| THE
UNIVERSITY OF HONG KONG |
DEPARTMENT OF PHYSIOLOGY
| Researcher : Ballard HJ |
| Project Title: | Interactions between vasoconstrictor and vasodilator mechanisms in the skeletal muscle vascular response to systemic hypoxia |
| Investigator(s): | Dr. Ballard H.J. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 07/2003 |
| Abstract: |
| To investigate the roles of the baroreflex, the central chemoreflex and adaptation of the peripheral chemoreflex in the variation of sympathetic outflow to the muscle during hypoxia, and the mechanism by which sympathetic nerve activation stimulates the formation of interstitial vasodilator metabolites; to investigate the roles of A1 and A2 adenosine receptors in the vascular response to sustained hypoxia, and determine whether the receptors are located on endothelium or vascular smooth muscle; to investigate the mechanisms of the interactions between the release and actions of the vasodilator substances in hypoxia; to investigate the properties and control of the specific isoenzyme of cytosolic 5' -nucleotidase isolated from skeletal muscle vascular endothelial cells. |
| Project Title: | Interactions between vasoconstrictor and vasodilator mechanisms in the skeletal muscle vascular response to systemic hypoxia |
| Investigator(s): | Dr. Ballard H.J. |
| Department: | Physiology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To investigate the roles of the baroreflex, the central chemoreflex and adaptation of the peripheral chemoreflex in the variation of sympathetic outflow to the muscle during hypoxia, and the mechanism by which sympathetic nerve activation stimulates the formation of interstitial vasodilator metabolites; to investigate the roles of A1 and A2 adenosine receptors in the vascular response to sustained hypoxia, and determine whether the receptors are located on endothelium or vascular smooth muscle; to investigate the mechanisms of the interactions between the release and actions of the vasodilator substances in hypoxia; to investigate the properties and control of the specific isoenzyme of cytosolic 5' -nucleotidase isolated from skeletal muscle vascular endothelial cells. |
| List of Research Outputs |
| Tam L.T.L. and Ballard H.J., Nitric oxide release in the renal circulation of normoxia-or hypoxia-adapted rats in response to acute local hypoxia, FASEB Journal . 2004, 18(5): A1278. |
| Tam L.T.L. and Ballard H.J., Nitric oxide release in the renal circulation of normoxia-or hypoxia-adapted rats in response to acute local hypoxia, Journal of the Hong Kong College of Cardiology. 2003, 1, A17: 11. |
| Wang H.P., Xia Q., Cao C. and Ballard H.J., Nitric oxide mediates the inhibitory effect of interleukin-2 on cardiac contraction in rat ventricular , FASEB Journal. 2004, 18(5): 3579. |
| Researcher : Bourreau JP |
| Project Title: | Prevention of terminal cardiovascular failure during the hypodynamic phase of septic shock |
| Investigator(s): | Dr. Bourreau J.P. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2000 |
| Completion Date: | 10/2003 |
| Abstract: |
| To validate "in vivo" the proposal that administration during the hypodynamic phase of septic shock of adrenomedullin antiserum alone, or combined with a selective iNOS inhibitors, would prevent terminal cardiovascular failure. |
| Project Title: | Can ETA blockade improve coronary circulation in heart isolated from rats in septic shock? Interference with NO and adrenomedullin |
| Investigator(s): | Dr. Bourreau J.P. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To assess the extent of coronary vasospasm triggered in shocked heart by iNOS and adrenomedullin inhibition; to assess tto what extent ETA receptors inhibition improves the perfusion. |
| Project Title: | Terminal cardiovascular failure during the hypodynamic phase of septic shock - role of adrenomedullin and cyclo-oxygenase |
| Investigator(s): | Dr. Bourreau J.P. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2002 |
| Completion Date: | 10/2003 |
| Abstract: |
| To ascertain whether there is any interaction between adrenomedullin and cyclo-oxygenase in the myocytes of failing hearts in LPS-induced septic shock in rats. |
| Project Title: | Role of cyclooxygenase in the ventricular effects of adrenomedullin: does prostacyclin contribute towards the cardiodepression in the late hypodynamic phase of septic shock? |
| Investigator(s): | Dr. Bourreau J.P. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To measure the levels of PGI2 by quantifying its stable hydrolysis product, 6-keto PGF1a by EIA after stimulation with ADM and at various time-points corresponding to the biphasic inotropic effects of ADM, and to mesure the PGI2 levels in our animal model of terminal septic shock; to observe the signal transduction pathway involved in the ventricular effects of ADM with respect to PGI2. |
| List of Research Outputs |
| Mittra S., Hyvelin J., Shan Q., Tang F. and Bourreau J.P., Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?, American Journal of Physiology. 2004, 286: H1034-H1042. |
| Researcher : Bruce IC |
| Project Title: | Biomedical writing for postgraduate students whose mother tongue is Chinese: a novel course based on interactive multimedia |
| Investigator(s): | Dr. Bruce I.C., Dr. Chan R.Y.P., Prof. Poon P.W.F., Prof. Xia Q. |
| Department: | Physiology |
| Source(s) of Funding: | Teaching Development Grants issued by The University Grants Committee of Hong Kong |
| Start Date: | 02/1999 |
| Abstract: |
| Two tasks need to be accomplished. Firstly, how best to teach and learn the art and craft of creating a manuscript suitable for submission to an international journal. Secondly, how to develop a teaching tool that is sensitive to the specific difficulties encountered by individuals whose usual channels of communication are Chinese. The unifying strategy is to create and interactive web site that can be used, in combination with face-to-face teaching, to develop the desired writing skills and attitudes. |
| List of Research Outputs |
| Cao C., Xia Q., Bruce I.C., Zhang X., Fu C. and Chen J.Z., Interleukin-2 increases activity of sarcoplasmic reticulum Ca2+-ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes , Journal of Pharmacology and Experimental Therapeutics. 2003, 306: 572-580. |
| Cao C.M., Xia Q., Bruce I.C., Shen Y.L., Ye Z.G., Lin G.H., Chen J.Z. and Li G.R., Influence of interleukin-2 on Ca2+ handling in rat ventricular myocytes., Journal of Molecular and Cellular Cardiology . 2003, 35: 1491-1503. |
| Gu H.Y., Hong C., Zhang J.Y., Yao Z.B., Zhou L.H., Bruce I.C. and Wu W., Survival, regeneration & functional recovery of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion, European Journal of Neuroscience . 2004, 19: 2123-2131. |
| Jin H.F., Shan Q.X., Jinag H.D., Tu J., Bruce I.C. and Xia Q., Vasorelaxant effect of total flavones from Dendrathema morifolium on rat thoracic aorta. , Proceedings, 25th Annual International Conference, IEEE Engineering in Medicine & Biology Society. 2003, 564. |
| Kravtsov G.M., Bruce I.C., Wong T.M. and Kwan C.Y., A new view of K+ -induced contraction in rat aorta: the role of Ca2+ binding, Pflügers Archiv - European Journal of Physiology . 2003, 446: 529-540. |
| Lucas P.W., Prinz J.F., Agrawal K.R. and Bruce I.C., Food texture & its effects o ingestion, mastication & swallowing, Journal of Texture Studies. 2004, 35: 159-170. |
| Shen Y.L., Chen Y.Y., Wu X.D., Bruce I.C. and Xia Q., Activation of mitochondrial ATP-sensitive potassium channels delays ischemia-induced cellular uncoupling in rat heart, Acta Pharmacologica Sinica. 2004, 25: 22-28. |
| Tao Z.W., Huang Y.W., Xia Q., Fu J., Zhao Z.H., Lu X. and Bruce I.C., Early association of electrocardiogram alteration with infarct size & cardiac function after myocardial infarction, Journal of Zhejiang University (Science) . 2004, 5: 494-498. |
| Tu J., Shan Q.X., Jin H.F., Bruce I.C. and Xia Q., Alterations of coronary perfusion pressure and cardiac contraction during lipopolysaccharide challenge. , Proceedings, 25th Annual International Conference, IEEE Engineering in Medicine & Biology Society. 2003, 560. |
| Researcher : Cao C |
| List of Research Outputs |
| Cao C., Xia Q. and Wong T.M., Cardioprotection of interleukin-2 is mediated via k -opioid receptor, Journal of Pharmacology and Experimental Therapeutics. 2004, 309 (2): 560-567. |
| Cao C., Xia Q., Bruce I.C., Zhang X., Fu C. and Chen J.Z., Interleukin-2 increases activity of sarcoplasmic reticulum Ca2+-ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes , Journal of Pharmacology and Experimental Therapeutics. 2003, 306: 572-580. |
| Wang H.P., Xia Q., Cao C. and Ballard H.J., Nitric oxide mediates the inhibitory effect of interleukin-2 on cardiac contraction in rat ventricular , FASEB Journal. 2004, 18(5): 3579. |
| Researcher : Chan STH |
| List of Research Outputs |
| Huang X.G., Yee B.K., Chan S.T.H. and Tang F., Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235, Experimental Neurology. 2003, 183: 673-681. |
| Researcher : Chan YS |
| Project Title: | Characterisation of the ventral medullary (VM) neurons of the normotensive and spontaneously hypertensive rats |
| Investigator(s): | Prof. Chan Y.S., Prof. Wong T.M. |
| Department: | Physiology |
| Source(s) of Funding: | Croucher Foundation |
| Start Date: | 01/1990 |
| Completion Date: | 12/2003 |
| Abstract: |
| To characterize the VM neurones of normotensive and hypertensive rats in different physiological states and hope that by doing so, we may obtain useful information as to the exact site(s) and its (their) role(s) in the control of circulation. |
| Project Title: | Mechanism of plastic changes in vestibulo-cardiovascular interaction following prolonged otolith stimulation |
| Investigator(s): | Prof. Chan Y.S., Dr. Chan R.K.W. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 12/2000 |
| Abstract: |
| To investigate the plastic changes of vestibulo-cardiovascular interaction. The project also attempts to delineate the cellular responsiveness in the vestibulo-baroreflex circuitry following short-term or sustained natural otolith stimulation. |
| Project Title: | The expression pattern of neurotrophin receptors in rat vestibular nucleus during development |
| Investigator(s): | Prof. Chan Y.S. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To employ in situ hybridization and immunocytochemical methods to map central otolith neurons that express both c-fos and neurotrophin receptors in defined stages of postnatal rats; to identify key neurotrophin receptors that participates in postnatal development of central otolith neurons. |
| Project Title: | Spatial organization of otolith information in the vestibulo-olivary pathway |
| Investigator(s): | Prof. Chan Y.S., Dr. Yung K.K.L. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 12/2001 |
| Abstract: |
| To ascertain that otolith information is topographically represented within the inferior olivary complex; to test if glutamate from the vestibular nucleus is a modulatory agent for otolith-related vestibulo-olivocerebellar circuit. |
| Project Title: | Formation of gravity-related spatial map in postnatal rats |
| Investigator(s): | Prof. Chan Y.S., Dr. Yung K.K.L. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 11/2002 |
| Abstract: |
| A fundamental question in otolith system development is how gravity-related spatial information of the adult pattern emerges. It is hypotheszed in the study that the maturation in coding of specific head orientations may not be in phase with each other, i.e. there is a critical maturation period before which recognition of a specific head orientation cannot operate. The project attempts to use linear acceleration along horizontal and vertical directions, selected to activate specific subset(s) of receptors on the utricular and saccular maculae respectively. |
| Project Title: | Sensitive period for topographic spatial representation in the rat otolith system |
| Investigator(s): | Prof. Chan Y.S., Dr. Yung K.K.L. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 11/2003 |
| Abstract: |
| To determine whether the functional organization of a gravity-related spatial reference in the postnatal inferior olive is perturbed by perinatal blockade of the vestibular nucleus; to determine whether the spatial coding capacity of adult neurons are perturbed well after an early postnatal blockade becomes ineffective; to examine if the pharmacological manipulations applied later in the postnatal period have any effect in the mature brain. |
| Project Title: | Sensitive period for topographic spatial representation in the rat otolith system |
| Investigator(s): | Prof. Chan Y.S., Dr. Yung K.K.L. |
| Department: | Physiology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 11/2003 |
| Abstract: |
| To determine whether the functional organization of a gravity-related spatial reference in the postnatal inferior olive is perturbed by perinatal blockade of the vestibular nucleus; to determine whether the spatial coding capacity of adult neurons are perturbed well after an early postnatal blockade becomes ineffective; to examine if the pharmacological manipulations applied later in the postnatal period have any effect in the mature brain. |
| Project Title: | The role of central glial cells in the pathogenesis of Parkinson's Disease |
| Investigator(s): | Prof. Chan Y.S. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To employ immuno-hybridization histochemical methods to map the spatiotemporal distribution of different activated glial cells during the development of PD as induced by systemic administration of a neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). |
| List of Research Outputs |
| Chan W.S., Chung E.K., Lau W.K., Chan Y.S. and Yung K.K., Differential expression of a-amino-3-hydroxy-5-methyl-4-isoxazole-proprionate glutamate receptors in the rat neostriatum during postnatal development, NeuroSignals. 2003, 12: 302-309. |
| Chan Y.S., Neural coding of spatial orientations in the developing otolith system, Chinese Association of Physiological Sciences News Communication. 2003, 21 (Suppl. 2): 132. |
| Chan Y.S., Lai C.H., Shum D.K.Y., Yung K.K.L. and Zhang F., Receptors of glutamate and neurotrophin in vestibular neuronal functions, Journal of Biomedical Science. 2003, 10: 577-587. |
| Chau C.H., Shum D.K.Y., Li H., Pei J., Lui Y.Y., Wirthlin L., Chan Y.S. and Xu X.M., Chondronitase ABC enhances axonal regrowth through Schwann cell-seeded guidance channels after spinal cord injury, FASEB Journal. 2004, 18(1): 194-196. |
| Chen L.W., Yung K.K. and Chan Y.S., Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson’s disease, Current Drug Targets - CNS & Neurological Disorders. 2004, 5: 197-206. |
| Hu H.J., Chen L.W., Yung K.K. and Chan Y.S., Differential expression of AMPA receptor subunits GluR1, 2, 3, and 4 in substance P receptor-containing neurons of the neostriatal regions of rats, Neuroscience Research. 2004, 49: 281-288. |
| Kwok J.C.F., Ng K.Y., Zhang F., Shum D.K.Y. and Chan Y.S., Chondroitin sulfates restrict axonal growth along the projection path of VN neurons across the hindbrain of prenatal Sprague-Dawley rats, The Annual Meeting of the Hong Kong Neuroscience Society, 9-10 Dec, 2003, Faculty of Medicine, HKU . 2003. |
| Kwok J.C.F., Ng K.Y., Shum D.K.Y. and Chan Y.S., Tracking commissural projections of vestibular neurons in a chondroitin, sulfate-enriched environment of the developing hindbrain , The Gordon Research Conference on Molecular & Cellular, June 6-11, 2004,HKUST, Hong Kong . 2004. |
| Lai C.H., Tse Y.C., Shum D.K.Y., Yung K.K. and Chan Y.S., Fos expression in central otolith neurons of postnatal rats following off-vertical axis rotation, Journal of Comparative Neurology. 2004, 470: 282-296. |
| Lai S.K., Lai C.H., Yung K.K. and Chan Y.S., Fos expression in saccule-related brainstem and cerebellar neurons during vertical linear acceleration, 6th IBRO World Congress of Neuroscience. 2003, 2210. |
| Lai S.K., Lai C.H., Yung K.K. and Chan Y.S., Postnatal expression of glutamate transporter EAAC1 and glutamate receptors in saccule-related vestibular nuclear neurons of rats, Society of Neuroscience Abstract (U.S.A.). 2003, 703.9. |
| Lai S.K., Tse Y.C., Ng K.Y., Lau W.K., Yang M.S., Wong C.K., Chan Y.S. and Yung K.K., Selective knockdown of gene expression of N-methyl-D-aspartate receptor ameliorates parkinsonian motor symptom in 6-hydroxydopamine-lesioned rats, Neurochemistry International. 2004, 45: 11-22. |
| Lai S.K., Li C., Lai C.H. and Chan Y.S., Spatial coding capacity of otolith-related neurons in the dorsomedial cell column during postnatal development in rats, Neuroscience Letters Supplement. 2003, 58: S13. |
| Leung K.W., Chan Y.S. and Yung K.K., Dichlorodipenyltrichloroethane specifically knockout dopamine neurons in primary cell culture, Neuroembryology. 2003, 2: 95-102. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Development expression of glutamate receptor subunits in rat dorsomedial cell column neurons responsive to horizontal linear acceleration, Society of Neuroscience Abstract (U.S.A.). 2003, 703.10. |
| Li C., Zhang Y.K., Guan Z. and Chan Y.S., Vestibular afferent connection in vestibular efferent nucleus of rats, 6th IBRO World Congress of Neuroscience. 2003, 2211. |
| Lui P.W., Suen K.C., Chan Y.S., Yung W.H. and Yung K.K., Striatal neurons but not nigral dopaminergic neurons in primary cell culture express endogenous functional N-methyl-D-aspartate receptors, Molecular Brain Research. 2003, 120: 9-21. |
| Ng K.Y., Lai C.H., Yung K.K. and Chan Y.S., Localization of GABAB receptor and GAD immunoreactivity in the rat vestibular nucleus, 6th IBRO World Congress of Neuroscience. 2003, 2212. |
| Sun B., Guan Z. and Chan Y.S., Neural circuitries for vestibulo-cardiovascular interaction, Neuroscience Letters Supplement. 2003, 58: S23-24. |
| Sun X., Chan Y.S. and He J., Corticofugal modulation alters acoustically induced Fos expression in the rat auditory thalamus, Neuroscience Letters Supplement. 2003, 58: S13. |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Developmental expression of glutamate receptor in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters Supplement. 2003, 58: S23. |
| Xiong Y., Yu Y.Q., Chan Y.S. and He J.F., Slow oscillation in non-lemniscal auditory thalamus, Society of Neuroscience Abstract (U.S.A.). 2003, 182.6. |
| Yu Y.Q., Xiong Y., Chan Y.S. and He J.F., Corticofugal gating of auditory information in the thalamus: an in-vivo intracellular electrophysiology study, Society of Neuroscience Abstract (U.S.A.). 2003, 181.11. |
| Yu Y.Q., Xiong Y., Chan Y.S. and He J., Corticofugal gating of auditory information in the thalamus: an in-vivo intracellular recording study, Journal of Neuroscience. 2004, 24: 3060-3069. |
| Yu Y.Q., Chan Y.S. and He J., Off / On-off neurons in the guinea pig auditory thalamus: an in-vivo intracellular study, Neuroscience Letters Supplement. 2003, 57: S13. |
| Zhang F., Ng K.Y., Shum D.K.Y. and Chan Y.S., Axonal trajectories of the vestibular nuclei in the developing rat embryo, Neuroscience Letters Supplement. 2003, 58: S23. |
| Researcher : Chen M |
| List of Research Outputs |
| Chen M., Zhou J., Kam W.L., Qi J., Yan W.Y., Wu S. and Wong T.M., ATP-sensitive K+ Channels are involved in U50, 488H-preconditioning induced delayed cardioprotection and Ca2+ homeostasis changes in rat hearts , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A15. |
| Chen M., Sun H.Y., Wang Y., Fung M.L. and Gao T.M., Increased BKCa channel activity mediates apoptosis in cultured hippocampal neurons during hypoxia/ reperfusion, 205th Xiangshan Conference and The Third Symposium on Hypoxia Across Strait: Hypoxia & Health, Wuwei, PRC. 2003. |
| Chen M., Qi J.S., Zhou J.J., Kam W.L., Yan W.Y., Wu S., Wu S. and Wong T.M., Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ XVin the rat heart as revealed by k-opioid receptor stimulation with U50,488H, British Journal of Pharmacology. 2003, 140: 750-758. |
| Kam W.L., Qi J.S., Chen M. and Wong T.M., Estrogen Reduces Cardiac Injury And Expression Of beta1-adrenoceptor Upon Ischemic Insult In The Rat Heart, Journal of Pharmacology and Experimental Therapeutics. 2004, 309(1): 8-15. |
| Kam W.L., Qi J., Chen M. and Wong T.M., Novel Cardioprotective Protective Mechanism of Estrogen-Interaction with the b-Adrenergic Receptor , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A8. |
| Qi J.S., Kam W.L., Chen M., Wu S. and Wong T.M., Failure to confer cardioprotection and to increase the expression of heat shock protein 70 by preconditioning with a k-opioid receptor agonist during ischemia and reperfusion in streptozotocin-induced diabetic rats, Diabetologia. 2004, 47: 214-220. |
| Researcher : Chen Y |
| List of Research Outputs |
| Tjong Y.W., Chen Y., Liong E.C., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis, Journal of Pineal Research. 2004, 36: 49-57. |
| Researcher : Das R |
| List of Research Outputs |
| Pei J., Kravtsov G.M., Wu S., Das R., Fung M.L. and Wong T.M., Calcium homeostasis in the rat cardiomyocytes during chronic hypoxia – a time course study, American Journal of Physiology Cell Physiology. 2003, 285(6): C1420-1428. |
| Researcher : Fung ML |
| Project Title: | Angiotensin II receptors in the carotid body: its function and expression in perinatal and postnatal hypoxia |
| Investigator(s): | Dr. Fung M.L., Dr. Leung P.S. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2001 |
| Abstract: |
| To determine the functional change upon the activation of ATRs in rat carotid body during chronic hypoxia from birth; to measure the intracellular calcium Ca++i response to the activation of ATRs in type I (gloumus) cells dissociated from the carotid body in normoxi and CH rats; to determine the transcriptional changes of the gene expression of ATRs in the carotid body with chronic hypoxia; to determine the localization of the ATRs in normoxic and CH carotid body. |
| Project Title: | Molecular and cellular mechanisms underlying anatomical and physiological adaption of the carotid body in chronic hypoxia: role of HIF-1 and its target genes |
| Investigator(s): | Dr. Fung M.L., Prof. Fung P.C.W., Dr. Tipoe G.L. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2002 |
| Abstract: |
| This project is an experimental study to examine the hypothesis that HIF-1 plays a paramount role in the transcriptional regulation of the structural and physiological adaptation of the carotid body in chronic hypoxia. In particular, the team will go into the increased expression and activities of HIF-1 and the activation of expression of HIF-1 target genes for encoding proteins, such as endothelin-1, vascular endothelial growth factor (VEGF), VEGF receptors and inducible nitric oxide synthase in the rat carotid body during chronic hypoxia. |
| Project Title: | Mechanistic role of protein S-nitrosylation pathway in cellular responses to oxygen signalling |
| Investigator(s): | Dr. Fung M.L., Prof. Gao T.M. |
| Department: | Physiology |
| Source(s) of Funding: | National Natural Science Foundation of China |
| Start Date: | 12/2002 |
| Abstract: |
| To examine the role of redox state and NO-activated cGMP-independent pathway in modulating channel functions in different Oxgyen tensions; to determine the specificity of S-nitrosylation in mediating cGMP-independent NO-effects on the channel functions in different Oxgyen tensions; to determine S-nitrosylated mediators for modulating the channel functions and the role of redox state in setting the channel sensitivity to S-nitrosylating modulation in different Oxygen tensions; to examine the role of protein S-nitrosylation pathway in modulating cellular functions in tissue and organ levels in different Oxygen tensions. |
| Project Title: | Physiological roles of melatonin in circadian modulation of carotid chemoreceptor functions |
| Investigator(s): | Dr. Fung M.L., Dr. Tipoe G.L. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 07/2003 |
| Abstract: |
| To delineate (1) the physiological pathway pathway underlying the circadian modulation of cardiopulmonary activities and (2) the cellular and molecular mechanisms mediating the physiological effects of melatonin on the carotid body function and its modulation during chronic hypoxia. |
| Project Title: | Physiological roles of melatonin in circadian modulation of carotid chemoreceptor functions |
| Investigator(s): | Dr. Fung M.L., Dr. Tipoe G.L. |
| Department: | Physiology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To delineate (1) the physiological pathway pathway underlying the circadian modulation of cardiopulmonary activities and (2) the cellular and molecular mechanisms mediating the physiological effects of melatonin on the carotid body function and its modulation during chronic hypoxia. |
| Project Title: | Mechanistic role of carotid body afferent activity in the modulation of glutamatergic transmission in the nucleus tractus solitarii of rats in chronic hypoxia |
| Investigator(s): | Dr. Fung M.L., Dr. Denoroy L., Dr. Pequignot J.M. |
| Department: | Physiology |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme |
| Start Date: | 01/2004 |
| Abstract: |
| To examine the modulation of the N-methyl-D-aspartate (NMDA)-glutamate receptor/nitric oxide (NO) pathway in the NTS of rats in chronic hypoxia; to determine the role of carotid body afferent activity in the change of NMDA/NO pathway in the NTS of rats in chronic hypoxia. |
| List of Research Outputs |
| Chen M., Sun H.Y., Wang Y., Fung M.L. and Gao T.M., Increased BKCa channel activity mediates apoptosis in cultured hippocampal neurons during hypoxia/ reperfusion, 205th Xiangshan Conference and The Third Symposium on Hypoxia Across Strait: Hypoxia & Health, Wuwei, PRC. 2003. |
| Fung M.L., Tipoe G.L., Liong E.C. and Ip S.F., Alterations in systemic and pulmonary circulation in cyclooxygenase-1-deficient mice in chronic hypoxia, 205th Xiangshan Conference and The Third Symposium on Hypoxia Across Strait: Hypoxia & Health, Wuwei, PRC. 2003. |
| Fung M.L., Tipoe G.L., Liong E.C. and Ip S.F., Elevated systemic pressure and nitric oxide synthesis in cyclooxygenase-1-deficient mice in chronic hypoxia, The Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P11, 2003. Journal of the Hong Kong College of Cardiology, 11(Suppl. 1):A21. 2003. |
| Fung M.L., Hypoxia-inducible factor-1: a molecular hint of physiological changes in the carotid body during long-term hypoxemia?, Current Drug Targets - Cardiovascular & Hematological Disorders. 2004, 3(3): 254-259. |
| Fung M.L., Tipoe G.L., Tjong Y.W., Chen Y., Ye J.S. and Liong E.C., Molecular regulation and functions of vasoactive factors in the carotid body during chronic hypoxia, The Fourth Symposium on Cardiovascular Science Across Strait, Taipei, Taiwan . 2003. |
| Fung M.L., Response and adaptations to hypoxia: roles of vasoactive factors in the carotid body, The Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, IL5, 2003. Journal of the Hong Kong College of Cardiology, 11(Suppl. 1):A4. 2003. |
| Fung M.L. and Tipoe G.L., Role of HIF-1 in physiological adaptation of the carotid body during chronic hypoxia, In: Jean-Marc Pequignot, Constancio Gonzalez, Colin A. Nurse, Nanduri R. Prabhakar, Yvette Dalmaz, Advances in Experimental Medicine & Biology: Chemoreception. New York, Kluwer Academic/Plenum Publishers, 2003, 536: 593-601. |
| Jian K.H., Chan M., Fung M.L. and Gao T.M., Endogenous nitric oxide regulates hippocampal L-type calcium channels by S-nitrosylation, 23rd Annual Meeting Hong Kong Society of Neuroscience. 2003. |
| Lam S.S.Y., Fung M.L. and Leung P.S., Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body, Journal of Applied Physiology. 2004, 96(2): 809-813. |
| Lau T.Y.H., Fung M.L., Tom W.M., Nanji A.A. and Tipoe G.L., Hypoxia-inducible factor-1 (HIF-1) in hepatic adaptation to chronic hypoxia, 8th Research Postgraduate Symposium, HKU. 2003. |
| Pei J., Kravtsov G.M., Wu S., Das R., Fung M.L. and Wong T.M., Calcium homeostasis in the rat cardiomyocytes during chronic hypoxia – a time course study, American Journal of Physiology Cell Physiology. 2003, 285(6): C1420-1428. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., Changes in HIF-1 binding and adrenomedullin gene expression in the lung of rats subjected to acute hypoxia: the effect of aging, Hong Kong – Taiwan Joint Physiology Symposium, HKU. 2003. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, 15. |
| Tipoe G.L. and Fung M.L., Expression of HIF-1 alpha, VEGF and VEGF receptors in the carotid body of chronically hypoxic rat, Respiratory Physiology and Neurobiology. 2003, 138: 143-154. |
| Tipoe G.L., Lau Y.H., Fung M.L., Liong E. and Nanji A.A., Vascular adaptive response in chronic liver hypoxia, Hong Kong – Shanghai International Liver Congress. 2004, ABS00102: P85. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Differential roles of nitric oxide pathways in rat hippocampal calcium response to hypoxia and oxygen-glucose deprivation, 23rd Annual Meeting Hong Kong Society of Neuroscience. 2003. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Involvement of nitric oxide pathways in hippocampal calcium response to hypoxia, 8th Research Postgraduate Symposium, HKU. 2003. |
| Tjong Y.W., Chen Y., Liong E.C., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis, Journal of Pineal Research. 2004, 36: 49-57. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Nitric oxide-cGMP and S-nitrosylated pathways mediate the rat hippocampal CA1 calcium response to oxygen-glucose deprivation, FASEB meeting Experimental Biology 2004, Washington DC, USA. FASEB Journal. 2004, 18(5):A1069: 693.10. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Role of NMDA receptor and nitric oxide pathway in intracellular calcium elevation in rat hippocampal CA1 region during hypoxia, International Society for Neurochemistry and The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry meeting, Hong Kong, P13-45, 2003. Journal of Neurochemistry 87. 2003. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Roles of sodium and calcium channels in nitric oxide pathways involved in hippocampal calcium response to hypoxia, Hong Kong – Taiwan Joint Physiology Symposium, HKU. 2003. |
| Researcher : Guan Z |
| List of Research Outputs |
| Li C., Zhang Y.K., Guan Z. and Chan Y.S., Vestibular afferent connection in vestibular efferent nucleus of rats, 6th IBRO World Congress of Neuroscience. 2003, 2211. |
| Sun B., Guan Z. and Chan Y.S., Neural circuitries for vestibulo-cardiovascular interaction, Neuroscience Letters Supplement. 2003, 58: S23-24. |
| Researcher : Hau WKT |
| List of Research Outputs |
| Hau W.K.T., Fractional Flow Reserve and Complex Coronary Pathologic Conditions, European Heart Journal. 2004, 25: 723-727. |
| Hau W.K.T., Fractional Flow Reserve: Overview and Implications for Clinical Decision Making, Journal of the Hong Kong College of Cardiology. 2003, 11(3): 83-89. |
| Researcher : Huang FY |
| List of Research Outputs |
| Ip M.P.M., Huang F.Y., Lo S.Y.M. and Sheng H.P., Perinatal nutrition programs fat metabolism in skeletal muscle, FASEB J. 2004, 18: A137. |
| Researcher : Hwang ISS |
| List of Research Outputs |
| Cheung B.M.Y., Wong L.Y.F., Li C.Y.Y., Hwang I.S.S. and Tang F., Adrenomedullin expression and cytokine response in experimentally induced endotoxaemia, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, P16. |
| Kravtsov G.M., Hwang I.S.S. and Tang F., The inhibitory effect of adrenomedullin in the rat ileum: cross talk with b3 adrenoceptor in the sertonin-induced muscle contraction, Journal of Pharmacology and Experimental Therapeutics. 2004, 308: 241-248. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., Changes in HIF-1 binding and adrenomedullin gene expression in the lung of rats subjected to acute hypoxia: the effect of aging, Hong Kong – Taiwan Joint Physiology Symposium, HKU. 2003. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, 15. |
| Researcher : Hyvelin J |
| List of Research Outputs |
| Mittra S., Hyvelin J., Shan Q., Tang F. and Bourreau J.P., Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?, American Journal of Physiology. 2004, 286: H1034-H1042. |
| Researcher : Ip MPM |
| List of Research Outputs |
| Ip M.P.M., Huang F.Y., Lo S.Y.M. and Sheng H.P., Perinatal nutrition programs fat metabolism in skeletal muscle, FASEB J. 2004, 18: A137. |
| Researcher : Ip SF |
| List of Research Outputs |
| Fung M.L., Tipoe G.L., Liong E.C. and Ip S.F., Alterations in systemic and pulmonary circulation in cyclooxygenase-1-deficient mice in chronic hypoxia, 205th Xiangshan Conference and The Third Symposium on Hypoxia Across Strait: Hypoxia & Health, Wuwei, PRC. 2003. |
| Fung M.L., Tipoe G.L., Liong E.C. and Ip S.F., Elevated systemic pressure and nitric oxide synthesis in cyclooxygenase-1-deficient mice in chronic hypoxia, The Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P11, 2003. Journal of the Hong Kong College of Cardiology, 11(Suppl. 1):A21. 2003. |
| Tjong Y.W., Chen Y., Liong E.C., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis, Journal of Pineal Research. 2004, 36: 49-57. |
| Researcher : Kam WL |
| List of Research Outputs |
| Chen M., Zhou J., Kam W.L., Qi J., Yan W.Y., Wu S. and Wong T.M., ATP-sensitive K+ Channels are involved in U50, 488H-preconditioning induced delayed cardioprotection and Ca2+ homeostasis changes in rat hearts , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A15. |
| Chen M., Qi J.S., Zhou J.J., Kam W.L., Yan W.Y., Wu S., Wu S. and Wong T.M., Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ XVin the rat heart as revealed by k-opioid receptor stimulation with U50,488H, British Journal of Pharmacology. 2003, 140: 750-758. |
| Kam W.L., Qi J.S., Chen M. and Wong T.M., Estrogen Reduces Cardiac Injury And Expression Of beta1-adrenoceptor Upon Ischemic Insult In The Rat Heart, Journal of Pharmacology and Experimental Therapeutics. 2004, 309(1): 8-15. |
| Kam W.L., Qi J., Chen M. and Wong T.M., Novel Cardioprotective Protective Mechanism of Estrogen-Interaction with the b-Adrenergic Receptor , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A8. |
| Qi J.S., Kam W.L., Chen M., Wu S. and Wong T.M., Failure to confer cardioprotection and to increase the expression of heat shock protein 70 by preconditioning with a k-opioid receptor agonist during ischemia and reperfusion in streptozotocin-induced diabetic rats, Diabetologia. 2004, 47: 214-220. |
| Researcher : Kravtsov GM |
| List of Research Outputs |
| Kravtsov G.M., Bruce I.C., Wong T.M. and Kwan C.Y., A new view of K+ -induced contraction in rat aorta: the role of Ca2+ binding, Pflügers Archiv - European Journal of Physiology . 2003, 446: 529-540. |
| Kravtsov G.M., Hwang I.S.S. and Tang F., The inhibitory effect of adrenomedullin in the rat ileum: cross talk with b3 adrenoceptor in the sertonin-induced muscle contraction, Journal of Pharmacology and Experimental Therapeutics. 2004, 308: 241-248. |
| Pei J., Kravtsov G.M., Wu S., Das R., Fung M.L. and Wong T.M., Calcium homeostasis in the rat cardiomyocytes during chronic hypoxia – a time course study, American Journal of Physiology Cell Physiology. 2003, 285(6): C1420-1428. |
| Researcher : Kui CY |
| List of Research Outputs |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Developmental expression of glutamate receptor in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters Supplement. 2003, 58: S23. |
| Researcher : Lai CH |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Shum D.K.Y., Yung K.K.L. and Zhang F., Receptors of glutamate and neurotrophin in vestibular neuronal functions, Journal of Biomedical Science. 2003, 10: 577-587. |
| Lai C.H., Tse Y.C., Shum D.K.Y., Yung K.K. and Chan Y.S., Fos expression in central otolith neurons of postnatal rats following off-vertical axis rotation, Journal of Comparative Neurology. 2004, 470: 282-296. |
| Lai S.K., Lai C.H., Yung K.K. and Chan Y.S., Fos expression in saccule-related brainstem and cerebellar neurons during vertical linear acceleration, 6th IBRO World Congress of Neuroscience. 2003, 2210. |
| Lai S.K., Lai C.H., Yung K.K. and Chan Y.S., Postnatal expression of glutamate transporter EAAC1 and glutamate receptors in saccule-related vestibular nuclear neurons of rats, Society of Neuroscience Abstract (U.S.A.). 2003, 703.9. |
| Lai S.K., Li C., Lai C.H. and Chan Y.S., Spatial coding capacity of otolith-related neurons in the dorsomedial cell column during postnatal development in rats, Neuroscience Letters Supplement. 2003, 58: S13. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Development expression of glutamate receptor subunits in rat dorsomedial cell column neurons responsive to horizontal linear acceleration, Society of Neuroscience Abstract (U.S.A.). 2003, 703.10. |
| Ng K.Y., Lai C.H., Yung K.K. and Chan Y.S., Localization of GABAB receptor and GAD immunoreactivity in the rat vestibular nucleus, 6th IBRO World Congress of Neuroscience. 2003, 2212. |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Developmental expression of glutamate receptor in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters Supplement. 2003, 58: S23. |
| Researcher : Lai SK |
| List of Research Outputs |
| Lai S.K., Lai C.H., Yung K.K. and Chan Y.S., Fos expression in saccule-related brainstem and cerebellar neurons during vertical linear acceleration, 6th IBRO World Congress of Neuroscience. 2003, 2210. |
| Lai S.K., Lai C.H., Yung K.K. and Chan Y.S., Postnatal expression of glutamate transporter EAAC1 and glutamate receptors in saccule-related vestibular nuclear neurons of rats, Society of Neuroscience Abstract (U.S.A.). 2003, 703.9. |
| Lai S.K., Tse Y.C., Ng K.Y., Lau W.K., Yang M.S., Wong C.K., Chan Y.S. and Yung K.K., Selective knockdown of gene expression of N-methyl-D-aspartate receptor ameliorates parkinsonian motor symptom in 6-hydroxydopamine-lesioned rats, Neurochemistry International. 2004, 45: 11-22. |
| Lai S.K., Li C., Lai C.H. and Chan Y.S., Spatial coding capacity of otolith-related neurons in the dorsomedial cell column during postnatal development in rats, Neuroscience Letters Supplement. 2003, 58: S13. |
| Researcher : Lam SSY |
| List of Research Outputs |
| Lam S.S.Y., Fung M.L. and Leung P.S., Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body, Journal of Applied Physiology. 2004, 96(2): 809-813. |
| Researcher : Li C |
| List of Research Outputs |
| Lai S.K., Li C., Lai C.H. and Chan Y.S., Spatial coding capacity of otolith-related neurons in the dorsomedial cell column during postnatal development in rats, Neuroscience Letters Supplement. 2003, 58: S13. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Development expression of glutamate receptor subunits in rat dorsomedial cell column neurons responsive to horizontal linear acceleration, Society of Neuroscience Abstract (U.S.A.). 2003, 703.10. |
| Li C., Zhang Y.K., Guan Z. and Chan Y.S., Vestibular afferent connection in vestibular efferent nucleus of rats, 6th IBRO World Congress of Neuroscience. 2003, 2211. |
| Researcher : Li M |
| List of Research Outputs |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Differential roles of nitric oxide pathways in rat hippocampal calcium response to hypoxia and oxygen-glucose deprivation, 23rd Annual Meeting Hong Kong Society of Neuroscience. 2003. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Involvement of nitric oxide pathways in hippocampal calcium response to hypoxia, 8th Research Postgraduate Symposium, HKU. 2003. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Nitric oxide-cGMP and S-nitrosylated pathways mediate the rat hippocampal CA1 calcium response to oxygen-glucose deprivation, FASEB meeting Experimental Biology 2004, Washington DC, USA. FASEB Journal. 2004, 18(5):A1069: 693.10. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Role of NMDA receptor and nitric oxide pathway in intracellular calcium elevation in rat hippocampal CA1 region during hypoxia, International Society for Neurochemistry and The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry meeting, Hong Kong, P13-45, 2003. Journal of Neurochemistry 87. 2003. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Roles of sodium and calcium channels in nitric oxide pathways involved in hippocampal calcium response to hypoxia, Hong Kong – Taiwan Joint Physiology Symposium, HKU. 2003. |
| Researcher : Li YY |
| List of Research Outputs |
| Cheung B.M.Y., Wong L.Y.F., Li Y.Y., Hwang I.S.S. and Tang F., Adrenomedullin expression and cytokine response in experimentally induced endotoxaemia, Neuropeptides. 2004, 38: 126. |
| Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181(2): 339-345. |
| Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., The cytokine response of rat macrophages to lipopolysaccharide is modulated by adrenomedullin, Hong Kong Medical Journal. 2003, 9(1) Suppl: 26. |
| Li Y.Y., Tang F. and Cheung B.M.Y., Endotoxin increases adrenomedullin expression in heart, lung and mesenteric artery, Hong Kong Medical Journal. 2003, 9(1) Suppl: 30. |
| Li Y.Y., Tang F. and Cheung B.M.Y., Increased adrenomedullin expression in the heart, the lung and the mesenteric artery by endotoxin, Hong Medical Journal. 2003, 9(1) Suppl: 26. |
| Li Y.Y., The Changes in Adrenomedullin Levels and Gene Expression in a Rat Model of Endotoxaemia, M. Phil thesis, 2003. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, Neuropeptides. 2004, 38: 117. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin suppresses MIF production and cytokine response of rat macrophages to lipopolysaccharide, Journal of Hong Kong College of Cardiology. 2003, 11(Suppl 1): A17. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y., Tang F. and Lan H.Y., Adrenomedullin suppresses migration inhibitory factor production and cytokine response of rat macrophages to lipopolysaccharide, Hong Kong Medical Journal. 2003, 9(1) Suppl: 29. |
| Researcher : Liong EC |
| List of Research Outputs |
| Ho M.C.T., Lau T.Y.H., Jin Y., Lu H.B., Liong E.C., Leung K.M. and Tipoe G.L., Overexpression of iNOS and down-regulation of BMPs-2, 4 and 7 in retinoic acid induced cleft palate formation, Histology and Histopathology. 2004, 19: 95-104. |
| Tjong Y.W., Chen Y., Liong E.C., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis, Journal of Pineal Research. 2004, 36: 49-57. |
| Researcher : Liu J |
| List of Research Outputs |
| Liu J. and Wong T.M., The relationship between heat shock protein 70 and cytosolic calcium in delayed cardioprotection of preconditioning , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A16. |
| Researcher : Lo SYM |
| List of Research Outputs |
| Ip M.P.M., Huang F.Y., Lo S.Y.M. and Sheng H.P., Perinatal nutrition programs fat metabolism in skeletal muscle, FASEB J. 2004, 18: A137. |
| Researcher : Lung MAKY |
| Project Title: | Air pollutants and nasal congestion |
| Investigator(s): | Dr. Lung M.A.K.Y. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 12/2000 |
| Abstract: |
| To perform a systematic study on the nasal airway response to some common air pollutants as to unveil the underlying vascular events and control mechanisms of the pollutant-induced nasal congestion. |
| Project Title: | Endodthelium-dependent relaxation in nasal mucosa: relative role of multiple factors in the regulation of vascular tone |
| Investigator(s): | Dr. Lung M.A.K.Y. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To study the role of each of the endothelium-derived relaxing factors in the control of the vascular tone of different segments of the nasal vascular bed. |
| Researcher : Mittra S |
| List of Research Outputs |
| Mittra S., Hyvelin J., Shan Q., Tang F. and Bourreau J.P., Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?, American Journal of Physiology. 2004, 286: H1034-H1042. |
| Researcher : Ng KY |
| List of Research Outputs |
| Kwok J.C.F., Ng K.Y., Zhang F., Shum D.K.Y. and Chan Y.S., Chondroitin sulfates restrict axonal growth along the projection path of VN neurons across the hindbrain of prenatal Sprague-Dawley rats, The Annual Meeting of the Hong Kong Neuroscience Society, 9-10 Dec, 2003, Faculty of Medicine, HKU . 2003. |
| Kwok J.C.F., Ng K.Y., Shum D.K.Y. and Chan Y.S., Tracking commissural projections of vestibular neurons in a chondroitin, sulfate-enriched environment of the developing hindbrain , The Gordon Research Conference on Molecular & Cellular, June 6-11, 2004,HKUST, Hong Kong . 2004. |
| Lai S.K., Tse Y.C., Ng K.Y., Lau W.K., Yang M.S., Wong C.K., Chan Y.S. and Yung K.K., Selective knockdown of gene expression of N-methyl-D-aspartate receptor ameliorates parkinsonian motor symptom in 6-hydroxydopamine-lesioned rats, Neurochemistry International. 2004, 45: 11-22. |
| Ng K.Y., Lai C.H., Yung K.K. and Chan Y.S., Localization of GABAB receptor and GAD immunoreactivity in the rat vestibular nucleus, 6th IBRO World Congress of Neuroscience. 2003, 2212. |
| Zhang F., Ng K.Y., Shum D.K.Y. and Chan Y.S., Axonal trajectories of the vestibular nuclei in the developing rat embryo, Neuroscience Letters Supplement. 2003, 58: S23. |
| Researcher : Pei J |
| List of Research Outputs |
| Pei J., Kravtsov G.M., Wu S., Das R., Fung M.L. and Wong T.M., Calcium homeostasis in the rat cardiomyocytes during chronic hypoxia – a time course study, American Journal of Physiology Cell Physiology. 2003, 285(6): C1420-1428. |
| Researcher : Poon AMS |
| Project Title: | Regulation of uterine stromal proliferation and differentiation in early pregnancy by melatonin |
| Investigator(s): | Dr. Poon A.M.S. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To investigate the influences of melatonin in the proliferation and differentiation of the endometrial stromal cells in the early stages of pregnancy. |
| List of Research Outputs |
| Cheung K.M.C., Lu D., Poon A.M.S., Wang T., Luk K.D.K. and Leong J.C.Y., Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy, Spine. 2003, 28(17): 1941-1944. |
| Cheung K.M.C., Lu D., Poon A.M.S., Wang T., Luk K.D.K. and Leong J.C.Y., The effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy, 38th Annual Meeting of the Scoliosis Research Society, Quebec, Canada, September 10-13, 2003. |
| Cheung K.M.C., Lu D.S., Poon A.M.S., Wang T., Luk K.D.K. and Leong J.C.Y., The effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy, 38th annual meeting of the Scoliosis Research Society. Quebec City, Canada. 2003. |
| Cheung K.M.C., Lu D., Poon A.M.S., Wang T., Luk K.D.K. and Leong J.C.Y., The effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy, 7th Biennial Meeting of International Research Society of Spinal Deformities (IRSSD), Vancouver, Canada, June 10-12, 2004. |
| Hughes M.R., Bennett D.C., Gray D.A., Sharp P.J. and Poon A.M.S., Influences of sex and saline on diurnal changes in plasma melatonin and osmoregulatory hormones of pekin ducks (Anas Platyrhynchos), 8th International Symposium on Avian Endocrinology (ISAE), Scottsdale, Arizona. 2004. |
| Researcher : Qi J |
| List of Research Outputs |
| Chen M., Zhou J., Kam W.L., Qi J., Yan W.Y., Wu S. and Wong T.M., ATP-sensitive K+ Channels are involved in U50, 488H-preconditioning induced delayed cardioprotection and Ca2+ homeostasis changes in rat hearts , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A15. |
| Kam W.L., Qi J., Chen M. and Wong T.M., Novel Cardioprotective Protective Mechanism of Estrogen-Interaction with the b-Adrenergic Receptor , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A8. |
| Researcher : Shan Q |
| List of Research Outputs |
| Mittra S., Hyvelin J., Shan Q., Tang F. and Bourreau J.P., Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?, American Journal of Physiology. 2004, 286: H1034-H1042. |
| Researcher : Sheng HP |
| List of Research Outputs |
| Ip M.P.M., Huang F.Y., Lo S.Y.M. and Sheng H.P., Perinatal nutrition programs fat metabolism in skeletal muscle, FASEB J. 2004, 18: A137. |
| Sheng H.P., Body composition. In: Encyclopedia of food and culture. Vol I: Acceptance to Food Politics. Katz SH, Editor-in-Chief, New York NY, Charles Scribner's Sons Reference Books. 2003, 221-225. |
| Sheng H.P., Electrolytes, Encyclopedia of food and culture. Acceptance to Food Politics. New York, Charles Scribner's Sons Reference Books, 2003, vol 1: 562-566. |
| Researcher : Shiu SYW |
| Project Title: | Combating prostate diseases: development of prostate proteomics detection database and unraveling novel ethnobotanical drug treatment methods |
| Investigator(s): | Dr. Shiu S.Y.W. |
| Department: | Physiology |
| Source(s) of Funding: | HKU Foundation Seed Grant |
| Start Date: | 04/2002 |
| Abstract: |
| To study combating prostate diseases: development of prostate proteomics detection database and unraveling novel ethnobotanical drug treatment methods. |
| Project Title: | Role of PDZD2 in the modulation of prostate cancer cell proliferation |
| Investigator(s): | Dr. Shiu S.Y.W., Dr. Yao K.M. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To determine the expression of full-length and secreted forms of PDZD2 in common prostate cancer cell lines; to detect any changes in the expression of the full-length and secreted forms of PDZD2 upon hormonal stimulation of prostate cancer cell proliferation; to study the effect of decreased endogenous expression of PDZD2 on prostate cancer cell proliferation. |
| List of Research Outputs |
| Shiu S.Y.W., Law I.C., Law K.W., Tam P.C., Yip A.W.C. and Ng W.T., Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype, Journal of Pineal Research. 2003, 35: 177-182. |
| Shiu S.Y.W., Reiter R.J., Tan D.X. and Pang S.F., Urgent search for safe and effective treatments of severe acute respiratory syndrome: is melatonin a promising candidate drug?, Journal of Pineal Research . 2003, 35: 69-70. |
| Researcher : Sun B |
| List of Research Outputs |
| Sun B., Guan Z. and Chan Y.S., Neural circuitries for vestibulo-cardiovascular interaction, Neuroscience Letters Supplement. 2003, 58: S23-24. |
| Sun B., Vestibular influence on central cardiovascular regulation in the rat: functional and anatomical aspects, PhD thesis, 2003. |
| Researcher : Sun X |
| List of Research Outputs |
| Sun X., Chan Y.S. and He J., Corticofugal modulation alters acoustically induced Fos expression in the rat auditory thalamus, Neuroscience Letters Supplement. 2003, 58: S13. |
| Researcher : Tam LTL |
| List of Research Outputs |
| Tam L.T.L. and Ballard H.J., Nitric oxide release in the renal circulation of normoxia-or hypoxia-adapted rats in response to acute local hypoxia, FASEB Journal . 2004, 18(5): A1278. |
| Tam L.T.L. and Ballard H.J., Nitric oxide release in the renal circulation of normoxia-or hypoxia-adapted rats in response to acute local hypoxia, Journal of the Hong Kong College of Cardiology. 2003, 1, A17: 11. |
| Researcher : Tang F |
| Project Title: | A study of the neurochemical changes in the brain of an established chemical rat model for Alzheimer's Disease and the possible therapeutic effects of melatonin |
| Investigator(s): | Prof. Tang F., Prof. Chan S.T.H., Prof. Pang S.F., Dr. Shiu S.Y.W. |
| Department: | Physiology |
| Source(s) of Funding: | Medical Faculty Research Grant Fund |
| Start Date: | 03/1999 |
| Abstract: |
| To study the therapeutic effects of melatonin in the b-amyloid treated rat model to see if b-amyloid deposit and the related neurochemical changes (i.e. choline acetyltransferase and somatostatin) can be reversed. |
| Project Title: | The change in adrenomedullin levels in the plasma, heart atria and ventricles, and the blood vessels of spontaneously hypertensive rats |
| Investigator(s): | Prof. Tang F. |
| Department: | Physiology |
| Source(s) of Funding: | Elaine G.C.F. Tso Memorial Fund |
| Start Date: | 07/1999 |
| Abstract: |
| To study (1) the adrenomedullin levels in the plasma, the heart and the blood vessels, and (2) the preproadrenomedullin mRNA levels in the heart and blood vessels of spontaneoulsy hypertensive rats to compare with those in the normal control rats so as to understand the synthesis and release of adrenomedullin in the cardiovascular system of the rat in hypertension. |
| Project Title: | Effect of Ginkgo biloba extract on memory and neurochemical parameters in the brain of normal rat and chemically-lesioned rat of an Alzheimer's disease model |
| Investigator(s): | Prof. Tang F. |
| Department: | Physiology |
| Source(s) of Funding: | Vice-Chancellor's Development Fund on Chinese Medicine |
| Start Date: | 07/2000 |
| Abstract: |
| To study the effect of a commercially available Ginkgo biloba extract on (1) memory deficit base on performance in the Morris water-maze, (2) b-amyloid deposit, and(3) brain choline acetyltransferase activity and somatostatin levels in normal rats and in rats infused with b-amyloid (1-40). |
| Project Title: | Adrenomedullin and its gene expression in ageing |
| Investigator(s): | Prof. Tang F. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To see whether there are age-related changes in adrenomedullin levels especially in the cardiovascular system; to study adrenomedullin in neonatal rats and prepubertal rats. |
| Project Title: | The effect of ageing on the response of the adrenomedullin system ot hypoxia in the rat |
| Investigator(s): | Prof. Tang F., Dr. Fung M.L. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2002 |
| Abstract: |
| To investigate the age-related changes in the levels of adenomedullin and preproAM mRNA levels in the lung, the heart and blood vessels and their responses to acute and chronic hypoxia. |
| Project Title: | The gene expression and levels of adrenomedullin in the ovary and the uterus of the rat: changes during the oestrous cycle and in pregnancy |
| Investigator(s): | Prof. Tang F., Dr. O W.S. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To study the mRNA and peptide levels of adrenomedullin in the ovary and the uterus in relation to the different stages of the oestrous cycle and in pregnancy. |
| List of Research Outputs |
| Cheung B.M.Y., Wong L.Y.F., Li C.Y.Y., Hwang I.S.S. and Tang F., Adrenomedullin expression and cytokine response in experimentally induced endotoxaemia, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, P16. |
| Cheung B.M.Y., Wong L.Y.F., Li Y.Y., Hwang I.S.S. and Tang F., Adrenomedullin expression and cytokine response in experimentally induced endotoxaemia, Neuropeptides. 2004, 38: 126. |
| Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181(2): 339-345. |
| Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., The cytokine response of rat macrophages to lipopolysaccharide is modulated by adrenomedullin, Hong Kong Medical Journal. 2003, 9(1) Suppl: 26. |
| Huang X.G., Yee B.K., Chan S.T.H. and Tang F., Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235, Experimental Neurology. 2003, 183: 673-681. |
| Kravtsov G.M., Hwang I.S.S. and Tang F., The inhibitory effect of adrenomedullin in the rat ileum: cross talk with b3 adrenoceptor in the sertonin-induced muscle contraction, Journal of Pharmacology and Experimental Therapeutics. 2004, 308: 241-248. |
| Li Y.Y., Tang F. and Cheung B.M.Y., Endotoxin increases adrenomedullin expression in heart, lung and mesenteric artery, Hong Kong Medical Journal. 2003, 9(1) Suppl: 30. |
| Li Y.Y., Tang F. and Cheung B.M.Y., Increased adrenomedullin expression in the heart, the lung and the mesenteric artery by endotoxin, Hong Medical Journal. 2003, 9(1) Suppl: 26. |
| Mittra S., Hyvelin J., Shan Q., Tang F. and Bourreau J.P., Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?, American Journal of Physiology. 2004, 286: H1034-H1042. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., Changes in HIF-1 binding and adrenomedullin gene expression in the lung of rats subjected to acute hypoxia: the effect of aging, Hong Kong – Taiwan Joint Physiology Symposium, HKU. 2003. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, 15. |
| Tang F., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, Neuropeptides Joint InternationalSymposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium onadrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, 38: 125-126. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, Neuropeptides. 2004, 38: 117. |
| Wong L.Y.F., Cheung B.M.Y., Li C.Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharides, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, S20. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin suppresses MIF production and cytokine response of rat macrophages to lipopolysaccharide, Journal of Hong Kong College of Cardiology. 2003, 11(Suppl 1): A17. |
| Wong L.Y.F., Cheung B.M.Y., Li Y.Y., Tang F. and Lan H.Y., Adrenomedullin suppresses migration inhibitory factor production and cytokine response of rat macrophages to lipopolysaccharide, Hong Kong Medical Journal. 2003, 9(1) Suppl: 29. |
| Wong L.Y.F., Cheung B.M.Y., Li C.Y.Y. and Tang F., The role of adrenomedullin in the cardiovascular system, Journal of Hong Kong College of Cardiology. 2004, 12: 1-7. |
| Zou L., Tang F. and Cheung R.T.F., Mice overexpressing amyloid precursor protein (APP) and harbouring presenilin-1 (PS1) gene are more susceptible to photothrombotic stroke and post-stroke memory impairment than APP transgenic mice, Society for Neuroscience Annual Meeting. 2003. |
| Zou L., Tang F. and Cheung R.T.F., Presenilin-1 (PS1) increased susceptibility to photothrombotic stroke and post-stroke memory impairment in transgenic mice overexpressing amyloid precursor protein (APP), 9th Medical Research Conference. 2004. |
| Researcher : Tjong YW |
| List of Research Outputs |
| Fung M.L., Tipoe G.L., Tjong Y.W., Chen Y., Ye J.S. and Liong E.C., Molecular regulation and functions of vasoactive factors in the carotid body during chronic hypoxia, The Fourth Symposium on Cardiovascular Science Across Strait, Taipei, Taiwan . 2003. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Differential roles of nitric oxide pathways in rat hippocampal calcium response to hypoxia and oxygen-glucose deprivation, 23rd Annual Meeting Hong Kong Society of Neuroscience. 2003. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Involvement of nitric oxide pathways in hippocampal calcium response to hypoxia, 8th Research Postgraduate Symposium, HKU. 2003. |
| Tjong Y.W., Chen Y., Liong E.C., Ip S.F., Tipoe G.L. and Fung M.L., Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis, Journal of Pineal Research. 2004, 36: 49-57. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Nitric oxide-cGMP and S-nitrosylated pathways mediate the rat hippocampal CA1 calcium response to oxygen-glucose deprivation, FASEB meeting Experimental Biology 2004, Washington DC, USA. FASEB Journal. 2004, 18(5):A1069: 693.10. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Role of NMDA receptor and nitric oxide pathway in intracellular calcium elevation in rat hippocampal CA1 region during hypoxia, International Society for Neurochemistry and The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry meeting, Hong Kong, P13-45, 2003. Journal of Neurochemistry 87. 2003. |
| Tjong Y.W., Li M., Gao T.M. and Fung M.L., Roles of sodium and calcium channels in nitric oxide pathways involved in hippocampal calcium response to hypoxia, Hong Kong – Taiwan Joint Physiology Symposium, HKU. 2003. |
| Researcher : Tse YC |
| List of Research Outputs |
| Lai C.H., Tse Y.C., Shum D.K.Y., Yung K.K. and Chan Y.S., Fos expression in central otolith neurons of postnatal rats following off-vertical axis rotation, Journal of Comparative Neurology. 2004, 470: 282-296. |
| Lai S.K., Tse Y.C., Ng K.Y., Lau W.K., Yang M.S., Wong C.K., Chan Y.S. and Yung K.K., Selective knockdown of gene expression of N-methyl-D-aspartate receptor ameliorates parkinsonian motor symptom in 6-hydroxydopamine-lesioned rats, Neurochemistry International. 2004, 45: 11-22. |
| Li C., Tse Y.C., Lai C.H. and Chan Y.S., Development expression of glutamate receptor subunits in rat dorsomedial cell column neurons responsive to horizontal linear acceleration, Society of Neuroscience Abstract (U.S.A.). 2003, 703.10. |
| Tse Y.C., Kui C.Y., Lai C.H., Yung K.K. and Chan Y.S., Developmental expression of glutamate receptor in utricle-related vestibular nuclear neurons of rats, Neuroscience Letters Supplement. 2003, 58: S23. |
| Researcher : Wong PF |
| List of Research Outputs |
| Tang F., Hwang I.S.S., Wong P.F., Liong E.C. and Fung M.L., Changes in HIF-1 binding and adrenomedullin gene expression in the lung of rats subjected to acute hypoxia: the effect of aging, Hong Kong – Taiwan Joint Physiology Symposium, HKU. 2003. |
| Tang F., Hwang I.S.S., Wong P.F., Liong E. and Fung M.L., The effects of ageing on the responses in HIF-1 binding and adrenomedullin gene expression in the rat lung to acute hypoxia, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, 15. |
| Researcher : Wong TM |
| Project Title: | Cardioprotective effects of female sex hormone as a result of negative modulation of b-adrenoceptor - mechanisms of action |
| Investigator(s): | Prof. Wong T.M. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 10/2001 |
| Abstract: |
| To test the hypothhesis that female sex hormone may produce cardioprotection by negatively modulating the b-AR, the predominant receptor in the heart responding to the sympathetic nervous system; to determine whether the signaling pathway that mediates the rappid actions of estrogen, involves the messengers, known to mediate the action of membrane receptors. |
| Project Title: | Signaling mechanism of preconditioning with U50, 488H in the rat - the role of Katp channels |
| Investigator(s): | Prof. Wong T.M. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2002 |
| Abstract: |
| To determine the roles of two types of KATP channels, mitochondrial and sarcolemmal in delayed cardioprotection of preconditioning with a k opioid receptor k-OR agonist, U50, 488H; to determine the relationship between KATP channels and heat shock protein 70 (HSP70), which has already been shown to mediate delayed cardioprotection of preconditioning with U50, 488H. |
| Project Title: | Ca2+ homeostasis and delayed cardioprotection of preconditioning with metabolic inhibition or kappa opioid receptor agonist: role of stress inducible heat shock protein and mitochondrial K ATP channel |
| Investigator(s): | Prof. Wong T.M., Dr. Li G.R., Dr. Sham J.S.K. |
| Department: | Physiology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2003 |
| Abstract: |
| To test the hypothesis that preconditioning with a kppa-OR agonist or MI, that confers delayed cardioprotection, prevents the elevations in cytoplasmic and mitochondrial Ca2+; to test the hypothesis that the HSP and K(ATP) channel, that mediates and triggers delayed cardioprotection of MIP and UP, respectively prevents the alterations in the Ca2+ handling induced by MI insult. |
| Project Title: | Ca2+ homeostasis and delayed cardioprotection of preconditioning with metabolic inhibition or kappa opioid receptor agonist: role of stress inducible heat shock protein and mitochondrial K ATP channel |
| Investigator(s): | Prof. Wong T.M., Dr. Li G.R., Dr. Sham J.S.K. |
| Department: | Physiology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 09/2003 |
| Abstract: |
| To test the hypothesis that preconditioning with a kppa-OR agonist or MI, that confers delayed cardioprotection, prevents the elevations in cytoplasmic and mitochondrial Ca2+; to test the hypothesis that the HSP and K(ATP) channel, that mediates and triggers delayed cardioprotection of MIP and UP, respectively prevents the alterations in the Ca2+ handling induced by MI insult. |
| Project Title: | Electrophysiological actions of morphine in the rodent and human heart |
| Investigator(s): | Prof. Wong T.M., Dr. Cheung Y.F., Dr. Li G.R. |
| Department: | Physiology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To study the electrophysiological properties of morphine at clinical concentrations in human and rodent myocytes, and the involvement of opioid receptor subtype. |
| List of Research Outputs |
| Cao C., Xia Q. and Wong T.M., Cardioprotection of interleukin-2 is mediated via k -opioid receptor, Journal of Pharmacology and Experimental Therapeutics. 2004, 309 (2): 560-567. |
| Chen M., Zhou J., Kam W.L., Qi J., Yan W.Y., Wu S. and Wong T.M., ATP-sensitive K+ Channels are involved in U50, 488H-preconditioning induced delayed cardioprotection and Ca2+ homeostasis changes in rat hearts , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A15. |
| Chen M., Qi J.S., Zhou J.J., Kam W.L., Yan W.Y., Wu S., Wu S. and Wong T.M., Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ XVin the rat heart as revealed by k-opioid receptor stimulation with U50,488H, British Journal of Pharmacology. 2003, 140: 750-758. |
| Gao Z., Lau C.P., Wong T.M. and Li G.R., Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes, Cellular Signaling. 2004, 16: 333-341. |
| Kam W.L., Qi J.S., Chen M. and Wong T.M., Estrogen Reduces Cardiac Injury And Expression Of beta1-adrenoceptor Upon Ischemic Insult In The Rat Heart, Journal of Pharmacology and Experimental Therapeutics. 2004, 309(1): 8-15. |
| Kam W.L., Qi J., Chen M. and Wong T.M., Novel Cardioprotective Protective Mechanism of Estrogen-Interaction with the b-Adrenergic Receptor , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A8. |
| Kravtsov G.M., Bruce I.C., Wong T.M. and Kwan C.Y., A new view of K+ -induced contraction in rat aorta: the role of Ca2+ binding, Pflügers Archiv - European Journal of Physiology . 2003, 446: 529-540. |
| Liu J. and Wong T.M., The relationship between heat shock protein 70 and cytosolic calcium in delayed cardioprotection of preconditioning , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A16. |
| Pei J., Kravtsov G.M., Wu S., Das R., Fung M.L. and Wong T.M., Calcium homeostasis in the rat cardiomyocytes during chronic hypoxia – a time course study, American Journal of Physiology Cell Physiology. 2003, 285(6): C1420-1428. |
| Qi J.S., Kam W.L., Chen M., Wu S. and Wong T.M., Failure to confer cardioprotection and to increase the expression of heat shock protein 70 by preconditioning with a k-opioid receptor agonist during ischemia and reperfusion in streptozotocin-induced diabetic rats, Diabetologia. 2004, 47: 214-220. |
| Wong N.S., Diao C.T.M. and Wong T.M., The overexpression of Bcl-2 antagonizes the proapoptotic function of the kappa-opioid receptor, Annual New York Academy of Sciences. 2003, 1010: 358-260. |
| Wong S.S.C., Wu S. and Wong T.M., Effects of testosterone on intracellular Ca2+ homeostasis and its responses to b-Adrenoceptor stimulation in gonadectomy and male rat ventricular myocytes , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A20. |
| Wong T.M., Cardioprotection of Preconditioning: Mechanisms and Clinical Implications , , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A2. |
| Xiao G., Zhou J., Cheung Y.F., Li G. and Wong T.M., Effect of U50,488H on the outward rectifier and ultra-rapid potassium currents in human atrial myocytes. , European Journal of Pharmacology. 2003, 473: 97-103. |
| Xiao G., Zhou J., Cheung Y.F., Li G.R. and Wong T.M., Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes, Europen Journal of Pharmacology . 2003, 473: 97-103. |
| Xiao G., Zhou J., Cheung Y.F., Li G.R. and Wong T.M., Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes, European Journal of Pharmacology. 2003, 473: 97-103. |
| Zhang Y., Irwin M.G. and Wong T.M., Pretreatment with remifentanil reduces myocardial infarct induced by ischaemia and reperfusion in anaesthetized rats , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A16. |
| Researcher : Wu S |
| List of Research Outputs |
| Chen M., Zhou J., Kam W.L., Qi J., Yan W.Y., Wu S. and Wong T.M., ATP-sensitive K+ Channels are involved in U50, 488H-preconditioning induced delayed cardioprotection and Ca2+ homeostasis changes in rat hearts , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A15. |
| Chen M., Qi J.S., Zhou J.J., Kam W.L., Yan W.Y., Wu S., Wu S. and Wong T.M., Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ XVin the rat heart as revealed by k-opioid receptor stimulation with U50,488H, British Journal of Pharmacology. 2003, 140: 750-758. |
| Pei J., Kravtsov G.M., Wu S., Das R., Fung M.L. and Wong T.M., Calcium homeostasis in the rat cardiomyocytes during chronic hypoxia – a time course study, American Journal of Physiology Cell Physiology. 2003, 285(6): C1420-1428. |
| Qi J.S., Kam W.L., Chen M., Wu S. and Wong T.M., Failure to confer cardioprotection and to increase the expression of heat shock protein 70 by preconditioning with a k-opioid receptor agonist during ischemia and reperfusion in streptozotocin-induced diabetic rats, Diabetologia. 2004, 47: 214-220. |
| Wong S.S.C., Wu S. and Wong T.M., Effects of testosterone on intracellular Ca2+ homeostasis and its responses to b-Adrenoceptor stimulation in gonadectomy and male rat ventricular myocytes , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A20. |
| Yu X.C., Wu S., Chen K.F. and Pang K.T., Anti-hypertensive effects of an extract of Radix Stephaniae Tetrandrae in the rat, Journal of Pharmacy and Pharmacology. 2004, 56: 115-122. |
| Researcher : Xiao G |
| List of Research Outputs |
| Xiao G., Zhou J., Cheung Y.F., Li G. and Wong T.M., Effect of U50,488H on the outward rectifier and ultra-rapid potassium currents in human atrial myocytes. , European Journal of Pharmacology. 2003, 473: 97-103. |
| Xiao G., Zhou J., Cheung Y.F., Li G.R. and Wong T.M., Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes, Europen Journal of Pharmacology . 2003, 473: 97-103. |
| Xiao G., Zhou J., Cheung Y.F., Li G.R. and Wong T.M., Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes, European Journal of Pharmacology. 2003, 473: 97-103. |
| Researcher : Yan WY |
| List of Research Outputs |
| Chen M., Zhou J., Kam W.L., Qi J., Yan W.Y., Wu S. and Wong T.M., ATP-sensitive K+ Channels are involved in U50, 488H-preconditioning induced delayed cardioprotection and Ca2+ homeostasis changes in rat hearts , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A15. |
| Chen M., Qi J.S., Zhou J.J., Kam W.L., Yan W.Y., Wu S., Wu S. and Wong T.M., Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ XVin the rat heart as revealed by k-opioid receptor stimulation with U50,488H, British Journal of Pharmacology. 2003, 140: 750-758. |
| Yan W.Y., The role of Ca2+ in protection of preconditioning and ischaemia-induced injury in the rat heart, M Phil thesis, 2004. |
| Researcher : Zhang F |
| List of Research Outputs |
| Chan Y.S., Lai C.H., Shum D.K.Y., Yung K.K.L. and Zhang F., Receptors of glutamate and neurotrophin in vestibular neuronal functions, Journal of Biomedical Science. 2003, 10: 577-587. |
| Kwok J.C.F., Ng K.Y., Zhang F., Shum D.K.Y. and Chan Y.S., Chondroitin sulfates restrict axonal growth along the projection path of VN neurons across the hindbrain of prenatal Sprague-Dawley rats, The Annual Meeting of the Hong Kong Neuroscience Society, 9-10 Dec, 2003, Faculty of Medicine, HKU . 2003. |
| Zhang F., Ng K.Y., Shum D.K.Y. and Chan Y.S., Axonal trajectories of the vestibular nuclei in the developing rat embryo, Neuroscience Letters Supplement. 2003, 58: S23. |
| Researcher : Zhang YK |
| List of Research Outputs |
| Li C., Zhang Y.K., Guan Z. and Chan Y.S., Vestibular afferent connection in vestibular efferent nucleus of rats, 6th IBRO World Congress of Neuroscience. 2003, 2211. |
| Researcher : Zhou J |
| List of Research Outputs |
| Chen M., Zhou J., Kam W.L., Qi J., Yan W.Y., Wu S. and Wong T.M., ATP-sensitive K+ Channels are involved in U50, 488H-preconditioning induced delayed cardioprotection and Ca2+ homeostasis changes in rat hearts , Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1): A15. |
| Xiao G., Zhou J., Cheung Y.F., Li G. and Wong T.M., Effect of U50,488H on the outward rectifier and ultra-rapid potassium currents in human atrial myocytes. , European Journal of Pharmacology. 2003, 473: 97-103. |
| Xiao G., Zhou J., Cheung Y.F., Li G.R. and Wong T.M., Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes, Europen Journal of Pharmacology . 2003, 473: 97-103. |
| Xiao G., Zhou J., Cheung Y.F., Li G.R. and Wong T.M., Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes, European Journal of Pharmacology. 2003, 473: 97-103. |