 17(12): 1932-1936.

Lo C.Y., Multiple endocrine neoplasia syndrome in Hong Kong (Invited Lecture), 9th Congress of the Asian Association of Endocrine Surgeons, Taipei, Taiwan, 2-6 March 2004.

Lo C.Y., Wat N.M.S., Lam K.Y., Tiu S.C., Chan J.K.Y. and Lam K.S.L., Multiple endocrine neoplasia type 2 in Chinese families, Clinical Endocrinology. 2003, 58: 528.

Lo C.Y., Optimising the outcome of thyroid surgery: towards a zero morbidity, Australian and New Zealand Journal of Surgery. 2004, 74 (Supplement): A42-48.

Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Optimizing the treatment of AMES high-risk papillary thyroid carcinoma (Oral presentation), Conference of the International Association of Endocrine Surgeons (IAES), Uppsala, Sweden, 13-17 June 2004.

Lo C.Y., Papillary thyroid cancer in children, Australian and New Zealand Journal of Surgery. 2004, 74 (Supplement): A42-48.

Lo C.Y., Parathyroid preoperative localization and intraoperative PTH assay during minimally invasive parathyroidectomy, Australian and New Zealand Journal of Surgery. 2004, 74 (Supplement): A42-48.

Lo C.Y., Parathyroid preservation and autotransplantation, Australian and New Zealand Journal of Surgery. 2004, 74 (Supplement): A42-48.

Lo C.Y., Preoperative localization and intraoperative parathyroid hormone assay during minimally invasive parathyroidectomy for primary hyperparathyroidism (Invited Lecture), 9th Joint Shanghia-HongKong Surgical Convention, Shanghai, China, 12 January 2004.

Lo C.Y., Preoperative localization for primary hyperparathyroidism, 10th Congress of the Asian Association of Endocrine Surgeons, Taipei, Taiwan, 2-6 March 2004.

Lo C.Y., President (2004 - 2006), 10th Congress Asian Association of Endocrine Surgeons. 2004.

Lo C.Y., Reviewer, Annals of College of Surgeons of Hong Kong. 2004.

Lo C.Y., Reviewer, Asian Journal of Surgery. 2004.

Lo C.Y., Reviewer, British Journal of Surgery. 2004.

Lo C.Y., Reviewer, Cancer. 2004.

Lo C.Y., Reviewer, Endoscopy. 2004.

Lo C.Y., Reviewer, Hong Kong Medical Journal. 2004.

Lo C.Y., Reviewer, Surgery. 2004.

Lo C.Y., Surgical management of endocrine diseases, CNE Lecture, 15 December 2003. 2003.

Lo C.Y., Chan W.F., Kung A.W.C., Lam K.Y., Tam S.C.F. and Lam K.S.L., Surgical treatment for primary hyperparathyroidism in Hong Kong: Changes in clinical pattern over 3 decades, Archives of Surgery. 2004, 139(1): 77-82.

Lo C.Y., Chan W.F., Lo C.M., Fan S.T. and Tam P.K.H., Surgical treatment of pancreatic insulinomas in the era of laparoscopy, Surgical Endoscopy. 2004, 18(2): 297-302.

Lo C.Y., Well-differentiated thyroid carcinoma, Australian and New Zealand Journal of Surgery. 2004, 74 (Supplement): A42-48.

Tso A.W.K., Rong R., Lo C.Y., Tan K.C.B., Tiu S.C., Wat N.M.S., Xu J., Villablanca A., Larsson C., Teh B.T. and Lam K.S.L., Multiple endocrine neoplasia type 1 (MEN 1): genetic and clinical analysis in Southern Chinese, Clinical Endocrinology. 2003, 59: 129-35.

Yong J.L., Law W.L., Lo C.Y., Chu K.M., Law S.Y.K., Lam C.M. and Lau H., A comparative study of routine laparoscopic versus open appendicectomy, The 12th International Congress and Endo Expo 2003, SLS Annual Meeting, The Society of Laparoendoscopic Surgeons, Las Vegas, Nevada, U.S.A., 22-25 September 2003.

Researcher : Loo TY

List of Research Outputs

Chow L.W.C., Zhu L. and Loo T.Y., HER-2/NEU expression in breast cancer patients: pre- and postexposure to neoadjuvant endocrine therapy, 10th Hong Kong International Cancer Congress, Hong Kong, November 2003.

Chow L.W.C., Loo T.Y., Sham J.S.T. and Cheung M.N.B., Radix bupleuri containing compound (KY88 Liver-Livo) induces apoptosis and production of interleukin-4 and tumor necrosis factor-a in liver cancer cells in-vitro, American Journal of Chinese Medicine. 2004, 32(2): 185-193.

Researcher : Lui VCH

Project Title:	Defining the role of RET receptor tyrosine kinase in enteric neurogenesis
Investigator(s):	Dr. Lui V.C.H., Dr. Sham M.H., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2000

Abstract:

To create a knock-in dominant negative Ret mutation equivalent of human mutation in green fluorescent embryonic stem (ES) cells and generate mice using the targeted ES cells. The project aims to characterize the molecular mechanism involving RET in lineage commitment and differentiation of enteric NC cells.

Project Title:	Engrailed-Hoxb5 chimaeric transcription repressor: a novel approach to investigate Hoxb5 function in enteric neurons and gut development in transgenic mice
Investigator(s):	Dr. Lui V.C.H., Dr. Sham M.H., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2002

Abstract:

By using the Cre/loxP recombinase technology in transgenic mice, the project team will try to express the en-Hoxb5 repressor gene in mouse embryos and analyse the transgenic mouse embryos for anomalies in the enteric nervous system (ENS) development. This approach will circumvent the problem of functional redundancy such that the function of a specific Hox gene is masked by others, and allow us to address directly the functional role of Hoxb5 in the development of the ENS.

Project Title:	A mechanistic study of the inductive roles of sonic hedgehog in the enteric neural crest cells migration, proliferation and differentiation
Investigator(s):	Dr. Lui V.C.H., Dr. Sham M.H., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002
Completion Date:	09/2003

Abstract:

To investigate the inductive functions of Sonic Hedgehog on GDNF-induced migration, proliferation and differentiation of enteric neural crest cells.

Project Title:	Sonic hedgehog in neural crest cell development in gut: a mechanistic study
Investigator(s):	Dr. Lui V.C.H., Dr. Sham M.H., Prof. Tam P.K.H., Dr. Vassilis P.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To investigate the direct and indirect mechanisms by which Sonic Hedgehog (Shh) controls the migration and differentiation of neural crest cells (NCCs) in gut.

Project Title:	Cre-inducible disruption of Hedgehog signaling in neural crest cell: a novel approach to study roles of Hedgehog in enteric nerous system development
Investigator(s):	Dr. Lui V.C.H., Dr. Sham M.H., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To generate a DNA construct for Cre-inducible expression of a Ptc1^Dloop2 protein; to generate transgenic mice carrying the Ptc1^Dloop2 DNA construct by microinjection; transgenic mice will be crossed with a vagal NCC specific Cre mouse strain; to analysis of abnormal phenotypes in the devleoping ENS of the transgenic mutant mice.

List of Research Outputs

Chan K.K., Chen A.Y.S., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric ganglia development in transgenic mice with ectopic expression of mutant Sox10 in the vagal neural crest. , The 4th International Meeting on Hirschprung Disease and Related Neurocristopathies HSCR, April 2004, Genova italy. 2004.

Chan K.K., Chen Y.S., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric ganglia development in transgenic mice with ectopic expression of mutant Sox10 in the vagal neural crest, 4th Hirschsprung Disease and Related Neurocristopathics, Genoa, Italy, 22-24 April 2004.

Chan K.K., Wong C.K.Y., Lui V.C.H., Tam P.K.H. and Sham M.H., Analysis of SOX10 mutations identified in Waardenburg-Hirschsprung patients: differential effects on target gene regulation, Journal of Cellular Biochemistry. 2003, 90(3): 573-585.

Chen Y., Lui V.C.H. and Tam P.K.H., Resident macrophages are key players in ischeamia reperfusion injury in gut, 50th Annual International Congress of the British Association of Paediatric Surgeons, Estorial, Portugal, 15-18 July 2003.

Fu M., Tam P.K.H., Sham M.H. and Lui V.C.H., Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study, Anatomy and Embryology. 2004, 208(1): 33-41.

Fu M., Lui V.C.H., Sham M.H., Cheung A.N.Y. and Tam P.K.H., HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts, Developmental Dynamics. 2003, 228(1): 1-10.

Garcia-Barcelo M.M., Sham M.H., Lui V.C.H., Chen B.L.S., Song Y., Lee W.S., Yung S.K., Romeo G. and Tam P.K.H., Chinese patients with sporadic Hirschsprung’s disease are predominantly represented by a single RET haplotype. , Journal of Medical Genetics. 2003, 40(11): e122.

Garcia-Barcelo M.M., Sham M.H., Lee W.S., Lui V.C.H., Chen B.L.S., Wong K.K.Y., Wong J.S.W. and Tam P.K.H., Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease, Clinical Chemistry. 2004, 50(1): 93-100.

Garcia-Barcelo M.M., Lui V.C.H., Sham M.H. and Tam P.K.H., Is there a role for Hedgehog genes in Hirschsprung's diseases?, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May, 2004.

Garcia-Barcelo M.M., Lee W.S., Sham M.H., Lui V.C.H. and Tam P.K.H., Is there a role for the IHH gene in Hirschsprung's disease?, Neurogastroenterology and Motility. 2003, 15(6): 663-668.

Lee K.Y., Samy E.T., Sham M.H., Tam P.K.H. and Lui V.C.H., 3' Splicing variants of ret receptor tyrosine kinase are differentially expressed in mouse embryos and in adult mice, Biochimica Biophysica Acta-Gene Structure Expression. 2003, 1627: 26-38.

Lee K.Y., Lui V.C.H. and Tam P.K.H., Differential expression of RET isoforms in neural crest derived tissues during development, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Lui V.C.H., Fu M., Sham M.H., Pachnis V. and Tam P.K.H., Sonic hedgehog (SHH) regulates the proliferation, migration and differentiation of enteric neural crest stem cells (NCSCS) in gastrointestinal tract, 4th Hirschsprung Disease and Related Neurocristopathies, Genoa, Italy, 22-24 April 2004.

Ren Y., Li Z., Chan H.M., Lin C.L., Lui V.C.H., Bacher M. and Tam P.K.H., N-MYC induction stimulated by macrophage migration inhibitory factor through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Ren Y., Chan H.M., Li Z., Lin C.L., Nicholls J.M., Chan G.C.F., Lee P.Y., Lui V.C.H., Bacher M. and Tam P.K.H., Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma, Oncogene. UK, Nature Publishing Group, 2004, 23: 4146-4154.

Wong E.Y.M., Tse J.Y.M., Yao K.M., Lui V.C.H., Tam P.C. and Yeung W.S.B., Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein, Biology of Reproduction. 2003, 70: 775-784.

Yuan Z.W., Lui V.C.H. and Tam P.K.H., Deficient motor innervation of the sphincter mechanism in fetal rats with anorectal malformation: a quantitative study by fluorogold retrograde tracing, Journal of Pediatric Surgery. 2003, 38(9): 1383-1388.

Researcher : Lui WM

List of Research Outputs

Au Yeung K.M., Lui W.M., Chow L.C.K. and Chan F.L., Massive epistaxis related to petrous carotid artery pseudoaneurysm after radiation therapy: emergency treatment with covered stent in two cases, American Journal of Neuroradiology. 2003, 24(7): 1449-1452.

Lam W.W.M., Ai V.H.G., Wong V.C.N., Lui W.M., Chan F.L. and Leong Fung L.L.Y., Ultrasound Measurement of Lumbosacral Spine in Children, Pediatric Neurology. Elsevier Inc, 2004, 30(2): 115-121.

Ting A.C.W., Cheng S.W.K., Yeung K.M., Cheng P.W., Lui W.M., Ho P. and Tso H.W.K., Carotid stenting for radiation-induced extracranial carotid artery occlusive disease: efficacy and midterm outcomes, Journal of Endovascular Therapy. 2004, 11(1): 53-59.

Ting A.C.W., Au Yeung K.M., Cheng P.W., Lui W.M., Ho P., Poon J.T.C., Tso W.K. and Cheng S.W.K., Carotid stenting for radiation-induced extracranial carotid artery occlusive disease: long-term results, 17th International Congress on Endovascular Interventions (Arizona Heart Institute), The Phoenician, Scottsdale, Arizona, U.S.A., 8-12 February 2004.

Researcher : Luk JMC

Project Title:	Roles of connexin junctional molecules in spermatogenesis
Investigator(s):	Dr. Luk J.M.C., Dr. Chan S.Y., Dr. Yeung W.S.B.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2001

Abstract:

To generate monoclonal antibodies (mAbs) specific for connexin Cx31 and Cx33; to isolate cDNA and genomic clones for Cx31 and other related testicular junctional moldecules (e.g. Cx26, Cx32, and Cx33) for molecular analysis and in situ histochemical study; to characterize by in situ hybridization (ISH) and quantitative PCR the differential expression of Cx31 and other junctional Cx genes at distinct developmental stages in the process of spermatogenesis. This approach capitalizes on the established Vitamin A-deficiency (VAD) rat model; to define the cellular and subcellular localization of Cx31 in testicular germ cells with the aids of laser microdissection and immunohistochemistry; to generate and characterize genoic target constructs for establishing Cx31 and Cx33 transgenic mice.

Project Title:	Prevention of endotoxin-mediated liver injury by recombinant integrin subunit (RIS), Anti-CD18 Fv and TW-PS22
Investigator(s):	Dr. Luk J.M.C., Prof. Fan S.T.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2002

Abstract:

The project attempts to exploit new approaches for preventing endotoxin-mediated liver injury in experimental sepsis and ischemia/reperfusion (I/R) animal models.

Project Title:	Structural and functional of VAD1.3-a novel testis-specific gene in spermatogenesis
Investigator(s):	Dr. Luk J.M.C., Dr. Ngan E.S.W., Dr. Yeung W.S.B.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To characterize the structure and function of VAD1.3, a novel gene that has not been studied before, by employing immunological, structural and transgenic approaches; to elucidate its physiologic function(s) in the regulatory mechanisms of spermatogenesis.

Project Title:	Adrenomedullin peptide in hepatic cirrhosis: regulatory mechanism in hemodynamic changes
Investigator(s):	Dr. Luk J.M.C., Dr. Hwang I.S.S., Prof. Tang F.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To study the gene expression, level of AM and receptor mRNA in liver and the vasculature of cirrhotic rat; to determine the correlation between AM and parameters of ascites formation in cirrhotic rat (plasma renin activity, aldosterone concentration and sympathetic nervous system activity); to identify the types of cells that secret AM in rat liver and the morphological changes of AM antigen in cirrhotic liver; to study the relationship between changes in AM and nitric oxide (NO) generation (and carbon dioxide generation) in cirrhotic rat model.

List of Research Outputs

Cheng C.L., Guo J., Luk J.M.C. and Koo M.W.L., The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats, Life Sciences. 2004, 74: 2237-2249.

Davis P.B., Ferkol T., Eckman E., Schreiber J. and Luk J.M.C., Bifunctional molecules for delivery of therapeutics, Invention Disclosure: CWRU Docket No. JAKE-1996-0143 and JAKE-A2004-02153. 2004.

Guo J., Chau J.F.L., Shen X.Z., Cho C.H., Luk J.M.C. and Koo M.W.L., Over-Expression of Inducible Heat Shock Protein 70 in the Gastric Mucosa of Partially Sleep-Deprived Rats, Scandinavian Journal of Gastroenterology. 2004, 39: 510-515.

Ho D.W.Y., Luk J.M.C. and Fan S.T., Proteomic analysis of plasma biomarkers of fulminant hepatic failure in a porcine model (Abstract), Hong Kong - Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Hwang I.S.S., Luk J.M.C., Tan F. and Fan S.T., Vasoactive role of adrenomedullin in CC14-plus-ethanol-induced hepatic cirrhosis (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Ko S., Chu K.M., Luk J.M.C., Wong W.Y., Leung S.Y., Yuen S.T. and Wong J., Expression of CDX2 and LI-cadherin in intestinal metaplasia and adenocarcinoma of the stomach, 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Ko S., Chu K.M., Luk J.M.C., Wong B.W.Y., Yuen S.T., Leung S.Y.L. and Wong J., Over-expression of LI-cadherin in gastric cancer is associated with lymph node metastasis, Biochemical and Biophysical Research Communications. 2004, 319(2): 562-568.

Lau G., Zhang H.Y., Luk J.M.C., Locarnini S. and Liang R.H.S., Pre-emptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation, Hepatology. 2004, 39: 867-868.

Lee C.K.F., Yeung W.S.B., Chow J.F.C., Shum C.K. and Luk J.M.C., Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis, Biology of Reproduction. 2004, 70: 1010-1017.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., Identification of human oviducutal cell derived embryotrophic factor-3 (ETF-3), Symposium on Reproductive Health, Macau, Hong Kong and Inland China, Macau, May 29-31, 2004 . 2004.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction, The Journal of Biological Chemistry. 2004, 279(13): 12763-12768.

Liu Y., Poon R.T.P., Feng X., Yu W.C., Luk J.M.C. and Fan S.T., Reduced expression of chemokine receptors on peripheral blood lymphocytes in patients with hepatocellular carcinoma, American Journal of Gastroenterology. 2004, 99(6): 1111-1121.

Lo C.Y., Chan W.F. and Luk J.M.C., Minimally invasive endoscopic-assisted parathyroidectomy for primary hyperparathyroidism, Surgical Endoscopy. 2003, 17(12): 1932-1936.

Luk J.M.C., Functional proteomics in liver diseases (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan Hepatitis Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004 . 2004.

Luk J.M.C., Grant Reviewer, National University of Singapore Academic Research Fund Committee. 2004.

Luk J.M.C., Honorary Ph.D. Supervisor, Fudan Medical University, Shanghai, China. 2004.

Luk J.M.C., Mok B.W.Y., Shum C.K., Yeung W.S.B., Tam P.C., Tse J.Y.M., Chow J.F.C., Woo J., Kam K. and Lee C.K.F., Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display, Biochemical and Biophysical Research Communications. 2003, 307(4): 782-790.

Luk J.M.C., Lam C.T., Hu M.Y. and Fan S.T., Liver cancer proteomics: identifications of chapersones Hsp70 and GRP78 in hepatocellular carcinoma (Abstract), Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003.

Luk J.M.C., Wong W.Y., Hu M.Y. and Fan S.T., Liver-intestine cadherin: a potential disease marker for hepatocellular carcinoma (Abstract), Hepatology. 2003, 38(4 Suppl.): 515.

Luk J.M.C., Ho D.W.Y., Hu M.Y. and Fan S.T., Poteomic analysis of plasma biomarkers for fulminant hepatic failure in a porcine model (Abstract), Keystone Symposia, Tahoe City, California, U.S.A., 24-29 February 2004.

Luk J.M.C., Lam C.T., Hu M. and Fan S.T., Proteomic identification of chaperones Hsp70 and GRP78 in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ma J. and Luk J.M.C., Searching LPS binding site(s) on CD18 (Abstract), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Schwab P., Luk J.M.C. and Klickstein L.B., The beta (2) C-terminal region exerts in inhibitory effect on the calcium-binding region of the alpha (L) beta propeller domain to maintain resting LFA-1 in a non-adhesive conformation, Arthritis and Rheumatism. 2003, 48(9): 623.

Siu A.F.M., Ng K.M., Ho C.M., Che C.M., Luk J.M.C., Fan S.T. and Tsang C.W., Mass spectrometric proteomic analysis (Abstract), The 8th International Symposium on Applied Bioinorganic Chemistry, 2-5 April 2004, Hong Kong. 2004.

Su Y.C.F., Hu M.Y., Fan S.T. and Luk J.M.C., Generation and characterization of monoclonal antibodies against hepatocellular carcinoma (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang P., Wang J.H., Yang Z.P. and Luk J.M.C., Hepatocyte-like phenotypes of bone marrow stromal cells in vitro after hepatocytes growth factor induction and intraportal transplantation in cirrhotic liver (Abstract), The 90th Scientific Assembly and Annual Meeting, Chicago, U.S.A., 28 November - 3 December 2003.

Wang P.P., Wang J.H., Yan Z.P., Hu M.Y., Fan S.T. and Luk J.M.C., Intraportal transplantation of bone marrow stromal cells in cirrhotic liver (Abstract), Hong Kong-Shanghai International Liver Congress, the 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and the 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang X., Luk J.M.C. and Fan S.T., Characterization of LI-cadherin mutation in HCC (Oral Presentation), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang X., Wong W.Y., Leung P.L., Leung P.L., Leung P.L., Fan S.T. and Luk J.M.C., Molecular characterization of LI-cardherin mutations in hepatocellular carcinoma (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang Y., Luk J.M.C., Ikeda K., Man K., Chu A.C.Y., Kaneda K. and Fan S.T., Regulatory role of vHL/HIF-1a in hypoxia-induced VEGF production in hepatic stellate cells, Biochemical and Biophysical Research Communications. 2004, 317(2): 358-362.

Wong B.W., Luk J.M.C., Ng I.O.L., Hu M.Y., Liu K.D. and Fan S.T., Identification of liver-intestine cadherin in hepatocellular carcinoma--a potential disease marker, Biochemical and Biophysical Research Communications. 2003, 311(3): 618-624.

Researcher : Luo Y

List of Research Outputs

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Hepatitis B virus (HBV)-specific immune response after liver transplantation for chronic hepatitis B (Abstract), Liver Transplantation. 2004, 10(6): C42.

Luo Y., Cheung C.K.Y. and Lo C.M., Hepatitis B virus-specific immune response after liver transplantation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus (HBV)-specific lymphocytes in human liver allografts from HBV immune donors (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Researcher : Ma J

List of Research Outputs

Ma J. and Luk J.M.C., Searching LPS binding site(s) on CD18 (Abstract), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Researcher : Man K

Project Title:	The anit-cancer effect of FTY720 on liver tumors in vitro and in vivo
Investigator(s):	Dr. Man K., Prof. Fan S.T., Dr. Ho J.W.Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To investigate the anti-cancer effect of FTY720 on liver tumors in vitro and in vivo by detection of different cell signalling pathways including cell survival, apoptosis, and cell invasion and migration, as well as the comparison of tumor growth and metastasis.

List of Research Outputs

Ho J.W.Y., Man K., Sun K.W., Zhao Y., Fan S.T. and Poon R.T.P., FTY720, a study of its impact on angiogensis and tumor growth in nude mice bearing hepatocellular carcinoma (Oral Presentation), AACR-NCI-EORTIC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Xu R. and Fan S.T., FTY720 selectively induced human hepatoma cell line apoptosis via Akt dephosphorylation (Abstract) , AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Ng I.O.L., Xu R. and Fan S.T., FTY720 selectively induces human hepatoma cell lines apoptosis via Akt dephosphorylation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Lee K.W., Man K., Ling M.T., Wang X., Wong Y.C., Lo C.M., Poon R.T.P., Ng I.O.L. and Fan S.T., Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16^INK4a/RB pathway, Carcinogenesis. 2003, 24(11): 1729-1736.

Li X.L., Man K., Liu Y.F., Lee K.W., Tsui H.T., Lau C.K., Lo C.M. and Fan S.T., Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation, Transplantation. 2003, 76(1): 44-49.

Li X.L., Man K., Ng T.P., Sun K.W., Lo C.M. and Fan S.T., The dysregulation of P13-Kinase/Akt pathway contributes to the ischemia/reperfusion injury during graft preservation by UW solution (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Man K., Lo C.M., Ng T.P., Zhao Y., Ho J.W.Y., Sun K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed liver tumor growth and metastasis (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Ng T.P., Lo C.M., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed tumor growth and matastasis (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., Distinct intragraft response pattern in liver transplantation using marginal grafts and cirrhotic recipients (Abstract), The 11th Congress of the European Society for Organ Transplantation, Venice, Italy, 20-24 September 2003.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., FTY attenuates ischemia-reperfusion injury in normal and cirrhotic rat liver by down-regulation of Egr-1 and activation of Akt pathway, Liver transplantation. 2003, 9(6): c-37.

Man K., Ng T.P., Lee K.W., Lo C.M., Sun K.W., Li X.L., Zhao Y., Ho J.W.Y. and Fan S.T., FTY720 attenuates hepatic ischemia-reperfusion injury by Egr-1 down-regulation involving Raf-MEK-Erk pathway and Akt activation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathway (Abstract), Liver Transplantation. 2004, 10(6): C69.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ho J.W.Y., Lee K.W., Zhao Y., Wang X.H., Ng T.P., Sun K.W. and Fan S.T., Marked suppression of tumor growth by FTY720 in rat and mouse liver tumor models (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Man K., Zhao Y., Xu A.M., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus adiponectin combination therapy (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Zhao Y., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus asiponectin combination therapy (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lo C.M., Ho J.W.Y., Zhao Y., Sun K.W., Lee K.W., Li X.L. and Fan S.T., The significance of hepatic ischemia-reperfusion injury on liver tumor development - activation of cell invasion and migration pathways (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Pang R., Yuen J., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E., PIN1 over-expression and b-catenin gene mutations are distinct oncologic events in human hepatocarcinogenesis (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Shi J., Zheng D., Man K., Fan S.T. and Xu R., TRAIL: a potential agent for cancer therapy, Current Molecular Medicine. 2003, 3(8): 727-736.

Wang Y., Luk J.M.C., Ikeda K., Man K., Chu A.C.Y., Kaneda K. and Fan S.T., Regulatory role of vHL/HIF-1a in hypoxia-induced VEGF production in hepatic stellate cells, Biochemical and Biophysical Research Communications. 2004, 317(2): 358-362.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Lee K.W., Sun K.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Sun K.W., Dai X.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Researcher : Mok BWY

List of Research Outputs

Luk J.M.C., Mok B.W.Y., Shum C.K., Yeung W.S.B., Tam P.C., Tse J.Y.M., Chow J.F.C., Woo J., Kam K. and Lee C.K.F., Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display, Biochemical and Biophysical Research Communications. 2003, 307(4): 782-790.

Researcher : Neoh KHA

List of Research Outputs

Ganster R.W., Lau M.F., Neoh K.H.A. and Tam P.K.H., NF-kB, Stat1, and Stat3 are over-expressed in papillary thyroid carcinoma: identification of molecular switches which dys-regulate gene transcription causing thyroid cancer, 95th Annual Meeting of American Association for Cancer Research, Florida, U.S.A., 27-31 March 2004.

Lau M.F., Neoh K.H.A., Tam P.K.H. and Ganster R.W., Regulation of gene transcription by NF-kB and Stats downstream of the Ret receptor tyrosine kinase in thyroid cancer and Hirschsprung's disease, 95th Annual Meeting of American Association for Cancer Research, Florida, U.S.A., 27-31 March 2004.

Researcher : Ng TP

List of Research Outputs

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Xu R. and Fan S.T., FTY720 selectively induced human hepatoma cell line apoptosis via Akt dephosphorylation (Abstract) , AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Ng I.O.L., Xu R. and Fan S.T., FTY720 selectively induces human hepatoma cell lines apoptosis via Akt dephosphorylation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Li X.L., Man K., Ng T.P., Sun K.W., Lo C.M. and Fan S.T., The dysregulation of P13-Kinase/Akt pathway contributes to the ischemia/reperfusion injury during graft preservation by UW solution (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Man K., Lo C.M., Ng T.P., Zhao Y., Ho J.W.Y., Sun K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed liver tumor growth and metastasis (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Ng T.P., Lo C.M., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed tumor growth and matastasis (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., Distinct intragraft response pattern in liver transplantation using marginal grafts and cirrhotic recipients (Abstract), The 11th Congress of the European Society for Organ Transplantation, Venice, Italy, 20-24 September 2003.

Man K., Ng T.P., Lee K.W., Li X.L., Lo C.M. and Fan S.T., FTY attenuates ischemia-reperfusion injury in normal and cirrhotic rat liver by down-regulation of Egr-1 and activation of Akt pathway, Liver transplantation. 2003, 9(6): c-37.

Man K., Ng T.P., Lee K.W., Lo C.M., Sun K.W., Li X.L., Zhao Y., Ho J.W.Y. and Fan S.T., FTY720 attenuates hepatic ischemia-reperfusion injury by Egr-1 down-regulation involving Raf-MEK-Erk pathway and Akt activation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathway (Abstract), Liver Transplantation. 2004, 10(6): C69.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ho J.W.Y., Lee K.W., Zhao Y., Wang X.H., Ng T.P., Sun K.W. and Fan S.T., Marked suppression of tumor growth by FTY720 in rat and mouse liver tumor models (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Man K., Zhao Y., Xu A.M., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus adiponectin combination therapy (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Zhao Y., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus asiponectin combination therapy (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lo C.M., Ho J.W.Y., Zhao Y., Sun K.W., Lee K.W., Li X.L. and Fan S.T., The significance of hepatic ischemia-reperfusion injury on liver tumor development - activation of cell invasion and migration pathways (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Lee K.W., Sun K.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Sun K.W., Dai X.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Researcher : Ng WM (Miss Ng Wai Man)

List of Research Outputs

Wei W.I., Tuen H.H.L., Ng W.M. and Lam L.K., Safe tracheostomy for patients with severe acute respiratory syndrome, The Laryngoscope. 2003, 113(10): 1777-1779.

Researcher : Ng WM (Dr Ng Wai Man)

List of Research Outputs

Lam K.Y., Ng W.M. and Hui Y., ?維喉鏡下氣管食管穿刺朮及PROVOX發音鈕植入之體會, Chinese Journal of Otorhinolaryngology - Skull Base Surgery. 2003, 9(5): 276-277.

Ng W.M., Instructor (1997 - present), Advanced Burn Life Support Course, American Burn Association. 2004.

Wei W.I., Ng W.M. and Ho W.K., "How I do it" - Pharyngeal entry through the vallecula, Laryngoscope. 2004, 114(1): 181-183.

Wei W.I., Lam L.K., Ng W.M., Liu C.L., Lo C.M., Fan S.T. and Wong J., Microvascular reconstruction of the hepatic artery in live donor liver transplantation: experience across a decade, Archives of Surgery. 2004, 139(3): 304-307.

Researcher : Patil NG

Project Title:	Risk factors for inguinal hernia in adults: a case-control study
Investigator(s):	Dr. Patil N.G., Dr. Lau H.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To evaluate and identify the risk factors for the development of inguinal hernia in adults.

Project Title:	Risk factors for hernia development in patients receiving continuous ambulatory peritoneal dialysis (CAPD)
Investigator(s):	Dr. Patil N.G., Dr. Lau H.
Department:	Surgery
Source(s) of Funding:	Run Run Shaw Research and Teaching Endowment Fund
Start Date:	11/2003

Abstract:

To evaluate the incidence of and identify the risk factors for the development of hernia in patients who are undergoing CAPD.

List of Research Outputs

Chu K.M., Patil N.G., Saing H. and Wong J., A level grades and undergraduate academic performance in Hong Kong, British Medical Journal. 2003, (online).

Chu K.M., Patil N.G., Saing H. and Wong J., Female gender is associated with better undergraduate academic performance, British Medical Journal. 2004, (online).

Lau H. and Patil N.G., A prospective comparison of ambulatory endoscopic totally inguinal hernioplasty vs open mesh hernioplasty, Ambulatory Surgery. 2003, 10(3): 137-141.

Lau H. and Patil N.G., Acute pain after endoscopic totally extraperitoneal (TEP) inguinal hernioplasty: multivariate analysis of predictive factors, Surgical Endoscopy. 2004, 18(1): 92-96.

Lau H. and Patil N.G., Acute pain following endoscopic totally extraperitoneal inguinal hernioplasty: multivariate analysis of predictive factors (Abstract), The Medical Journal of Malaysia. 2003, 58 (Supplement F): S24-3.

Lau H. and Patil N.G., Acute pain following endoscopic totally extraperitoneal inguinal hernioplasty: multivariate analysis of predictive factors, 5th Asia-Pacific Congress of Endoscopic Surgery, Kuala Lumpur, Malaysia, 10-13 September 2003.

Lau H. and Patil N.G., Impact of previous appendectomy on the outcomes of endoscopic totally extraperitoneal inguinal hernioplasty, Hernia Repair 2004, Annual Scientific Meeting of American Hernia Society, Florida, U.S.A., 25-28 February 2004.

Lau H., Lam B. and Patil N.G., Management of postoperative urinary retention: a randomized trial of in-out versus overnight catheterization (Abstract), Annals of The College of Surgeons of Hong Kong. 2004, 8(2): A5.

Lau H., Lam B. and Patil N.G., Management of postoperative urinary retention: a randomized trial of in-out versus overnight catheterization, 11th Annual Scientific Meeting, College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Lau H., Patil N.G., Yuen W.K. and Lee F.C.W., Prevalence and severity of chronic groin pain after endoscopic totally extraperitoneal inguinal hernioplasty, Surgical Endoscopy. 2003, 17: 1620-1623.

Lau H., Patil N.G. and Yuen W.K., Prevalence and severity of chronic groin pain following endoscopic totally extraperitoneal inguinal hernioplasty, New Challenges in Healthcare, 10th Anniversary of Celebration Programme of the Hong Kong Academy of Medicine, Hong Kong, 28-30 November 2003.

Lau H. and Patil N.G., Selective non-stapling of mesh during unilateral endoscopic total extraperitoneal inguinal hernioplasty (a case-control study), Archives of Surgery. 2003, 138(12): 1352-1355.

Lau H. and Patil N.G., Umbilical hernia in adults: laparoscopic vs open repair, 5th Asia-Pacific Congress of Endoscopic Surgery, Kuala Lumpur, Malaysia, 10-13 September 2003.

Lau H. and Patil N.G., Umbilical hernia in adults, Surgical Endoscopy. 2003, 17 (12): 2016-2020.

Patil N.G., A book chapter entitled 'Postgraduate Medical Curriculum', Practical Guide for Medical Teachers. 2004.

Patil N.G., A surgeon with mission: Tan Sri Guan Bee Ong, Hong Kong Medical Diary. 2004, 9(3).

Patil N.G., A workshop on "Clinical PBL" for delegation from Faculty of Medicine, The University of Hong Kong, Fu Jen Catholic University, Taiwan. 2004.

Patil N.G., Academic medicine and its global impact, Academic Medicine. 2003, (online).

Patil N.G., Curriculum reforms at Faculty of Medicine, The University of Hong Kong - lessons learned, 1st Asian Pacific Medical Conference, Singapore, 4 December 2003. 6.

Patil N.G., Do we need PBL in the clinical years?, 1st Asia Pacific Medical Conference, Singapore, 4 December 2003. 5.

Patil N.G., General Advisor 2003-2004, Asian Medical Students' Association in Hong Kong (AMSAHK). 2003.

Patil N.G., Invisibly visible: the story of SARS, Faculty Nobel Forum, Karolinska Institute, Sweden, 17 June 2004.

Patil N.G., Invited Speaker, Medical Education Forum, Singapore . 2004.

Patil N.G., Ladies' fingers and a lion's heart, Newsletter. 2004, 8(1).

Patil N.G., Our renowned graduate Guan Bee Ong, Medical Faculty News 2004. 2004, 9(1): 2-3.

Patil N.G., Professor Tan Sri Guan Bee Ong, P.S.M., O.B.E., M.D., D.Sc., Asian Journal of Surgery. 2004, 27(2): 162.

Patil N.G. and Chan H.Y., SARS and its effect on medical education in Hong Kong, Medical Education. 2003, 37(12): 1127-1128.

Patil N.G., Cheng S.W.K. and Wong J., Surgical competence, World Journal of Surgery. 2003, 27(8): 943-947.

Patil N.G., Timely reminder, Academic Medicine . 2003, (online).

Patil N.G., Tutor, Basic Surgical Skill Course, College of Surgeons of HK/RCSED. 2003.

Researcher : Poon RTP

Project Title:	Study of clinical significance of Endoglin (CD105) and vascular cell adhesion molecule-1 (VCAM-1) expression in hepatocellular carcinoma (HCC)
Investigator(s):	Dr. Poon R.T.P., Dr. Ho J.W.Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To evaluate the clinical significance of the angiogenesis related factors, endoglin and VCAM-1, in terms of their prognostic implications in HCC patients after hepatectomy.

Project Title:	Prospective randomized trial of radiofrequency ablation versus hepatic resection for hepatocellular carcinoma <= 5 cm
Investigator(s):	Dr. Poon R.T.P., Prof. Fan S.T.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2002

Abstract:

The project attempts to compare the immediate and long-term outcomes between radiofrequency ablation (RFA) nad hepatic resection for patients with hepatocellular carcinoma (HCC) less than or equal to 5 cm.

Project Title:	Genetic analysis of epidermal growth factor receptor (EGFR) in hepatocellular carcinoma (HCC) and anti-cancer effect of the selective EGFR-tyrosine kinase inhibitor Iressa (ZD1839) in HCC cell lines
Investigator(s):	Dr. Poon R.T.P., Dr. Ho J.W.Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To analyse the genetic expression of EGFR and its receptor family in HCC, and to evaluate the anti-cancer effect of EGFR tyrosine kinase inhibitor ZD1839 (Iressa) in HCC.

List of Research Outputs

Chen D.W., Poon R.T.P., Liu C.L., Fan S.T. and Wong J., Immediate and long-term outcomes of hepatectomy for hepatolithiasis, Surgery. 2004, 135(4): 386-393.

Ho J.W.Y., Poon R.T.P., Tong C.S.W. and Fan S.T., Clinical significance of serum vascular cell adhesion molecule-1 levels in patients with hepatocellular carcinoma, World Journal of Gastroenterology. 2004, 10(14): 2014-2018.

Ho J.W.Y., Sun K.W., Zhou L., Poon R.T.P. and Fan S.T., Clinicopathological and prognostic implications of endoglin (CD105) staining in hepatocellular carcinoma and its adjacent liver (Abstract), Hong Kong-Shanghai International Liver Congress, the 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and the 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Ho J.W.Y., Man K., Sun K.W., Zhao Y., Fan S.T. and Poon R.T.P., FTY720, a study of its impact on angiogensis and tumor growth in nude mice bearing hepatocellular carcinoma (Oral Presentation), AACR-NCI-EORTIC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lam C.M., Chan O.O., Ho P., Ng I.O.L., Lo C.M., Liu C.L., Poon R.T.P. and Fan S.T., Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients - implications for screening, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 771-777.

Lam C.M., Ng K.K.C., Poon R.T.P., Ai V.H.G., Yuen J. and Fan S.T., Impact of radiofrequency ablation on the management of patients with hepatocellular carcinoma in a specialized centre, British Journal of Surgery. 2004, 91(3): 334-338.

Lang B.H.H., Poon R.T.P., Fan S.T. and Wong J., Influence of laparoscopy on postoperative recurrence and survival in patients with ruptured hepatocellular carcinoma undergoing hepatic resection, British Journal of Surgery. 2004, 91(4): 444-449.

Lang B.H.H., Poon R.T.P., Fan S.T. and Wong J., Perioperative and long-term outcome of major hepatic resection for small solitary hepatocellular carcinoma in patients with cirrhosis, Archives of Surgery. 2003, 138(11): 1207-1213.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Increased expression of SPARC and SPARC-like 1 in relation to tumor angiogenesis in hepatocellular carcinoma (Abstract), Proceedings of the American Association for Cancer Research. 2004, 45: 3256.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Increased expression of SPARC and SPARC-like 1 in relation to tumor angiogenesis in hepatocellular carcinoma (Abstract), The 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Lau C.P.Y., Poon R.T.P., Cheung S.T. and Fan S.T., Relationship between expression of SPARC and SPARC-like 1 and tumor angiogenesis in hepatocellular carcinoma (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Lee K.W., Man K., Ling M.T., Wang X., Wong Y.C., Lo C.M., Poon R.T.P., Ng I.O.L. and Fan S.T., Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16^INK4a/RB pathway, Carcinogenesis. 2003, 24(11): 1729-1736.

Liu C.L., Fan S.T., Lo C.M., Wong Y., Ng I.O.L., Lam C.M., Poon R.T.P. and Wong J., Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases, Annals of Surgery. 2004, 239(2): 194-201.

Liu Y., Li Q.Y., Poon R.T.P., Shao W.B., Tong C.S.W. and Fan S.T., Blockage of vascular endothelial growth factor receptor in antitumour effect of hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Liu Y., Poon R.T.P., Feng X., Yu W.C., Luk J.M.C. and Fan S.T., Reduced expression of chemokine receptors on peripheral blood lymphocytes in patients with hepatocellular carcinoma, American Journal of Gastroenterology. 2004, 99(6): 1111-1121.

Lo O.S.H., Poon R.T.P., Lam C.M. and Fan S.T., Inflammatory pseudotumor of the liver in association with a gastrointestinal stromal tumor: a case report, World Journal of Gastroenterology. 2004, 10(12): 1841-1843.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Comparison of systemic responses of radiofrequency ablation, cryotherapy and surgical resection in a porcine liver model (Abstract), Annals of the College of Surgeons of Hong Kong. 2004, 8(Suppl.): A7.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Comparison of systemic responses of radiofrequency ablation, cryotherapy and surgical resection in a porcine liver model (Oral Presentation), The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Fan S.T. and Wong J., Delayed portal vein thrombosis after experimental radiofrequency ablation near the main portal vein, British Journal of Surgery. 2004, 91(5): 632-639.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M., Ng I.O.L. and Fan S.T., Impact of preoperative fine-needle aspiration cytologic examination on clinical outcome in patients with hepatocellular carcinoma in a tertiary referral center, Archives of Surgery. 2004, 139(2): 193-200.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to hepatic radiofrequency ablation in a rat model (Abstract), The 5th Annual Scientific Meeting Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Abstract), Annals of the College of Surgeons of Hong Kong. 2004, 8(Suppl.): A7.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H. and Fan S.T., Maximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Oral Presentation), The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Ng K.K.C., Lam C.M., Poon R.T.P., Law W.L., Seto C.L. and Fan S.T., Radiofrequency ablation as a salvage procedure for ruptured hepatocellular carcinoma, Hepatogastroenterology. 2003, 50(53): 1641-1643.

O'Suilleabhain C.B., Poon R.T.P., Lau C.W. and Fan S.T., Repeated resections of extrahepatic metastases after hepatic resection: an aggressive approach to hepatocellular carcinoma, Hepatogastroenterology. 2004, 51(57): 825-829.

Pang R., Yuen J., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E., PIN1 over-expression and b-catenin gene mutations are distinct oncologic events in human hepatocarcinogenesis (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Pawlik T.M., Poon R.T.P., Abdalla E., Ikai I., Curley S., Nagorney D., Belghiti J., Ng I.O.L., Yamaoka Y., Lauwers G. and Vauthey J.N., Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study (Oral Presentation), The 6th World Congress of the International Hepato-Pancreato-Biliary Association, Washington, D.C., U.S.A., 2-6 June 2004.

Pawlik T.M., Poon R.T.P., Abdalla E., Ikai I., Curley S., Nagorney D., Belghiti J., Ng I.O.L., Yamaoka Y., Lauwers G. and Vauthey J.N., Hepatitis serology defines tumor and liver disease characteristics but not prognosis after resection of hepatocellular carcinoma (Oral Presentation), The 45th Annual Scientific Meeting of the Society for Surgery of Alimentary Tract, New Orleans, U.S.A., 17 May 2004.

Poon R.T.P., Angiogenesis in hepatocellular carcinoma (Invited Lecture), Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003.

Poon R.T.P., Associate Editor (July 2003 - present), Cancer Reviews: Asia-Pacific. 2004.

Poon R.T.P., Chairman, "Central role of the surgeons in clinical cancer trials" by Wells S. , The 10th Hong Kong International Cancer Congress, Hong Kong, 20 November 2003. 2003.

Poon R.T.P., Chairman, Current opinions, The 5th Annual Scientific Meeting of Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004. 2004.

Poon R.T.P., Chairman, Endocrine Surgery Symposium, Joint Shanghai-Hong Kong Surgical Convention, Shanghai, China, 12 January 2004. 2004.

Poon R.T.P., Chairman, Free Paper Session on Gastrointestinal Cancers, The 10th Hong Kong International Cancer Congress, Hong Kong, 19-21 November 2003. 2003.

Poon R.T.P., Clinical implications of angiogenesis in hepatocellular carcinoma, Cancer Reviews: Asia-Pacific. 2003, 1: 167-178.

Poon R.T.P., Fan S.T. and Wong J., Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches (Review), Annals of Surgery. 2003, 238(1): 9-28.

Poon R.T.P., Chung K.K., Cheung S.T., Lau C., Tong C.S.W., Leung K.L., Yu W.C., Tuszynski G.P. and Fan S.T., Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 Pt1): 4150-4157.

Poon R.T.P., Committee Member, Organizing Committee, Frontiers in Biomedical Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, 12 December 2003. 2003.

Poon R.T.P., Committee Member, Organizing Committee, Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004 . 2004.

Poon R.T.P., Committee Member, Research Support Unit, The College of Surgeons of Hong Kong. 2004.

Poon R.T.P., Concurrent colorectal carcinoma and hepatocellular carcinoma (Case Presentation), Hong Kong Surgical Forum, Hong Kong, 6 July 2003.

Poon R.T.P., Country specific issues in treatment of liver cancer - Hong Kong (Invited Lecture), The 1st Asia-Pacific Cancer Advisory Board Meeting, Novartis, Singapore, 21 October 2003.

Poon R.T.P., Deputy Chairman (2003 - present), Institutional Review Board Hospital Authority Hong Kong West Cluster and The University of Hong Kong. 2004.

Poon R.T.P., Editor (January 2001 - present), Hong Kong Medical Journal. 2004.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J. and Fan S.T., Effectiveness of radiofrequency ablation for hepatocellular carcinoma larger than 3 cm in diameter, Archives of Surgery. 2004, 139(3): 281-287.

Poon R.T.P., Epidemiology of liver cancer - Asian perspective (Abstract), Medical Journal of Malaysia. 2003, 58 (Suppl. B): 48.

Poon R.T.P., Epidemiology of liver cancer - Asian perspective (Invited Lecture), The 5th Liver Update, Malaysian Liver Foundation, Selangor, Malaysia, 10-13 July 2003.

Poon R.T.P., Expression of angiogenesis related genes in hepatocellular carcinoma (Invited Lecture), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Poon R.T.P., Fellow (2002 - present), American College of Surgeons. 2004.

Poon R.T.P., Gallstone and CBD stone (Invited Lecture), The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Poon R.T.P. and Fan S.T., Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome, Liver Transplantation. 2004, 10(2 Suppl 1): S39-S45.

Poon R.T.P., Lau C.P.Y., Yu W.C., Fan S.T. and Wong J., High serum levels of vascular endothelial growth factor predict poor response to transarterial chemoembolizatin in hepatocellular carcinoma: a prospective study, Oncology Reports. 2004, 11(5): 1077-1084.

Poon R.T.P., Honorary Advisor (December 1999 - present), Continuing Medical Education Programme, The Association of Licentiates of Medical Council of Hong Kong. 2004.

Poon R.T.P., Honorary Consultant (April 2002 - now), Queen Mary Hospital, Hospital Authority, Hong Kong. 2004.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database (Oral Presentation), The 124th Annual Meeting of the American Surgical Association, San Francisco, U.S.A., 15-17 April 2004.

Poon R.T.P., Instructor (1998 - present), Advanced Trauma Life Support Course, American College of Surgeons. 2004.

Poon R.T.P., Yeung C., Liu C.L., Lam C.M., Yuen W.K., Lo C.M., Tang A. and Fan S.T., Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial, Gut. 2003, 52(12): 1768-1773.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J., Fan S.T. and Wong J., Learning curve for radiofrequency ablation of liver tumors: prospective analysis of initial 100 patients in a tertiary institution, Annals of Surgery. 2004, 239(4): 441-449.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J., Fan S.T. and Wong J., Learning curve for radiofrequency ablation of liver tumours: prospective analysis of initial 100 patients in a teritary institution (Oral Presentation), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Poon R.T.P., Liver abscess (Abstract), Medical Journal of Malaysia. 2003, 58 (Suppl. B): 27.

Poon R.T.P., Liver abscess (Invited Lecture), The 5th Liver Update, Malaysian Liver Foundation, Selangor, Malaysia, 10-13 July 2003.

Poon R.T.P. and Wong J., Long-term disease-free survival after resection of hepatocellular carcinoma: both tumor behavior and surgeon's performance are important determinants (Editorial), Annals of Surgical Oncology. 2003, 10(8): 834-836.

Poon R.T.P., Yu W.C., Fan S.T. and Wong J., Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 779-788.

Poon R.T.P., Management of hepatocellular carcinoma (Invited Lecture), The 7th Congress of the Asian Society of Hepato-Biliary-Pancreatic Surgery Association, Chennai, India, 29-31 August 2003.

Poon R.T.P., Member of Editorial Board (March 2003 - present), Cancer Therapy. 2004.

Poon R.T.P., Member of Editorial Board (November 2002 - present), Digestive Surgery (Chinese). 2004.

Poon R.T.P., New treatments for obstructive jaundice (Invited Lecture), The 5th Joint Annual Scientific Meeting of the Hong Kong Society of Gastroenterology, The Hong Kong Society of Digestive Endoscopy, The Hong Kong Society of Gastrointestinal Motility, and The Hong Kong Association for the Study of Liver Diseases, Hong Kong, 27 September 2003.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement, World Journal of Surgery. 2004, 28(6): 602-608.

Poon R.T.P., Peer Reviewer, American Journal of Surgery. 2004.

Poon R.T.P., Peer Reviewer, Annals of Surgery. 2004.

Poon R.T.P., Peer Reviewer, Asian Journal of Surgery. 2004.

Poon R.T.P., Peer Reviewer, Cancer. 2004.

Poon R.T.P., Peer Reviewer, HBP Surgery. 2004.

Poon R.T.P., Peer Reviewer, Journal of Biomedical Science. 2004.

Poon R.T.P., Peer Reviewer, Journal of Clinical Oncology. 2004.

Poon R.T.P., Peer Reviewer, Lancet. 2004.

Poon R.T.P., Peer Reviewer, Liver Transplantation. 2004.

Poon R.T.P., Peer Reviewer, Medical Science Monitor. 2004.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J. and Fan S.T., Radiofrequency ablation for subcapsular hepatocellular carcinoma, Annals of Surgical Oncology. 2004, 11(3): 281-289.

Poon R.T.P., Recent progress in clinical management of hepatocellular carcinoma (Invited Lecture), Liver Cancer Institute, Fudan University, Shanghai, China, 9 December 2003. 2003.

Poon R.T.P. and Fan S.T., Resection prior to liver transplantation for hepatocellular carcinoma: a strategy of optimizing the role of resection and transplantation in cirrhotic patients with preserved liver function (Commentary), Liver Transplantation. 2004, 10(6): 813-815.

Poon R.T.P., Results of resection of liver cancer and prognostic factors of outcomes (Invited Lecture), Hong Kong Surgical Forum, Hong Kong, 6 July 2003.

Poon R.T.P., Sze P.K., Tang E.W.H. and Fan S.T., Role of serum alpha-fetoprotein monitoring in detection of recurrent hepatocellular carcinoma after curative hepatectomy, Cancer Reviews: Asia-Pacific. 2003, 1: 289-296.

Poon R.T.P., Surgical management of hepatocellular carcinoma (Invited Lecture), Surgical Conference of Department of Surgery, Caritus Medical Centre, Hong Kong, 19 November 2003.

Poon R.T.P., Lau C.P.Y., Ho J.W.Y., Yu W.C., Fan S.T. and Wong J., Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma, Clinical Cancer Research. 2003, 9(14): 5339-5345.

Poon R.T.P., Translational research related to tumour angiogenesis in hepatobiliary cancers (Invited Lecture), The 7th Congress of the Asian Society of Hepato-Biliary-Pancreatic Surgery Association, Chennai, India, 29-31 August 2003.

Poon R.T.P., Transplantation for hepatocellular carcinoma (Invited Lecture), Hepatobiliary Surgery Symposium of Nanjing University, Nanjing, China, 6 March 2004.

Poon R.T.P., Treatment of liver metastasis (Invited Lecture), Hong Kong Surgical Forum, Hong Kong, 9 January 2004.

Poon R.T.P., Treatment of liver metastasis (Invited Lecture), Joint Hong Kong-Shanghai Surgical Convention, Shanghai, China, 12 January 2004.

Poon R.T.P., Treatment of primary liver cancer (Invited Lecture), The 1st Asia-Pacific Summit on Oncology, Hainan Island, China, 21-22 February 2004.

Poon R.T.P., Vice-Chairman, Organizing Committee, The 10th Hong Kong International Cancer Congress, Hong Kong, 19-21 November 2003. 2003.

Ren Y., Poon R.T.P., Tsui H.T., Chen W.H., Li Z., Lau C., Yu W.C. and Fan S.T., Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis, Clinical Cancer Research. 2003, 9(16 Pt1): 5996-6001.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Tang T.C.M., Poon R.T.P., Guan X.Y. and Fan S.T., The effect of cyclooxygenase-2 (COX-2) inhibitor, Celecoxib, on xenograft of hepatocellular carcinoma (HCC) in nude mice (Oral Presentation), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Tang T.C.M., Poon R.T.P., Guan X.Y. and Fan S.T., The effects of cyclooxygenase-2, Celecoxib, on xenografts of hepatocellular carcinoma in nude mice (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Yang Z., Poon R.T.P., To J.Y.T., Ho D.W.Y. and Fan S.T., The potential role of hypoxia inducible factor 1a in tumour progression after hypoxia and chemotherapy in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Ren Y

Project Title:	High expression of macrophage migration inhibitory factor in neuroblastoma and its role in tumorigenesis
Investigator(s):	Dr. Ren Y., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002
Completion Date:	09/2003

Abstract:

To confirm preliminary results indicating that MIF over-expression in neuroblastoma and MIF expression if correlated with tumor differentiation; to investigate whether MIF can stimulate tumor cell proliferation and differentiation; to explore whether MIF can enhance tumor cell invasion and migration; to examine the ability of MIF in regulation of angiogenesis; to examine the mechanism of MIF in up-regulating oncogene N-myc in neuroblastoma.

Project Title:	Lipopolysaccharide (LPS) potentiates phagocyte clearance of neutrophils undergoing apoptosis
Investigator(s):	Dr. Ren Y., Prof. Savill J.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	01/2003

Abstract:

The project aims at dissecting the role of lipopolysaccharide (LPS) in modulating phagocytosis of apoptotic neutrophils (PMN) by macophage.

Project Title:	Proteomics computational analysis of Severe Acute Respiratory Syndrome
Investigator(s):	Dr. Ren Y., Prof. Fan J.Q., Dr. He Q.Y., Prof. Peiris J.S.M., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	SARS Research Fund
Start Date:	07/2003

Abstract:

To investigate by using proteomics approach, combining Western blotting and ELISA: (a) identification of specific pattern in serum for the diagnosis and prognosis, (b) detection of immune-relevant proteins in SARS, (c) detection of proteins in different stages of SARS patients, (d) proteome analysis of SCV (proteome maps), (e) detection of expression patterns in virus infected cells.

Project Title:	Combined laser capture microdissection and proteomic approaches for the identification of invasiveness and metastasis-specific protein markers in esophageal squamous cell carcinoma
Investigator(s):	Dr. Ren Y., Dr. Law S.Y.K., Prof. Wong J.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To apply LCM to procure esophageal carcinoma cells from primary, invasive and metastatic tumor tissues, respectively, and to define invasive and metastatic - specific and normal-specific protein markers by proteomics. Such studies would greatly facilitate our understanding of invasiveness and metastatic properties of ESCC.

List of Research Outputs

He Q., Ren Y., Tam P.C. and Chiu J., Truncated a1-Antitrypsin as an Infection Biomarker for Severe Acute Respiratory Syndrome (SARS), Abstracts of The American Society for Cell Biology, 43rd Annual Meeting, December 13-17, 2003, San Francisco. 2003, 523a.

Ren Y., Chen Y.X., Li W., Jiang G., Liu Q., Chan H.M. and Tam P.K.H., Expression and function of macrophage migration inhibitory factor in human neuroblastoma, 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, 27-31 March 2004.

Ren Y., Cao B., Li W., Chan G.C.F., Woude G.F.V. and Tam P.K.H., Hepatocyte growth factor enhances angiogenesis and tumor cell migration in human neuroblastoma, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004. 33.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Zhao P., Huang X., Vande Woude G. and Wong J., Hepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A101-A102.

Ren Y., Tang J., Mok T.M.Y., Chan A.W., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48(10): 2888 - 2897.

Ren Y., Tang J.L., Mok T.M.Y., Chan W.K., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48: 2888-97.

Ren Y., Poon R.T.P., Tsui H.T., Chen W.H., Li Z., Lau C., Yu W.C. and Fan S.T., Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis, Clinical Cancer Research. 2003, 9(16 Pt1): 5996-6001.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Ren Y., Li Z., Chan H.M., Lin C.L., Lui V.C.H., Bacher M. and Tam P.K.H., N-MYC induction stimulated by macrophage migration inhibitory factor through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Ren Y., Chan H.M., Li Z., Lin C.L., Nicholls J.M., Chan G.C.F., Lee P.Y., Lui V.C.H., Bacher M. and Tam P.K.H., Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma, Oncogene. UK, Nature Publishing Group, 2004, 23: 4146-4154.

Ren Y., He Q.Y., Fan J.Q., Li Z., Zhou Y., Chan H.M., Bacher M., Haab B., Chiu J.F., Vande Woude G. and Tam P.K.H., cDNA microarray and proteomic analysis of differential gene and protein expression in human neuroblastoma cells induced by macrophage migration inhibitory factor, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Researcher : Saing H

List of Research Outputs

Chu K.M., Patil N.G., Saing H. and Wong J., A level grades and undergraduate academic performance in Hong Kong, British Medical Journal. 2003, (online).

Chu K.M., Patil N.G., Saing H. and Wong J., Female gender is associated with better undergraduate academic performance, British Medical Journal. 2004, (online).

Liu C.L., Saing H., Fan S.T., Lo C.M., Chan K.L., Tam P.K.H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Liu C.L., Fan S.T., Lo C.M., Tam P.K.H., Saing H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, Liver Transplantation. 2003, 9(11): 1185-1190.

Saing H., Associate Editor, Asian Journal of Surgery. 2004.

Saing H., Chairman, Publication Committee (1997 - present), Asian Association of Paediatric Surgeons. 2004.

Saing H., Fellow, American Academy of Pediatrics (FAAP). 2004.

Saing H., Fellow, American College of Surgeons (FACS). 2004.

Saing H., Founding Executive Committee Member, Association of University Surgeons of Asia. 2004.

Saing H., Honorary Consultant Surgeon (1979 - present), The Department of Health, Government of Hong Kong. 2004.

Saing H., Honorary Consultant Surgeon (1979 - present), The Hospital Authority. 2004.

Saing H., Honorary Professor of Paediatric Surgery (1995 - present), Ministry of Health, Government of the Union of Myannmar, Myanmar. 2004.

Saing H., Member of Editorial Board, Hong Kong Journal of Paediatrics. 2004.

Saing H., Member of Editorial Board, Journal of Pediatric Surgery. 2004.

Saing H., Member, Executive Committee, The Society for the Relief of Diabled Children. 2004.

Saing H., Member, Board of Directors, Asian Association of Paediatric Surgeons, Asian Societe Internationale de Chirurgie . 2004.

Saing H., Member, Nominations Committee, Pacific Association of Pediatric Surgeons. 2004.

Saing H., Member, Publications Committee, Pacific Association of Pediatric Surgeons. 2004.

Saing H., President, The Students' Rowing Club, Hong Kong. 2004.

Saing H., Reviewer, Journal of Fetal Diagnosis and Therapy. 2004.

Wong K.K.Y., Chan K.L., Saing H., Fan S.T. and Tam P.K.H., The management of biliary atresia in the era of liver transplantation, Hong Kong Journal of Paediatrics. 2003, 8: 322-326.

van Heurn L.W.E., Saing H. and Tam P.K.H., Portoenterostomy for biliary atresia: long-term survival and prognosis after esophageal variceal bleeding, Journal of Pediatric Surgery. 2004, 39(1): 6-9.

Researcher : Samy ET

List of Research Outputs

Lee K.Y., Samy E.T., Sham M.H., Tam P.K.H. and Lui V.C.H., 3' Splicing variants of ret receptor tyrosine kinase are differentially expressed in mouse embryos and in adult mice, Biochimica Biophysica Acta-Gene Structure Expression. 2003, 1627: 26-38.

Researcher : Siu YT

List of Research Outputs

Tsui T.Y., Siu Y.T., Ho D.W.Y., Lau C.K. and Fan S.T., Carbon monoxide, the natural product of HO activity, protects mice from fulminant hepatic failure (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Su YCF

List of Research Outputs

Su Y.C.F., Hu M.Y., Fan S.T. and Luk J.M.C., Generation and characterization of monoclonal antibodies against hepatocellular carcinoma (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Researcher : Sun KW

List of Research Outputs

Ho J.W.Y., Sun K.W., Zhou L., Poon R.T.P. and Fan S.T., Clinicopathological and prognostic implications of endoglin (CD105) staining in hepatocellular carcinoma and its adjacent liver (Abstract), Hong Kong-Shanghai International Liver Congress, the 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and the 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Ho J.W.Y., Man K., Sun K.W., Zhao Y., Fan S.T. and Poon R.T.P., FTY720, a study of its impact on angiogensis and tumor growth in nude mice bearing hepatocellular carcinoma (Oral Presentation), AACR-NCI-EORTIC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Xu R. and Fan S.T., FTY720 selectively induced human hepatoma cell line apoptosis via Akt dephosphorylation (Abstract) , AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Lee K.W., Man K., Ho J.W.Y., Sun K.W., Ng T.P., Ng I.O.L., Xu R. and Fan S.T., FTY720 selectively induces human hepatoma cell lines apoptosis via Akt dephosphorylation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Li X.L., Man K., Ng T.P., Sun K.W., Lo C.M. and Fan S.T., The dysregulation of P13-Kinase/Akt pathway contributes to the ischemia/reperfusion injury during graft preservation by UW solution (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Man K., Lo C.M., Ng T.P., Zhao Y., Ho J.W.Y., Sun K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed liver tumor growth and metastasis (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Ng T.P., Lo C.M., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed tumor growth and matastasis (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lee K.W., Lo C.M., Sun K.W., Li X.L., Zhao Y., Ho J.W.Y. and Fan S.T., FTY720 attenuates hepatic ischemia-reperfusion injury by Egr-1 down-regulation involving Raf-MEK-Erk pathway and Akt activation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathway (Abstract), Liver Transplantation. 2004, 10(6): C69.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ho J.W.Y., Lee K.W., Zhao Y., Wang X.H., Ng T.P., Sun K.W. and Fan S.T., Marked suppression of tumor growth by FTY720 in rat and mouse liver tumor models (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Man K., Zhao Y., Xu A.M., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus adiponectin combination therapy (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Zhao Y., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus asiponectin combination therapy (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lo C.M., Ho J.W.Y., Zhao Y., Sun K.W., Lee K.W., Li X.L. and Fan S.T., The significance of hepatic ischemia-reperfusion injury on liver tumor development - activation of cell invasion and migration pathways (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Lee K.W., Sun K.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Sun K.W., Dai X.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Researcher : Sun X

List of Research Outputs

Xu R., Sun X., Tse L.Y., Li H., Chan P.C., Xu S., Xiao W., Kung H., Krissansen G.W. and Fan S.T., Long-term expression of angiostatin suppresses metatatic liver cancer in mice (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Tam PC

List of Research Outputs

He Q., Ren Y., Tam P.C. and Chiu J., Truncated a1-Antitrypsin as an Infection Biomarker for Severe Acute Respiratory Syndrome (SARS), Abstracts of The American Society for Cell Biology, 43rd Annual Meeting, December 13-17, 2003, San Francisco. 2003, 523a.

Ho K.L., Chu S.S.M. and Tam P.C., Reduction of strangulated urethral prolapse using local anaesthesia with hyaluronidase, Journal of Urology. 2003, 169: 288.

Ho K.M.T., Shen J., Fung P.C.W., Lee F.C.W. and Tam P.C., Effect of ischemia-reperfusion on nitric oxide production in the pig-bladder (Abstract), European Urology. 2003, No. 1, Supplements 2: 170.

Ling M.T., Wang X., Lee D.T.W., Tam P.C., Tsao G.S.W. and Wong Y.C., Id-1 expression induces androgen-independent prostate cancer call growth through activation of epidermal growth factor receptor (EGF-R), Carcinogenesis. 2004, 25 No. 4: 517-525.

Luk J.M.C., Mok B.W.Y., Shum C.K., Yeung W.S.B., Tam P.C., Tse J.Y.M., Chow J.F.C., Woo J., Kam K. and Lee C.K.F., Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display, Biochemical and Biophysical Research Communications. 2003, 307(4): 782-790.

Shiu S.Y.W., Law I.C., Law K.W., Tam P.C., Yip A.W.C. and Ng W.T., Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT₁ receptor subtype, Journal of Pineal Research. 2003, 35: 177-182.

Tam P.C., An update on erectile dysfunction: new trends and perspectives, New Option to Successful ED Management, organised by Hong Kong Urological Association, Hong Kong, 12 March 2004.

Tam P.C., Chairman (2002 - present), Urology Board, The College of Surgeons of Hong Kong . 2004.

Tam P.C., Contemporary and future of ED management, 14th Biennial Congress of the Asian Surgical Association in conjuction with The College of Surgeons, Academy of Malaysia, Kota Kinabalu, 4-6 December 2003.

Tam P.C., Corresponding Member (1996 - present), American Urological Association. 2004.

Tam P.C., Deputy Secretary General (1996 - present), Asian Surgical Association. 2004.

Tam P.C., Medical therapy of benign prostatic hyperplasia, The Hong Kong Medical Association, Hong Kong, 9 June 2004. 2004.

Tam P.C., Medical treatment of BPH, 14th Biennial Congress of the Asian Surgical Association in conjunction with The College of Surgeons, Academy of Malaysia, Kota Kinabalu, 4-6 December 2003.

Tam P.C., Member (2000 - present), Working Group on Male Sexual and Reproductive Health, The Family Planning Association of Hong Kong. 2004.

Tam P.C., Microsurgical subinguinal varicocelectomy, Symposium on Varicocelectomy, The College of Surgeons of Hong Kong, Hong Kong, 7 July 2003.

Tam P.C., Office evaluation and treatment of erectile dysfunction, Urology Course for General Practitioners, Hong Kong, 27 March 2004. 2004.

Tam P.C., Overview of benign prostatic hyperplasia, Advances in Medicine 2003, The Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, 10 August 2003.

Tam P.C., Radical cystectomy: refining the technique, 2nd Asia-Pacific Society of Uro-Oncology Meeting, Hong Kong, 12 December 2003.

Tam P.C., Varicocele: current concepts in pathophysiology and management, Symposium on Varicocelectomy, The College of Surgeons of Hong Kong, Hong Kong, 7 July 2003.

Tam P.C., Varicocele: current controversies in pathophysiology and treatment, Annals of The College of Surgeons of Hong Kong. 2004, 8: 90-97.

Tam P.C., Vice-Chairman (2003 - present), Specialty Group in Urology Service, Hospital Authority. 2004.

Tse J.Y.M., Wong E.Y.M., Cheung A.N.Y., O W.S., Tam P.C. and Yeung W.S.B., Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility , Biology of Reproduction. 2003, 69: 746-751.

Wong E.Y.M., Tse J.Y.M., Yao K.M., Lui V.C.H., Tam P.C. and Yeung W.S.B., Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein, Biology of Reproduction. 2003, 70: 775-784.

Researcher : Tam PKH

Project Title:	Transgenesis animals as bioreactors: production of a new immunosuppressive protein CTLA4Ig by transgenesis
Investigator(s):	Prof. Tam P.K.H., Prof. Cheah K.S.E., Prof. Dallman M.J., Prof. Sun F.Z., Dr. Wong N.S.
Department:	Surgery
Source(s) of Funding:	Vice-Chancellor's Development Fund
Start Date:	07/1997

Abstract:

The use of transgenic farm animals as bioreactors is a potentially powerful and important new industry for the next century. This application of transgenic technology, in combination with the recent advance in ability to clone animals from adult cells, enhances the potential of transgenic animal bioreactors as major producers of therapeutic proteins. Therefore by initiating research in this area there are immediate and long-term benefits to Hong Kong and China.

Project Title:	Establishing a "train-the-trainers" programme for paediatric surgery in China
Investigator(s):	Prof. Tam P.K.H., Dr. Lin C.L.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	10/1998

Abstract:

To improve the standard of surgical care of children in China through the establishment of a scheme of "train-the-trainers"; to improve our understanding of special paediatric surgical issues relevant to the Chinese population (e.g. disease patterns, transferability of western "advances" to China etc.) through systematic exchanges with major centres in China and hence enhance our ability to deliver better surgical care to children in Hong Kong.

Project Title:	Expanding the "Train-the-Trainers" programme for paediatric surgery in China
Investigator(s):	Prof. Tam P.K.H., Dr. Lin C.L., Prof. Shi C.R., Prof. Wang W.L., Prof. Zhang J.Z.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	10/2000

Abstract:

To improve the standard of surgical care of children in China through the consolidation and expansion of a scheme of "Train-the-Trainers"; to improve our understanding of special paediatric surgical issues relevant to the Chinese population (e.g. disease patterns, transferability of western "advances" to China etc) through systematic exchanges with major centres in China and hence enhance our ability to deliver better surgical care to children in Hong Kong; to promote modern concepts of medical education among leaders of the new generation of doctors through the introduction of structured training, problem-based learning, life-long learning, and the use of evidence-based medicine and information technology.

Project Title:	OX40/OX40L-costimulatory pathway in transplantation rejection and tolerance induction
Investigator(s):	Prof. Tam P.K.H., Prof. Dallman M.J., Dr. Tian L.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2001

Abstract:

To investigate the immunological role of OX40/OX40L in transplantation rejection in vitro, and in vivo using rat cardiac and intestinal allograft models; to explore the posibility of inducing donor specific tolerance by a combination approach of donor specific transfusion, OX40/OX40l pathway interruption and rapamycin administration; to compare the effects of OX40/OXL costimulatory blockade against CD28 costimulatory inhibition in transplanation models.

Project Title:	Sonic hedgehog signalling in chronic allograft rejection
Investigator(s):	Prof. Tam P.K.H., Prof. Dallman M.J., Prof. Lamb J.R., Dr. Tian L.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2002

Abstract:

To investigates the role of Notch, Sonic hedgehog (Shh) signalling in acute and chronic graft rejection in a rat model of small bowel transplantation; to study if the blockade of Shh signalling alone or in conjunction with the use of TFG-b inhibitors can ameliorate chronic rejection.

Project Title:	The role of T regulatory cell in the long-term survival of orthotopic small bowel allograft
Investigator(s):	Prof. Tam P.K.H., Prof. Dallman M.J., Prof. Lamb J.R., Dr. Tian L.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To determine the role of T reg cells in the long-term survival of small bowel allografts mediated by selected treatment with FK506.

Project Title:	Improving the survival and quality of life of children with cancers in China
Investigator(s):	Prof. Tam P.K.H., Dr. Chan G.C.F., Prof. Li Z.Z., Dr. Lin C.L., Dr. Ren Y., Prof. Shi C.R., Prof. Wang W.L., Dr. Wong I.H.N., Prof. Zhang J.Z.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	10/2003

Abstract:

To improve the survival and quality of life of poor and sick children suffering from cancer through the establishment of a Chinese Children Cancer Consortium which will be responsible for the introduction and implementation of modern, comprehensive management protocols, and for training and educating health care workers around the country to adopt the new standard of cares for children with cancer.

Project Title:	The study of co-stimulatory function of sonic hedgehog in CD⁴⁺ lymphocytes
Investigator(s):	Prof. Tam P.K.H., Dr. Chan V.S.F., Prof. Lamb J.R.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To study the distribution of Shh and its receptors on the surface of T cells during T cell activation; to study the effect of Shh on TH1 and TH2 cell differentiation; to identify the downstream targets of Shh signaling pathway in CD⁴⁺ T lymphocytes.

List of Research Outputs

Cai K., Sham M.H., Tam P.K.H., Lam W.K. and Xu R., Lung cancer gene therapy, Gene Therapy and Molecular Biology. 2003, 7: 245-262.

Chan K.K., Chen A.Y.S., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric ganglia development in transgenic mice with ectopic expression of mutant Sox10 in the vagal neural crest. , The 4th International Meeting on Hirschprung Disease and Related Neurocristopathies HSCR, April 2004, Genova italy. 2004.

Chan K.K., Chen Y.S., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric ganglia development in transgenic mice with ectopic expression of mutant Sox10 in the vagal neural crest, 4th Hirschsprung Disease and Related Neurocristopathics, Genoa, Italy, 22-24 April 2004.

Chan K.K., Wong C.K.Y., Lui V.C.H., Tam P.K.H. and Sham M.H., Analysis of SOX10 mutations identified in Waardenburg-Hirschsprung patients: differential effects on target gene regulation, Journal of Cellular Biochemistry. 2003, 90(3): 573-585.

Chan K.L., Ng S.P., Chan K.W., Wo Y.H. and Tam P.K.H., Pathogenesis of neonatal necrotizing enterocolitis: a study of the role of intraluminal pressure, age and bacterial concentration, Pediatric Surgery International. 2003, 19(8): 573-577.

Chan K.L., Hui T.W.C. and Tam P.K.H., Prospective randomized, single-blinded comparison of laparoscopic versus open repair of pediatric inguinal hernia, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Chan K.L. and Tam P.K.H., Technical refinements in laparoscopic repair of childhood inguinal hernias, Surgical Endoscopy. 2004, 18(6): 957-960.

Chan K.Y.K., Song Y., Mak W., Cheung A.N.Y., Peiris J.S.M., Yip S.P., Tin V., Liu W., Xue W.C., Chan L.C., Tam P.K.H., Ngan H.Y.S. and Khoo U.S., Polymorphisms of the ACE2 and CD13 (ANPEP) genes, and susceptibility to SARS coronavirus infection in Chinese from Hong Kong., The Human Genome organisation Meeting, April 2004, Berlin, Germany. 2004, Abstract No. 159.

Chen Y., Lui V.C.H. and Tam P.K.H., Resident macrophages are key players in ischeamia reperfusion injury in gut, 50th Annual International Congress of the British Association of Paediatric Surgeons, Estorial, Portugal, 15-18 July 2003.

Chung P.Y., Chen Y., Chan V.S.F., Tam P.K.H. and Lin C.L., Dendritic cells: sentinels against pathogens, Histology and Histopathology. 2004, 19(1): 317-324.

Facer P., Tam P.K.H., Chen M.X., Knowles C.H., Chan C.L.H., Plumpton C., Tate S.N., Bountra C., Williams N.S. and Anand P., Decreased calcium-activated potassium channel IK1-immunoreactivity in Hirschsprung's disease, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Fan J.Q., Tam P.K.H., Vande Woude G.F. and Ren J., Normalization and analysis of cDNA microarrays using within-array replications applied to neuroblastoma cell response to a cytokine, Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2004, 101(5): 1135-1140.

Fu M., Tam P.K.H., Sham M.H. and Lui V.C.H., Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study, Anatomy and Embryology. 2004, 208(1): 33-41.

Fu M., Lui V.C.H., Sham M.H., Cheung A.N.Y. and Tam P.K.H., HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts, Developmental Dynamics. 2003, 228(1): 1-10.

Ganster R.W., Lau M.F., Neoh K.H.A. and Tam P.K.H., NF-kB, Stat1, and Stat3 are over-expressed in papillary thyroid carcinoma: identification of molecular switches which dys-regulate gene transcription causing thyroid cancer, 95th Annual Meeting of American Association for Cancer Research, Florida, U.S.A., 27-31 March 2004.

Garcia-Barcelo M.M., Sham M.H., Lui V.C.H., Chen B.L.S., Song Y., Lee W.S., Yung S.K., Romeo G. and Tam P.K.H., Chinese patients with sporadic Hirschsprung’s disease are predominantly represented by a single RET haplotype. , Journal of Medical Genetics. 2003, 40(11): e122.

Garcia-Barcelo M.M., Sham M.H., Lee W.S., Lui V.C.H., Chen B.L.S., Wong K.K.Y., Wong J.S.W. and Tam P.K.H., Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease, Clinical Chemistry. 2004, 50(1): 93-100.

Garcia-Barcelo M.M., Lui V.C.H., Sham M.H. and Tam P.K.H., Is there a role for Hedgehog genes in Hirschsprung's diseases?, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May, 2004.

Garcia-Barcelo M.M., Lee W.S., Sham M.H., Lui V.C.H. and Tam P.K.H., Is there a role for the IHH gene in Hirschsprung's disease?, Neurogastroenterology and Motility. 2003, 15(6): 663-668.

Lan L.C.L., Wong K.K.Y., Lin S.C.L., Sprigg A., Clarke S., Johnson P.R.V. and Tam P.K.H., Endoscopic balloon dilatation of esophageal strictures in infants and children: 17 years' experience and a literature review, Journal of Pediatric Surgery. 2003, 38(12): 1712-1715.

Lau M.F., Neoh K.H.A., Tam P.K.H. and Ganster R.W., Regulation of gene transcription by NF-kB and Stats downstream of the Ret receptor tyrosine kinase in thyroid cancer and Hirschsprung's disease, 95th Annual Meeting of American Association for Cancer Research, Florida, U.S.A., 27-31 March 2004.

Lee K.Y., Samy E.T., Sham M.H., Tam P.K.H. and Lui V.C.H., 3' Splicing variants of ret receptor tyrosine kinase are differentially expressed in mouse embryos and in adult mice, Biochimica Biophysica Acta-Gene Structure Expression. 2003, 1627: 26-38.

Lee K.Y., Lui V.C.H. and Tam P.K.H., Differential expression of RET isoforms in neural crest derived tissues during development, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Lin C.L., Khong P.L. and Tam P.K.H., Double intestinal atresia in imperforate anus: a diagnostic conundrum for paediatric surgeons, Asian Journal of Surgery. 2004, 27(1): 52-53.

Lin C.L., Wong K.K.Y., Lan L.C.L., Chen C.C. and Tam P.K.H., Earlier appearance and higher incidence of the rectoanal relaxation reflex in patients with imperforate anus repaired with laparoscopically assisted anorectoplasty, Surgical Endoscopy. 2003, 17(10): 1646-1649.

Liu C.L., Saing H., Fan S.T., Lo C.M., Chan K.L., Tam P.K.H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Liu C.L., Fan S.T., Lo C.M., Tam P.K.H., Saing H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, Liver Transplantation. 2003, 9(11): 1185-1190.

Lo C.Y., Chan W.F., Lo C.M., Fan S.T. and Tam P.K.H., Surgical treatment of pancreatic insulinomas in the era of laparoscopy, Surgical Endoscopy. 2004, 18(2): 297-302.

Lui V.C.H., Fu M., Sham M.H., Pachnis V. and Tam P.K.H., Sonic hedgehog (SHH) regulates the proliferation, migration and differentiation of enteric neural crest stem cells (NCSCS) in gastrointestinal tract, 4th Hirschsprung Disease and Related Neurocristopathies, Genoa, Italy, 22-24 April 2004.

Ren Y., Chen Y.X., Li W., Jiang G., Liu Q., Chan H.M. and Tam P.K.H., Expression and function of macrophage migration inhibitory factor in human neuroblastoma, 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, 27-31 March 2004.

Ren Y., Cao B., Li W., Chan G.C.F., Woude G.F.V. and Tam P.K.H., Hepatocyte growth factor enhances angiogenesis and tumor cell migration in human neuroblastoma, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004. 33.

Ren Y., Li Z., Chan H.M., Lin C.L., Lui V.C.H., Bacher M. and Tam P.K.H., N-MYC induction stimulated by macrophage migration inhibitory factor through mitogen-activated protein kinase signaling pathway in human neuroblastoma cells, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Ren Y., Chan H.M., Li Z., Lin C.L., Nicholls J.M., Chan G.C.F., Lee P.Y., Lui V.C.H., Bacher M. and Tam P.K.H., Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma, Oncogene. UK, Nature Publishing Group, 2004, 23: 4146-4154.

Ren Y., He Q.Y., Fan J.Q., Li Z., Zhou Y., Chan H.M., Bacher M., Haab B., Chiu J.F., Vande Woude G. and Tam P.K.H., cDNA microarray and proteomic analysis of differential gene and protein expression in human neuroblastoma cells induced by macrophage migration inhibitory factor, The 50th Annual Congress of the British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003.

Tam P.K.H., Advisor/Reviewer (1999 - present), Quality Education Fund Projects. 2004.

Tam P.K.H., Chairperson: Metallic Stents: Where do we stand?, 10th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 2-3 August 2003. 2003.

Tam P.K.H., Chairperson: Migut and Abdomen, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004. 2004.

Tam P.K.H., Chairperson: Mrs. Esther FC Wu Travelling Scholarship, 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004. 2004.

Tam P.K.H., Chairperson: NEC session, 50th Annual Congress of British Association of Paediatric Surgeons, Estoril, Portugal, 15-18 July 2003. 2003.

Tam P.K.H., Chairperson: Report from FACS Younger Fellows Forum, 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004. 2004.

Tam P.K.H., Chief (1996 - present), Division of Paediatric Surgery, Queen Mary Hospital. 2004.

Tam P.K.H., Chief of Service (Paediatric Surgery) (1996 - present), Duchess of Kent Children's Hospital. 2004.

Tam P.K.H., Council Member (2000 - present), College of Surgeons of Hong Kong. 2004.

Tam P.K.H., Editorial Consultant (2002 - present), Journal of Pediatric Surgery. 2004.

Tam P.K.H., Examiner (1995 - present), Intercollegiate Specialty Board in Paediatric Surgery, U.K.. 2004.

Tam P.K.H., Examiner in Fellowship, General Surgery (1990- present), Royal College of Surgeons, Edinburgh, U.K.. 2004.

Tam P.K.H., Examiner, Diploma in Child Health (1995 - present), Royal College of Physicians, U.K.. 2004.

Tam P.K.H., Foundation Vice-President (1999 - present), Hong Kong Society of Paediatric Gastroenterology, Hepatology and Nutrition. 2004.

Tam P.K.H., Genetics and genomics: relevance to surgeons in Hong Kong, 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Tam P.K.H., Grant Reviewer, Academy of Medical Sciences, United Kingdom. 2004.

Tam P.K.H., Grant Reviewer, Action Research, United Kingdom. 2004.

Tam P.K.H., Grant Reviewer, New Zealand Research Council. 2004.

Tam P.K.H., Grant Reviewer, Research Grants Council, Hong Kong. 2004.

Tam P.K.H., Grant Reviewer, Royal College of Surgeons of England, United Kingdom. 2004.

Tam P.K.H., Grant Reviewer, The Wellcome Trust, United Kingdom. 2004.

Tam P.K.H., HKU representative at Research Grants Council Meeting 1998 Member (1998 - 2003/9), Research Committee, Queen Mary Hospital. 2004.

Tam P.K.H., Honorary Advisor & Board Member (2001 - present), Chinese Medical Association - China Society of Pediatric Surgery . 2004.

Tam P.K.H., Honorary Consultant (1998 - present), Queen Mary Hospital. 2004.

Tam P.K.H., Honorary Consultant (1999 - present), Kwong Wah Hospital. 2004.

Tam P.K.H., Implications of antenatal diagnosis of small-intestinal atresia, World Congress of Pediatric Surgery, Zagreb, Coroatia, 22-27 June, 2004.

Tam P.K.H., International Advisor (1997 - present), Annals of the Faculty of Medicine, Federal University of Pernambuco, Brazil. 2004.

Tam P.K.H., Laparoscopic surgery for Hirschsprung's disease and anorectal anomaly, 14th Biennial Congress of the Asian Surgical Association, Kota Kinabalu, Sabah, Malaysia, 4-6 December 2003.

Tam P.K.H., Management of biliary atresia in the era of liver transplantation., 6th Congress of China Society of Pediatric Surgeons, Changsha, China, 25-28 November 2003.

Tam P.K.H., Management of liver tumours, 14th Biennial Congress of the Asian Surgical Association, Kota Kinabalu, Sabah, Malaysia, 4-6 December 2003.

Tam P.K.H., Member (2000 - present), Research Grants Council (RGC) Biology and Medicine Panel, University Grants Committee. 2004.

Tam P.K.H., Member of Editorial Advisory Board (2002 - present), Lippincott Williams & Wilkins. 2004.

Tam P.K.H., Member of Editorial Board (1997 - present), Pediatric Surgery International. 2004.

Tam P.K.H., Member, Board of Directors (2004-present), Pacific Association of Pediatric Surgeons. 2004.

Tam P.K.H., Member, Board of Paediatric Surgery (1998 - present), College of Surgeons of Hong Kong. 2004.

Tam P.K.H., Member, Co-ordinating Committee in Surgery (1996 - present), Hospital Authority. 2004.

Tam P.K.H., Member, Executive Committee (2004-present), World Federation of Association of Pediatric Surgeons. 2004.

Tam P.K.H., Member, Expert Panel in Surgery Specialty (March 2004 - July 2006), Hospital Authority. 2004.

Tam P.K.H., Member, Nominating Committee (2000 - present), Pacific Association of Pediatric Surgeons . 2004.

Tam P.K.H., Member, Publication Committee (2001 - present), Pacific Association of Pediatric Surgeons. 2004.

Tam P.K.H., Opportunities at the Crossroads of East and West, Nature 2004 China-California Forum: A Biomedical Alliance, San Diego, U.S.A., 30 March 2004.

Tam P.K.H., Overseas Council Member (1999 - present), British Association of Paediatric Surgeons, U.K.. 2004.

Tam P.K.H., PHOX2 B as candidate gene for Hirschsprung disease, 4th Hirschsprung Disease ad Related Neurocristopathics, Genoa, Italy, 22-24 April 2004.

Tam P.K.H., Program Director for Higher Training in Paediatric Surgery, Hospital Authority. 2003.

Tam P.K.H., Quandom Fellow (1996 - present), Lincoln College, University of Oxford, U.K.. 2004.

Tam P.K.H., RET haplotype in Chinese Hirschsprung patients, 4th Hirschsprung Disease and Related Neurocristopathics, Genoa, Italy, 22-24 April 2004.

Tam P.K.H., Reviewer, Annals of Royal College of Surgeons of England. 2004.

Tam P.K.H., Reviewer, Annals of Surgery. 2004.

Tam P.K.H., Reviewer, Archives of Disease in Childhood. 2004.

Tam P.K.H., Reviewer, Asian Journal of Surgery. 2004.

Tam P.K.H., Reviewer, British Journal of Surgery. 2004.

Tam P.K.H., Reviewer, Digestive and Liver Disease. 2004.

Tam P.K.H., Reviewer, International Archives of Allergy and Immunology. 2004.

Tam P.K.H., Reviewer, Journal of Medical Genetics. 2004.

Tam P.K.H., Reviewer, Journal of Pediatric Gastroenterology and Nutrition. 2004.

Tam P.K.H., Reviewer, Journal of Pediatric Surgery. 2004.

Tam P.K.H., Reviewer, Lancet. 2004.

Tam P.K.H., Reviewer, Pediatric Surgery International. 2004.

Tam P.K.H., Reviewer, Surgery. 2004.

Tam P.K.H., Reviewer, Thorax. 2004.

Tam P.K.H., Reviewer, Transplantation. 2004.

Tam P.K.H., Reviewer, World Journal of Surgery. 2004.

Tam P.K.H., Spokesperson in Paediatric Surgery (1998 - present), Hong Kong Paediatric Society. 2004.

Tam P.K.H., The International HapMap Consortium. The International HapMap Project, Nature. 2003, 426: 18-25.

Tian L., Lu L., Yuan Z.W., Lam J.R. and Tam P.K.H., Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery, Transplantation. 2004, 77(2): 183-189.

Tian L., Yuan Z.W., Li X.S., Huang F., Lamb J.R., Dallman M. and Tam P.K.H., Orthotopic small bowel but not heterotopic cardiac allograft recipients treated with an unique FK506 regimen contributes to the induction of regulatory T cells, Basic Sciences Symposium 2003: Transplantation Immunology in the Real World, Colorado, U.S.A, 14-17 September 2003.

Tian L., Li X.S., Yuan Z.W., Huang F.P., Lamb J.R., Dallman J. and Tam P.K.H., Regulatory T cells can be induced in orthotopic small bowel but not in cardiac allograft recipients treated with an unique FK506 regimen resulting in long-term survival of small bowel allograft, VIII International Small Bowel Transplant Symposium, Bal Harbour, Florida, U.S.A, 10-13 September 2003.

Tian L., Li X.S. and Tam P.K.H., Sequential FK506 pre-treatment and rapamycin post-transplantation regimen eliminates acute rejection and reduces chronic rejection in rat small bowel transplantation, VIII International Small Bowel Transplant Symposium, Bal Harbour, Florida, U.S.A., 10-13 September 2003.

Tian L., Li X. and Tam P.K.H., Targeting both acute and chronic rejection: a regimen that ensures hundred percent permanent survival of orthotopic small bowel allograft in rat, Basic Sciences Symposium 2003: Transplantation Immunology in the Real World, Colorado, USA, 14-17 September 2003.

Wong I.H.N., Chan J.K.Y., Wong J.S.W. and Tam P.K.H., Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May, 2004. 43.

Wong I.H.N., Chan J., Wong J. and Tam P.K.H., Ubiquitous aberrant RASSFIA promoter methylation in childhood neoplasia, Clinical Cancer Research. 2004, 10(3): 994-1002.

Wong K.K.Y., Fan A., Lan L., Lin C.L. and Tam P.K.H., Effective antibiotic regime for post-operative acute cholangitis in biliary atresia: an evolving scene, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May, 2004. 46.

Wong K.K.Y. and Tam P.K.H., Electronic prescribing is helpful in children too, British Medical Journal. 2004, 328: 1566.

Wong K.K.Y., Khong P.L., Lin S.C.L., Lam W.W.M., Lan L.C.L. and Tam P.K.H., Post-operative magnetic resonance evaluation of children after laparoscopic rectoanoplasty for imperforate anus, BAPS Congress, Estorial, Portugal 15-18 July 2003.

Wong K.K.Y., Fan A., Lan L.C.L., Lin C.L. and Tam P.K.H., The impact of computerized prescription on medication incidence rate: experience of a single centre, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Korea, 16-20 May, 2004.

Wong K.K.Y., Chan K.L., Saing H., Fan S.T. and Tam P.K.H., The management of biliary atresia in the era of liver transplantation, Hong Kong Journal of Paediatrics. 2003, 8: 322-326.

Wong K.K.Y., Lan L., Chan G., Lin C.L. and Tam P.K.H., The use of positron emission tomography in detecting hepatoblastoma recurrence: a cautionary tale, 37th Annual Meeting of the Pacific Association of Pediatric Surgoens, Seoul, Korea, 16-20 May 2004. 31.

Wong S.W., Wong K.K.Y., Lin C.L. and Tam P.K.H., Recent advances on the surgical management of common paediatric gastrointestinal diseases, Hong Kong Journal of Paediatrics. 2004, 9(2): 133-137.

Yip P.K.F., Tam P.K.H. and Li M.K.W., Transinguinal laparoscopy at ultra-low pressure: ideal complement of ambulatory hernia surgery in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Yuan Z.W., Lui V.C.H. and Tam P.K.H., Deficient motor innervation of the sphincter mechanism in fetal rats with anorectal malformation: a quantitative study by fluorogold retrograde tracing, Journal of Pediatric Surgery. 2003, 38(9): 1383-1388.

van Heurn L.W.E., Saing H. and Tam P.K.H., Portoenterostomy for biliary atresia: long-term survival and prognosis after esophageal variceal bleeding, Journal of Pediatric Surgery. 2004, 39(1): 6-9.

Researcher : Tang A

List of Research Outputs

Poon R.T.P., Yeung C., Liu C.L., Lam C.M., Yuen W.K., Lo C.M., Tang A. and Fan S.T., Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial, Gut. 2003, 52(12): 1768-1773.

Researcher : Tang TCM

List of Research Outputs

Tang T.C.M., Poon R.T.P., Guan X.Y. and Fan S.T., The effect of cyclooxygenase-2 (COX-2) inhibitor, Celecoxib, on xenograft of hepatocellular carcinoma (HCC) in nude mice (Oral Presentation), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Tang T.C.M., Poon R.T.P., Guan X.Y. and Fan S.T., The effects of cyclooxygenase-2, Celecoxib, on xenografts of hepatocellular carcinoma in nude mice (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Yang Z., Tsui T.Y., Ho D.W.Y., Tang T.C.M. and Fan S.T., Heme oxygenase-1 potentiates the survival of small-for-size liver graft, Liver Transplantation. 2004, 10(6): 784-793.

Researcher : Tian L

Project Title:	The study of gene expression pattern in chronic rejection and the mechanism of drug action in the sequential treatment regimen resulting in long-term allograft survival in small bowel transplantation in rat
Investigator(s):	Dr. Tian L., Prof. Lamb J.R., Prof. Tam P.K.H.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To explore the global gene expression patterns of the intra-graft and CD4+ cells in the animals treated with FK506 alone or in combination with Rapa; to identify the novel genes that highly regulated by this treatment.

List of Research Outputs

Tian L., Lu L., Yuan Z.W., Lam J.R. and Tam P.K.H., Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery, Transplantation. 2004, 77(2): 183-189.

Tian L., Yuan Z.W., Li X.S., Huang F., Lamb J.R., Dallman M. and Tam P.K.H., Orthotopic small bowel but not heterotopic cardiac allograft recipients treated with an unique FK506 regimen contributes to the induction of regulatory T cells, Basic Sciences Symposium 2003: Transplantation Immunology in the Real World, Colorado, U.S.A, 14-17 September 2003.

Tian L., Li X.S., Yuan Z.W., Huang F.P., Lamb J.R., Dallman J. and Tam P.K.H., Regulatory T cells can be induced in orthotopic small bowel but not in cardiac allograft recipients treated with an unique FK506 regimen resulting in long-term survival of small bowel allograft, VIII International Small Bowel Transplant Symposium, Bal Harbour, Florida, U.S.A, 10-13 September 2003.

Tian L., Li X.S. and Tam P.K.H., Sequential FK506 pre-treatment and rapamycin post-transplantation regimen eliminates acute rejection and reduces chronic rejection in rat small bowel transplantation, VIII International Small Bowel Transplant Symposium, Bal Harbour, Florida, U.S.A., 10-13 September 2003.

Tian L., Li X. and Tam P.K.H., Targeting both acute and chronic rejection: a regimen that ensures hundred percent permanent survival of orthotopic small bowel allograft in rat, Basic Sciences Symposium 2003: Transplantation Immunology in the Real World, Colorado, USA, 14-17 September 2003.

Researcher : Ting ACW

List of Research Outputs

Cheng S.W.K., Ting A.C.W., Ho P. and Wong Wu L.H., Accelerated progression of carotid stenosis in patients with previous external neck irradiation, Journal of Vascular Surgery. 2004, 39 (2): 409-415.

Cheng S.W.K., Ting A.C.W. and Ho P., Angioplasty and primary stenting of high-grade, long-segment superficial femoral artery disease: is it worthwhile?, Annals of Vascular Surgery. 2003, 17(4): 430-437.

Ho P., Law W.L., Tung P.H.M., Poon J.T.C., Ting A.C.W. and Cheng S.W.K., Laparoscopic transperitoneal clipping of the inferior mesenteric artery for the management of type II endoleak after endovascular repair of an aneurysm (Case report), Surgical Endoscopy. 2004, 18(5): 870.

Ting A.C.W., Cheng S.W.K., Yeung K.M., Cheng P.W., Lui W.M., Ho P. and Tso H.W.K., Carotid stenting for radiation-induced extracranial carotid artery occlusive disease: efficacy and midterm outcomes, Journal of Endovascular Therapy. 2004, 11(1): 53-59.

Ting A.C.W., Au Yeung K.M., Cheng P.W., Lui W.M., Ho P., Poon J.T.C., Tso W.K. and Cheng S.W.K., Carotid stenting for radiation-induced extracranial carotid artery occlusive disease: long-term results, 17th International Congress on Endovascular Interventions (Arizona Heart Institute), The Phoenician, Scottsdale, Arizona, U.S.A., 8-12 February 2004.

Ting A.C.W., Cheng S.W.K., Ho P., Wu L.L.H. and Cheung G.C.Y., Clinical outcomes and changes in venous hemodynamics after subfascial endoscopic perforating vein surgery, International Union of Angiology - Asian Chapter Congress, Hong Kong, 25-26 November 2003.

Ting A.C.W., Cheng S.W.K., Ho P., Wu L.L. and Cheung G.C.Y., Clinical outcomes and changes in venous hemodynamics after subfascial endoscopic perforating vein surgery, Surgical Endoscopy. 2003, 17(8): 1314-1318.

Ting A.C.W., Cheng S.W.K., Ho P. and Poon J.T.C., Endovascular repair for multiple Salmonella mycotic aneurysms of the thoracic aorta presenting with Cardiovocal syndrome, European Journal of Cardiothoracic Surgery. 2004, 26(1): 221-224.

Ting A.C.W., Cheng S.W.K., Ho P., Poon J.T.C. and Tsu J.H.L., Surgical treatment of infected aneurysms of the thoracic and abdominal aorta, International Union of Angiology - Asian Chapter Congress, Hong Kong, 25-26 November 2003.

Researcher : To JYT

List of Research Outputs

Li G.R., Sun H., To J.Y.T., Tse H.F. and Lau C.P., Demonstration of calcium-activated transient outward chloride current and delayed rectifier potassium currents in Swine atrial myocytes, Journal of Molecular and Cellular Cardiology . 2004, 36: 495-504.

Yang Z., Poon R.T.P., To J.Y.T., Ho D.W.Y. and Fan S.T., The potential role of hypoxia inducible factor 1a in tumour progression after hypoxia and chemotherapy in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Toi M

List of Research Outputs

Chow L.W.C., Toi M. and Takebayashi Y., Neoadjuvant use of 5-fluoroue/racil, epirubicin and cyclophosphamide with and without celecoxib for locally advanced breast cancer: a phase II study correlating response to celecoxib with high levels of COX-2 gene expression in the tumor, 40th Annual Meeting, American Society of Clinical Oncology, New Orleans, June 2004.

Researcher : Tong CSW

List of Research Outputs

Ho J.W.Y., Poon R.T.P., Tong C.S.W. and Fan S.T., Clinical significance of serum vascular cell adhesion molecule-1 levels in patients with hepatocellular carcinoma, World Journal of Gastroenterology. 2004, 10(14): 2014-2018.

Liu Y., Li Q.Y., Poon R.T.P., Shao W.B., Tong C.S.W. and Fan S.T., Blockage of vascular endothelial growth factor receptor in antitumour effect of hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Poon R.T.P., Chung K.K., Cheung S.T., Lau C., Tong C.S.W., Leung K.L., Yu W.C., Tuszynski G.P. and Fan S.T., Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 Pt1): 4150-4157.

Researcher : Tso HWK

List of Research Outputs

Ting A.C.W., Cheng S.W.K., Yeung K.M., Cheng P.W., Lui W.M., Ho P. and Tso H.W.K., Carotid stenting for radiation-induced extracranial carotid artery occlusive disease: efficacy and midterm outcomes, Journal of Endovascular Therapy. 2004, 11(1): 53-59.

Researcher : Tsui HT

List of Research Outputs

Li X.L., Man K., Liu Y.F., Lee K.W., Tsui H.T., Lau C.K., Lo C.M. and Fan S.T., Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation, Transplantation. 2003, 76(1): 44-49.

Ren Y., Poon R.T.P., Tsui H.T., Chen W.H., Li Z., Lau C., Yu W.C. and Fan S.T., Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis, Clinical Cancer Research. 2003, 9(16 Pt1): 5996-6001.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Researcher : Tsui TY

Project Title:	Identification possible role of heme oxygenase-1 on the regulation of T cell activation
Investigator(s):	Dr. Tsui T.Y., Prof. Bach F.H.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To identify the possible role of HO-1 in the process of T cell activation. The findings obtained from this study might be essential in the establishment of the link between cellular defense system and the T cell immunity. HO-1 and its products could be used as novel therapeutic agents to control the disorders of T cell immunity in the future.

List of Research Outputs

Soares M.P., Seldon M.P., Gregoire I.P., Vassilevskaia T., Berberat P.O., Yu J., Tsui T.Y. and Bach F.H., Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation, Journal of Immunology. 2004, 172(6): 3553-3563.

Tsui T.Y., Siu Y.T., Ho D.W.Y., Lau C.K. and Fan S.T., Carbon monoxide, the natural product of HO activity, protects mice from fulminant hepatic failure (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Yamashita K., McDaid J., Ollinger R., Tsui T.Y., Berberat P.O., Usheva A., Csizmadia E., Smith R.N., Soares M.P. and Bach F.H.B., Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts, FASEB Journal. 2004, 18(6): 765-767.

Yang Z., Tsui T.Y., Ho D.W.Y., Tang T.C.M. and Fan S.T., Heme oxygenase-1 potentiates the survival of small-for-size liver graft, Liver Transplantation. 2004, 10(6): 784-793.

Researcher : Tuen HHL

List of Research Outputs

Wei W.I., Tuen H.H.L., Ng W.M. and Lam L.K., Safe tracheostomy for patients with severe acute respiratory syndrome, The Laryngoscope. 2003, 113(10): 1777-1779.

Researcher : Vande Woude GF

List of Research Outputs

Fan J.Q., Tam P.K.H., Vande Woude G.F. and Ren J., Normalization and analysis of cDNA microarrays using within-array replications applied to neuroblastoma cell response to a cytokine, Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2004, 101(5): 1135-1140.

Researcher : Wang P

List of Research Outputs

Wang P., Wang J.H., Yang Z.P. and Luk J.M.C., Hepatocyte-like phenotypes of bone marrow stromal cells in vitro after hepatocytes growth factor induction and intraportal transplantation in cirrhotic liver (Abstract), The 90th Scientific Assembly and Annual Meeting, Chicago, U.S.A., 28 November - 3 December 2003.

Researcher : Wang X

List of Research Outputs

Wang X., AFLAC Travel Awards, ATR dependent activation of Chk2 and Chk1 (Abstract), American Association of Cancer Research, U.S.A.. 2003.

Wang X., Luk J.M.C. and Fan S.T., Characterization of LI-cadherin mutation in HCC (Oral Presentation), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang X., Wong W.Y., Leung P.L., Leung P.L., Leung P.L., Fan S.T. and Luk J.M.C., Molecular characterization of LI-cardherin mutations in hepatocellular carcinoma (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wang X., Young Investigator Award, Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004. 2004.

Researcher : Wang Y

List of Research Outputs

Wang Y., Luk J.M.C., Ikeda K., Man K., Chu A.C.Y., Kaneda K. and Fan S.T., Regulatory role of vHL/HIF-1a in hypoxia-induced VEGF production in hepatic stellate cells, Biochemical and Biophysical Research Communications. 2004, 317(2): 358-362.

Yang Z., Ho D.W.Y., Chu A.C.Y., Wang Y. and Fan S.T., Linking inflammation to acute rejection in small-for-size allografts: the potential role of early macrophage activation, American Journal of Transplantation. 2004, 4(2): 196-209.

Researcher : Wei WI

Project Title:	Speech rehabilitation after total laryngectomy - self help and mutual help
Investigator(s):	Prof. Wei W.I., Miss Ho M.L., Miss Kwok I.C.L., Mr. Ng H.S.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	09/2001
Completion Date:	09/2003

Abstract:

To visit the hospitals and centres in China where total laryngectomy is performed for patients suffering from cancer of the larynx. During the visit, the members will introduce to patients the various methods of speech rehabilitation and to show how patients can help each other during the convalescent period.

Project Title:	Head and neck course in China - to teach technique of contemporary operations and patient care for doctors and nurses working in underdeveloped areas in China
Investigator(s):	Prof. Wei W.I., Dr. Hui Y., Dr. Lam L.K.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	12/2001
Completion Date:	11/2003

Abstract:

To teach head and neck surgeons in China the current methods of managing patients suffering from head and neck cancer and also to introduce the concept of contemporary nursing care for these patients.

Project Title:	Efficacy of anti-snoring therapy in different ethnic group
Investigator(s):	Prof. Wei W.I., Prof. Hormann K.
Department:	Surgery
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2003

Abstract:

To identify the differences in the perception of snoring between caucasians and orientals; to identify the variations in anatomical structures leading to snoring and the social effects of snoring between 2 races; to evaluate the efficacy of anti-snoring therapy in the 2 races.

Project Title:	Immunity status against coronavirus among health care personnels working in a moderately high risk environment
Investigator(s):	Prof. Wei W.I.
Department:	Surgery
Source(s) of Funding:	SARS Research Fund
Start Date:	07/2003
Completion Date:	12/2003

Abstract:

To evaluate the antibody titre against coronavirus in health care personnels, working in a moderately risk area such as Queen Mary Hospital; to see if the antibody titre changes in 6 weeks.

Project Title:	Head and neck course in China - to teach techniques of contemporary operations and patient care for doctors and nurses working in underdeveloped areas in China. This will benefit those poor patients suffereing from head and neck cancer in China
Investigator(s):	Prof. Wei W.I., Dr. Fong W.W.Y., Dr. Hui Y., Dr. Lam L.K., Miss Lo E.L.C., Dr. Ng W.M., Dr. Yue S.W.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	10/2003

Abstract:

To teach head and neck surgeons in China the contemporary methods of managing patients suffering from head and neck cancer and also to introduce the concept of optimal nursing care for these patients.

Project Title:	Speech rehabilitation after total laryngectomy - self help and mutual help
Investigator(s):	Prof. Wei W.I., Miss Ho M.L., Dr. Ho W.K., Miss Kwok I.C.L., Mr. Ng H.S.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	10/2003

Abstract:

To visit the hospitals and centres in China where total laryngectomy is performed for patients suffering from cancer of the larynx.

Project Title:	Cochlear implant for 14 profoundly deaf children in China
Investigator(s):	Prof. Wei W.I., Dr. Au D.K.K., Dr. Hui Y.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	10/2003

Abstract:

To help Chinese children who are profoundly deaf in China to receive the cochlear implant, so that they will be able to hear, speak and to receive education effectively.

List of Research Outputs

Au D.K.K., Chow C.K., Hui Y. and Wei W.I., Cognitive abilities of patients with cochlear implant in the discrimination of tone stimuli with minimal contrast, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003. 102.

Au D.K.K., Hui Y., Tsang A.W.C. and Wei W.I., ENT management of a child with CHARGE association, Asian Journal of Surgery. 2004, 27(2): 141-143.

Au D.K.K., Hui Y., Jin H. and Wei W.I., 香港失聰兒童早期人工耳蝸植入後的聽覺和言語康復, 中國長沙湖南中華耳鼻喉科雜誌創?50周年紀念暨全國人工耳蝸專題學術會議上宣讀, 2003年9月13-16日, 2003.

Chan H.H.L., Lam L.K., Wong S.Y. and Wei W.I., Role of skin cooling in improving patient tolerability of Q-switched Alexandrite (QS Alex) laser in nervus of Ota treatment, Lasers in Surgery and Medicine. 2003, 32: 148-151.

Chang H.W., Chan A., Kwong D.L.W., Wei W.I., Sham J.S.T. and Yuen P.W., Detection of hypermethylated RIZ1 gene in primary tumor, mouth, and throat rinising fluid, nasopharyngeal swab, and peripheral blood of nasopharyngeal carcinoma patient, Clinical Cancer Research . 2003, 9: 1033-1038.

Chang H.W., Chan A., Kwong D.L.W., Wei W.I., Sham J.S.T. and Yuen P.W., Evaluation of hypermethylated tumor suppressor genes as tumor marker in mouth and throat rinsing fluid, nasopharyngeal swab, peripheral blood of naospharyngeal carcinoma patients, International Journal of Cancer. 2003, 105(6): 851-855.

Chang H.W., Ling G.S., Wei W.I. and Yuen P.W., Smoking and drinking can induce p15 hypermethylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma , Cancer. 2004, 101: 125-132.

Chow C.K.L., Hui Y. and Wei W.I., Permeatal temporalis fascia graft harvesting for minimally invasive myringoplasty, Laryngoscope. 2004, 114(2): 386-388.

Chu K., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Short electrode insertion in cochlear implants: the performance on speech perception, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Sciences (APSCI), Taipei, Taiwan, 4-6 December 2003. 99.

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Narrative abilities in children with cochlear implants, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004. 181.

Chua D.T.T., Wei W.I., Sham J.S.T., Cheng C.K. and Au G.K.H., Treatment Outcome For Synchronous Loco-regional Failures Of Nasopharyngeal Carcinoma, Head And Neck. 2003, 25(7): 585-594.

Ho W.K., Wei W.I. and Chung K.F., Managing disturbing snoring with palatal implants - a pilot study, Archives of Otolaryngology, Head and Neck Surgery. 2004, 130: 753-758.

Ho W.K., Yuen P.W., Tang K.C., Wei W.I. and Lam P.K.Y., Time course in the relief of nasal blockage after septal and turbinate surgery - a prospective study, Archives of Otolaryngology, Head and Neck Surgery. 2004, 130(3): 324-328.

Hui Y., Wong Y.K. and Wei W.I., Speech outcomes of prelingually deafened Cantonese-speakers after cochlear implantation, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Science, Taipei, Taiwan, 6 December 2003 . 2003.

Hui Y., Wong S.Y., Wong L.Y., Ho W.K. and Wei W.I., Year Book of Otolaryngology - Head and Neck Surgery. Mosby, 2004.

Lam P.K.Y., Au-Yeung K.M., Cheng P.W., Wei W.I., Yuen P.W., Trendell-Smith N., Li J.H. and Li R., Correlating MRI and histologic tumor thickness in the assessment of oral tongue cancer, American Journal of Roentgenology. 2004, 182(3): 803-808.

Lau S.K.P., Woo P.C.Y., Wong B.H.L., Tsoi H.W., Woo G.K.S., Poon R.W.S., Chan K.H., Wei W.I., Peiris J.S.M. and Yuen K.Y., Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in SARS patients by enzyme-linked immunosorbent assay, Journal of Clinical Microbiology. 2004, 42(7): 2884-2889.

Law S.Y.K., Lo O.S.H., Wei W.I., Lam L.K., Wong K.H., Kwok K.F. and Wong J., Treating esophageal cancer with synchronous or antecedent head and neck cancers: a more formidable challenge? (Abstract), Diseases of the Esophagus. 2004, 17, Supplement 1: A42-A43.

Lin W.M., Yuan X., Yuen P.W., Wei W.I., Sham J.S.T., Shi P.C. and Qu J., Classification of in vivo autofluorescence spectra using support vector machines, Journal of Biomedical Optics. 2004, 9(1): 180-186.

Liu C.L., Saing H., Fan S.T., Lo C.M., Chan K.L., Tam P.K.H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Liu C.L., Fan S.T., Lo C.M., Tam P.K.H., Saing H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, Liver Transplantation. 2003, 9(11): 1185-1190.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Yong B.H., Lai C.L. and Wong J., Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure, Transplantation. 2003, 76: 1174-1179.

Lo S., Ho W.K. and Wei W.I., Outcome of patients with positive Epstein-Barr virus serologic status in the absence of nasopharyngeal carcinoma in Hong Kong, Archives of Otolaryngology, Head and Neck Surgery. 2004, 130(6): 770-772.

Patel S.G., Singh B., Polluri A., Bridger P.G., Cantu G., Cheesman A.D., deSa G.M., Donald P., Fliss D., Gullane P., Janecka I., Kamata S.E., Kowaiski L.P., Kraus D.H., Levine P.A., dos Santos L.R.M., Pradhan S., Schramm V., Snyderman C., Wei W.I. and Shah J.P., Craniofacial surgery for malignant skull base tumors: report of an international collaborative study, Cancer. 2003, 98(6): 1179-1187.

Rinaldo A., Ferlito A., Pellitteri P.K., Robbins K.T., Shaba A.R., Bradley P.J., Kowalski L.P. and Wei W.I., Managment of malignant submandibular gland tumors, Acta Otolaryngology. 2003, 123(8): 896-904.

Wei W.I., Ng W.M. and Ho W.K., "How I do it" - Pharyngeal entry through the vallecula, Laryngoscope. 2004, 114(1): 181-183.

Wei W.I., Advanced skin cancers (video), Head & Neck Course 2004, Queen Mary Hospital, Hong Kong, 3-4 June 2004. 2004.

Wei W.I., Advanced thyroid cancer, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Advisory Professor (June 2004 - present), 寧夏醫學院附屬醫院, Ningxia, China, 2004.

Wei W.I., Advisory Professor (March 2002 - present), Zhengzhou University, Henan, China. 2004.

Wei W.I., Associate Editor (January 1985 - present), Asian Journal of Surgery. 2004.

Wei W.I., Audit Committee Member (3 October 2002 - present), International Federation of Oto-Rhino-Laryngological Societies. 2004.

Wei W.I., Basic technique - microsurgery, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I. and Sham J.S.T., Cancer of the nasopharynx, In: Myers E, Suen J, Myers J and Hann E, Cancer of the Head & Neck. W.B. Saunders Company, 2003, 229-250.

Wei W.I., Chief of Service (1994 - present), Department of ENT, Queen Mary Hospital, Hong Kong. 2004.

Wei W.I., Cluster Chief of Service (Ear, Nose and Throat)(December 2003 - March 2005), Hong Kong West Cluster, Hospital Authority, Hong Kong. 2004.

Wei W.I., Co-ordinator (July 2003- June 2004), eKG Otorhinolaryngology Sub-specialty, Head & Neck Surgery. 2004.

Wei W.I., Congratulatory message to Kin Lok Club, Kin Lok Club, the 10th Anniversary Commenorative Bronchure. 2004.

Wei W.I., Contribution towards the management of nasopharyngeal carcinoma, 8th Hong Kong Medical Forum, Faculty of Medicine, The University of Hong Kong, Hong Kong, 5 July 2003.

Wei W.I., Corresponding Fellow (1997 - present), American Academy of Otolaryngology - Head and Neck Surgery. 2004.

Wei W.I., Corresponding Fellow (April 1995 - present), American Laryngological Association. 2004.

Wei W.I., Corresponding Member (April 2001 - present), German Society of Otolaryngology and Head & Neck Surgery. 2004.

Wei W.I., Corresponding Member (October 1998 - present), American Head and Neck Society. 2004.

Wei W.I., Course Director, Session on "Comprehensive management of head and neck cancer", International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 December 2003. 2003.

Wei W.I., Course Director, Session on "Cutaneous lesions and soft tissue tumours", Head & Neck Course 2004, Queen Mary Hospital, Hong Kong, 3-4 June 2004. 2004.

Wei W.I., Course Director, The Croucher Advanced Study Institute on Microvascular Free Tisse Transfer for Reconstruction of Head & Neck Disease, Hong Kong, 10-14 February 2004. 2004.

Wei W.I., Craniofacial resection techniques and results, Annual Scientific Congress, Royal Australasian College of Surgeons, Melbourne, Australia, 3-7 May 2004.

Wei W.I., Current status of the "gastric pull up" procedure, Annual Scientific Congress, Royal Australasian College of Surgeons, Melbourne, Australia, 3-7 May 2004.

Wei W.I., Cutaneous free flap (video), International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003. 2003.

Wei W.I., Development of head and neck cancer in the past 2 decades, 1st Cancer Conference of Western China, Yinchuan, Ningxia, China, 12-15 June 2004.

Wei W.I., Examiner (FRCS) - Intecollegiate Examination in Otorhinolaryngology (March 2001 - present), Royal College of Surgeons of Edinburgh. 2004.

Wei W.I., Examiner in Surgery (July 1985 - present), Final Examination, Licentiate Examination Board for Non-Commonwealth Doctors, Medical Council of Hong Kong. 2004.

Wei W.I., Executive Committee Member (October 2002 - present), International Federation of Oto-Rhino-Laryngological Societies. 2004.

Wei W.I., Executive Member - representing East Asia (October 2002 - present), International Federation of Oto-Rhino-Laryngological Societies. 2004.

Wei W.I., Expert Panel in the Surgery Specialty (March 2004 - June 2007), Hospital Authority, Hong Kong. 2004.

Wei W.I., Fellow (1984 - present), American College of Surgeons. 2004.

Wei W.I., Founding Member (November 2001 - present), Association of University Surgeons of Asia. 2004.

Wei W.I., Free flaps - why and which, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Gastric pull up operation - current techniques and results, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Guest Professor (October 2002 - present), Tongji Medical College, Huazhong University of Science & Technology, China. 2004.

Wei W.I., Head & neck surgery in the new millennium, Visit to Union Hospital of Tongji Medical College, Huz-Zhong University of Science & Technology, Wuhan, Hebei, China, 3 November 2003. 2003.

Wei W.I., Head & neck surgery, 11th Annual Scientific Meeting, The College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004.

Wei W.I., Head and neck surgery: common head and neck disorders and surgeries (Invited Lecture), Diploma in Surgical Nursing, HKU SPACE, The University of Hong Kong, Hong Kong, 6 February 2004. 2004.

Wei W.I., Honorary Advisor (1987 - present), The New Voice Club of Hong Kong. 2004.

Wei W.I., Honorary Advisor (December 1993 - present), Hong Kong Association of Cleft Lip and Palate. 2004.

Wei W.I., Honorary Advisor (February 1993 - present), Alliance for Patients' Mutual Help Organizations, Hong Kong. 2004.

Wei W.I., Honorary Advisor (February 1995 - present), Kin Lok Club, Hong Kong (Nasopharyngeal Carcinoma Patient Support Group). 2004.

Wei W.I., Honorary Advisor (July 2000 - present), Youth International Enterprise Ltd., Hong Kong. 2004.

Wei W.I., Honorary Advisor (October 1995 - present), Driver Rehabilitation Service, ReHabAid Centre, Hong Kong Polytechnic University, Hong Kong. 2004.

Wei W.I., Honorary Clinical Supervisor (January 2001 - present), Vocational Training Programme in Family Medicine, The Hong Kong College of Family Physicians. 2004.

Wei W.I., Honorary Consultant (December 1991 - present), Department of Surgery, Queen Mary Hospital, Hong Kong. 2004.

Wei W.I., Honorary Director (December 1997 - present), The First Medical School, West China University of Medical Sciences, Chengdu, Sichuan, China. 2004.

Wei W.I., Honorary Fellow (February 2000 - present), Philippine Society of Otolaryngology-Head and Neck Surgery, Philippines. 2004.

Wei W.I., Honorary Fellow (May 2004 - present), Royal Australasian College of Surgeons. 2004.

Wei W.I., Honorary Medical Advisor, The Cancer Crusade Angels Service Society of Hong Kong. 2004.

Wei W.I., Honorary Member (September 1997 - present), Philippine Academy for Head & Neck Surgery, Philippines. 2004.

Wei W.I., Honorary Member of Editorial Board (1999 - present), Chinese Journal of Cancer. 2004.

Wei W.I., Honorary Professor (December 2002 - present), 廣州市耳鼻咽喉頭頸外科醫院, 2004.

Wei W.I., Honorary Reviewer, Archives of Otolaryngology - Head & Neck Surgery. 2004.

Wei W.I., Honorary Reviewer, Asian Journal of Surgery, Hong Kong. 2004.

Wei W.I., Honorary Reviewer, Bone Marrow Transplantation, U.K.. 2004.

Wei W.I., Honorary Reviewer, British Journal of Surgery, United Kingdom. 2004.

Wei W.I., Honorary Reviewer, Cancer, Interdiscipline International Journal of the American Cancer Society. 2004.

Wei W.I., Honorary Reviewer, Clinical Cancer Research, U.S.A.. 2004.

Wei W.I., Honorary Reviewer, Head & Neck, Journal of the Sciences and Specialities of the Head and Neck, U.S.A.. 2004.

Wei W.I., Honorary Reviewer, International Journal of Cancer (Official Journal of UICC), Germany. 2004.

Wei W.I., Honorary Reviewer, Oncology, International Journal of Cancer Research and Treatment, Switzerland. 2004.

Wei W.I., Honorary Reviewer, The American Journal of Rhinology, U.S.A.. 2004.

Wei W.I., Honorary Reviewer, The American Journal of Surgery, U.S.A.. 2004.

Wei W.I., Honorary Reviewer, The Hong Kong Practitioner, Hong Kong. 2004.

Wei W.I., Honorary Reviewer, The Laryngoscope, U.S.A.. 2004.

Wei W.I., Honorary Senior Consultant (ENT) (April 2001 - present), Tung Wah Hospital. 2004.

Wei W.I., Hypopharyngeal carcinoma - how much to resect, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Immediate Past President (February 2002 - December 2004), Hong Kong College of Otorhinolaryngologists. 2004.

Wei W.I., Instructor (1997 - present), Advanced Trauma Life Support Program, American College of Surgeons. 2004.

Wei W.I., Management of recurrences after total laryngectomy, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Management of the neck in head and neck cancer, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Maxillary swing approach to central skull base, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Member (1981- present), Bernard O'Brien Society, The Microsurgery Research Centre, Australia. 2004.

Wei W.I., Member (2001 - September 2003), HA's Expert Panel in Otorhinolaryngology Specialty. 2004.

Wei W.I., Member (March 2003 - present), Hong Kong Adventist Hospital Foundation Children's Hearing Fund. 2004.

Wei W.I., Member (May 2002 - May 2004), Appeals Committee, Hong Kong Academy of Medicine, Hong Kong. 2004.

Wei W.I., Member (November 1992 - present), Hong Kong Institution of Science. 2004.

Wei W.I., Member (October 2002 - present), Audit Committee, International Federation of Oto-Rhino-Laryngological Societies. 2004.

Wei W.I., Member of Ad Hoc Committee Oncology and Head and Neck Surgery (October 2002 - present), International Federation of Otorhinolaryngological Societies. 2004.

Wei W.I., Member of Editorial Board (1996 - present), Chinese Journal of Otolaryngology. 2004.

Wei W.I., Member of Editorial Board (2001 - 2004), Chinese Journal of Otorhinolaryngology - Skull Base Surgery. 2004.

Wei W.I., Member of Editorial Board (2001 - 2007), Head & Neck. 2004.

Wei W.I., Member of Editorial Board (2003 - Present), Medical Progress. 2004.

Wei W.I., Member of Editorial Board (January 1997 - present), Journal of Clinical Otorhinolaryngology (China). 2004.

Wei W.I., Member of Editorial Board (June 1995 - present), Australian and New Zealand Journal of Surgery. 2004.

Wei W.I., Member of Editorial Board (November 1994 - present), The American Journal of Otolaryngology. 2004.

Wei W.I., Member of Editorial Board (October 1995 - present), Chinese Journal of Clinical Oncology. 2004.

Wei W.I., Member of Editorial Board, The ASEAN ORL Head and Neck Journal. 2004.

Wei W.I., Member of International Advisor Board, Otolaryngology Head and Neck Surgery. 2004.

Wei W.I., Microvascular free tissue transfer: our experience towards and optimal reconstruction of head and neck defects, 8th National ENT, Head and Neck Surgery Meeting, Chongqing, China, 12-14 October 2003.

Wei W.I., Lam L.K., Ng W.M., Liu C.L., Lo C.M., Fan S.T. and Wong J., Microvascular reconstruction of the hepatic artery in live donor liver transplantation: experience across a decade, Archives of Surgery. 2004, 139(3): 304-307.

Wei W.I., NPC: surgical salvage, Instructural Course, 10th Asia-Oceania ORL Head & Neck Congress, Kuala Lumpur, Malaysia, 22-26 February 2004.

Wei W.I. and Ho W.K., Nasopharyngeal carcinoma, In: Kamel R. and Lumley J., Textbook of Tropical Surgery. London, Westminster Publishing Ltd., 2004, 345-348.

Wei W.I., National Delegate (1987 - present), Hong Kong Representative, Asian Federation of Laryngectomees Association. 2004.

Wei W.I., National Delegate, Newsletter Editor, International Federation of Head and Neck Oncologic Societies. 2004.

Wei W.I., Neck dissection in head and neck cancer, Visit to Ruprecht-Karls University of Heidelberg, Faculty of Clinical Medicine Mannheim, Germany, 9 December 2003. 2003.

Wei W.I., Opening Ceremony Speech, The New Voice Club of Hong Kong, Hong Kong, 13 December 2003. 2003.

Wei W.I., Optimal reconstruction of hypopharynx, 14th Biennial Congress of Asian Surgical Association, Kota Kinabalu, Malaysia, 4-6 December 2003.

Wei W.I., Oral cavity cancer (Invited Lecture), Mixed Cancer Talks, Organized by the five Cancer Patient Resource Centres, Queen Elizabeth Hospital, Hong Kong, 3 October 2003. 2003.

Wei W.I., Paradigms in the management of neck metastases, XIX Brazilian Meeting of Head and Neck Surgery, Curitiba, Brazil, 3-6 September 2003.

Wei W.I., Patient presentation, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Pectoralis major myocutaneous flap - our technique, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Pharyngocutaneous fistula, 14th Biennial Congress of Asian Surgical Association, Kota Kinabalu, Malaysia, 4-6 December 2003.

Wei W.I., President (August 2001 - present), Hong Kong Institute of Allergy, Hong Kong. 2004.

Wei W.I., President (February 2004 - present), Hong Kong Head & Neck Society. 2004.

Wei W.I., Quantitative analysis of plasma Epstein-barr viral DNA before and after salvage nasopharyngectomy for nasopharyngeal carcinoma , Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum, Helsinki, Finland, 24-27 August 2003. 2003.

Wei W.I., Research grant assessor, University Grants Committee, Hong Kong. 2004.

Wei W.I., Results of free flaps and management of complications, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Tuen H.H.L., Ng W.M. and Lam L.K., Safe tracheostomy for patients with severe acute respiratory syndrome, The Laryngoscope. 2003, 113(10): 1777-1779.

Wei W.I., Selective neck dissection in head & neck - how, when & why, 10th Asia-Oceania ORL Head & Neck Congress, Kuala Lumpur, Malaysia, 22-26 February 2004.

Wei W.I., Severe acute respiratory syndromes, In: Kamel R. and Lumley J., Textbook of Tropical Surgery. London, Westminster Publishing Ltd., 2004, 416-418.

Wei W.I., Soft tissue tumours - clinical diagnosis, Head & Neck Course 2004, Queen Mary Hospital, Hong Kong, 3-4 June 2004.

Wei W.I., Surgery for advanced thyroid cancer - indications and limitations, 1st Cancer Conference of Western China, Yinchuan, Ningxia, China, 12-15 June 2004.

Wei W.I., Surgery for sarcoma in head and neck region (video), Head & Neck Course 2004, Queen Mary Hospital, Hong Kong, 3-4 June 2004. 2004.

Wei W.I., Technique of maxillary swing approach to central skull base, 14th Biennial Congress of Asian Surgical Association, Kota Kinabalu, Malaysia, 4-6 December 2003.

Wei W.I., The health care system in Hong Kong - before and after 1997, 1st Cancer Conference of Western China, Yinchuan, Ningxia, China, 12-15 June 2004.

Wei W.I. and Ho W.K., Theory & surgery in Traditional Chinese Medicine, In: Kamel R. and Lumley J., Textbook of Tropical Surgery. London, Westminster Publishing Ltd., 2004, 170-175.

Wei W.I., Total laryngectomy & voice rehabilitation (Invited Lecture), ENT Surgery Course for Theatre Nurse, Queen Mary Hospital, Hong Kong, 19 July 2003. 2003.

Wei W.I., Total laryngectomy - techniques to improve outcome, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., Treasurer (1990 - present), Asian Surgical Association (formerly Association of Surgeons of Southeast Asia). 2004.

Wei W.I., Treasurer (1991 - present), Hong Kong Society of Otorhinolaryngology, Head and Neck Surgery. 2004.

Wei W.I., Treasurer (1995 - present), Hong Kong Chapter, American College of Surgeons. 2004.

Wei W.I., Treatment of hypopharyngeal carcinoma: state of the art, XIX Brazilian Meeting of Head and Neck Surgery, Curitiba, Brazil, 3-6 September 2003.

Wei W.I., Treatment of primary and recurrent nasopharyngeal cancer, XIX Brazilian Meeting of Head and Neck Surgery, Curitibia, Brazil, 3-6 September 2003.

Wei W.I., Visceral free flaps (Video), International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003. 2003.

Wei W.I., Visiting Professor (2002 - present), Zhongshan University, Guangzhou, China. 2004.

Wei W.I., Visiting Professor, University of Mannheim, Mannheim, Germany, 8 - 10 December. 2003.

Wei W.I., Voice rehabilitation after total laryngectomy, International Comprehensive Head & Neck Course 2003, Nanchang, Jiangxi, China, 8-10 November 2003.

Wei W.I., 鼻咽癌的外科手術, In: 屠規益, 現代頭頸腫瘤外科學, 科學出版社, 2004, 846-857.

Wong L.Y., Wei W.I., Lam L.K. and Yuen P.W., Salvage of recurrent head and neck squamous cell carcinoma after primary curative surgery, Head & Neck. 2003, 25(1): 953-959.

Wong T.S., Kwong D.L.W., Sham J.S.T., Wei W.I., Kwong Y.L. and Yuen P.W., Clinicopathologic significance of plasma matrix metalloproteinase-2 and -9 levels in patients with undifferentiated nasopharyngeal carcinoma, European Journal of Surgical Oncology. 2004, 30(5): 560-564.

Wong T.S., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Wei W.I., Kwong Y.L. and Yuen P.W., Promoter Hypermethylation Of High-in-normal 1 Gene In Primary Nasopharyngeal Carcinoma, Clinical Cancer Research. 2003, 9: 3042-3046.

Wong T.S., Kwong D.L.W., Sham J.S.T., Wei W.I., Kwong Y.L. and Yuen P.W., Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma, Clinical Cancer Research. 2004, 10(7): 2401-2406.

Wong T.S., Man M., Lam A.K.Y., Wei W.I., Kwong Y.L. and Yuen P.W., The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR, European Journal of Cancer. 2003, 39(13): 1881-1887.

金 ..., Hui Y., Au D.K.K. and Wei W.I., Effects of stimulation rate on Cantonese tone perception performance for cochlear implant users, 刺激速率對廣東話人工耳蝸使用者聲調認知能力的影響, Chinese Scientific Journal of Hearing and Speech Rehabilitation. 2004, 4: 7-9.

金 ..., Au D.K.K., Hui Y. and Wei W.I., 噪聲環境下刺激速率對廣東語聲調認知能力的影響, 中國長沙湖中華耳鼻咽喉科雜誌創?50週年紀念暨全國人工耳蝸專題學術會議, 2003年9日13-16日, 2003.

黃 ......, 陳伊.寧., 農輝.圖., 唐安.洲., 徐志.文., 莫福.琴., 宋斌. and Wei W.I., 全喉切除術後無喉者的語言康復實踐, 臨床耳鼻咽喉科雜誌, 2004, 18: 437-438.

Researcher : Wo YH

List of Research Outputs

Chan K.L., Ng S.P., Chan K.W., Wo Y.H. and Tam P.K.H., Pathogenesis of neonatal necrotizing enterocolitis: a study of the role of intraluminal pressure, age and bacterial concentration, Pediatric Surgery International. 2003, 19(8): 573-577.

Researcher : Wong J

Project Title:	The expression and the role of macrophage migration inhibitory factor in tumorigenesis in esophageal squamous cell carcinoma and its possible association with prognosis
Investigator(s):	Prof. Wong J., Dr. Law S.Y.K., Dr. Ren Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003
Completion Date:	12/2003

Abstract:

To investigate the mechanism by which MIF affects the development of ESCC.

Project Title:	Clinical significance of hepatocyte growth factor in esophageal squamous cell carcinoma
Investigator(s):	Prof. Wong J., Dr. Law S.Y.K., Dr. Ren Y.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To investigate whether relationships exist between serum HGF levels and angiogenic factors, clinico- pathological factors, and long-term survival; to study whether HGF correlates with angiogenic factors such as VEGF and IL-8 in patients' sera; to detect the possible sources of HGF in ESCC specimens.

List of Research Outputs

Bann S., Kwok K.F., Lo C.Y., Darzi A. and Wong J., Objective assessment of technical skills of surgical trainees in Hong Kong , British Journal of Surgery. 2003, 90: 1294-1299.

Chan S.C., Lo C.M., Liu C.L., Wong Y., Fan S.T. and Wong J., Tailoring donor hepatectomy per segment 4 venous drainage in right lobe live donor liver transplantation, Liver Transplantation. 2004, 10(6): 755-762.

Chen D.W., Poon R.T.P., Liu C.L., Fan S.T. and Wong J., Immediate and long-term outcomes of hepatectomy for hepatolithiasis, Surgery. 2004, 135(4): 386-393.

Chen X., Leung S.Y., Yuen S.T., Chu K.M., Ji J., Li R., Chan A.S.Y., Law S.Y.K., Troyanskaya O.G., Wong J., So S., Botstein D. and Brown P.O., Variation in gene expression patterns in human gastric cancers, Molecular Biology of the Cell. 2003, 14(8): 3208-3215.

Chu K.M., Patil N.G., Saing H. and Wong J., A level grades and undergraduate academic performance in Hong Kong, British Medical Journal. 2003, (online).

Chu K.M., Patil N.G., Saing H. and Wong J., Female gender is associated with better undergraduate academic performance, British Medical Journal. 2004, (online).

Fan S.T., Lo C.M., Liu C.L., Yong B.H. and Wong J., Determinants of hospital mortality of adult recipients of right lobe live donor liver transplantation, Annals of Surgery. 2003, 238(6): 864-869.

Fan S.T., Lo C.M., Liu C.L., Wang W.X. and Wong J., Safety and necessity of including the middle hepatic vein in the right lobe graft in adult-to-adult live donor liver transplantation, Annals of Surgery. 2003, 238(1): 137-148.

Ko S., Chu K.M., Luk J.M.C., Wong W.Y., Leung S.Y., Yuen S.T. and Wong J., Expression of CDX2 and LI-cadherin in intestinal metaplasia and adenocarcinoma of the stomach, 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Ko S., Chu K.M., Luk J.M.C., Wong B.W.Y., Yuen S.T., Leung S.Y.L. and Wong J., Over-expression of LI-cadherin in gastric cancer is associated with lymph node metastasis, Biochemical and Biophysical Research Communications. 2004, 319(2): 562-568.

Kwong D.L.W., Lam A., Guan X.Y., Law S.Y.K., Tai A., Wong J. and Sham J.S.T., Chromosomal aberrations in esophageal squamous cell carcinoma among Chinese: gain of 12p predicts poor prognosis after surgery, Human Pathology. 2004, 35(3): 309-316.

Lang B.H.H., Poon R.T.P., Fan S.T. and Wong J., Influence of laparoscopy on postoperative recurrence and survival in patients with ruptured hepatocellular carcinoma undergoing hepatic resection, British Journal of Surgery. 2004, 91(4): 444-449.

Lang B.H.H., Poon R.T.P., Fan S.T. and Wong J., Perioperative and long-term outcome of major hepatic resection for small solitary hepatocellular carcinoma in patients with cirrhosis, Archives of Surgery. 2003, 138(11): 1207-1213.

Law B.F.F., Srivastava G., Wong K.Y., Chen W.Y.W., Liang A.C.T., Lam K.Y., Law S.Y.K., Wong J. and Tang J.C.O., A novel tumor transforming gene at 7q22, GAESCC1, is frequently amplified and overexpressed in primary esophageal squamous cell carcinomas, Abstract of the Proceedings of the 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, USA, March 2004.

Law S.Y.K. and Wong J., Current status of esophageal cancer treatment in Asia, (Abstract) The 58th Annual Meeting of the Japan Esophageal Society, Tokyo, Japan, June 2004.

Law S.Y.K. and Wong J., Hand-sewn anastomoses (Viewpoint - What's new in esophageal anastomoses?), (Abstract) IX World Congress of the International Society for Diseases of the Esophagus, Madrid, Spain, 27-29 May 2004.

Law S.Y.K., Kwong D.L.W., Kwok K...F., Wong K...H., Chu K.M., Sham J.S.T. and Wong J., Improvement in treatment results and long-term survival of patients with esophageal cancer: impact of chemoradiation and change in treatment strategy, Annals of Surgery. 2003, 238(3): 339-348.

Law S.Y.K. and Wong J., Neoadjuvant chemotherapy vs. surgery alone in esophageal cancer (Lecture), (Abstract) IX World Congress of the International Society for Diseases of the Esophagus, Madrid, Spain, 27-29 May 2004.

Law S.Y.K., Boey J...P., Kwok K...F., Wong K...H., Chu K.M. and Wong J., Pleural drainage after transthoracic esophagectomy: experience with a vacuum system, Diseases of the Esophagus. 2004, 17(1): 81-86.

Law S.Y.K. and Wong J., Right thoraco-abdominal approaches / Ivor Lewis-McKeown procedures for esophageal resection in resectable and potentially curable tumors (Symposium - Controversies in the treatment of squamous cell carcinoma of the esophagus), (Abstract) IX World Congress of the International Society for Diseases of the Esophagus, Madrid, Spain, 27-29 May 2004.

Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., Supra-carinal esophageal cancers have worse prognosis compared to more distally located tumors, preoperative chemoradiation results in better survival (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A43.

Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., The need to re-classify stage IVb esophageal cancer: evidence from differential response to chemoradiation therapy (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A42.

Law S.Y.K. and Wong J., Therapeutic options for esophageal cancer, Journal of Gastroenterology and Hepatology. 2004, 19(1): 4-12.

Law S.Y.K., Lo O.S.H., Wei W.I., Lam L.K., Wong K.H., Kwok K.F. and Wong J., Treating esophageal cancer with synchronous or antecedent head and neck cancers: a more formidable challenge? (Abstract), Diseases of the Esophagus. 2004, 17, Supplement 1: A42-A43.

Liu C.L., Fan S.T., Lo C.M., Wong Y., Ng I.O.L., Lam C.M., Poon R.T.P. and Wong J., Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases, Annals of Surgery. 2004, 239(2): 194-201.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Tso W.K. and Wong J., Hepatic resection for incidentaloma (Poster of Distinction), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Tso W.K. and Wong J., Heptic resection for incidentaloma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Lai C.L. and Wong J., Interleukin-2 receptor antibody (basiliximab) for immunosuppressive induction therapy after liver transplantation: a protocol with early elimination of steroids and reduction of tacrolimus dosage, Liver Transplantation. 2004, 10(6): 728-733.

Liu C.L., Lo C.M., Chan S.C., Fan S.T. and Wong J., Internal hernia of the small bowel after right-lobe live donor liver transplantation, Clinical Transplantation. 2004, 18(2): 211-213.

Liu C.L., Saing H., Fan S.T., Lo C.M., Chan K.L., Tam P.K.H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May 2004.

Liu C.L., Fan S.T., Lo C.M., Tam P.K.H., Saing H., Wei W.I., Yong B.H., Tsoi N.S. and Wong J., Live donor liver transplantation for fulminant hepatic failure in children, Liver Transplantation. 2003, 9(11): 1185-1190.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Yong B.H., Lai C.L. and Wong J., Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure, Transplantation. 2003, 76: 1174-1179.

Liu C.L., Fan S.T., Lo C.M., Chan S.C. and Wong J., Safety of donor right hepatectomy for live donor liver transplantation without abdominal drainage (Abstract), Liver Transplantation. 2004, 10(6): C30.

Liu C.L., Fan S.T., Lo C.M., Chan S.C. and Wong J., Safety of donor right hepatectomy for live donor liver transplantation without abdominal drainage (Oral Presentation), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Lo C.M., Fan S.T., Liu C.L., Yong B.H., Wong Y., Ng I.O.L. and Wong J., Safety and outcome of hepatitis B core antibody-positive donors in right-lobe living donor liver transplantation, Liver Transplantation. 2003, 9(8): 827-832.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Lo C.M., Fan S.T., Liu C.L., Chan S.C. and Wong J., The role and limitation of living donor liver transplantation for hepatocellular carcinoma, Liver Transplantation. 2004, 10(3): 440-447.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Hepatitis B virus (HBV)-specific immune response after liver transplantation for chronic hepatitis B (Abstract), Liver Transplantation. 2004, 10(6): C42.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus (HBV)-specific lymphocytes in human liver allografts from HBV immune donors (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Murthy S.C., Law S.Y.K., Whooley B.P., Alexandrou A., Chu K.M. and Wong J., Atrial fibrillation after esophagectomy is a marker for postoperative morbidity and mortality, The Journal of Thoracic and Cardiovascular Surgery. 2003, 126(4): 1162-1167.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Fan S.T. and Wong J., Delayed portal vein thrombosis after experimental radiofrequency ablation near the main portal vein, British Journal of Surgery. 2004, 91(5): 632-639.

Patil N.G., Cheng S.W.K. and Wong J., Surgical competence, World Journal of Surgery. 2003, 27(8): 943-947.

Poon R.T.P., Fan S.T. and Wong J., Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches (Review), Annals of Surgery. 2003, 238(1): 9-28.

Poon R.T.P., Lau C.P.Y., Yu W.C., Fan S.T. and Wong J., High serum levels of vascular endothelial growth factor predict poor response to transarterial chemoembolizatin in hepatocellular carcinoma: a prospective study, Oncology Reports. 2004, 11(5): 1077-1084.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database (Oral Presentation), The 124th Annual Meeting of the American Surgical Association, San Francisco, U.S.A., 15-17 April 2004.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J., Fan S.T. and Wong J., Learning curve for radiofrequency ablation of liver tumors: prospective analysis of initial 100 patients in a tertiary institution, Annals of Surgery. 2004, 239(4): 441-449.

Poon R.T.P., Ng K.K.C., Lam C.M., Ai V.H.G., Yuen J., Fan S.T. and Wong J., Learning curve for radiofrequency ablation of liver tumours: prospective analysis of initial 100 patients in a teritary institution (Oral Presentation), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Poon R.T.P. and Wong J., Long-term disease-free survival after resection of hepatocellular carcinoma: both tumor behavior and surgeon's performance are important determinants (Editorial), Annals of Surgical Oncology. 2003, 10(8): 834-836.

Poon R.T.P., Yu W.C., Fan S.T. and Wong J., Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 779-788.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement, World Journal of Surgery. 2004, 28(6): 602-608.

Poon R.T.P., Lau C.P.Y., Ho J.W.Y., Yu W.C., Fan S.T. and Wong J., Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma, Clinical Cancer Research. 2003, 9(14): 5339-5345.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Zhao P., Huang X., Vande Woude G. and Wong J., Hepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A101-A102.

Suen D.T.K., Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., Cervical or intrathoracic oesophageal anastomosis after oesophagectomy for cancer: comparisons in 218 patients using a single-layer, continuous hand-sewn method, (Abstract) The 10th Hong Kong International Cancer Congress, Hong Kong, 19-21 November 2003.

Wei W.I., Lam L.K., Ng W.M., Liu C.L., Lo C.M., Fan S.T. and Wong J., Microvascular reconstruction of the hepatic artery in live donor liver transplantation: experience across a decade, Archives of Surgery. 2004, 139(3): 304-307.

Wong I.H.N., Chan J., Wong J. and Tam P.K.H., Ubiquitous aberrant RASSFIA promoter methylation in childhood neoplasia, Clinical Cancer Research. 2004, 10(3): 994-1002.

Wong J., Active Member (1980 - present), James IV Association of Surgeons. 2004.

Wong J., Adviser (1996 - present), Chinese Society of Vascular Surgery. 2004.

Wong J., Board of Directors (1991 - present), British Isles Group , James IV Association of Surgeons. 2004.

Wong J., Chair Professor, Staff Review Committee (1999 - present), Lingnan University, Hong Kong. 2004.

Wong J., Chairman, Advisory Committee (2000 - present), International Society for Digestive Surgery. 2004.

Wong J., Challenges in managing esophageal cancer: lessons from 2,400 patients, Liu Lecture, Oregan Health and Science University, U.S.A., 19 April 2004. 2004.

Wong J., Chief of Service , Queen Mary Hospital, Hong Kong. 2004.

Wong J., Cluster Chief of Service (Surgery) (December 2003-present), Hong Kong West Cluster, Hospital Authority, Hong Kong. 2003.

Wong J., Consultant Professor (1995 - present), Shanghai Second Medical University, Shanghai, China. 2004.

Wong J., Corresponding Member (1993 - present), Societe Italiana Di Gastroenterologia. 2004.

Wong J., Council Member (1992 - present), The Hong Kong Liver Foundation. 2004.

Wong J., Current status of esophageal cancer treatment - Europe, North America and Asia, 58th Annual Meeting of Japan Esophageal Society, Tokyo, Japan, 24-25 June 2004.

Wong J., Director (1998 - present), The Hong Kong Digestive Foundation. 2004.

Wong J. and Law S.Y.K., Esophageal cancer surgery: lessons from 1,200 resections, (Abstract) 26th Congress of Pan-Pacific Surgical Association, Honolulu, USA, 14 February 2004.

Wong J., Executive Committee Member (1992 - present), International Gastro-Surgical Club. 2004.

Wong J., Executive Committee Member (1997 - present), Asian Breast Cancer Society. 2004.

Wong J., Honorary Adviser (1999 - present), International Council of Surgical Gastroenterology (ICSG). 2004.

Wong J., Honorary Advisor (1994 - present), Hong Kong Council of Enterostomal Therapists. 2004.

Wong J., Honorary Consultant in Surgery (1994 - present), Kwong Wah Hospital. 2004.

Wong J., Honorary Fellow (1980 - present), American College of Surgeons. 2004.

Wong J., Honorary Fellow (2003 - present), The Royal College of Surgeons of England. 2004.

Wong J., Honorary Member (1994 - present), The Australian Alumni Association of Hong Kong. 2004.

Wong J., Honorary Professor (1995 - present), Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China. 2004.

Wong J., Honorary Senior Consultant, General Surgery (1996 - present), Tung Wah Hospital. 2004.

Wong J., Life Member (1990 - present), Fellow Leadership Society, American College of Surgeons. 2004.

Wong J., Life Member (1994 - present), Association of Thoracic and Cardiovascular Surgeons of Asia. 2004.

Wong J., Member (1996 - present), Board of Governors, Prince Philip Dental Hospital, Hong Kong. 2004.

Wong J., Member (1997 - present), Internship Sub-Committee, The Licentiate Committee of the Medical Council of Hong Kong. 2004.

Wong J., Member of Editorial Board, Advances in Surgery. 2004.

Wong J., Member of Editorial Board, Australian & New Zealand Journal of Surgery. 2004.

Wong J., Member of Editorial Board, Chinese Journal of Clinical Oncology. 2004.

Wong J., Member of Editorial Board, Clinics in Surgery and Gastroenterology. 2004.

Wong J., Member of Editorial Board, Croatian Journal of Gastroenterology and Hepatology. 2004.

Wong J., Member of Editorial Board, Current Practice in Surgery. 2004.

Wong J., Member of Editorial Board, Digestive Surgery. 2004.

Wong J., Member of Editorial Board, Diseases of the Esophagus. 2004.

Wong J., Member of Editorial Board, Hepato-Gastroenterology. 2004.

Wong J., Member of Editorial Board, Italian Journal of Gastroenterology. 2004.

Wong J., Member of Editorial Board, Journal of Clinical Oncology (Chinese edition). 2004.

Wong J., Member of Editorial Board, Journal of Gastroenterology & Hepatology. 2004.

Wong J., Member of Editorial Board, Journal of the American College of Surgeons. 2004.

Wong J., Member of Editorial Board, Journal of the Spanish Surgical Association (Cirugia Espanola). 2004.

Wong J., Member of Editorial Board, Surgery. 2004.

Wong J., Member of Editorial Board, The Journal of Gastrointestinal Surgery . 2004.

Wong J., Member of Editorial Board, The Lancet Oncology. 2004.

Wong J., Member of Editorial Board, WebSurg. 2004.

Wong J., Member, Coordinating Committee in Surgery (1992 - present), Hospital Authority, Hong Kong. 2004.

Wong J., Member, Hospital Governing Committee (1991 - present), The Grantham Hospital, Hong Kong. 2004.

Wong J., Member, House Committee (1996 - present), The Grantham Hospital, Hong Kong. 2004.

Wong J., Member, Professional Standards Review Committee (1996 - present), Queen Mary Hospital, Hong Kong. 2004.

Wong J., Member, Public Relations Committee (1996 - present), The Grantham Hospital, Hong Kong. 2004.

Wong J., Permanent Scientific Committee Member (1993 - present), International Organization for Statistical Studies on Diseases of the Esophagus (O.E.S.O.). 2004.

Wong J., President (1995 - present), Hong Kong Chapter, American College of Surgeons . 2004.

Wong J., President (2000 - present), Pan-Pacific Surgical Association. 2004.

Wong J., Radical surgery for esophageal cancer: has its time passed?, 8th Annual George E. Block Memorial Lecture, University of Chicago, U.S.A., 11 May 2004. 2004.

Wong J. and Law S.Y.K., Surgery for cancer of the oesophagus: The GB Ong legacy, Annals of The College of Surgeons of Hong Kong. 2003, (Supplement 2), 7: B18-B20.

Wong J., The Department of Surgery: after Professor GB Ong, Annals of The College of Surgeons of Hong Kong. 2003, (Supplement 2), 7: B2-B6.

Wong J., Trustee (1996 - present), S.K. Yee Medical Foundation, Hong Kong. 2004.

Wong J., Visiting Professor (1996 - present), The Third Hospital, Beijing Medicine University, Beijing, China. 2004.

Wong J., Visiting Professor of General Surgery (1998 - present), Sun Yat-sen University of Medical Scieinces, Guangzhou, China. 2004.

Wong J., Zero operative mortality: an illusion?, Layman A. Brewer, III, Lecture, University of Southern California, Los Angeles, U.S.A., 14-15 November 2003. 2003.

Researcher : Wong KKY

List of Research Outputs

Garcia-Barcelo M.M., Sham M.H., Lee W.S., Lui V.C.H., Chen B.L.S., Wong K.K.Y., Wong J.S.W. and Tam P.K.H., Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease, Clinical Chemistry. 2004, 50(1): 93-100.

Lan L.C.L., Wong K.K.Y., Lin S.C.L., Sprigg A., Clarke S., Johnson P.R.V. and Tam P.K.H., Endoscopic balloon dilatation of esophageal strictures in infants and children: 17 years' experience and a literature review, Journal of Pediatric Surgery. 2003, 38(12): 1712-1715.

Lin C.L., Wong K.K.Y., Lan L.C.L., Chen C.C. and Tam P.K.H., Earlier appearance and higher incidence of the rectoanal relaxation reflex in patients with imperforate anus repaired with laparoscopically assisted anorectoplasty, Surgical Endoscopy. 2003, 17(10): 1646-1649.

Wong K.K.Y., Fan A., Lan L., Lin C.L. and Tam P.K.H., Effective antibiotic regime for post-operative acute cholangitis in biliary atresia: an evolving scene, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Seoul, Korea, 16-20 May, 2004. 46.

Wong K.K.Y. and Tam P.K.H., Electronic prescribing is helpful in children too, British Medical Journal. 2004, 328: 1566.

Wong K.K.Y., Carpenter M.J., Young L.L., Walker S.J., McKenzie G., Rust A.J., Ward G., Packwood L., Wahl K., Delriviere L., Hoyne G., Gibbs P., Champion B.R., Lamb J.R. and Dallman M.J., Notch ligation by Deltal inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism, The Journal of Clinical Investigation. 2003, 112(11): 1741-1750.

Wong K.K.Y., Fan A., Lan L.C.L., Lin C.L. and Tam P.K.H., The impact of computerized prescription on medication incidence rate: experience of a single centre, 37th Annual Meeting of the Pacific Association of Pediatric Surgeons, Korea, 16-20 May, 2004.

Wong K.K.Y., Chan K.L., Saing H., Fan S.T. and Tam P.K.H., The management of biliary atresia in the era of liver transplantation, Hong Kong Journal of Paediatrics. 2003, 8: 322-326.

Wong K.K.Y., Lan L., Chan G., Lin C.L. and Tam P.K.H., The use of positron emission tomography in detecting hepatoblastoma recurrence: a cautionary tale, 37th Annual Meeting of the Pacific Association of Pediatric Surgoens, Seoul, Korea, 16-20 May 2004. 31.

Wong S.W., Wong K.K.Y., Lin C.L. and Tam P.K.H., Recent advances on the surgical management of common paediatric gastrointestinal diseases, Hong Kong Journal of Paediatrics. 2004, 9(2): 133-137.

Researcher : Wong LYC

List of Research Outputs

Law W.L., Choi H.K., Chu K.W., Ho J.W.C. and Wong L.Y.C., Bowel preparation for colonoscopy: a randomized controlled trial comparing polyethylene glycol solution, one dose and two doses of oral sodium phosphate solution, Asian Journal of Surgery. 2004, 27(2): 120-124.

Researcher : Wong SY (Wong Sau Yan)

List of Research Outputs

Chan H.H.L., Lam L.K., Wong S.Y. and Wei W.I., Role of skin cooling in improving patient tolerability of Q-switched Alexandrite (QS Alex) laser in nervus of Ota treatment, Lasers in Surgery and Medicine. 2003, 32: 148-151.

Chan H.H.L., Lam L.K., Wong S.Y., Kono T. and Trendall-Smith N., Use of 1,320 nm Nd:YAG laser for wrinkle reduction and the treatment of atrophic acne scarring in Asians, Lasers in Surgery and Medicine. 2004, 34: 98-103.

Hui Y., Wong S.Y., Wong L.Y., Ho W.K. and Wei W.I., Year Book of Otolaryngology - Head and Neck Surgery. Mosby, 2004.

Wong S.Y. and Wong L.Y., "Cystic" parotid swelling on FNA: significance on clinical management, Otolaryngology - Head and Neck Surgery. 2004, 130: 593-596.

Wong S.Y., Council Member (1999 - present), Plastic Surgery Board, Hong Kong Academy of Medicine. 2004.

Wong S.Y., Council Member, The Hong Kong Head & Neck Society. 2004.

Wong S.Y., Examiner, Exit Examination in Plastic Surgery (2000 - present), Plastic Surgery Board, Hong Kong Academy of Medicine. 2004.

Wong S.Y., Cheung S.T. and Fan S.T., Expression of granulin/epithelin precursor (GEP) in hepatocellular carcinoma associated with growth and invasion competency (Abstract), Proceedings of the American Association for Cancer Research. 2003, 44: 1302.

Wong S.Y., Fellow (2002 - present), American College of Surgeons. 2004.

Wong S.Y., Instructor (1997 - present), Advanced Burn Life Support Course, American Burn Association. 2004.

Wong S.Y., President Elect (2001 - 2003), Hong Kong Burns Society. 2004.

Wong S.Y., Registered Trainer in Plastic & Reconstructive Surgery for Post-fellowship Trainees (1995 - present), Hong Kong Academy of Medicine. 2004.

Wong S.Y., Registered Trainer in Plastic & Reconstructive Surgery for Pre-fellowship Trainees (1992 - present), Hong Kong Academy of Medicine. 2004.

Wong S.Y., Secretary, Plastic Surgery Board, Hong Kong Academy of Medicine. 2004.

Wong S.Y., Treasurer, Organizing Committee, 3rd Asian-Pacific Meeting on Dermatologic Laser & Facial Cosmetic Surgery, October 2005. 2004.

Wong S.Y., Treasurer, Hong Kong Burns Society. 2004.

Wong S.Y., Treasurer, Hong Kong Society for Plastic & Reconstructive Sutgeons. 2004.

Researcher : Wong SY (Wong San Yu)

List of Research Outputs

Cheung S.T., Wong S.Y. and Fan S.T., GEP as a novel therapeutic target for liver cancer: identification using cDNA microarray approach (Poster Presentation), The International Society for Cancer Gene Therapy 2004 Singapore Conference, Singapore, 20-22 February 2004.

Wong S.Y., Cheung S.T. and Fan S.T., Expression of granulin/epithelin precursor (GEP) in hepatocellular carcinoma associated with growth and invasion competency (Abstract), Proceedings of The 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., U.S.A., 11-14 July 2003. 44: 1302.

Wong S.Y., Significance of the granulin-epithelin precursor (GEP) gene in hepatocellular carcinoma, Thesis, Master of Philosophy, The University of Hong Kong. 2003.

Researcher : Wong TS

List of Research Outputs

Wong T.S., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Wei W.I., Kwong Y.L. and Yuen P.W., Promoter Hypermethylation Of High-in-normal 1 Gene In Primary Nasopharyngeal Carcinoma, Clinical Cancer Research. 2003, 9: 3042-3046.

Wong T.S., Man M., Lam A.K.Y., Wei W.I., Kwong Y.L. and Yuen P.W., The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR, European Journal of Cancer. 2003, 39(13): 1881-1887.

Researcher : Wong WY

List of Research Outputs

Ko S., Chu K.M., Luk J.M.C., Wong W.Y., Leung S.Y., Yuen S.T. and Wong J., Expression of CDX2 and LI-cadherin in intestinal metaplasia and adenocarcinoma of the stomach, 95th Annual Meeting of the American Association for Cancer Research, Orlando, U.S.A., 27-31 March 2004.

Luk J.M.C., Wong W.Y., Hu M.Y. and Fan S.T., Liver-intestine cadherin: a potential disease marker for hepatocellular carcinoma (Abstract), Hepatology. 2003, 38(4 Suppl.): 515.

Wang X., Wong W.Y., Leung P.L., Leung P.L., Leung P.L., Fan S.T. and Luk J.M.C., Molecular characterization of LI-cardherin mutations in hepatocellular carcinoma (Abstract), Hong Kong-Shanghai International Liver Congress, The 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and The 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Wong W.Y., Identification and characterization of LI-cadherin in hepatocellular carcinoma, Thesis, Master of Philosophy, The University of Hong Kong. 2004.

Researcher : Wong YK

List of Research Outputs

Chow C.K., Hui Y., Au D.K.K., LAM W.W.M. and Wong Y.K., Management of bilateral cochlear fistula in cochlear implantation, 7th European Symposium on Paediatric Cochlear Implantation, Geneva, Switzerland, 2-5 May 2004.

Hui Y., Wong Y.K. and Wei W.I., Speech outcomes of prelingually deafened Cantonese-speakers after cochlear implantation, 4th Congress of Asia Pacific Symposium on Cochlear Implant and Related Science, Taipei, Taiwan, 6 December 2003 . 2003.

Researcher : Wong Wu LH

List of Research Outputs

Cheng S.W.K., Ting A.C.W., Ho P. and Wong Wu L.H., Accelerated progression of carotid stenosis in patients with previous external neck irradiation, Journal of Vascular Surgery. 2004, 39 (2): 409-415.

Researcher : Wu PMC

List of Research Outputs

Law M., Cheng K.C., Wu P.M.C., Ho W.Y. and Chow L.W.C., Patient effective dose from sentinel lymph node lymphoscintigraphy in breast cancer: a study using a female humanoid phantom and thermoluminescent dosemeters, The British Journal of Radiology. 2003, 76(911): 818-823.

Researcher : Xie Y

List of Research Outputs

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Zhao P., Huang X., Vande Woude G. and Wong J., Hepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor (Abstract), Diseases of the Esophagus . 2004, 17, Supplement 1: A101-A102.

Researcher : Xu S

List of Research Outputs

Xu R., Sun X., Tse L.Y., Li H., Chan P.C., Xu S., Xiao W., Kung H., Krissansen G.W. and Fan S.T., Long-term expression of angiostatin suppresses metatatic liver cancer in mice (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Xu R., Cai K., Zheng D.X., Ma H., Xu S. and Fan S.T., Molecular therapeutics of HBV, Current Gene Therapy. 2003, 3 (4): 341-355.

Researcher : Yang Z

List of Research Outputs

Yang Z., Tsui T.Y., Ho D.W.Y., Tang T.C.M. and Fan S.T., Heme oxygenase-1 potentiates the survival of small-for-size liver graft, Liver Transplantation. 2004, 10(6): 784-793.

Yang Z., Ho D.W.Y., Chu A.C.Y., Wang Y. and Fan S.T., Linking inflammation to acute rejection in small-for-size allografts: the potential role of early macrophage activation, American Journal of Transplantation. 2004, 4(2): 196-209.

Yang Z., Poon R.T.P., To J.Y.T., Ho D.W.Y. and Fan S.T., The potential role of hypoxia inducible factor 1a in tumour progression after hypoxia and chemotherapy in hepatocellular carcinoma (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Researcher : Yau TO

List of Research Outputs

Chan C.F., Yau T.O., Jin D., Wong C.M., Fan S.T. and Ng I.O.L., Evaluation of nuclear factor-kB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 pt. 1): 4140-4149.

Researcher : Yeung C

List of Research Outputs

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database (Oral Presentation), The 124th Annual Meeting of the American Surgical Association, San Francisco, U.S.A., 15-17 April 2004.

Poon R.T.P., Yeung C., Liu C.L., Lam C.M., Yuen W.K., Lo C.M., Tang A. and Fan S.T., Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial, Gut. 2003, 52(12): 1768-1773.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement, World Journal of Surgery. 2004, 28(6): 602-608.

Yeung C., Fellow (1990 - present), American College of Surgeons. 2004.

Researcher : Yeung JSL

List of Research Outputs

Jin O., Tan K.C., Yeung J.S.L., Tam S.C.F. and Lau W.C.S., Influence on hyperlipidaemia on macrophage phagocytosis of apoptotic cells, 7th International Congress on SLE & Related Conditions, New York. 2004.

Researcher : Yip AWC

List of Research Outputs

Shiu S.Y.W., Law I.C., Law K.W., Tam P.C., Yip A.W.C. and Ng W.T., Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT₁ receptor subtype, Journal of Pineal Research. 2003, 35: 177-182.

Researcher : Yu WC

List of Research Outputs

Liu Y., Poon R.T.P., Feng X., Yu W.C., Luk J.M.C. and Fan S.T., Reduced expression of chemokine receptors on peripheral blood lymphocytes in patients with hepatocellular carcinoma, American Journal of Gastroenterology. 2004, 99(6): 1111-1121.

Poon R.T.P., Chung K.K., Cheung S.T., Lau C., Tong C.S.W., Leung K.L., Yu W.C., Tuszynski G.P. and Fan S.T., Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma, Clinical Cancer Research. 2004, 10(12 Pt1): 4150-4157.

Poon R.T.P., Lau C.P.Y., Yu W.C., Fan S.T. and Wong J., High serum levels of vascular endothelial growth factor predict poor response to transarterial chemoembolizatin in hepatocellular carcinoma: a prospective study, Oncology Reports. 2004, 11(5): 1077-1084.

Poon R.T.P., Yu W.C., Fan S.T. and Wong J., Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 779-788.

Poon R.T.P., Lau C.P.Y., Ho J.W.Y., Yu W.C., Fan S.T. and Wong J., Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma, Clinical Cancer Research. 2003, 9(14): 5339-5345.

Ren Y., Poon R.T.P., Tsui H.T., Chen W.H., Li Z., Lau C., Yu W.C. and Fan S.T., Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis, Clinical Cancer Research. 2003, 9(16 Pt1): 5996-6001.

Ren Y., Tsui H.T., Poon R.T.P., Ng I.O.L., Li Z., Chen Y., Jiang G., Lau C.P.Y., Yu W.C., Bacher M. and Fan S.T., Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma, International Journal of Cancer. 2003, 107(1): 22-29.

Researcher : Yuen AWC

List of Research Outputs

Lam C.M., Fan S.T., Yuen A.W.C., Law W.L. and Poon K., Validation of POSSUM scoring systems for audit of major hepatectomy, British Journal of Surgery. 2004, 91(4): 450-454.

Researcher : Yuen PW

Project Title:	The evaluation of the clinical application of hypermethylated promoter DNA as tumor marker for the early detection of residual or recurrent head and neck squamous cell carcinoma
Investigator(s):	Prof. Yuen P.W., Dr. Chang H.W.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2002

Abstract:

The project is to evaluate the sensitivity and specificity of serial monitoring of methylated promoter of DNA in peripheral blood of patients as tumour marker for early detection of residual or recurrent head and neck squamous cell carcinoma (HNSCC).

Project Title:	The quantitative evaluation of hypermethylated p15 and death associate protein kinase (DAP-kinase) gene promoter DNA copy number in mouth and throat rinsing fluid as premalignant genetic marker in the development of squamous cell carcinoma of head and neck associated with tobacco consumption
Investigator(s):	Prof. Yuen P.W., Dr. Chang H.W.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002
Completion Date:	10/2003

Abstract:

To evaluate quantitative genetic markers of head and neck premalignancy associated with chronic tobacco consumption in mouth and throat rinsing fluid.

Project Title:	The identification of proteomic tumor marker of upper aerodigestive tract squamous cell carcinoma
Investigator(s):	Prof. Yuen P.W., Dr. Chiu J.F., Dr. He Q.Y.
Department:	Surgery
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2003

Abstract:

To identify the proteomic tumor markers of UADTSCC that are differentially expressed in both UADTSCC primary tumor and sera of patients. These differentially expressed proteins can provide information on the molecular mechanism of carcinogenesis of UADTSCC and may also be used clinically for screening of cancer and monitoring recurrence after treatment.

Project Title:	The identification of proteomic tumor marker of upper aerodigestive tract squamous cell carcinoma
Investigator(s):	Prof. Yuen P.W., Dr. Chiu J.F., Dr. He Q.Y.
Department:	Surgery
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	09/2003

Abstract:

Project Title:	The identification of a panel of methylated gene promoters as tumor markers of nasopharyngeal carcinoma
Investigator(s):	Prof. Yuen P.W.
Department:	Surgery
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To identify a panel of methylated genes as tumor marker of nasopharyngeal carcinoma (NPC).

List of Research Outputs

Chang H.W., Chan A., Kwong D.L.W., Wei W.I., Sham J.S.T. and Yuen P.W., Detection of hypermethylated RIZ1 gene in primary tumor, mouth, and throat rinising fluid, nasopharyngeal swab, and peripheral blood of nasopharyngeal carcinoma patient, Clinical Cancer Research . 2003, 9: 1033-1038.

Chang H.W., Chan A., Kwong D.L.W., Wei W.I., Sham J.S.T. and Yuen P.W., Evaluation of hypermethylated tumor suppressor genes as tumor marker in mouth and throat rinsing fluid, nasopharyngeal swab, peripheral blood of naospharyngeal carcinoma patients, International Journal of Cancer. 2003, 105(6): 851-855.

Chang H.W., Ling G.S., Wei W.I. and Yuen P.W., Smoking and drinking can induce p15 hypermethylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma , Cancer. 2004, 101: 125-132.

He Q., Chen J., Kung H., Yuen P.W. and Chiu J., Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics, Proteomics. 2004, 4: 271-8.

Ho W.K., Yuen P.W., Tang K.C., Wei W.I. and Lam P.K.Y., Time course in the relief of nasal blockage after septal and turbinate surgery - a prospective study, Archives of Otolaryngology, Head and Neck Surgery. 2004, 130(3): 324-328.

Jin Y., Jin C., Law S.Y.K., Chu K.M., Zhang H., Stromback B., Yuen P.W. and Kwong Y.L., Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas, Cancer Genetics Cytogenetics. 2004, 148(1): 21-28.

Jin Y., Zhang H., Tsao G.S.W., Jin C., Lv M., Strombeck B., Wiegant J., Wan T.S.K., Yuen P.W. and Kwong Y.L., Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20, Gynecologic Oncology. 2004, 92: 183-191.

Lam P.K.Y., Au-Yeung K.M., Cheng P.W., Wei W.I., Yuen P.W., Trendell-Smith N., Li J.H. and Li R., Correlating MRI and histologic tumor thickness in the assessment of oral tongue cancer, American Journal of Roentgenology. 2004, 182(3): 803-808.

Lin W.M., Yuan X., Yuen P.W., Wei W.I., Sham J.S.T., Shi P.C. and Qu J., Classification of in vivo autofluorescence spectra using support vector machines, Journal of Biomedical Optics. 2004, 9(1): 180-186.

Wong L.Y., Wei W.I., Lam L.K. and Yuen P.W., Salvage of recurrent head and neck squamous cell carcinoma after primary curative surgery, Head & Neck. 2003, 25(1): 953-959.

Wong T.S., Kwong D.L.W., Sham J.S.T., Wei W.I., Kwong Y.L. and Yuen P.W., Clinicopathologic significance of plasma matrix metalloproteinase-2 and -9 levels in patients with undifferentiated nasopharyngeal carcinoma, European Journal of Surgical Oncology. 2004, 30(5): 560-564.

Wong T.S., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Wei W.I., Kwong Y.L. and Yuen P.W., Promoter Hypermethylation Of High-in-normal 1 Gene In Primary Nasopharyngeal Carcinoma, Clinical Cancer Research. 2003, 9: 3042-3046.

Wong T.S., Kwong D.L.W., Sham J.S.T., Wei W.I., Kwong Y.L. and Yuen P.W., Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma, Clinical Cancer Research. 2004, 10(7): 2401-2406.

Wong T.S., Man M., Lam A.K.Y., Wei W.I., Kwong Y.L. and Yuen P.W., The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR, European Journal of Cancer. 2003, 39(13): 1881-1887.

Yuen P.W., Allgeric rhinitis and its complications - case management discussion (Invited Lecture), Pharmacy Central Continuing Education Committee, Hong Kong, 27 November 2003. 2003.

Yuen P.W., Associate Member (1996 - present), American Association of Cancer Research. 2004.

Yuen P.W., Censor-in-chief (2002 - present), The Hong Kong College of Otorhinolaryngologists. 2004.

Yuen P.W., Council Member (1999 - present), The Hong Kong College of Otorhinolaryngologists . 2004.

Yuen P.W., Examiner (1997 - present), Conjoint Fellowship Examination of The Hong Kong College of Otorhinolaryngologists and The Royal College of Surgeons of Edinburgh. 2004.

Yuen P.W., Fellow (1989 - present), The Hong Kong Society of Otorhinolaryngology, Head and Neck Surgery. 2004.

Yuen P.W., Fellow (1991 - present), Hong Kong Head and Neck Society. 2004.

Yuen P.W., Head and neck resection and reconstruction - what is new? (Invited Lecture), St. Teresa's Hospital, Hong Kong, 13 June 2004. 2004.

Yuen P.W., Honorary Adviser, Public Doctors Association on "Medical Consultation" Column of the Hong Kong Economic Times. 2004.

Yuen P.W., Honorary Councilor (1993 - present), The New Voice Club, Hong Kong. 2004.

Yuen P.W., Member (1995 - present), Working Groups on Hospital Medical Record, Computer Sevices, Operation Theatre Services, Research Committee, Queen Mary Hospital. 2004.

Yuen P.W., Member (1996 - present), Education Committee, The Hong Kong College of Otorhinolaryngologists . 2004.

Yuen P.W., Member (1996 - present), The American Academy of Otolaryngology Head and Neck Surgery. 2004.

Yuen P.W., Member of Editorial Board (1996 - present), Korean Journal of Rhinology. 2004.

Yuen P.W., Member of Editorial Board (2001 - present), Hong Kong Medical Journal. 2004.

Yuen P.W., Member of Organizing Committee and Session Chairman (1996 - present), Asian Research Symposium in Rhinology. 2004.

Yuen P.W., Member of Reviewers Board (2001 - present), Medical Science Monitor. 2004.

Yuen P.W., Reviewer, Asian Journal of Surgery. 2004.

Yuen P.W., Reviewer, British Journal of Cancer. 2004.

Yuen P.W., Reviewer, Head Neck. 2004.

Yuen P.W., Reviewer, Hong Kong Medical Journal. 2004.

Yuen P.W., Reviewer, Oncogene. 2004.

Yuen P.W., Reviewer, Oncology. 2004.

Zhang H., Tsao G.S.W., Jin C., Stromback B., Yuen P.W., Kwong Y.L. and Jin Y., Sequential Cytogenetic and Molecular Cytogenetic Characterization of an SV40T Immortalized Nasopharyngeal Cell Line transformed by Epstein-Barr virus latent membrane protein-1 gene, Cancer Genetics and Cytogenetics . 2004, 150: 144-52.

Researcher : Yuen WK

List of Research Outputs

Kwan E., Lau H. and Yuen W.K., Laparoscopic resection of a mesenteric cyst (Case Report), Gastrointestinal Endoscopy. 2004, 59(1): 154-156.

Lau H., Patil N.G., Yuen W.K. and Lee F.C.W., Prevalence and severity of chronic groin pain after endoscopic totally extraperitoneal inguinal hernioplasty, Surgical Endoscopy. 2003, 17: 1620-1623.

Lau H., Patil N.G. and Yuen W.K., Prevalence and severity of chronic groin pain following endoscopic totally extraperitoneal inguinal hernioplasty, New Challenges in Healthcare, 10th Anniversary of Celebration Programme of the Hong Kong Academy of Medicine, Hong Kong, 28-30 November 2003.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database (Oral Presentation), The 124th Annual Meeting of the American Surgical Association, San Francisco, U.S.A., 15-17 April 2004.

Poon R.T.P., Yeung C., Liu C.L., Lam C.M., Yuen W.K., Lo C.M., Tang A. and Fan S.T., Intravenous bolus somatostatin after diagnostic cholangiopancreatography reduces the incidence of pancreatitis associated with therapeutic endoscopic retrograde cholangiopancreatography procedures: a randomised controlled trial, Gut. 2003, 52(12): 1768-1773.

Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Lam C.M., Yuen W.K., Yeung C. and Wong J., Pancreaticoduodenectomy with en bloc portal vein resection for pancreatic carcinoma with suspected portal vein involvement, World Journal of Surgery. 2004, 28(6): 602-608.

Sit K.Y., Lau H. and Yuen W.K., Laparoscopic resection of accessory spleen (Abstract), Annals of The College of Surgeons of Hong Kong. 2004, 8 Suppl.: S24.

Sit K.Y., Lau H. and Yuen W.K., Laparoscopic resection of accessory spleen, 12th Annual Scientific Meeting of the Hong Kong Society of Minimal Access Surgery jointly with Macao Surgery Association, Macau, 10 January. 2004.

Yuen W.K., Chairman (September 1997 - present), Trauma Service Executive Committee, Queen Mary Hospital, Hong Kong. 2004.

Yuen W.K., Course Director (1997 - present), Advanced Trauma Life Support Course, American College of Surgeons. 2004.

Yuen W.K., Fellow (1998 - present), American College of Surgeons. 2004.

Yuen W.K., Member (2000 - present), Working Group on Trauma Service (HAHO). 2004.

Yuen W.K., Member (2002 - present), Specialty Group on General Surgery COC (Surgery HAHO). 2004.

Researcher : Zhang H

List of Research Outputs

Jin Y., Jin C., Law S.Y.K., Chu K.M., Zhang H., Stromback B., Yuen P.W. and Kwong Y.L., Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas, Cancer Genetics Cytogenetics. 2004, 148(1): 21-28.

Jin Y., Zhang H., Tsao G.S.W., Jin C., Lv M., Strombeck B., Wiegant J., Wan T.S.K., Yuen P.W. and Kwong Y.L., Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20, Gynecologic Oncology. 2004, 92: 183-191.

Zhang H., Tsao G.S.W., Jin C., Stromback B., Yuen P.W., Kwong Y.L. and Jin Y., Sequential Cytogenetic and Molecular Cytogenetic Characterization of an SV40T Immortalized Nasopharyngeal Cell Line transformed by Epstein-Barr virus latent membrane protein-1 gene, Cancer Genetics and Cytogenetics . 2004, 150: 144-52.

Researcher : Zhao Y

List of Research Outputs

Ho J.W.Y., Man K., Sun K.W., Zhao Y., Fan S.T. and Poon R.T.P., FTY720, a study of its impact on angiogensis and tumor growth in nude mice bearing hepatocellular carcinoma (Oral Presentation), AACR-NCI-EORTIC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Liu C.L., Zhao Y., Lo C.M. and Fan S.T., Hepatic venoplasty in right lobe live donor liver transplantation, Liver Transplantation. 2003, 9(12): 1265-1272.

Man K., Lo C.M., Ng T.P., Zhao Y., Ho J.W.Y., Sun K.W. and Fan S.T., Attenuation of hepatic I/R injury on small liver remnant by FTY720 markedly suppressed liver tumor growth and metastasis (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Ng T.P., Lee K.W., Lo C.M., Sun K.W., Li X.L., Zhao Y., Ho J.W.Y. and Fan S.T., FTY720 attenuates hepatic ischemia-reperfusion injury by Egr-1 down-regulation involving Raf-MEK-Erk pathway and Akt activation (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathway (Abstract), Liver Transplantation. 2004, 10(6): C69.

Man K., Ng T.P., Lo C.M., Zhao Y., Sun K.W., Ho J.W.Y., Lee K.W. and Fan S.T., Hepatic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ho J.W.Y., Lee K.W., Zhao Y., Wang X.H., Ng T.P., Sun K.W. and Fan S.T., Marked suppression of tumor growth by FTY720 in rat and mouse liver tumor models (Abstract), AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, U.S.A., 17-21 November 2003.

Man K., Zhao Y., Xu A.M., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus adiponectin combination therapy (Abstract), Liver Transplantation. 2004, 10(6): C75.

Man K., Zhao Y., Lo C.M., Ng T.P., Sun K.W., Lee K.W. and Fan S.T., Rescue of small-for-size fatty liver grafts injury by FTY720 plus asiponectin combination therapy (Abstract), The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.

Man K., Ng T.P., Lo C.M., Ho J.W.Y., Zhao Y., Sun K.W., Lee K.W., Li X.L. and Fan S.T., The significance of hepatic ischemia-reperfusion injury on liver tumor development - activation of cell invasion and migration pathways (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Lee K.W., Sun K.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 3 January 2004.

Zhao Y., Man K., Lo C.M., Ng T.P., Li X.L., Sun K.W., Dai X.W. and Fan S.T., FTY720 attenuates small-for-size liver graft injury - the significance of activation of cell survival signaling pathway (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Zhao Y., Lo C.M., Liu C.L. and Fan S.T., Use of elderly donors (>60 years) for liver transplantation, Asian Journal of Surgery. 2004, 27(2): 114-119.

Researcher : Zhou L

List of Research Outputs

Ho J.W.Y., Sun K.W., Zhou L., Poon R.T.P. and Fan S.T., Clinicopathological and prognostic implications of endoglin (CD105) staining in hepatocellular carcinoma and its adjacent liver (Abstract), Hong Kong-Shanghai International Liver Congress, the 3rd Scientific Meeting of Cheng Si Yuan (China-International) Hepatic Research Foundation, and the 5th Shanghai International Symposium on Liver Cancer and Hepatitis, Hong Kong, 14-17 February 2004.

Researcher : Zhu L

List of Research Outputs

Chow L.W.C., Zhu L. and Loo T.Y., HER-2/NEU expression in breast cancer patients: pre- and postexposure to neoadjuvant endocrine therapy, 10th Hong Kong International Cancer Congress, Hong Kong, November 2003.

Kong W., Yu L., Hui Y., Yue J., Xiong X., Zhu L. and Duan J., 先天性話前聾中國兒童雙耳人工耳蝸植入療效觀察, 臨床耳鼻咽喉科雜誌, 2003, 17 (10): 577-579.

孔 .?.?..?.?., Hui Y., Yue J., Xiong X., Zhu L., 孔祥.泉., 韓萍. and 馬輝., 人工耳蝸植入術前聽神經完整性的評估, Chinese Journal of Otology. 2003, 1 (2): 26-30.

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