Dept of Obstetrics & Gynaecology

THE UNIVERSITY OF HONG KONG
Research and Scholarship 2004

DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Researcher : Basir GS

List of Research Outputs

Basir G.S., Leung W.C., Lam H.S.W., Cheung P.T. and Lao T.T.H., Comparison of maternal and fetal doppler haemodynamics in pregnancies conceived by IVF-ET versus spontaneous conception in the third trimester, Abstract for Hong Kong Academy of Medicine, November 28-30, 2003, Hong Kong. 2003.

Basir G.S., Cheung P.T., Cheung A.N.Y. and Lao T.T.H., Effect of the mode of conception on incidences of apoptotic and proliferative cells in full term human placentas, Abstract for 194th Meeting of the Society for Endocrinology and Society for Endocrinology jointly with Diabetes U.K., November 3-5, 2003, London, U.K. . 2003.

Basir G.S., Cheung P.T., Cheung A.N.Y. and Lao T.T.H., Immunohistochemical localization of insulin like growth factor 1 (IGF-1) and insulin like growth factor 1 receptors (IGF-1R) in the placentas of normal and complicated pregnancies, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Researcher : Chan CCW

List of Research Outputs

Chan C.C.W., Ng E.H.Y., Chan M.M.Y., Tang F.O.S., Lau E.Y.L., Yeung W.S.B. and Ho P.C., Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women, Human Reproduction. 2003, 18(11): 2294-2297.

Chan C.C.W., Ng E.H.Y., Li I.C.F. and Ho P.C., Impaired ovarian blood flow and reduced antral follicle count following laparoscopic salpingectomy for ectopic pregnancy, Human Reproduction. 2003, 18(10): 2175-2180.

Chan C.C.W., Lao T.T.H., Ho P.C., Sung E.O.P. and Cheung A.N.Y., The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study, Journal of Clinical Endocrinology & Metabolism. 2003, 88(12): 5846-5850.

Chan C.C.W., Chu F. and Pun T.C., Treating a recurrent uterine arteriovenous malformation with uterine artery embolization - A case report, The Journal of Reproductive Medicine. 2003, 48(11): 905-907.

Li I.C.F., Chan C.C.W. and Ho P.C., A comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation, Obstetrics and Gynecology. 2003, 102(3): 583-588.

Li I.C.F., Chan C.C.W. and Ho P.C., A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy, Contraception. 2003, 68: 269-272.

Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial blood flow measured during early luteal phase by three-dimensional power Doppler ultrasound in excessive ovarian responders, Human Reproduction. 2004, 19(4): 924-931.

Tang F.O.S., Lau W.N.T., Chan C.C.W. and Ho P.C., A prospective randomized trial on the use of sublingual versus vaginal misoprostol for second trimester medical abortion, 19th Annual Meeting of the European Society of Human Reproduction and Embryology, Madrid, Spain, June 28-July 2, 2004.

Tang F.O.S., Chan C.C.W., Ng E.H.Y., Lee W.H. and Ho P.C., A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misprostol for medical abortions of less than 9 weeks gestation, Human Reproduction. 2003, 18(11): 2315-2318.

Researcher : Chan CP

List of Research Outputs

Au W.Y., Chan C.P., Chung L.P. and Choy C.K.W., Primary B-Cell lymphoma and lymphoma-like lesions of the uterine cervix, American Journal of Hematology. 2003, 73: 176-179.

Chan C.P., Shek T.W.H. and Lee C.P., First-trimester diagnosis of hydrolethalus syndrome in a Chinese family, Prenatal Diagnosis. 2004, 24: 587-590.

Researcher : Chan KKL

Project Title:	Relationship between placental ratio and placental function
Investigator(s):	Dr. Chan K.K.L., Prof. Lao T.T.H.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003

Abstract:

To examine the relationship between PR and placental function in terms of fetal acid- base balance, haematology and biochemiatry; to determine if there is a cut-off in the PR for the detection of fetal growth restriction (FRG) as reflected by changes in placental function in newborns with birthweigth within the normal range.

Project Title:	The role resistin in gestational diabetes and its relationship with pregnancy outcome
Investigator(s):	Dr. Chan K.K.L., Prof. Lam K.S.L., Prof. Lao T.T.H., Dr. Tso A.W.K.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To investigate the hypothesis that resistin expression is associated with insulin resistance in pregnancy and has implications on neonatal outcome.

List of Research Outputs

Chan K.K.L., Ho L.F. and Lao T.T.H., Nutritional intake and placental size in gestational diabetic pregnancies - a preliminary observation, Placenta. 2003, 24: 985-988.

Researcher : Chan STH

List of Research Outputs

Xu J., Chan S.T.H., Lee W.M., Lee C.K.F. and Yeung W.S.B., Differential growth, cell proliferation and apoptosis of mouse embryo in variuos culture media and in coculture, Molecular Reproduction and Development. 2004, 68(1): 72-80.

Researcher : Chan YM (Chan Yuk May)

List of Research Outputs

Tam K.F., Cheung A.N.Y., Liu K.L., Ng T.Y., Pun T.C., Chan Y.M., Wong R.L.C., Ng W.Y. and Ngan H.Y.S., A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification, Gynecologic Oncology. 2003, 91(3): 603-607.

Researcher : Chan YM (Chan Yik Ming)

List of Research Outputs

Chan Y.M., Ng T.Y., Ngan H.Y.S. and Wong R.L.C., Screening for HIV infection in women with newly diagnosed cervical cancer, Gynecologic Oncology. 2003, 92(1): 300-303.

Chan Y.M., Ng T.Y., Lee P.W.H., Ngan H.Y.S. and Wong R.L.C., Symptoms, coping strategies, and timing of presentations in patients with newly diagnosed ovarian cancer, Gynecologic Oncology. 2003, 90(3): 651-656.

Chan Y.M., Lee P.W.H., Ng T.Y., Ngan H.Y.S. and Wong R.L.C., The use of music to reduce anxiety for patients undergoing colposcopy: a randomized trial, Gynecologic Oncology. 2003, 91: 213-217.

Researcher : Chen M

List of Research Outputs

Chen M., Lee C.P., Leung K.Y., Hui P.W. and Tang M.H.Y., Pilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population, Prenatal Diagnosis. 2004, 24: 87-91.

Chen M., Lam Y.H., Lee C.P. and Tang M.H.Y., Ultrasound screening of fetal structural abnormalities at 12 to 14 weeks in Hong Kong, Prenatal Diagnosis. 2004, 24: 92-97.

Leung K.Y., Chen M., Lee C.P., Tang M.H.Y. and Ho P.C., The use of three-dimensional fetal and placental volume to predict homozygous alpha-thalassaemia, Frontier in Biomedical Research, The University of Hong Kong, December 12, 2003, Hong Kong. 2003.

Leung K.Y. and Chen M., Three-dimensional ultrasound fetal volume measurement: a study comparing the multiplanar technique with the rotational (VOCAL) technique, 13th World Congress on Ultrasound in Obstetrics and Gynaecology, August 31-September 4, 2003, Paris, France. 2003.

Researcher : Cheng DKL

List of Research Outputs

Cheung A.N.Y., Khoo U.S., Lai C.Y.L., Chan Y.K., Xue W., Cheng D.K.L., Chiu P.M., Tsao G.S.W. and Ngan H.Y.S., Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis, Cancer. 2004, 100(7): 1411-1417.

Researcher : Chiu CN

List of Research Outputs

Chiu C.N., Hong S., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., A capillary - cumulus model to study the selection of sperm by cumulus oophorus, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Chiu C.N., Tsang H.Y., Koistinen R., Koistinen H., Seppala M., Lee C.K.F. and Yeung W.S.B., The contribution of D-Mannose, L-Fucose, N-Acetylglucosamine, and selectin residues on the binding of glycodelin isoforms to human spermatozoa, Biology of Reproduction. 2004, 70: 1710-1719.

Hong S., Chiu C.N., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., Establishment of a capillary-cumulus model to study the selection of sperm for fertilization by the cumulus oophorus, Human Reproduction. 2004, 19(7): 1562-1569.

Koistinen H., Easton R.L., Chiu C.N., Chalabi S., Halttunen M., Dell A., Morris H.R., Yeung W.S.B., Seppala M. and Koistinen R., Differences in glycosylation and sperm-egg binding inhibition of pregnancy-related glycodelin, Biology of Reproduction. 2003, 69: 1545-1551.

Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., New isofrom of glycodeln involving in fertilization, 2003 International Symposium Gametgenesis, Gene Expression and Human Reproduction, November 8-9, 2003, Dongguan, China. 2003.

Researcher : Chow JFC

List of Research Outputs

Lee C.K.F., Yeung W.S.B., Chow J.F.C., Shum C.K. and Luk J.M.C., Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis, Biology of Reproduction. 2004, 70: 1010-1017.

Researcher : Ho PC

Project Title:	Randomized study comparing the use of sublingual with vaginal misoprostol for preoperative cervical priming before surgical termination of pregnancy in the first trimester
Investigator(s):	Prof. Ho P.C., Dr. Tang F.O.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002
Completion Date:	10/2003

Abstract:

To compare the efficacy of sublingual with vaginal misoprostol in cervical priming before first trimester surgical termination of pregnancy.

Project Title:	A randomized trial to compare the use of sublingual misoprostol with or without an extended one-week course in the management of first trimester silent miscarriage
Investigator(s):	Prof. Ho P.C., Dr. Ong C.Y.T., Dr. Tang F.O.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To study the effect of a 1-week course of sublingual misoprostol on the incidence of complete miscarriage after medical management of silent miscarriage.

Project Title:	Role of glycodelin in fertilization
Investigator(s):	Prof. Ho P.C., Prof. Dell A., Dr. Koistinen R.A., Dr. Lee C.K.F., Prof. Seppala M., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2003

Abstract:

To establish a 3D capillary cumulus cell-matrix model to study the effect of the cumulus cell mass on the spermatozoa passing through it; to study the effect of GdA and GdF on the quality of spermatozoa passing through the cumulus mass; to study the metabolism of GdA and Gdf in cumulus cells; and to study the production of GdA and GdF by the granulosa cells, endometrial cells and oviducal cells.

Project Title:	Role of glycodelin in fertilization
Investigator(s):	Prof. Ho P.C., Prof. Dell A., Dr. Koistinen R.A., Dr. Lee C.K.F., Prof. Seppala M., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	12/2003

Abstract:

List of Research Outputs

Chan C.C.W., Ng E.H.Y., Chan M.M.Y., Tang F.O.S., Lau E.Y.L., Yeung W.S.B. and Ho P.C., Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women, Human Reproduction. 2003, 18(11): 2294-2297.

Chan C.C.W., Ng E.H.Y., Li I.C.F. and Ho P.C., Impaired ovarian blood flow and reduced antral follicle count following laparoscopic salpingectomy for ectopic pregnancy, Human Reproduction. 2003, 18(10): 2175-2180.

Chan C.C.W., Lao T.T.H., Ho P.C., Sung E.O.P. and Cheung A.N.Y., The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study, Journal of Clinical Endocrinology & Metabolism. 2003, 88(12): 5846-5850.

Chiu C.N., Hong S., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., A capillary - cumulus model to study the selection of sperm by cumulus oophorus, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Ho P.C., Doppler studies in the prediction of implantation in ART, First Scientific Meeting of International Society of Ultrasound in Obstetrics and Gynaecology, Singapoore, March 21-24, 2004.

Ho P.C., Emergency Contraception, XVIII FIGO World Congress of Obstetrics and Gynaecology, Santiago, Chile, November 2-7, 2003.

Ho P.C., Oestradiol levels and endometrial receptivity, Abstract for The 11th World Congress of Gynecological Endocrinology, Florence, Italy, February 26-29, 2004.

Ho P.C., Polycystic ovarian syndrome, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Ho P.C., Recent advances in ovarian stimulation in assisted reproduction, Seminar on Assisted Reproduction, Shanghai, P.R. China, December 13-14, 2003.

Hong S., Chiu C.N., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., Establishment of a capillary-cumulus model to study the selection of sperm for fertilization by the cumulus oophorus, Human Reproduction. 2004, 19(7): 1562-1569.

Kan A.S.Y., Ng E.H.Y. and Ho P.C., The role and comparison of two techniques of paracervical block for pain relief during suction evacuation for first-trimester pregnancy termination, Contraception. 2004, 70: 159-163.

Leung K.Y., Chen M., Lee C.P., Tang M.H.Y. and Ho P.C., The use of three-dimensional fetal and placental volume to predict homozygous alpha-thalassaemia, Frontier in Biomedical Research, The University of Hong Kong, December 12, 2003, Hong Kong. 2003.

Leung T.W., Leung W.C., Ng E.H.Y., Tiwari A., Taylor W.K., Sullivan P. and Ho P.C., Comparrison of prevalence of intimate partner violence among different groups of obstetric-gynaecology patients and evaluation of the impact of abuse on their quality of life, Abstract presented in the 5th Annual Scientific Meeting of RANZCOG, September 16-19, 2003, Auckland, New Zealand. 2003.

Leung T.W., Ng E.H.Y., Leung W.C. and Ho P.C., Intimate partner violence among infertile women, International Journal of Gynecology and Obstetrics. 2003, 83: 323-324.

Li I.C.F., Chan C.C.W. and Ho P.C., A comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation, Obstetrics and Gynecology. 2003, 102(3): 583-588.

Li I.C.F., Chan C.C.W. and Ho P.C., A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy, Contraception. 2003, 68: 269-272.

Makkar G., Ng E.H.Y., Yeung W.S.B. and Ho P.C., Prognostic factors for successful outcome in patients undergoing controlled ovarian stimulation and intrauterine insemination, Hong Kong Medical Journal. 2003, 9(5): 341-345.

Ng E.H.Y., Miao B., Cheung W. and Ho P.C., A randomised comparison of side effects and patient inconvenience of two vaginal progesterone formulations used for luteal support in in vitro fertilisation cycles, European Journal of Obstetrics & Gynecology and Reproduction Biology. 2003, 111: 50-54.

Ng E.H.Y., Yeung W.S.B. and Ho P.C., Absence of high grade perifollicular vascularity in poor ovarian responders is not associated with reduced pregnancy rate of in vitro fertilization treatment, Abstract of The 18th World Congress on Fertility and Sterility, Montreal, Canada, May 23-28, 2004.

Ng E.H.Y., Laird S.M., Li T.C., Yeung W.S.B. and Ho P.C., Concentations of endometrial protein PP 14 and CA-125 in uterine flushings performed in natural and stimulated cycles, Human Reproduction. 2004, 19(4): 905-910.

Ng E.H.Y., Laird S.M., Li T.C., Yeung W.S.B. and Ho P.C., Concentrations of endometrial protein PP 14 and CA-125 in uterine flushing of patients with excessive ovarian response during in vitro fertilization treatment, Abstract of The 18th World Congress on Fertility and Sterility, Montreal, Canada, May 23-28, 2004.

Ng E.H.Y., Yeung W.S.B., Fong D.Y.T. and Ho P.C., Effects of age on hormonal and ultrasound markers of ovarian reserve in Chinese women with proven fertility, Human Reproduction. 2003, 18(10): 2169-2174.

Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial blood flow measured during early luteal phase by three-dimensional power Doppler ultrasound in excessive ovarian responders, Human Reproduction. 2004, 19(4): 924-931.

Ngai C.S.W., Tang F.O.S. and Ho P.C., Prostaglandins for induction of second-trimester termination and intrauterine death, Best Practice & Research Clinical Obstetrics and Gynaecology. 2003, 17(5): 765-775.

Tang F.O.S., Lau W.N.T., Chan C.C.W. and Ho P.C., A prospective randomized trial on the use of sublingual versus vaginal misoprostol for second trimester medical abortion, 19th Annual Meeting of the European Society of Human Reproduction and Embryology, Madrid, Spain, June 28-July 2, 2004.

Tang F.O.S., Chan C.C.W., Ng E.H.Y., Lee W.H. and Ho P.C., A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misprostol for medical abortions of less than 9 weeks gestation, Human Reproduction. 2003, 18(11): 2315-2318.

Tang F.O.S., Mok T.K.H. and Ho P.C., A randomized study comparing the use of sublingual to vaginal misoprostol for pre-operative cervical priming prior to surgical termination of pregnancy in the first trimester, Human Reproduction. 2004, 19(5): 1101-1104.

Xu J., Chan S.T.H., Ho P.C. and Yeung W.S.B., Coculture of human oviductal cells maintains mitochondrial function and decreases caspase activity of cleavage-stage mouse embryos, Fertility and Sterility. 2003, 80(1): 178-183.

Researcher : Hon EHC

List of Research Outputs

Woo P.C.Y., Fung A.S.M., Lau S.K.P., Teng L.L., Wong B.H., Wong M.K., Hon E.H.C., Tang G.W.K. and Yuen K.Y., Actinomyces hongkongensis sp. nov. a novel Actinomyces species isolated from a patient with pelvic actinomycosis, Systematic and Applied Microbiology . 2003, 26(4): 518-22.

Researcher : Hong S

List of Research Outputs

Chiu C.N., Hong S., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., A capillary - cumulus model to study the selection of sperm by cumulus oophorus, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Hong S., Chiu C.N., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., Establishment of a capillary-cumulus model to study the selection of sperm for fertilization by the cumulus oophorus, Human Reproduction. 2004, 19(7): 1562-1569.

Researcher : Kwok KL

List of Research Outputs

Lee C.K.F., Kwok K.L., Ngan E.S.W., Xu J. and Yeung W.S.B., Demilune cell and parotid protein (DCPP) messenger RNA expression in mouse oviduct: hormonal regulation and embryo development, 20th Anniversary (1983-2003)& 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Researcher : Lam HSW

List of Research Outputs

Basir G.S., Leung W.C., Lam H.S.W., Cheung P.T. and Lao T.T.H., Comparison of maternal and fetal doppler haemodynamics in pregnancies conceived by IVF-ET versus spontaneous conception in the third trimester, Abstract for Hong Kong Academy of Medicine, November 28-30, 2003, Hong Kong. 2003.

Researcher : Lam KW

List of Research Outputs

Lam K.W., Pun T.C., Ng E.H.Y. and Wong K.S., Efficacy of preemptive analgesia for wound pain after laparoscopic operations in infertile women: a randomised, double-blind and placebo control study, British Journal of Obstetrics and Gynaecology. 2004, 111: 340-344.

Researcher : Lam YH

List of Research Outputs

Chen M., Lam Y.H., Lee C.P. and Tang M.H.Y., Ultrasound screening of fetal structural abnormalities at 12 to 14 weeks in Hong Kong, Prenatal Diagnosis. 2004, 24: 92-97.

Lau E.T., Kwok Y.K., Chui D.H.K., Luo H.Y., Leung K.Y., Lee C.P., Lam Y.H. and Tang M.H.Y., Prenatal detection of Hb Bart's Disease in Maternal Blood, 12th International Conference on Prenatal Diagnosis and Therapy, Budapest Hungary, June 24-27, 2004.

Researcher : Lao TTH

Project Title:	Study on the incidence of gestational diabetes in China
Investigator(s):	Prof. Lao T.T.H., Dr. Duthie S.J., Dr. Lee C.P., Dr. Wang Z.Q.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Croucher Foundation
Start Date:	03/1990
Completion Date:	12/2003

Abstract:

To investigate into the incidence of gestational glucose intolerance and to correlate this to the dietary habits in various parts of China.

Project Title:	Placental apoptotic and proliferative activities and infant outcome in complicated pregnancies - the relationship with insulin-like growth factor-I, insulin-like growth factor binding proteins, and placental insulin-like growth factor expression
Investigator(s):	Prof. Lao T.T.H., Dr. Cheung P.T., Dr. Cheung A.N.Y.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2000
Completion Date:	11/2003

Abstract:

To examine the relationship between the concentrations of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) in maternal and fetal blood, and the expression of IGF-1, IGFBPs, and IGFI-R in the placental trophoblast, with placental apoptotic and proliferative indices in complicated pregnancies resulting in infants that are small-, appropriate- and large-for gestational age in our community.

Project Title:	Dietary caloric intake and the development of gestational diabetes mellitus in at-risk Chinese women
Investigator(s):	Prof. Lao T.T.H., Dr. Leung W.C.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To determine the relationship between daily total caloric intake in the third trimester and the development of gestational diabetes mellitus in at-risk pregnant Chinese women; to compare the roles of toal caloric intake versus the carbohydrate: protein: fat ratio in the daily diet and development of gestational diabetes mellitus in the at-risk Chinese women.

Project Title:	The role of adiponectin in the development of gestational diabetes mellitus and its effect on pregnancy outcome
Investigator(s):	Prof. Lao T.T.H., Dr. Chan K.K.L., Prof. Lam K.S.L., Dr. Tso A.W.K.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To determine if plasma adiponectin concentration is reduced, at the time of the oral glucose tolerance test (OGTT), in women who develop GDM in the latter half of pregnancy versus women with normal OGTT; to determine, following the diagnosis of GDM, whether the subsequent changes in adiponectin concentration is associated with obstetric complications and perinatal morbidity; to correlate circulatory concentration of adiponectin with polymorphisms and mutations in the apM1 gene in high risk women with and without GDM, and with the expression of adiponectin in subcutaneous and omental fat cells obtained from biopsy at the time of caesarean delivery for obstetric indications; to correlate antenatal adiponectin concentration and result of the genetic study with the postnatal glucose tolerance status in the women who have developed GDM.

Project Title:	A study on the interrelationship among insulin-like growth factors, apoptosis and proliferation of trophoblast, and placental size throughout pregnancy, and their effects on infant outcome, in normal and diabetic pregnancies
Investigator(s):	Prof. Lao T.T.H., Dr. Cheung P.T., Dr. Cheung A.N.Y., Dr. Lam H.S.W., Dr. Leung W.C.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2003

Abstract:

To compare in the normal and diabetic pregnancies the relationship between ultrasound-estimated placenta size and its vasculature, and fetal size, with maternal circulatory levels of IGFs and IGFBPs in the three trimesters; to compare in the normal and diabetic pregnancies the relationship among placental expression of IGFs with placental apoptotic and proliferative indices and placental size at the time of delivery; to determine whether the interactions between IGFs and IGFBPs with placental growth and size in the different trimesters can be predictive of obstetric and perinatal complications; to determine whether the interactions between IGFs and IGFBPs with placental growth and size in the different trimesters can be predictive of fetal growth and size at birth; to examine the relationship between placental and newborn size with the placental expression of IGFs as well as the apoptotic and proliferative indices in normal and diabetic pregnancies.

Project Title:	A study on the interrelationship among insulin-like growth factors, apoptosis and proliferation of trophoblast, and placental size throughout pregnancy, and their effects on infant outcome, in normal and diabetic pregnancies
Investigator(s):	Prof. Lao T.T.H., Dr. Cheung P.T., Dr. Cheung A.N.Y., Dr. Lam H.S.W., Dr. Leung W.C.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	12/2003

Abstract:

List of Research Outputs

Basir G.S., Leung W.C., Lam H.S.W., Cheung P.T. and Lao T.T.H., Comparison of maternal and fetal doppler haemodynamics in pregnancies conceived by IVF-ET versus spontaneous conception in the third trimester, Abstract for Hong Kong Academy of Medicine, November 28-30, 2003, Hong Kong. 2003.

Basir G.S., Cheung P.T., Cheung A.N.Y. and Lao T.T.H., Effect of the mode of conception on incidences of apoptotic and proliferative cells in full term human placentas, Abstract for 194th Meeting of the Society for Endocrinology and Society for Endocrinology jointly with Diabetes U.K., November 3-5, 2003, London, U.K. . 2003.

Basir G.S., Cheung P.T., Cheung A.N.Y. and Lao T.T.H., Immunohistochemical localization of insulin like growth factor 1 (IGF-1) and insulin like growth factor 1 receptors (IGF-1R) in the placentas of normal and complicated pregnancies, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

But B., Chan C.W., Chan F., Chan K.W., Cheng A.W.F., Cheung P., Choi K.L., Chow C.B., Chow F.C.C., Eastman C., Fok T.F., Fung L.M., Gomes C., Huen K.F., Ip T.P., Kung A.W.C., Lam K.S.L., Lam Y.Y., Lao T.T.H., Lee C.Y., Lee K.F., Leung J., Leung N.K., Li D., Li J., Lo K.W., Low L.C.K., Ng K.L., Siu S.C., Tam S.C.F., Tan K.C.B., Tiu S.C., Tse H.Y., Tse W., Wong G., Wong S., Wong W., Yeung V.T.F., Young R., Yu C.M. and Yu R., Consensus statement on iodine deficiency disorders in Hong Kong, Hong Kong Medical Journal. 2003, 9: 446-453.

Chan C.C.W., Lao T.T.H., Ho P.C., Sung E.O.P. and Cheung A.N.Y., The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study, Journal of Clinical Endocrinology & Metabolism. 2003, 88(12): 5846-5850.

Chan K.K.L., Ho L.F. and Lao T.T.H., Nutritional intake and placental size in gestational diabetic pregnancies - a preliminary observation, Placenta. 2003, 24: 985-988.

Lao T.T.H. and Ho L.F., Does maternal glucose intolerance affect the length of gestation in singleton pregnancies?, Journal of The Society for Gynecologic Investigation. 2003, 10(6): 366-371.

Lao T.T.H., Fetal assessment in gestational diabetes mellitus, Obstetrics and Gynecology. 2003, 8(12): 675-678.

Lao T.T.H., Fetal surveillance in diabetic pregnancies, Journal of Paediatrics, Obstetrics and Gynaecology . 2003, July/August: 21-28.

Lao T.T.H., Gestational diabetes mellitus, Obstetrics. 2003, 4(10): 10-12.

Lao T.T.H., Tam K.F., Tse K.Y., Ho L.F. and Chan L.Y., HBsAg carrier status and the association between gestational diabetes with increased serum ferritin concentration in Chinese women, Diabetes Care. 2003, 26(11): 3011-3016.

Lao T.T.H. and Ho L...F..., Impact of iron deficiency anemia on prevalence of gestational diabetes mellitus, Diabetes Care. 2004, 27(3): 650-656.

Lao T.T.H., Leung W.C. and Wong R.M.S., Interval twin delivery following one second trimester miscarriage, Invited Speaker to attend the Perinatal Conference in Qingdao, China, June 26-July 1, 2004.

Lao T.T.H., Teenage pregnancies and obstetric outcome, JPOG-Continuing Medical Education . 2004, May/June: 121-128.

Lao T.T.H., Thyroid disorders complicating pregnancy, Journal of Perinatal Medicine . 2003, 31(suppl.1): 19.

Leung W.C., Lau E.T., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy screening (FISH or QF-PCR): the changing scene in prenatal diagnosis?, Expert Review of Molecular Diagnostics. 2004, 4(3): 89-93.

Leung W.C., Wong K.Y., Leung K.Y., Lee C.P., Tang M.H.Y. and Lao T.T.H., Serial amnioreductions in triplet fetofetal transfusion syndrome, Invited Speaker to attend the Perinatal Conference in Qingdao, China, June 26-July 1, 2004 . 2004.

Ma R.M., Xiao H., Jing X.T. and Lao T.T.H., Hemorrhagic fever with renal syndrome presenting with intrauterine fetal death (A case report)48(, The Journal of Reproductive Medicine. 2003, 48(8): 661-664.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Condidtions, New York. 2004.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-05.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Conditions, New York. 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-053.

Ong C.Y.T., Lao T.T.H., Spencer K. and Nicolaides K.H., Maternal serum level of placental growth factor in diabetic pregnancies, The Journal of Reproductive Medicine. 2004, 49(6): 477-480.

Quan A., Leung S.W.S., Lao T.T.H. and Man R.Y.K., 5-Hydroxytryptamine and Thromboxane A₂ as Physiologic Mediators of Human Umbilical Artery Closure, Journal of the Society for Gynecology Investigation. 2003, 10(8): 490-495.

Researcher : Lau EYL

List of Research Outputs

Chan C.C.W., Ng E.H.Y., Chan M.M.Y., Tang F.O.S., Lau E.Y.L., Yeung W.S.B. and Ho P.C., Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women, Human Reproduction. 2003, 18(11): 2294-2297.

Researcher : Lau WNT

List of Research Outputs

Tang F.O.S., Lau W.N.T., Chan C.C.W. and Ho P.C., A prospective randomized trial on the use of sublingual versus vaginal misoprostol for second trimester medical abortion, 19th Annual Meeting of the European Society of Human Reproduction and Embryology, Madrid, Spain, June 28-July 2, 2004.

Researcher : Lee CKF

Project Title:	The effect of embryos on the gene expression of mouse oviduct in the preimplantation period
Investigator(s):	Dr. Lee C.K.F., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2000

Abstract:

To study the mechanism by which embryos affect oviductal gene expression. The result of this project will cast light on the understanding of the physiological control of embryo development in vivo.

Project Title:	Molecular cloning and characterization of zona-binding inhibitory factor-1 (ZIF-1) receptor(s) from human spermatozoa
Investigator(s):	Dr. Lee C.K.F., Prof. Ho P.C., Dr. Luk J.M.C., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2001

Abstract:

To isolate the ZIF-1 receptors from human spermatozoa and determine their amino acid sequences; to localize these receptors on human spermatozoa; to determine the gene encoding for ZIF-1 receptors; to determine the ZIF-1 binding epitopes of these receptors.

Project Title:	Role(s) of endocrine gland derived vascular endothelial growth factor (EG-VEGF) in endometrial angiogenesis and embryo development
Investigator(s):	Dr. Lee C.K.F., Dr. Ngan E.S.W., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003
Completion Date:	12/2003

Abstract:

To elucidate the possible involvement of EG-VEGF in the endometrial and embryonic angiogenesis and the development of endometrosis, three specific objectives are proposed: (1) to examine the temporal expression pattern of EG-VEGF, VEGF and their receptors in mouse endometrium; (2) to examine the spatial expression pattern of EG-VEGF , VEGF and their receptors in mouse tissues; (3) to elucidate the potential functional interaction of EG-VEGF and VEGF in embryogenesis.

Project Title:	Hormonal regulation and molecular characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter
Investigator(s):	Dr. Lee C.K.F., Dr. Ngan E.S.W., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To study the effect of hormones on huogp mRNA and protein expressions; to identify the hormonal responsive element(s) of the huogp promoter; to identify the tissue-specific regulatory element(s) on the huogp promoter.

Project Title:	Proteomic profiling of uterine flushing during the Peri-implantation period
Investigator(s):	Dr. Lee C.K.F., Dr. Ng E.H.Y., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To optimise the method of collecting uterine fluid; to compare proteomic patterns of uterine fluid between receptive and non-receptive phases of the menstrual cycle; to determine the concentration of "unique" protein(s) identified above in uterine fluid from natural and stimulated cycles.

List of Research Outputs

Chiu C.N., Hong S., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., A capillary - cumulus model to study the selection of sperm by cumulus oophorus, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Chiu C.N., Tsang H.Y., Koistinen R., Koistinen H., Seppala M., Lee C.K.F. and Yeung W.S.B., The contribution of D-Mannose, L-Fucose, N-Acetylglucosamine, and selectin residues on the binding of glycodelin isoforms to human spermatozoa, Biology of Reproduction. 2004, 70: 1710-1719.

Hong S., Chiu C.N., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., Establishment of a capillary-cumulus model to study the selection of sperm for fertilization by the cumulus oophorus, Human Reproduction. 2004, 19(7): 1562-1569.

Lee C.K.F. and Yeung W.S.B., Cross-talk between the embryos and oviduct, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Lee C.K.F., Kwok K.L., Ngan E.S.W., Xu J. and Yeung W.S.B., Demilune cell and parotid protein (DCPP) messenger RNA expression in mouse oviduct: hormonal regulation and embryo development, 20th Anniversary (1983-2003)& 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Lee C.K.F., Yeung W.S.B., Chow J.F.C., Shum C.K. and Luk J.M.C., Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis, Biology of Reproduction. 2004, 70: 1010-1017.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., Identification of human oviducutal cell derived embryotrophic factor-3 (ETF-3), Symposium on Reproductive Health, Macau, Hong Kong and Inland China, Macau, May 29-31, 2004 . 2004.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction, The Journal of Biological Chemistry. 2004, 279(13): 12763-12768.

Luk J.M.C., Mok B.W.Y., Shum C.K., Yeung W.S.B., Tam P.C., Tse J.Y.M., Chow J.F.C., Woo J., Kam K. and Lee C.K.F., Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display, Biochemical and Biophysical Research Communications. 2003, 307(4): 782-790.

Mak A.N.S., Fung W.T., Vong Q.M.P., Lee C.K.F. and Shaw P.C., Molecular modeling and 'reverse' evolution of a two-polypeptide DNA methyltransferase EcoHK311, The XIX International Congress of Genetics, Melbourne, Australia, July 6-11, 2003.

Ngan E.S.W., Ng E.H.Y., Lee C.K.F., Liu V.W.S., Liu S., Ngan H.Y.S. and Yeung W.S.B., Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Tsang H.Y., Yeung W.S.B. and Lee C.K.F., Delineate the signaling pathway of the suppressive effect of glycodelin-F on progesterone-induced acrosome reaction on human spermatozoa, 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, December 13, 2003.

Xu J., Lee C.K.F. and Yeung W.S.B., Combined effect of human oviductal cells derived embryotrophic factors on mouse early embryo development, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Xu J., Chan S.T.H., Lee W.M., Lee C.K.F. and Yeung W.S.B., Differential growth, cell proliferation and apoptosis of mouse embryo in variuos culture media and in coculture, Molecular Reproduction and Development. 2004, 68(1): 72-80.

Yao Y., Xu J., Lee W.W.M., Yeung W.S.B. and Lee C.K.F., Identification of mRNAs that are up-regulated after fertilization in the murine zygote by suppression subtractive hybridization, Biochemical and Biophysical Research Communications. 2003, 304: 60-66.

Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., New isofrom of glycodeln involving in fertilization, 2003 International Symposium Gametgenesis, Gene Expression and Human Reproduction, November 8-9, 2003, Dongguan, China. 2003.

Yeung W.S.B., Xu J., Lee C.K.F. and Lee C.Y.L., Paracrine regulation of preimplantation embryo development by oviduct, Abstract for The 3rd International Huaxia Congress of Endocrinology, May 25-28, 2004, Shanghai, China. 2004.

Yeung W.S.B. and Lee C.K.F., Recent advances in assisted reproduction, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Researcher : Lee CP

List of Research Outputs

Chan C.P., Shek T.W.H. and Lee C.P., First-trimester diagnosis of hydrolethalus syndrome in a Chinese family, Prenatal Diagnosis. 2004, 24: 587-590.

Chen M., Lee C.P., Leung K.Y., Hui P.W. and Tang M.H.Y., Pilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population, Prenatal Diagnosis. 2004, 24: 87-91.

Chen M., Lam Y.H., Lee C.P. and Tang M.H.Y., Ultrasound screening of fetal structural abnormalities at 12 to 14 weeks in Hong Kong, Prenatal Diagnosis. 2004, 24: 92-97.

Hui P.W., Lee C.P., Leung W.C. and Tang M.H.Y., Is there an optimal gestation for ultrasound examination of fetal nasal bone in the first trimester?, The 5th World Congress on Controversies in Obstetrics, Gynecology and Infertility, Las Vegas, U.S.A., June 3-6, 2004,. 2004.

Lau E.T., Kwok Y.K., Chui D.H.K., Luo H.Y., Leung K.Y., Lee C.P., Lam Y.H. and Tang M.H.Y., Prenatal detection of Hb Bart's Disease in Maternal Blood, 12th International Conference on Prenatal Diagnosis and Therapy, Budapest Hungary, June 24-27, 2004.

Leung K.Y., Lee C.P., Tang M.H.Y., Chan H.Y. and Ma E.S.K., Detection of raised cerebral blood flow and cardiomegaly in fetuses affected by Hb H disease : two case reports, 13th World Congress on Ultrasound in Obstetrics and Gynaecology, August 31-September 4, 2003, Paris, France. 2003.

Leung K.Y., Chen M., Lee C.P., Tang M.H.Y. and Ho P.C., The use of three-dimensional fetal and placental volume to predict homozygous alpha-thalassaemia, Frontier in Biomedical Research, The University of Hong Kong, December 12, 2003, Hong Kong. 2003.

Leung W.C., Wong K.Y., Leung K.Y., Lee C.P., Tang M.H.Y. and Lao T.T.H., Serial amnioreductions in triplet fetofetal transfusion syndrome, Invited Speaker to attend the Perinatal Conference in Qingdao, China, June 26-July 1, 2004 . 2004.

Researcher : Lee CYL

List of Research Outputs

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., Identification of human oviducutal cell derived embryotrophic factor-3 (ETF-3), Symposium on Reproductive Health, Macau, Hong Kong and Inland China, Macau, May 29-31, 2004 . 2004.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction, The Journal of Biological Chemistry. 2004, 279(13): 12763-12768.

Yeung W.S.B., Xu J., Lee C.K.F. and Lee C.Y.L., Paracrine regulation of preimplantation embryo development by oviduct, Abstract for The 3rd International Huaxia Congress of Endocrinology, May 25-28, 2004, Shanghai, China. 2004.

Researcher : Lee WH

List of Research Outputs

Tang F.O.S., Chan C.C.W., Ng E.H.Y., Lee W.H. and Ho P.C., A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misprostol for medical abortions of less than 9 weeks gestation, Human Reproduction. 2003, 18(11): 2315-2318.

Researcher : Leung CY

List of Research Outputs

Liu S., Leung C.Y., Chan Y.K., Chiu P.M., Cheung A.N.Y., Tam K.F., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy, Clinical Cancer Research. 2004, 10: 3309-3316.

Researcher : Leung KY

List of Research Outputs

Chen M., Lee C.P., Leung K.Y., Hui P.W. and Tang M.H.Y., Pilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population, Prenatal Diagnosis. 2004, 24: 87-91.

Lau E.T., Kwok Y.K., Chui D.H.K., Luo H.Y., Leung K.Y., Lee C.P., Lam Y.H. and Tang M.H.Y., Prenatal detection of Hb Bart's Disease in Maternal Blood, 12th International Conference on Prenatal Diagnosis and Therapy, Budapest Hungary, June 24-27, 2004.

Leung K.Y., Lee C.P., Tang M.H.Y., Chan H.Y. and Ma E.S.K., Detection of raised cerebral blood flow and cardiomegaly in fetuses affected by Hb H disease : two case reports, 13th World Congress on Ultrasound in Obstetrics and Gynaecology, August 31-September 4, 2003, Paris, France. 2003.

Leung K.Y., Chen M., Lee C.P., Tang M.H.Y. and Ho P.C., The use of three-dimensional fetal and placental volume to predict homozygous alpha-thalassaemia, Frontier in Biomedical Research, The University of Hong Kong, December 12, 2003, Hong Kong. 2003.

Leung K.Y. and Chen M., Three-dimensional ultrasound fetal volume measurement: a study comparing the multiplanar technique with the rotational (VOCAL) technique, 13th World Congress on Ultrasound in Obstetrics and Gynaecology, August 31-September 4, 2003, Paris, France. 2003.

Leung W.C., Wong K.Y., Leung K.Y., Lee C.P., Tang M.H.Y. and Lao T.T.H., Serial amnioreductions in triplet fetofetal transfusion syndrome, Invited Speaker to attend the Perinatal Conference in Qingdao, China, June 26-July 1, 2004 . 2004.

Researcher : Leung TW

Project Title:	Detection of domestic violence among (1) pregnant women (2) women seeking termination of pregnancy & (3) non-abortion seeking general gynaecology patients using the abuse assessment screen (AAS) and the woman abuse screening tool (WAST) questionnaires
Investigator(s):	Dr. Leung T.W., Prof. Ho P.C., Dr. Leung W.C., Prof. Sullivan P.L., Dr. Taylor W.K., Dr. Tiwari A.F.Y.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001

Abstract:

To determine the prevalence of domestic violence among (1) pregnant women; (2) women seeking termination of pregnancy and (3) non-abortion seeking general gynaecology patients using the Woman Abuse Screening Tool (WAST) questionnaire; to study the pattern of abuse using both AAS and WAST; to test the reliability WAST (Chinese version) in a predominantly Chinese population; to determine if there is any relationship between women who are sexually and/or physically abused at home and those who are sexually and/or physcially abused at work.

Project Title:	The role of p73 in radiation response in cervical cancer
Investigator(s):	Dr. Leung T.W., Dr. Cheung A.N.Y., Prof. Ngan H.Y.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	10/2003

Abstract:

To study expression level, allelic loss, and promoter methylation status of p73 in radiosensitive and radioresistant cervical cancer; to study the association between the expression of p73 and the presence of HPV 16-E6 and -E7 in radiosensitive and radioresistant cervical cancer; to investigate the effect of HPV16-E6 and/or-E7 on radiosensitivity of the cancer cells independent and dependent of p73; to explore irradiation response of the cervical cancer cell independent and dependent of p73.

Project Title:	The role of p73 in radiation response in cervical cancer
Investigator(s):	Dr. Leung T.W., Dr. Cheung A.N.Y., Prof. Ngan H.Y.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	10/2003

Abstract:

List of Research Outputs

Leung T.W., Leung W.C., Ng E.H.Y., Tiwari A., Taylor W.K., Sullivan P. and Ho P.C., Comparrison of prevalence of intimate partner violence among different groups of obstetric-gynaecology patients and evaluation of the impact of abuse on their quality of life, Abstract presented in the 5th Annual Scientific Meeting of RANZCOG, September 16-19, 2003, Auckland, New Zealand. 2003.

Leung T.W., Ng E.H.Y., Leung W.C. and Ho P.C., Intimate partner violence among infertile women, International Journal of Gynecology and Obstetrics. 2003, 83: 323-324.

Leung T.W., Xue W., Cheung A.N.Y., Khoo U.S. and Ngan H.Y.S., Proliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix, Gynecologic Oncology. 2004, 92(3): 866-872.

Researcher : Leung WC

List of Research Outputs

Basir G.S., Leung W.C., Lam H.S.W., Cheung P.T. and Lao T.T.H., Comparison of maternal and fetal doppler haemodynamics in pregnancies conceived by IVF-ET versus spontaneous conception in the third trimester, Abstract for Hong Kong Academy of Medicine, November 28-30, 2003, Hong Kong. 2003.

Hui P.W., Lee C.P., Leung W.C. and Tang M.H.Y., Is there an optimal gestation for ultrasound examination of fetal nasal bone in the first trimester?, The 5th World Congress on Controversies in Obstetrics, Gynecology and Infertility, Las Vegas, U.S.A., June 3-6, 2004,. 2004.

Lao T.T.H., Leung W.C. and Wong R.M.S., Interval twin delivery following one second trimester miscarriage, Invited Speaker to attend the Perinatal Conference in Qingdao, China, June 26-July 1, 2004.

Leung T.W., Leung W.C., Ng E.H.Y., Tiwari A., Taylor W.K., Sullivan P. and Ho P.C., Comparrison of prevalence of intimate partner violence among different groups of obstetric-gynaecology patients and evaluation of the impact of abuse on their quality of life, Abstract presented in the 5th Annual Scientific Meeting of RANZCOG, September 16-19, 2003, Auckland, New Zealand. 2003.

Leung T.W., Ng E.H.Y., Leung W.C. and Ho P.C., Intimate partner violence among infertile women, International Journal of Gynecology and Obstetrics. 2003, 83: 323-324.

Leung W.C., Lau E.T. and Tang M.H.Y., Can rapid aneuploidy screening (RAS) replace traditional karyotyping for women with amniocenteses performed for advanced maternal age?, The 12th International Conference on Prenatal Diagnosis and Therapy, 24-27 June 2004, Budapest, Hungary . 2004.

Leung W.C., Jouannic J.M., Hyett J., Rodeck C. and Jauniaux E., Procedure-related complications of rapid amniodrainage in the treatment of polyhydramnios , Ultrasound Obstetrics and Gynecology. 2004, 23: 154-158.

Leung W.C., Lau E.T., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy screening (FISH or QF-PCR): the changing scene in prenatal diagnosis?, Expert Review of Molecular Diagnostics. 2004, 4(3): 89-93.

Leung W.C., Wong K.Y., Leung K.Y., Lee C.P., Tang M.H.Y. and Lao T.T.H., Serial amnioreductions in triplet fetofetal transfusion syndrome, Invited Speaker to attend the Perinatal Conference in Qingdao, China, June 26-July 1, 2004 . 2004.

Researcher : Li ICF

List of Research Outputs

Chan C.C.W., Ng E.H.Y., Li I.C.F. and Ho P.C., Impaired ovarian blood flow and reduced antral follicle count following laparoscopic salpingectomy for ectopic pregnancy, Human Reproduction. 2003, 18(10): 2175-2180.

Li I.C.F., Chan C.C.W. and Ho P.C., A comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation, Obstetrics and Gynecology. 2003, 102(3): 583-588.

Li I.C.F., Lee S.S.N. and Pun T.C., A pilot study on the acceptability of levonorgestrel-releasing intrauterine device by young, single, nulliparous Chinese females following surgical abortion, Contraception. 2004, 69: 247-250.

Li I.C.F., Chan C.C.W. and Ho P.C., A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy, Contraception. 2003, 68: 269-272.

Researcher : Liu KL

List of Research Outputs

Tam K.F., Cheung A.N.Y., Liu K.L., Ng T.Y., Pun T.C., Chan Y.M., Wong R.L.C., Ng W.Y. and Ngan H.Y.S., A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification, Gynecologic Oncology. 2003, 91(3): 603-607.

Researcher : Liu S

List of Research Outputs

Liu S., Cheung A.N.Y. and Ngan H.Y.S., p73 Expression and radiosensitivity in cervical carcinomas, American Association for Cancer Research 94th Annual Meeting, July 11-14, 2003, Toronto, Canada. 2003.

Liu S., Leung C.Y., Chan Y.K., Chiu P.M., Cheung A.N.Y., Tam K.F., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy, Clinical Cancer Research. 2004, 10: 3309-3316.

Ngan E.S.W., Ng E.H.Y., Lee C.K.F., Liu V.W.S., Liu S., Ngan H.Y.S. and Yeung W.S.B., Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Researcher : Liu VWS

List of Research Outputs

Chiu P.M., Liu V.W.S., Ngan H.Y.S., Khoo U.S. and Cheung A.N.Y., Detection of mitochondrial DNA mutations in gestational trophoblastic disease, Human Mutation. 2003, 22(2): 177.

Liu V.W.S., Wang Y. and Ngan H.Y.S., Differential occurrence of microsatellite instability in mitochondrial genomes of gynecological cancers, American Association for Cancer Research 2004 Annual Meeting, Florida, U.S.A., March 27-31, 2004.

Liu V.W.S., Yang H., Wang Y., Tsang P.C.K., Cheung A.N.Y., Chiu P.M., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., High frequency of mitochondrial genome instability in human endometrial carcinomas, British Journal of Cancer. 2003, 89(4): 697-701.

Liu V.W.S., Nagley P. and Ngan H.Y.S., Microsatellite instability in mitochondrial genome of common female cancers, Second Conference of Asian Society for Mitochondrial Research and Medicine, Taipei, Taiwan, April 1-2, 2004.

Liu V.W.S., Wang Y., Yang H., Tsang P.C.K., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer , Human Mutation. 2003, 22(2): 173-174.

Ngan E.S.W., Ng E.H.Y., Lee C.K.F., Liu V.W.S., Liu S., Ngan H.Y.S. and Yeung W.S.B., Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Yang H., Liu V.W.S., Tsang P.C.K., Yip M.W., Ng T.Y., Cheung A.N.Y. and Ngan H.Y.S., Comparison of human papillomavirus DNA levels in gynecological cancers: implication for cancer development, Tumour Biology. 2003, 24(6): 310-316.

Yang H., Liu V.W.S., Wang Y., Chan Y.K., Tsang P.C.K., Khoo U.S., Cheung A.N.Y. and Ngan H.Y.S., Detection of hypermethylated genes in tumor and plasma of cervical cancer patients, Gynecologic Oncology. 2004, 93(2): 435-440.

Researcher : Makkar G

List of Research Outputs

Makkar G., Ng E.H.Y., Yeung W.S.B. and Ho P.C., Prognostic factors for successful outcome in patients undergoing controlled ovarian stimulation and intrauterine insemination, Hong Kong Medical Journal. 2003, 9(5): 341-345.

Researcher : Miao B

List of Research Outputs

Ng E.H.Y., Miao B., Cheung W. and Ho P.C., A randomised comparison of side effects and patient inconvenience of two vaginal progesterone formulations used for luteal support in in vitro fertilisation cycles, European Journal of Obstetrics & Gynecology and Reproduction Biology. 2003, 111: 50-54.

Researcher : Mok TKH

List of Research Outputs

Tang F.O.S., Mok T.K.H. and Ho P.C., A randomized study comparing the use of sublingual to vaginal misoprostol for pre-operative cervical priming prior to surgical termination of pregnancy in the first trimester, Human Reproduction. 2004, 19(5): 1101-1104.

Researcher : Ng EHY

Project Title:	Stromal blood flow of the ovary as a new parameter of ovarian reserve
Investigator(s):	Dr. Ng E.H.Y., Prof. Ho P.C., Dr. Tse J.Y.M.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	11/2001

Abstract:

To assess the stromal blood flow of bth ovaries before and after pituitary down-regulation in the prediction of ovarian responses; to compare the predictive values of ovarian stromal blood flow assessed by coloured Doppler, Power Doppler and three-dimensional Power Doppler; to compare the predictive values of different markers for ovarian reserve including age of the patient, body mass index, early follicular FSG concentrations, ovarian volume, antral follicular number and ovarian stromal blood flow and; to study the changes of ovarian stromal blood flow with increasing age and following ovarian cystectomy; to study the endometrial blood flow measured by 3D power Doppler in the prediction of pregnancy following in vitro fertilization.

Project Title:	Assessing peri-follicular blood flow by power doppler ultrasound in patients having poor ovarian responses to gonadotrophin stimulation
Investigator(s):	Dr. Ng E.H.Y., Prof. Ho P.C., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001
Completion Date:	10/2003

Abstract:

To evaluate the role of peri-follicular blood flow studied by Power Doppler imaging in patients having poor responses to ovarian stimulation; to assess whether reduced ovarian blood flow will lead to poor ovarian responses.

Project Title:	Uterine contractility in patients having excessive ovarian responses during IVF cycles
Investigator(s):	Dr. Ng E.H.Y., Prof. Ho P.C.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To compare uterine contractions of infertile women with and without excessive ovarian responses during in vitro fertilization (IVF) treatment.

Project Title:	Intrauterine fetal growth of pregnancies from spontaneous conception and assisted reproduction
Investigator(s):	Dr. Ng E.H.Y., Prof. Ho P.C., Dr. Yeung W.S.B.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To compare the growth parameters of pregnancies from spontaneous conceptions, stimulated IVF cycles and natural IVE cycles; to identify ovarian markers that adversely affect growth parameters of pregnancies from assisted reproduction; to identify embryonic markers that adversely affect growth parameters of pregnancies from assisted reproduction.

Project Title:	Serum anti-mullerian hormone and vascular endothellal growth factor levels at different ages of women with proven fertility
Investigator(s):	Dr. Ng E.H.Y., Prof. Ho P.C.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To study the changes of serum anti-Mullerian hormone and vascular endothelial growth factor (VEGF) levels at different ages of women with proven fertility; to correlate serum anti-Mullerian hormone levels with other hormonal and ultrasound markers of ovarian reserve test; to correlate serum VEGF levels with ovarian stromal blood flow measured by three dimensional power Doppler ultrasound.

List of Research Outputs

Chan C.C.W., Ng E.H.Y., Chan M.M.Y., Tang F.O.S., Lau E.Y.L., Yeung W.S.B. and Ho P.C., Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women, Human Reproduction. 2003, 18(11): 2294-2297.

Chan C.C.W., Ng E.H.Y., Li I.C.F. and Ho P.C., Impaired ovarian blood flow and reduced antral follicle count following laparoscopic salpingectomy for ectopic pregnancy, Human Reproduction. 2003, 18(10): 2175-2180.

Kan A.S.Y., Ng E.H.Y. and Ho P.C., The role and comparison of two techniques of paracervical block for pain relief during suction evacuation for first-trimester pregnancy termination, Contraception. 2004, 70: 159-163.

Lam K.W., Pun T.C., Ng E.H.Y. and Wong K.S., Efficacy of preemptive analgesia for wound pain after laparoscopic operations in infertile women: a randomised, double-blind and placebo control study, British Journal of Obstetrics and Gynaecology. 2004, 111: 340-344.

Leung T.W., Leung W.C., Ng E.H.Y., Tiwari A., Taylor W.K., Sullivan P. and Ho P.C., Comparrison of prevalence of intimate partner violence among different groups of obstetric-gynaecology patients and evaluation of the impact of abuse on their quality of life, Abstract presented in the 5th Annual Scientific Meeting of RANZCOG, September 16-19, 2003, Auckland, New Zealand. 2003.

Leung T.W., Ng E.H.Y., Leung W.C. and Ho P.C., Intimate partner violence among infertile women, International Journal of Gynecology and Obstetrics. 2003, 83: 323-324.

Liu A.N.C., Ng E.H.Y., Chan C.L.W. and Chan C.H.Y., Third Party Assisted Human Reproduction in Hong Kong, In: E. Blyth & R. Landau (eds.), Third Party Assisted Conception Across Cultures: Social, Legal and Ethical Perspectives. Jessica Kingsley Publishers, 2003.

Makkar G., Ng E.H.Y., Yeung W.S.B. and Ho P.C., Prognostic factors for successful outcome in patients undergoing controlled ovarian stimulation and intrauterine insemination, Hong Kong Medical Journal. 2003, 9(5): 341-345.

Ng E.H.Y., Miao B., Cheung W. and Ho P.C., A randomised comparison of side effects and patient inconvenience of two vaginal progesterone formulations used for luteal support in in vitro fertilisation cycles, European Journal of Obstetrics & Gynecology and Reproduction Biology. 2003, 111: 50-54.

Ng E.H.Y., Yeung W.S.B. and Ho P.C., Absence of high grade perifollicular vascularity in poor ovarian responders is not associated with reduced pregnancy rate of in vitro fertilization treatment, Abstract of The 18th World Congress on Fertility and Sterility, Montreal, Canada, May 23-28, 2004.

Ng E.H.Y., Laird S.M., Li T.C., Yeung W.S.B. and Ho P.C., Concentations of endometrial protein PP 14 and CA-125 in uterine flushings performed in natural and stimulated cycles, Human Reproduction. 2004, 19(4): 905-910.

Ng E.H.Y., Laird S.M., Li T.C., Yeung W.S.B. and Ho P.C., Concentrations of endometrial protein PP 14 and CA-125 in uterine flushing of patients with excessive ovarian response during in vitro fertilization treatment, Abstract of The 18th World Congress on Fertility and Sterility, Montreal, Canada, May 23-28, 2004.

Ng E.H.Y., Yeung W.S.B., Fong D.Y.T. and Ho P.C., Effects of age on hormonal and ultrasound markers of ovarian reserve in Chinese women with proven fertility, Human Reproduction. 2003, 18(10): 2169-2174.

Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial blood flow measured during early luteal phase by three-dimensional power Doppler ultrasound in excessive ovarian responders, Human Reproduction. 2004, 19(4): 924-931.

Ng E.H.Y., Ovarian stromal blood flow in the assessment of ovarian reserve, Symposium on Reproductive Health-Macau, Hong Kong, Mainland China held by the Macau Association of O&G, The Journal of Reproductive Medicine in China and Department of O&G, The University of Hong Kong, Macau, China, May 29-31, 2004 . 2004.

Ng E.H.Y., Role of three-dimensional ultrasound in assisted reproduction technology, To attend The Second Shanghai-Hong Kong Assisted Reproduction Technology Meeting, December 13-14, 2003, Shanghai, China. 2003.

Ng E.H.Y., Role of three-dimensional ultrasound in asssisted reproduction technology, The Fourth Conference of the Pacific Rim Society for Fertility and Sterility, Okinawa, Japan, March 8-11, 2004.

Ng E.H.Y. and Ajonuma L.C., Teratogenic effect of hydrosalpinx fluid in human?, Human Reproduction. 2003, 18: 2237.

Ng E.H.Y., Use of paracervical block and anxiolytic premedication for pain relief during transvaginal ultrasound-guided oocyte retrieval, The Fourth Royan International Research Award and Scientific Meeting organized by Royan Institute, Tehran, Iran, September 15-17, 2003.

Ngan E.S.W., Ng E.H.Y., Lee C.K.F., Liu V.W.S., Liu S., Ngan H.Y.S. and Yeung W.S.B., Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Ngan E.S.W., Ng E.H.Y., Ngan H.Y.S. and Yeung W.S.B., Spatial and temporal expression of endocrine gland derived vascular endothelial growth factor, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Tang F.O.S., Chan C.C.W., Ng E.H.Y., Lee W.H. and Ho P.C., A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misprostol for medical abortions of less than 9 weeks gestation, Human Reproduction. 2003, 18(11): 2315-2318.

Researcher : Ng TY

Project Title:	A propective randomised controlled trial: prevention of lymphedema by omentoplasty after pelvic lymphadenectomy
Investigator(s):	Dr. Ng T.Y., Prof. Ngan H.Y.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001

Abstract:

To see whether these preliminary results are validated in a prospective randomised comparison.

Project Title:	A prospective randomized controlled trial: prevention o flymphedema by omentoplasty after pelvic lymphadenectomy
Investigator(s):	Dr. Ng T.Y., Dr. Chan Y.M., Prof. Ngan H.Y.S., Dr. Tam K.F.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Health and Health Services Research Fund
Start Date:	04/2004

Abstract:

Lymphedema is a debilitating condition that occurs in up to 40% of patients after pelvic lymphadenectomy. New surgical techniques have been advocated to reduce this complication. A pilot study using omentoplasty observed that 8% of patients after this procedure had clinical lymphedema compared with 40% in historical controls. This study aims to see whether these preliminary results are validated in a prospective randomised comparison.

List of Research Outputs

Chan Y.M., Ng T.Y., Ngan H.Y.S. and Wong R.L.C., Screening for HIV infection in women with newly diagnosed cervical cancer, Gynecologic Oncology. 2003, 92(1): 300-303.

Chan Y.M., Ng T.Y., Lee P.W.H., Ngan H.Y.S. and Wong R.L.C., Symptoms, coping strategies, and timing of presentations in patients with newly diagnosed ovarian cancer, Gynecologic Oncology. 2003, 90(3): 651-656.

Chan Y.M., Lee P.W.H., Ng T.Y., Ngan H.Y.S. and Wong R.L.C., The use of music to reduce anxiety for patients undergoing colposcopy: a randomized trial, Gynecologic Oncology. 2003, 91: 213-217.

Liu S., Leung C.Y., Chan Y.K., Chiu P.M., Cheung A.N.Y., Tam K.F., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy, Clinical Cancer Research. 2004, 10: 3309-3316.

Liu V.W.S., Yang H., Wang Y., Tsang P.C.K., Cheung A.N.Y., Chiu P.M., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., High frequency of mitochondrial genome instability in human endometrial carcinomas, British Journal of Cancer. 2003, 89(4): 697-701.

Liu V.W.S., Wang Y., Yang H., Tsang P.C.K., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer , Human Mutation. 2003, 22(2): 173-174.

Ng T.Y. and Wong R.L.C., Diagnosis and management of gestational trophoblastic neoplasia, Best Practice and Research Clinical Obstetrics and Gynaecology. 2003, 17(6): 893-903.

Shen D., Khoo U.S., Ngan H.Y.S., Ng T.Y., Chau M.T., Xue W. and Cheung A.N.Y., Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole, Archives of Pathology and Laboratory Medicine. 2003, 127(7): e291–e293.

Tam K.F., Cheung A.N.Y., Liu K.L., Ng T.Y., Pun T.C., Chan Y.M., Wong R.L.C., Ng W.Y. and Ngan H.Y.S., A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification, Gynecologic Oncology. 2003, 91(3): 603-607.

Yang H., Liu V.W.S., Tsang P.C.K., Yip M.W., Ng T.Y., Cheung A.N.Y. and Ngan H.Y.S., Comparison of human papillomavirus DNA levels in gynecological cancers: implication for cancer development, Tumour Biology. 2003, 24(6): 310-316.

Researcher : Ngai CSW

Project Title:	Vaginal misoprostol for first trimester termination of pregnancy prior to 9 weeks of gestation
Investigator(s):	Dr. Ngai C.S.W., Dr. Chan Y.M., Prof. Ho P.C., Dr. Tang F.O.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Health Services Research Fund
Start Date:	05/1999

Abstract:

To compare the effectiveness of vaginal misoprostol (water vs no water added) in first trimester termination of pregnancy.

Project Title:	Cervical assessment in prediction of preterm labour: is three-dimensional ultrasonography a better choice?
Investigator(s):	Dr. Ngai C.S.W., Dr. Chen M., Prof. Lao T.T.H., Dr. Leung K.Y.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To compare the usefulness of 3D versus 2D US in prediction of preterm labour.

List of Research Outputs

Ngai C.S.W., Tang F.O.S. and Ho P.C., Prostaglandins for induction of second-trimester termination and intrauterine death, Best Practice & Research Clinical Obstetrics and Gynaecology. 2003, 17(5): 765-775.

Researcher : Ngan ESW

List of Research Outputs

Lee C.K.F., Kwok K.L., Ngan E.S.W., Xu J. and Yeung W.S.B., Demilune cell and parotid protein (DCPP) messenger RNA expression in mouse oviduct: hormonal regulation and embryo development, 20th Anniversary (1983-2003)& 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Ngan E.S.W., Ng E.H.Y., Lee C.K.F., Liu V.W.S., Liu S., Ngan H.Y.S. and Yeung W.S.B., Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Ngan E.S.W., Ng E.H.Y., Ngan H.Y.S. and Yeung W.S.B., Spatial and temporal expression of endocrine gland derived vascular endothelial growth factor, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Researcher : Ngan HYS

Project Title:	Immunomodulation of G.E. Yun Zhi (PSK) in gynaecologic cancer patients
Investigator(s):	Prof. Ngan H.Y.S., Dr. Luk J.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Vita Green Health Products Co. Ltd.
Start Date:	04/1998

Abstract:

To study the effect of Yun Zhi on the immune system in patients with gynaecological cancer.

Project Title:	Early detection of cervical cancer dissemination by plasma/serum nucleic acid analysis
Investigator(s):	Prof. Ngan H.Y.S., Dr. Liu V.W.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002
Completion Date:	10/2003

Abstract:

To detect cervical cancer-associated markers in plasma using real-time quantitative PCR (aPCR) and to correlate with clinical and histological parameters and outcome in cervical cancer.

Project Title:	Microsatellite instability in mitochondrial genomes of human cancers and its role in tumourigenesis
Investigator(s):	Prof. Ngan H.Y.S., Dr. Liu V.W.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To analyze 13 candidate microsatellite regions (including 11 mononucleotides and 2 polynucleotide) within the mtDNA genome of primary ovarian cancer, endometrial cancer, cervical cancer and breast cancer to determine the prevalence of mtMSI in these four types of cancer; to analyze the frequency of common nMSI as recommended by the National Cancer Institute (NCI), USA and their correlation with mtMSI; to screen the known germline and somatic mutations of the mismatch repair genes and their correlation with mtMSI and nMSI.

List of Research Outputs

Beller U., Maisonneuve P., Benedet J.L., Heintz A.P., Ngan H.Y.S., Pecorelli S., Odicino F. and Creasman W.T., Carcinoma of the vagina, International Journal of Gynecology and Obstetrics. 2003, 83(Suppl. 1): 27-39.

Beller U., Maisonneuve P., Benedet J.L., Heintz A.P., Ngan H.Y.S., Pecorelli S., Odicino F. and Creasman W.T., Carcinoma of the vulva, International Journal of Gynecology and Obstetrics. 2003, 83(Suppl. 1): 7-26.

Benedet J.L., Odicino F., Maisonneuve P., Beller U., Creasman W.T., Heintz A.P., Ngan H.Y.S. and Pecorelli S., Carcinoma of the cervix uteri, International Journal of Gynecology and Obstetrics. 2003, 83(Suppl. 1): 41-78.

Chan K.Y.K., Song Y., Mak W., Cheung A.N.Y., Peiris J.S.M., Yip S.P., Tin V., Liu W., Xue W.C., Chan L.C., Tam P.K.H., Ngan H.Y.S. and Khoo U.S., Polymorphisms of the ACE2 and CD13 (ANPEP) genes, and susceptibility to SARS coronavirus infection in Chinese from Hong Kong., The Human Genome organisation Meeting, April 2004, Berlin, Germany. 2004, Abstract No. 159.

Chan Y.K., Shen D.H., Li S.S., Khoo U.S., Ngan H.Y.S., Xue W. and Cheung A.N.Y., Differential Expression and Methylation of p33/ING1b in Ovarian Tumors, Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Washington, USA, 11-14 July 2003.

Chan Y.K., Song Y.Q., Mak W., Cheung A.N.Y., Peiris J.S.M., Yip S.P., Tin V., Liu W., Xue W., Chan L.C., Tam P., Ngan H.Y.S. and Khoo U.S., Polymorphisms of the ACE2 and CD13 genes, and susceptibility to SARS coronavirus infection in Chinese from Hong Kong, Abstract for Human Genome Organization (HUGO) Meeting, April 4-7, 2004, Berlin, Germany. 2004.

Chan Y.K., Khoo U.S., Chan K.H.K., Ngan H.Y.S., Li S.S., Xue W., Chiu P.M. and Cheung A.N.Y., Reduced GSTP1 immunoreactivity in endometrial carcinomas in association with methylation status and genetic profiles, Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Washington, USA, 11-14 July 2003.

Chan Y.M., Ng T.Y., Ngan H.Y.S. and Wong R.L.C., Screening for HIV infection in women with newly diagnosed cervical cancer, Gynecologic Oncology. 2003, 92(1): 300-303.

Chan Y.M., Ng T.Y., Lee P.W.H., Ngan H.Y.S. and Wong R.L.C., Symptoms, coping strategies, and timing of presentations in patients with newly diagnosed ovarian cancer, Gynecologic Oncology. 2003, 90(3): 651-656.

Chan Y.M., Lee P.W.H., Ng T.Y., Ngan H.Y.S. and Wong R.L.C., The use of music to reduce anxiety for patients undergoing colposcopy: a randomized trial, Gynecologic Oncology. 2003, 91: 213-217.

Cheung A.N.Y., Khoo U.S., Lai C.Y.L., Chan Y.K., Xue W., Cheng D.K.L., Chiu P.M., Tsao G.S.W. and Ngan H.Y.S., Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis, Cancer. 2004, 100(7): 1411-1417.

Cheung A.N.Y., Xue W., Chan D.Y., Feng H., Chiu P.M., Tsao G.S.W. and Ngan H.Y.S., Promoter hypermethylation of multiple genes in hydatiform mole choriocarcinoma, Proceedings of the American Association for Cancer Research. 2004, 45: 1149 Abstract No. 4974.

Chiu P.M., Liu V.W.S., Ngan H.Y.S., Khoo U.S. and Cheung A.N.Y., Detection of mitochondrial DNA mutations in gestational trophoblastic disease, Human Mutation. 2003, 22(2): 177.

Creasman W.T., Odicino F., Maisonneuve P., Beller U., Benedet J.L., Heintz A.P., Ngan H.Y.S. and Pecorelli S., Carcinoma of the corpus uteri, International Journal of Gynecology and Obstetrics. 2003, 83(Suppl. 1): 79-118.

Feng H., Cheung A.N.Y., Xue W., Wang Y., Wang X., Fu S., Wang Q., Ngan H.Y.S. and Tsao G.S.W., Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma, Gynecologic Oncology. 2004, 94: 375-382.

Heintz A.P., Odicino F., Maisonneuve P., Beller U., Benedet J.L., Creasman W.T., Ngan H.Y.S. and Pecorelli S., Carcinoma of the fallopian tube, International Journal of Gynecology and Obstetrics. 2003, 83(Suppl. 1): 119-133.

Heintz A.P., Odicino F., Maisonneuve P., Beller U., Benedet J.L., Creasman W.T., Ngan H.Y.S. and Pecorelli S., Carcinoma of the ovary, International Journal of Gynecology and Obstetrics. 2003, 83(Suppl. 1): 135-166.

Khoo U.S., Chan Y.K., Yip S.P., Peiris M., Tin V., Liu W., Xue W., Ngan H.Y.S., Chan L.C. and Cheung A.N.Y., The tandem repeat polymorphism of the DC-SIGNR gene is associated with susceptibility to SARS coronavirus infection in Chinese from Hong Kong, Proceedings of the Human Genome Organization (HUGO) Meeting, April 4-7, 2004, Berlin, Germany. 2004.

Lai C.Y.L., Chan Y.K., Khoo U.S., Ngan H.Y.S., Xue W., Chiu P.M., Tsao G.S.W. and Cheung A.N.Y., Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization, Modern Pathology. 2004, 17: 40-48.

Leung T.W., Xue W., Cheung A.N.Y., Khoo U.S. and Ngan H.Y.S., Proliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix, Gynecologic Oncology. 2004, 92(3): 866-872.

Liu S., Cheung A.N.Y. and Ngan H.Y.S., p73 Expression and radiosensitivity in cervical carcinomas, American Association for Cancer Research 94th Annual Meeting, July 11-14, 2003, Toronto, Canada. 2003.

Liu S., Leung C.Y., Chan Y.K., Chiu P.M., Cheung A.N.Y., Tam K.F., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy, Clinical Cancer Research. 2004, 10: 3309-3316.

Liu V.W.S., Wang Y. and Ngan H.Y.S., Differential occurrence of microsatellite instability in mitochondrial genomes of gynecological cancers, American Association for Cancer Research 2004 Annual Meeting, Florida, U.S.A., March 27-31, 2004.

Liu V.W.S., Yang H., Wang Y., Tsang P.C.K., Cheung A.N.Y., Chiu P.M., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., High frequency of mitochondrial genome instability in human endometrial carcinomas, British Journal of Cancer. 2003, 89(4): 697-701.

Liu V.W.S., Nagley P. and Ngan H.Y.S., Microsatellite instability in mitochondrial genome of common female cancers, Second Conference of Asian Society for Mitochondrial Research and Medicine, Taipei, Taiwan, April 1-2, 2004.

Liu V.W.S., Wang Y., Yang H., Tsang P.C.K., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer , Human Mutation. 2003, 22(2): 173-174.

Ngan E.S.W., Ng E.H.Y., Lee C.K.F., Liu V.W.S., Liu S., Ngan H.Y.S. and Yeung W.S.B., Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Ngan E.S.W., Ng E.H.Y., Ngan H.Y.S. and Yeung W.S.B., Spatial and temporal expression of endocrine gland derived vascular endothelial growth factor, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Ngan H.Y.S., Cervical cancer screening in Hong Kong, 56th Annual Congress of the Japan Society of Obstetrics and Gynecology, Tokyo, Japan, April 10-13, 2004.

Ngan H.Y.S., FIGO clinical staging versus surgical staging in cervical cancer, 1st International Congress on Cervical Cancer and 28th Annual Conference of AOGO, Bhubaneswar, India, March 12-14, 2004.

Ngan H.Y.S., FIGO staging - is it useful?, International Conference on Gynaecologic Oncology Hyderabad, India, March 16-17, 2004.

Ngan H.Y.S., Gestational trophoblastic disease, Reviews In Gynaecological Practice. 2003, 3(3): 142-147.

Ngan H.Y.S., Odicino F., Maisonneuve P., Beller U., Benedet J.L., Heintz A.P., Pecorelli S. and Creasman W.T., Gestational trophoblastic diseases, International Journal of Gynecology and Obstetrics. 2003, 83(Suppl 1): 167-174.

Ngan H.Y.S., Bender H., Benedet J.L., Jones H., Montruccoli G.C., Pecorelli S. and FIGO C.O.M.M.I.T.T.E.E., Gestational trophoblastic neoplasia, FIGO 2000 staging and classification, International Journal of Gynecology and Obstetrics. 2003, 83(Suppl. 1): 175-177.

Ngan H.Y.S., HPV and cervical cancer - can it be eradicated?, International Conference on Gynaecologic Oncology Hyderabad, India, March 16-17, 2004.

Ngan H.Y.S., Preface, Best Practice and Research Clinical Obstetrics and Gynaecology. 2003, 17(6): 825.

Ngan H.Y.S., Reappraisal of FIGO staging in gynaecological cancers?, International Conference on Gynaecologic Oncology Hyderabad, India, March 16-17, 2004.

Ngan H.Y.S., The 2000 FIGO staging and risk factor scoring of trophoblastic neoplasia, XII World Congress on Gestational Trophoblastic Disease, Boston, MA, U.S.A., September 28-October 1, 2003 . 2003.

Ngan H.Y.S., The practicability of FIGO 2000 staging for gestational trophoblastic neoplasia, International Journal of Gynecological Cancer. 2004, 14(2) March-April: 202-205.

Ngan H.Y.S., The role of colposcope in Asia, Asian HPV Summit, Leura, Blue Mountains, Australia, November 11-14, 2003.

Ngan H.Y.S., Updates on the management of GTT, International Conference on Gynaecologic Oncology Hyderabad, India, March 16-17, 2004.

Shen D., Khoo U.S., Ngan H.Y.S., Ng T.Y., Chau M.T., Xue W. and Cheung A.N.Y., Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole, Archives of Pathology and Laboratory Medicine. 2003, 127(7): e291–e293.

Tam K.F., Cheung A.N.Y., Liu K.L., Ng T.Y., Pun T.C., Chan Y.M., Wong R.L.C., Ng W.Y. and Ngan H.Y.S., A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification, Gynecologic Oncology. 2003, 91(3): 603-607.

Xue W., Feng H., Tsao G.S.W., Chan Y.K., Ngan H.Y.S., Chiu P.M., Maccalman C.D. and Cheung A.N.Y., Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases, International Journal of Gynecological Cancer. 2003, 13(6): 879-888.

Xue W., Khoo U.S., Ngan H.Y.S., Chan Y.K., Chiu P.M., Tsao G.S.W. and Cheung A.N.Y., Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: correlation with Ki67, PCNA and clinicopathological parameters, Histopathology. 2003, 43: 485-490.

Xue W., Khoo U.S., Ngan H.Y.S., Chan Y.K., Ip P.P.C., Tsao G.S.W. and Cheung A.N.Y., c-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions, International Journal of Gynecological Pathology. 2004, 23(2): 145-150.

Yang C., Ngan H.Y.S., Khoo U.S., Chan Y.K., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms (SNPS) in the coding sequence of follicle stimulating hormone receptor (FSHR) is associated with ovarian cancer susceptibility, Proceedings of the 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, USA, March 2004.

Yang H., Liu V.W.S., Tsang P.C.K., Yip M.W., Ng T.Y., Cheung A.N.Y. and Ngan H.Y.S., Comparison of human papillomavirus DNA levels in gynecological cancers: implication for cancer development, Tumour Biology. 2003, 24(6): 310-316.

Yang H., Liu V.W.S., Wang Y., Chan Y.K., Tsang P.C.K., Khoo U.S., Cheung A.N.Y. and Ngan H.Y.S., Detection of hypermethylated genes in tumor and plasma of cervical cancer patients, Gynecologic Oncology. 2004, 93(2): 435-440.

Researcher : Ong CYT

Project Title:	To determine the correlation of changes in maternal levels of pregnancy-associated plasma protein A (PAPP-A) and free b human chorionic gonadotrophin (Fb-hCG) with placental development and fetal outcomes
Investigator(s):	Dr. Ong C.Y.T., Dr. Lam H.S.W., Prof. Lao T.T.H., Dr. Leung K.Y., Dr. Leung W.C.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To correlate the serial changes of maternal serum PAPP-A and free b-hCG concentrations with placental volume and vascular indices, swell as fetal size, as assessed by 3-D/4-D ultrasonographic studies throughout pregnancy; to determine whether different patterns in the changes of PAPP-A and free b-hCG in different trimesters will be predictive of different patterns of placental development and fetal growth, and whether this can help to identify specifically the eventual complications through the association with the various growth and developmental patterns.

List of Research Outputs

Ong C.Y.T., Liao A.W., Munim S., Spencer K. and Nicolaides K.H., First-trimester maternal serum activin A in pre-eclampsia and fetal growth restriction, The Journal of Maternal-Fetal and Neonatal Medicine. 2004, 15: 176-180.

Ong C.Y.T., Lao T.T.H., Spencer K. and Nicolaides K.H., Maternal serum level of placental growth factor in diabetic pregnancies, The Journal of Reproductive Medicine. 2004, 49(6): 477-480.

Researcher : Pun TC

List of Research Outputs

Chan C.C.W., Chu F. and Pun T.C., Treating a recurrent uterine arteriovenous malformation with uterine artery embolization - A case report, The Journal of Reproductive Medicine. 2003, 48(11): 905-907.

Lam K.W., Pun T.C., Ng E.H.Y. and Wong K.S., Efficacy of preemptive analgesia for wound pain after laparoscopic operations in infertile women: a randomised, double-blind and placebo control study, British Journal of Obstetrics and Gynaecology. 2004, 111: 340-344.

Li I.C.F., Lee S.S.N. and Pun T.C., A pilot study on the acceptability of levonorgestrel-releasing intrauterine device by young, single, nulliparous Chinese females following surgical abortion, Contraception. 2004, 69: 247-250.

Tam K.F., Cheung A.N.Y., Liu K.L., Ng T.Y., Pun T.C., Chan Y.M., Wong R.L.C., Ng W.Y. and Ngan H.Y.S., A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification, Gynecologic Oncology. 2003, 91(3): 603-607.

Tse K.Y. and Pun T.C., Cervical incarceration by ring pessaries, Acta Obstetricia et Gynecologica Scandinavia. 2004, 83: 313-314.

Researcher : Sung EOP

List of Research Outputs

Chan C.C.W., Lao T.T.H., Ho P.C., Sung E.O.P. and Cheung A.N.Y., The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study, Journal of Clinical Endocrinology & Metabolism. 2003, 88(12): 5846-5850.

Researcher : Tam KF

List of Research Outputs

Lao T.T.H., Tam K.F., Tse K.Y., Ho L.F. and Chan L.Y., HBsAg carrier status and the association between gestational diabetes with increased serum ferritin concentration in Chinese women, Diabetes Care. 2003, 26(11): 3011-3016.

Liu S., Leung C.Y., Chan Y.K., Chiu P.M., Cheung A.N.Y., Tam K.F., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy, Clinical Cancer Research. 2004, 10: 3309-3316.

Tam K.F., Cheung A.N.Y., Liu K.L., Ng T.Y., Pun T.C., Chan Y.M., Wong R.L.C., Ng W.Y. and Ngan H.Y.S., A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification, Gynecologic Oncology. 2003, 91(3): 603-607.

Researcher : Tang FOS

List of Research Outputs

Chan C.C.W., Ng E.H.Y., Chan M.M.Y., Tang F.O.S., Lau E.Y.L., Yeung W.S.B. and Ho P.C., Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women, Human Reproduction. 2003, 18(11): 2294-2297.

Hertzen H.V., Honkanen H., Piaggio G., Bartfai G., Erdenetungalag R., Gemzell-Danielsson K., Gopalan S., Horga M., Jerve F., Mittal S., Nguyen T.N.N., Peregoudov A., Prasad R.N.V., Pretnar-Darovec A., Shah R.S., Song S., Tang F.O.S. and Shang C.W., WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. I: Efficacy , British Journal of Obstetrics and Gynaecology. 2003, 110: 808-818.

Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial blood flow measured during early luteal phase by three-dimensional power Doppler ultrasound in excessive ovarian responders, Human Reproduction. 2004, 19(4): 924-931.

Ngai C.S.W., Tang F.O.S. and Ho P.C., Prostaglandins for induction of second-trimester termination and intrauterine death, Best Practice & Research Clinical Obstetrics and Gynaecology. 2003, 17(5): 765-775.

Tang F.O.S., Lau W.N.T., Chan C.C.W. and Ho P.C., A prospective randomized trial on the use of sublingual versus vaginal misoprostol for second trimester medical abortion, 19th Annual Meeting of the European Society of Human Reproduction and Embryology, Madrid, Spain, June 28-July 2, 2004.

Tang F.O.S., Chan C.C.W., Ng E.H.Y., Lee W.H. and Ho P.C., A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misprostol for medical abortions of less than 9 weeks gestation, Human Reproduction. 2003, 18(11): 2315-2318.

Tang F.O.S., Mok T.K.H. and Ho P.C., A randomized study comparing the use of sublingual to vaginal misoprostol for pre-operative cervical priming prior to surgical termination of pregnancy in the first trimester, Human Reproduction. 2004, 19(5): 1101-1104.

Researcher : Tang GWK

Project Title:	Menopause in the Far East
Investigator(s):	Prof. Tang G.W.K.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	International Health Foundation
Start Date:	09/1989

Abstract:

To study menopause in the Hong Kong population.

Project Title:	A cross sectional health care study of Chinese perimenopausal women in Hong Kong
Investigator(s):	Prof. Tang G.W.K., Dr. Chan M., Dr. Tse L.Y.,
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Wyeth-Ayerst International, Inc. Ltd.
Start Date:	01/1993

Abstract:

To study Chinese women in Hong Kong on: 1) their perception and understanding of the menopause; 2) their symptoms expressed and experienced before, during and after the menopause; 3) bone density in various age groups ranging from adolescence to postmenopause and to correlate such values with biophysical parameters and diet; 4) how best health care strategies can be planned based on the findings in the study so that women's needs are met most cost effectively.

List of Research Outputs

Tang G.W.K., Assessment of Clinical Skills, 1st Asian-Pacific Medical Education Conference, National University of Singapore, 2-5 December, 2003.

Tang G.W.K., Chinese medicine in the treatment of climacteric symptoms, 4th National Meeting of Malaysian Menopause Society, 25-27 July, 2003.

Tang G.W.K., Continuous Medical Education and Continuous Professional Development: relevance to Curriculum Reform, Second Symposium of Asian Medical Education Association. 2003.

Tang G.W.K., Osteoporosis and bone loss in Chinese women in Hong Kong, 4th National Meeting of Malaysian Menopause Society, 25-27 July, 2003.

Woo P.C.Y., Fung A.S.M., Lau S.K.P., Teng L.L., Wong B.H., Wong M.K., Hon E.H.C., Tang G.W.K. and Yuen K.Y., Actinomyces hongkongensis sp. nov. a novel Actinomyces species isolated from a patient with pelvic actinomycosis, Systematic and Applied Microbiology . 2003, 26(4): 518-22.

Researcher : Tang MHY

List of Research Outputs

Chen M., Lee C.P., Leung K.Y., Hui P.W. and Tang M.H.Y., Pilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population, Prenatal Diagnosis. 2004, 24: 87-91.

Chen M., Lam Y.H., Lee C.P. and Tang M.H.Y., Ultrasound screening of fetal structural abnormalities at 12 to 14 weeks in Hong Kong, Prenatal Diagnosis. 2004, 24: 92-97.

Hui P.W., Lee C.P., Leung W.C. and Tang M.H.Y., Is there an optimal gestation for ultrasound examination of fetal nasal bone in the first trimester?, The 5th World Congress on Controversies in Obstetrics, Gynecology and Infertility, Las Vegas, U.S.A., June 3-6, 2004,. 2004.

Lau E.T., Kwok Y.K., Chui D.H.K., Luo H.Y., Leung K.Y., Lee C.P., Lam Y.H. and Tang M.H.Y., Prenatal detection of Hb Bart's Disease in Maternal Blood, 12th International Conference on Prenatal Diagnosis and Therapy, Budapest Hungary, June 24-27, 2004.

Leung K.Y., Lee C.P., Tang M.H.Y., Chan H.Y. and Ma E.S.K., Detection of raised cerebral blood flow and cardiomegaly in fetuses affected by Hb H disease : two case reports, 13th World Congress on Ultrasound in Obstetrics and Gynaecology, August 31-September 4, 2003, Paris, France. 2003.

Leung K.Y., Chen M., Lee C.P., Tang M.H.Y. and Ho P.C., The use of three-dimensional fetal and placental volume to predict homozygous alpha-thalassaemia, Frontier in Biomedical Research, The University of Hong Kong, December 12, 2003, Hong Kong. 2003.

Leung W.C., Lau E.T. and Tang M.H.Y., Can rapid aneuploidy screening (RAS) replace traditional karyotyping for women with amniocenteses performed for advanced maternal age?, The 12th International Conference on Prenatal Diagnosis and Therapy, 24-27 June 2004, Budapest, Hungary . 2004.

Leung W.C., Lau E.T., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy screening (FISH or QF-PCR): the changing scene in prenatal diagnosis?, Expert Review of Molecular Diagnostics. 2004, 4(3): 89-93.

Leung W.C., Wong K.Y., Leung K.Y., Lee C.P., Tang M.H.Y. and Lao T.T.H., Serial amnioreductions in triplet fetofetal transfusion syndrome, Invited Speaker to attend the Perinatal Conference in Qingdao, China, June 26-July 1, 2004 . 2004.

Researcher : Tsang HY

List of Research Outputs

Chiu C.N., Tsang H.Y., Koistinen R., Koistinen H., Seppala M., Lee C.K.F. and Yeung W.S.B., The contribution of D-Mannose, L-Fucose, N-Acetylglucosamine, and selectin residues on the binding of glycodelin isoforms to human spermatozoa, Biology of Reproduction. 2004, 70: 1710-1719.

Tsang H.Y., Yeung W.S.B. and Lee C.K.F., Delineate the signaling pathway of the suppressive effect of glycodelin-F on progesterone-induced acrosome reaction on human spermatozoa, 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, December 13, 2003.

Researcher : Tsang PCK

List of Research Outputs

Liu V.W.S., Yang H., Wang Y., Tsang P.C.K., Cheung A.N.Y., Chiu P.M., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., High frequency of mitochondrial genome instability in human endometrial carcinomas, British Journal of Cancer. 2003, 89(4): 697-701.

Liu V.W.S., Wang Y., Yang H., Tsang P.C.K., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer , Human Mutation. 2003, 22(2): 173-174.

Yang H., Liu V.W.S., Tsang P.C.K., Yip M.W., Ng T.Y., Cheung A.N.Y. and Ngan H.Y.S., Comparison of human papillomavirus DNA levels in gynecological cancers: implication for cancer development, Tumour Biology. 2003, 24(6): 310-316.

Yang H., Liu V.W.S., Wang Y., Chan Y.K., Tsang P.C.K., Khoo U.S., Cheung A.N.Y. and Ngan H.Y.S., Detection of hypermethylated genes in tumor and plasma of cervical cancer patients, Gynecologic Oncology. 2004, 93(2): 435-440.

Researcher : Tse JYM

List of Research Outputs

Chiu C.N., Hong S., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., A capillary - cumulus model to study the selection of sperm by cumulus oophorus, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Hong S., Chiu C.N., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., Establishment of a capillary-cumulus model to study the selection of sperm for fertilization by the cumulus oophorus, Human Reproduction. 2004, 19(7): 1562-1569.

Luk J.M.C., Mok B.W.Y., Shum C.K., Yeung W.S.B., Tam P.C., Tse J.Y.M., Chow J.F.C., Woo J., Kam K. and Lee C.K.F., Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display, Biochemical and Biophysical Research Communications. 2003, 307(4): 782-790.

Tse J.Y.M., Wong E.Y.M., Cheung A.N.Y., O W.S., Tam P.C. and Yeung W.S.B., Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility , Biology of Reproduction. 2003, 69: 746-751.

Wong E.Y.M., Tse J.Y.M., Yao K.M., Lui V.C.H., Tam P.C. and Yeung W.S.B., Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein, Biology of Reproduction. 2003, 70: 775-784.

Researcher : Wang Y

List of Research Outputs

Liu V.W.S., Wang Y. and Ngan H.Y.S., Differential occurrence of microsatellite instability in mitochondrial genomes of gynecological cancers, American Association for Cancer Research 2004 Annual Meeting, Florida, U.S.A., March 27-31, 2004.

Liu V.W.S., Yang H., Wang Y., Tsang P.C.K., Cheung A.N.Y., Chiu P.M., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., High frequency of mitochondrial genome instability in human endometrial carcinomas, British Journal of Cancer. 2003, 89(4): 697-701.

Liu V.W.S., Wang Y., Yang H., Tsang P.C.K., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer , Human Mutation. 2003, 22(2): 173-174.

Yang H., Liu V.W.S., Wang Y., Chan Y.K., Tsang P.C.K., Khoo U.S., Cheung A.N.Y. and Ngan H.Y.S., Detection of hypermethylated genes in tumor and plasma of cervical cancer patients, Gynecologic Oncology. 2004, 93(2): 435-440.

Researcher : Wong EYM

List of Research Outputs

Tse J.Y.M., Wong E.Y.M., Cheung A.N.Y., O W.S., Tam P.C. and Yeung W.S.B., Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility , Biology of Reproduction. 2003, 69: 746-751.

Wong E.Y.M., Tse J.Y.M., Yao K.M., Lui V.C.H., Tam P.C. and Yeung W.S.B., Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein, Biology of Reproduction. 2003, 70: 775-784.

Researcher : Wong KY

List of Research Outputs

Leung W.C., Wong K.Y., Leung K.Y., Lee C.P., Tang M.H.Y. and Lao T.T.H., Serial amnioreductions in triplet fetofetal transfusion syndrome, Invited Speaker to attend the Perinatal Conference in Qingdao, China, June 26-July 1, 2004 . 2004.

Researcher : Wong RLC

List of Research Outputs

Chan Y.M., Ng T.Y., Ngan H.Y.S. and Wong R.L.C., Screening for HIV infection in women with newly diagnosed cervical cancer, Gynecologic Oncology. 2003, 92(1): 300-303.

Chan Y.M., Ng T.Y., Lee P.W.H., Ngan H.Y.S. and Wong R.L.C., Symptoms, coping strategies, and timing of presentations in patients with newly diagnosed ovarian cancer, Gynecologic Oncology. 2003, 90(3): 651-656.

Chan Y.M., Lee P.W.H., Ng T.Y., Ngan H.Y.S. and Wong R.L.C., The use of music to reduce anxiety for patients undergoing colposcopy: a randomized trial, Gynecologic Oncology. 2003, 91: 213-217.

Liu S., Leung C.Y., Chan Y.K., Chiu P.M., Cheung A.N.Y., Tam K.F., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy, Clinical Cancer Research. 2004, 10: 3309-3316.

Liu V.W.S., Yang H., Wang Y., Tsang P.C.K., Cheung A.N.Y., Chiu P.M., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., High frequency of mitochondrial genome instability in human endometrial carcinomas, British Journal of Cancer. 2003, 89(4): 697-701.

Liu V.W.S., Wang Y., Yang H., Tsang P.C.K., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer , Human Mutation. 2003, 22(2): 173-174.

Ng T.Y. and Wong R.L.C., Diagnosis and management of gestational trophoblastic neoplasia, Best Practice and Research Clinical Obstetrics and Gynaecology. 2003, 17(6): 893-903.

Tam K.F., Cheung A.N.Y., Liu K.L., Ng T.Y., Pun T.C., Chan Y.M., Wong R.L.C., Ng W.Y. and Ngan H.Y.S., A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification, Gynecologic Oncology. 2003, 91(3): 603-607.

Researcher : Xu J

List of Research Outputs

Lee C.K.F., Kwok K.L., Ngan E.S.W., Xu J. and Yeung W.S.B., Demilune cell and parotid protein (DCPP) messenger RNA expression in mouse oviduct: hormonal regulation and embryo development, 20th Anniversary (1983-2003)& 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., Identification of human oviducutal cell derived embryotrophic factor-3 (ETF-3), Symposium on Reproductive Health, Macau, Hong Kong and Inland China, Macau, May 29-31, 2004 . 2004.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction, The Journal of Biological Chemistry. 2004, 279(13): 12763-12768.

Xu J., Chan S.T.H., Ho P.C. and Yeung W.S.B., Coculture of human oviductal cells maintains mitochondrial function and decreases caspase activity of cleavage-stage mouse embryos, Fertility and Sterility. 2003, 80(1): 178-183.

Xu J., Lee C.K.F. and Yeung W.S.B., Combined effect of human oviductal cells derived embryotrophic factors on mouse early embryo development, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Xu J., Chan S.T.H., Lee W.M., Lee C.K.F. and Yeung W.S.B., Differential growth, cell proliferation and apoptosis of mouse embryo in variuos culture media and in coculture, Molecular Reproduction and Development. 2004, 68(1): 72-80.

Yao Y., Xu J., Lee W.W.M., Yeung W.S.B. and Lee C.K.F., Identification of mRNAs that are up-regulated after fertilization in the murine zygote by suppression subtractive hybridization, Biochemical and Biophysical Research Communications. 2003, 304: 60-66.

Yeung W.S.B., Xu J., Lee C.K.F. and Lee C.Y.L., Paracrine regulation of preimplantation embryo development by oviduct, Abstract for The 3rd International Huaxia Congress of Endocrinology, May 25-28, 2004, Shanghai, China. 2004.

Researcher : Yang H

List of Research Outputs

Liu V.W.S., Yang H., Wang Y., Tsang P.C.K., Cheung A.N.Y., Chiu P.M., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., High frequency of mitochondrial genome instability in human endometrial carcinomas, British Journal of Cancer. 2003, 89(4): 697-701.

Liu V.W.S., Wang Y., Yang H., Tsang P.C.K., Ng T.Y., Wong R.L.C., Nagley P. and Ngan H.Y.S., Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer , Human Mutation. 2003, 22(2): 173-174.

Yang H., Liu V.W.S., Tsang P.C.K., Yip M.W., Ng T.Y., Cheung A.N.Y. and Ngan H.Y.S., Comparison of human papillomavirus DNA levels in gynecological cancers: implication for cancer development, Tumour Biology. 2003, 24(6): 310-316.

Yang H., Liu V.W.S., Wang Y., Chan Y.K., Tsang P.C.K., Khoo U.S., Cheung A.N.Y. and Ngan H.Y.S., Detection of hypermethylated genes in tumor and plasma of cervical cancer patients, Gynecologic Oncology. 2004, 93(2): 435-440.

Researcher : Yao Y

List of Research Outputs

Yao Y., Xu J., Lee W.W.M., Yeung W.S.B. and Lee C.K.F., Identification of mRNAs that are up-regulated after fertilization in the murine zygote by suppression subtractive hybridization, Biochemical and Biophysical Research Communications. 2003, 304: 60-66.

Researcher : Yeung WSB

Project Title:	Characterization of a human oviductal embryotrophic factor that enhances embryo hatching
Investigator(s):	Dr. Yeung W.S.B., Dr. Lee C.K.F., Prof. Lee W.W.M., Dr. Luk J.M.C.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2001

Abstract:

To characterize a panel of monoclonal antibodies against ETF-3; to identify the embryotrohpic factors in EFT-3 by amino acid sequencing and to confirm that the immortalized oviductal cells produce ETF-3; to clone the gene responsible for the production of the embryotropic factor in ETF3; to study the mechanisms by which ETF-3 affects blastocyst hatching.

Project Title:	Effects of oviductal derived embryotrophic factor on embryo development
Investigator(s):	Dr. Yeung W.S.B., Dr. Lee C.K.F., Dr. Xu J.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002
Completion Date:	10/2003

Abstract:

To test this hypothesis by studying the effect of different combination of embryotrophic factors treatment on (1) embryo development; (2) expression of Oct4 and Na/K-ATPase-b1 gene in the ICM and TE of the treated embryos respectively.

Project Title:	Functional studies of VCY2 and VCY2 interacting protein (VCY2IP-1)
Investigator(s):	Dr. Yeung W.S.B., Dr. Huang J.D., Dr. Tam P.C., Dr. Tse J.Y.M.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To evaluate the role of VCY2 and VCY2IP-1in the microtubule network and their possible relationship to male infertility.

Project Title:	Role of leptin in interaction between the preimplantation embryo and the oviduct
Investigator(s):	Dr. Yeung W.S.B., Dr. Lee C.K.F., Dr. Xu J.S.
Department:	Obstetrics and Gynaecology
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To study the effect of steroids on the expression of leptin and Ob-R in mouse oviduct and a human oviductal cell line; to determine the effect of embryo on the expression of leptin in oviduct.

List of Research Outputs

Chan C.C.W., Ng E.H.Y., Chan M.M.Y., Tang F.O.S., Lau E.Y.L., Yeung W.S.B. and Ho P.C., Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women, Human Reproduction. 2003, 18(11): 2294-2297.

Chiu C.N., Hong S., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., A capillary - cumulus model to study the selection of sperm by cumulus oophorus, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Chiu C.N., Tsang H.Y., Koistinen R., Koistinen H., Seppala M., Lee C.K.F. and Yeung W.S.B., The contribution of D-Mannose, L-Fucose, N-Acetylglucosamine, and selectin residues on the binding of glycodelin isoforms to human spermatozoa, Biology of Reproduction. 2004, 70: 1710-1719.

Hong S., Chiu C.N., Lee C.K.F., Tse J.Y.M., Ho P.C. and Yeung W.S.B., Establishment of a capillary-cumulus model to study the selection of sperm for fertilization by the cumulus oophorus, Human Reproduction. 2004, 19(7): 1562-1569.

Koistinen H., Easton R.L., Chiu C.N., Chalabi S., Halttunen M., Dell A., Morris H.R., Yeung W.S.B., Seppala M. and Koistinen R., Differences in glycosylation and sperm-egg binding inhibition of pregnancy-related glycodelin, Biology of Reproduction. 2003, 69: 1545-1551.

Lee C.K.F. and Yeung W.S.B., Cross-talk between the embryos and oviduct, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Lee C.K.F., Kwok K.L., Ngan E.S.W., Xu J. and Yeung W.S.B., Demilune cell and parotid protein (DCPP) messenger RNA expression in mouse oviduct: hormonal regulation and embryo development, 20th Anniversary (1983-2003)& 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Lee C.K.F., Yeung W.S.B., Chow J.F.C., Shum C.K. and Luk J.M.C., Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis, Biology of Reproduction. 2004, 70: 1010-1017.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., Identification of human oviducutal cell derived embryotrophic factor-3 (ETF-3), Symposium on Reproductive Health, Macau, Hong Kong and Inland China, Macau, May 29-31, 2004 . 2004.

Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction, The Journal of Biological Chemistry. 2004, 279(13): 12763-12768.

Luk J.M.C., Mok B.W.Y., Shum C.K., Yeung W.S.B., Tam P.C., Tse J.Y.M., Chow J.F.C., Woo J., Kam K. and Lee C.K.F., Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display, Biochemical and Biophysical Research Communications. 2003, 307(4): 782-790.

Makkar G., Ng E.H.Y., Yeung W.S.B. and Ho P.C., Prognostic factors for successful outcome in patients undergoing controlled ovarian stimulation and intrauterine insemination, Hong Kong Medical Journal. 2003, 9(5): 341-345.

Ng E.H.Y., Yeung W.S.B. and Ho P.C., Absence of high grade perifollicular vascularity in poor ovarian responders is not associated with reduced pregnancy rate of in vitro fertilization treatment, Abstract of The 18th World Congress on Fertility and Sterility, Montreal, Canada, May 23-28, 2004.

Ng E.H.Y., Laird S.M., Li T.C., Yeung W.S.B. and Ho P.C., Concentations of endometrial protein PP 14 and CA-125 in uterine flushings performed in natural and stimulated cycles, Human Reproduction. 2004, 19(4): 905-910.

Ng E.H.Y., Laird S.M., Li T.C., Yeung W.S.B. and Ho P.C., Concentrations of endometrial protein PP 14 and CA-125 in uterine flushing of patients with excessive ovarian response during in vitro fertilization treatment, Abstract of The 18th World Congress on Fertility and Sterility, Montreal, Canada, May 23-28, 2004.

Ng E.H.Y., Yeung W.S.B., Fong D.Y.T. and Ho P.C., Effects of age on hormonal and ultrasound markers of ovarian reserve in Chinese women with proven fertility, Human Reproduction. 2003, 18(10): 2169-2174.

Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., Endometrial and subendometrial blood flow measured during early luteal phase by three-dimensional power Doppler ultrasound in excessive ovarian responders, Human Reproduction. 2004, 19(4): 924-931.

Ngan E.S.W., Ng E.H.Y., Lee C.K.F., Liu V.W.S., Liu S., Ngan H.Y.S. and Yeung W.S.B., Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Ngan E.S.W., Ng E.H.Y., Ngan H.Y.S. and Yeung W.S.B., Spatial and temporal expression of endocrine gland derived vascular endothelial growth factor, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Tsang H.Y., Yeung W.S.B. and Lee C.K.F., Delineate the signaling pathway of the suppressive effect of glycodelin-F on progesterone-induced acrosome reaction on human spermatozoa, 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, December 13, 2003.

Tse J.Y.M., Wong E.Y.M., Cheung A.N.Y., O W.S., Tam P.C. and Yeung W.S.B., Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility , Biology of Reproduction. 2003, 69: 746-751.

Wong E.Y.M., Tse J.Y.M., Yao K.M., Lui V.C.H., Tam P.C. and Yeung W.S.B., Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein, Biology of Reproduction. 2003, 70: 775-784.

Xu J., Chan S.T.H., Ho P.C. and Yeung W.S.B., Coculture of human oviductal cells maintains mitochondrial function and decreases caspase activity of cleavage-stage mouse embryos, Fertility and Sterility. 2003, 80(1): 178-183.

Xu J., Lee C.K.F. and Yeung W.S.B., Combined effect of human oviductal cells derived embryotrophic factors on mouse early embryo development, 20th Anniversary (1983-2003) and 15th Annual Scientific Meeting held by Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 19, 2003, Hong Kong. 2003.

Xu J., Chan S.T.H., Lee W.M., Lee C.K.F. and Yeung W.S.B., Differential growth, cell proliferation and apoptosis of mouse embryo in variuos culture media and in coculture, Molecular Reproduction and Development. 2004, 68(1): 72-80.

Yao Y., Xu J., Lee W.W.M., Yeung W.S.B. and Lee C.K.F., Identification of mRNAs that are up-regulated after fertilization in the murine zygote by suppression subtractive hybridization, Biochemical and Biophysical Research Communications. 2003, 304: 60-66.

Yeung W.S.B., Luo G.A., Wang Q.G. and Ou J.P., Capillary electrophoresis-based immunoassay, Journal of Chromatography B. 2003, 797: 217-228.

Yeung W.S.B., Chiu C.N., Lee C.K.F., Koistinen R., Koistinen H. and Seppala M., New isofrom of glycodeln involving in fertilization, 2003 International Symposium Gametgenesis, Gene Expression and Human Reproduction, November 8-9, 2003, Dongguan, China. 2003.

Yeung W.S.B., Xu J., Lee C.K.F. and Lee C.Y.L., Paracrine regulation of preimplantation embryo development by oviduct, Abstract for The 3rd International Huaxia Congress of Endocrinology, May 25-28, 2004, Shanghai, China. 2004.

Yeung W.S.B. and Lee C.K.F., Recent advances in assisted reproduction, Symposium on Reproductive Health, May 29-31, 2004, Macau, Hong Kong, Inland China. 2004.

Yeung W.S.B., Sequential culture versus coculture in assisted reproduction, The 4th Conference of the Pacific Rim Society for Fertility and Sterility, Okinawa, Japan, March 8-11, 2004.

Researcher : Yip MW

List of Research Outputs

Yang H., Liu V.W.S., Tsang P.C.K., Yip M.W., Ng T.Y., Cheung A.N.Y. and Ngan H.Y.S., Comparison of human papillomavirus DNA levels in gynecological cancers: implication for cancer development, Tumour Biology. 2003, 24(6): 310-316.

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