DEPARTMENT OF PHARMACOLOGY
| Researcher : Chau FLJ |
| List of Research Outputs |
| Guo J.S., Chau F.L.J., Cho C.H. and Koo M.W.L., Partial sleep deprivation compromises gastric mucosal integrity in rats, Life Sciences. 2005, 77 (2005): 220-229. |
| Researcher : Cheng CL |
| List of Research Outputs |
| Guo J., Cheng C.L. and Koo M.W.L., Inhibitory Effects of Centella asiatica Water Extract and Asiaticoside on Inducible Nitric Oxide Synthase During Gastric Ulcer Healing in Rats , Planta Medica. 2004, 70: 1150-1154. |
| Researcher : Cho CH |
| Project Title: | Delineation of the co-regulatory role of cyclooxygenase-2 and 12-lipoxygenase in colorectal cancer: a causal relationship with ulcerative colitis and cigarette smoking |
| Investigator(s): | Cho CH, Yuen ST, Wong BCY |
| Department: | Pharmacology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 09/2002 |
| Completion Date: | 08/2004 |
| Abstract: |
| The project aims at demonstrating the following hypotheses: 1) repeated inflammation may contribute to cancer formation in the colon; 2) COX-2 and 12-LOX could play a co-regulatory role in the pathogenesis of colorectal cancer (CRC); and 3) cigarette smoking could modulate the expression of these enzymes and increase CRC carcinogenesis. |
| Project Title: | Studying the ulcerogenic action of dexamethasone and its relationship with PGE2 on ulcer healing in the stomach |
| Investigator(s): | Cho CH |
| Department: | Pharmacology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To apply the non-ulcerogenic doses of dexamethasone, a potent corticosteroid, to explore its action on ulcer healing and the mechanistic pathway related to prostaglandin E[2] synthesis in a rat ulcer model in the stomach. |
| Project Title: | Delineation of the contributory role of EGF/polyamine/K+ channel in gastric mucosal repair |
| Investigator(s): | Cho CH, Li GR, Wong TM, Wang J.Y. |
| Department: | Pharmacology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 12/2003 |
| Abstract: |
| To clarify the integrating roles of EGF and polyamines together with the KV channels and the ca2+cy+ in gastric mucosal repair; to elucidate the mechanism of how cigarette smoke and its ingredien + affect ulcer healing. |
| Project Title: | Delineation of the contributory role of EGF/polyamine/K+ channel in gastric mucosal repair |
| Investigator(s): | Cho CH, Li GR, Wong TM, Wang J.Y. |
| Department: | Pharmacology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 12/2003 |
| Abstract: |
| To clarify the integrating roles of EGF and polyamines together with the KV channels and the ca2+cy+ in gastric mucosal repair; to elucidate the mechanism of how cigarette smoke and its ingredien + affect ulcer healing. |
| Project Title: | Nicotine and its active metabolite in the tumorigenesis of colon cancer |
| Investigator(s): | Cho CH, Chan K.K.C. |
| Department: | Pharmacology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 11/2004 |
| Abstract: |
| To investigate the differential roles of nicotinic receptor and B-adrenoceptor in the tumorigenesis of colon cancer cells; to investigate pathogenic signal pathway of nicotine and its metabol NNK in the development of colon cancer; to investigate the therapeutic strategy to target the oncogenes involved in this carcinogenic pathway to treat and prevent cancer formation especially in cigarette smokers. |
| Project Title: | Nicotine and its active metabolite in the tumorigenesis of colon cancer |
| Investigator(s): | Cho CH |
| Department: | Pharmacology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 01/2005 |
| Abstract: |
| Refer to hard copy |
| Project Title: | Cathelicidins and gastric ulcer healing |
| Investigator(s): | Cho CH |
| Department: | Pharmacology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2005 |
| Abstract: |
| refer to hard copy proposal |
| List of Research Outputs |
| Cho C.H. and Ko J.K.S., Herbal Medicines And Animal Models Of Gastrointestinal Diseases, Drug Discovery Handbook. John Wiley & Sons, Inc, 2005, chapter 22: 1013-1035. |
| Cho C.H., Wu K.K., Wong P.S.H., Shin V.Y., Lam K.Y. and Tai K.K., NNK from cigarette smoke stimulates colon cancer growth via b-Adrenoceptors , Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis . Seoul Korea, 2005, 14. |
| Cho C.H., Nitrosamine from cigarette smoke stimulates colon cancer growth via b-adrenoceptors, 2005 National Pharmacology Conference & Chinese Young Researchers' Symposium on Pharmacology, Xian, China. 2005, 5. |
| Cho C.H., Luo J., Shin V.Y., Wu K.K., Ye Y., So H.L. and Chang F.Y., Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 21. |
| Choi K.M., Cho C.H. and Chu K.M., Tumour infiltrating lymphocytes (TILs) - A prognostic factor for gastric adenocarcinoma, 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, Hong Kong, 4 December 2004. |
| Fong Y.Y.M., Koo M.W.L., Hui K.C., So H.L., Yang Y., Wu K.K. and Cho C.H., Green tea and tea powder solutions attenuate the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 52. |
| Guo J.S., Chau F.L.J., Cho C.H. and Koo M.W.L., Partial sleep deprivation compromises gastric mucosal integrity in rats, Life Sciences. 2005, 77 (2005): 220-229. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Ko J.K.S., Cho C.H. and Chan K.C., A Comparative Study of the Antitumor Effects of a Novel Herbal Extract and 5-FU/Oxaliplatin in a colon Tumor Xenograft Model, Digestive Disease Week, Chicage, USA, Gastroenterology May 14-19, 2005. A-178. |
| Ko J.K.S., Cho C.H. and Lam S.K., Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis, World Journal of Gastroenterology. 2004, 10(17): 2503-8. |
| Ko J.K.S. and Cho C.H., The Diverse Actions of Nicotine and Different Extracted Fractions from Tobacco Smoke against Hapten-Inducted Colitis in Rats, Toxicological Sciences. 2005, 87(1), 2005: 285-295. |
| Koo M.W.L. and Cho C.H., Review pharmacological effects of green tea on the gastrointestinal system , European Journal of Pharmacology. 2004, 500: 177-185. |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299. |
| Liu S.L.E., Shin V.Y., Ye Y., Luo J.C., Wu K.K. and Cho C.H., Cyclooxygenase-2 In Cancer Cells And Macrophages Induces Colon Cancer Cell Growth By Cigarette Smoke Extract, European Journal of Pharmacology. 2005, 518: 47-55. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L., Chu K.M. and Cho C.H., A mechanistic study of cigarette smoke and cyclooxygenase-2 on the proliferation of gastric cancer cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 59. |
| Shin V.Y., So H.L., Liu E.S.L., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, International Journal of Medical Sciences. 2004, 3: 137-145. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Shin V.Y. and Cho C.H., Nicotine and gastric cancer , Alcohol. 2005, 35: 259-264. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| So H.L., Shin V.Y., Liu S.L.E., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 60. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Wu K.K., Shin V.Y., Ye Y., So H.L., Li G.R., Yang Y. and Cho C.H., Multiple expression of voltage-gated potassium ion channels in rat gastric epithelial cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 62. |
| Wu S., Wong M.C.Y., Chen M., Cho C.H. and Wong T.M., Role of Opioid Receptors in Cardioprotection of Cold-Restraint Stress and Morphine, Journal of Biomedical Science. 2004, 11: 726-731. |
| Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking, Toxicology. 2004, 203: 179-188. |
| Ye Y. and Cho C.H., Dual Inhibition of 5-LOX and COX-2 Suppresses Colon Cancer Formation Promoted by Cigarette Smoke, 2nd Beijing International Digestive Disease Forum 2005, Beijing, China. 2005, 65-67. |
| Ye Y., Wu K.K., Shin V.Y., Bruce I.C., Wong B.C.Y. and Cho C.H., Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke, Carcinogenesis. 2005, 26, no. 4: 827-834. |
| Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of COX-2 and 5-LOX in the inflammation-associated colonic tumorigenesis promoted by cigarette smoke, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 63. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., The Modulating Role of Nuclear Factor-kB in the Action of a7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, The Journal of Pharmacology and Experimental Therapeutics. 2004, 311, No. 1: 123-130. |
| Researcher : Choy PC |
| List of Research Outputs |
| Woo C.W.H., Man R.Y.K., Siow Y.L., Choy P.C., Wan E.W.Y., Lau C.S. and O K.A.R.M.I.N., Ganoderma lucidum inhibits inducible nitric oxide synthase expression in macrophages, Molecular and Cellular Biochemistry. 2005, 275: 165-171, 2005. |
| Researcher : Fong YYM |
| List of Research Outputs |
| Fong Y.Y.M., Koo M.W.L., Hui K.C., So H.L., Yang Y., Wu K.K. and Cho C.H., Green tea and tea powder solutions attenuate the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 52. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Researcher : Guo J |
| List of Research Outputs |
| Guo J., Cheng C.L. and Koo M.W.L., Inhibitory Effects of Centella asiatica Water Extract and Asiaticoside on Inducible Nitric Oxide Synthase During Gastric Ulcer Healing in Rats , Planta Medica. 2004, 70: 1150-1154. |
| Researcher : Hui KC |
| List of Research Outputs |
| Fong Y.Y.M., Koo M.W.L., Hui K.C., So H.L., Yang Y., Wu K.K. and Cho C.H., Green tea and tea powder solutions attenuate the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 52. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Researcher : Keung WYW |
| List of Research Outputs |
| Keung W.Y.W., Vanhoutte P.M.G.R. and Man R.Y.K., Acute impairment of contractile responses by 17b-estradiol is cAMP and protein kinase G dependent in vascular smooth muscle cells of the porcine coronary arteries , British Journal of Pharmacology. 2004, 144: 71-79. |
| Keung W.Y.W. and Man R.Y.K., Effect of sex hormone levels on the non-genomic action of 17b-estradiol in rat mesenteric arteries, Journal of Molecular and Cellular Cardiology (Abstract for the 2004 ISHR World Congress). 2004, 37/1: 302. |
| Keung W.Y.W., Leung G.P.H. and Man R.Y.K., Gender difference in the non-genomic effect of 17b-estradiol and the involvement of a novel membrane estrogen receptor in the vascular smooth muscle, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 35. |
| Keung W.Y.W. and Man R.Y.K., Modulation of non-genomic effect of 17b-estradiol on vascular contraction by testosterone in female rat mesenteric arteries , Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 109, P33. |
| Keung W.Y.W. and Man R.Y.K., Non-genomic effect of 17b-estradiol in rat arteries is modulated by circulating estrogen and testosterone, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 85, No. 4.14. |
| Keung W.Y.W., Vanhoutte P.M.G.R. and Man R.Y.K., Non-genomic vascular effect of 17b-estradiol involves activation of adenylyl cyclase and protein kinase G in the rat mesenteric artery, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 93. |
| Keung W.Y.W. and Man R.Y.K., The role of gender in the non-genomic effect of 17b-estradiol in rat mesenteric arteries, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 47. |
| Leung S.W.S., Teoh H., Quan A., Keung W.Y.W. and Man R.Y.K., Non-genomic coronary vascular actions of gonadal hormones: physiological implications , Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 8. |
| Researcher : Ko JKS |
| List of Research Outputs |
| Cho C.H. and Ko J.K.S., Herbal Medicines And Animal Models Of Gastrointestinal Diseases, Drug Discovery Handbook. John Wiley & Sons, Inc, 2005, chapter 22: 1013-1035. |
| Ko J.K.S., Cho C.H. and Lam S.K., Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis, World Journal of Gastroenterology. 2004, 10(17): 2503-8. |
| Researcher : Koo MWL |
| Project Title: | Effects of antioxidants and the roles of heat shock protein 32 on cognitive functions in aging |
| Investigator(s): | Koo MWL |
| Department: | Pharmacology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Abstract: |
| To carify the roles of HOs in aging and its involvement in cognitive functions; to elucidate the usefulness of antioxidants in delaying cognitive function loss during aging. |
| Project Title: | Alleviating effect of Bu-zhong-yi-qi-tang on chemotherapy-induced bone marrow suppression in mice |
| Investigator(s): | Koo MWL |
| Department: | Pharmacology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To investigate the mechanisms of action from herbs particularly on bone marrow recovery and CSFs production. |
| List of Research Outputs |
| Chan W.K., Lam T.W., Law W.S., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma Lucidum mycelium extract can enhance maturation of monocyte-derived dendritic cells without inducing significant allogenic immune response in vitro, Joint Annual Scientific Meeting 2004, The Hong Kong Paediatric Society, Hong Kong, 27 November 2004. 55. |
| Fong Y.Y.M., Koo M.W.L., Hui K.C., So H.L., Yang Y., Wu K.K. and Cho C.H., Green tea and tea powder solutions attenuate the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 52. |
| Guo J., Cheng C.L. and Koo M.W.L., Inhibitory Effects of Centella asiatica Water Extract and Asiaticoside on Inducible Nitric Oxide Synthase During Gastric Ulcer Healing in Rats , Planta Medica. 2004, 70: 1150-1154. |
| Guo J.S., Chau F.L.J., Cho C.H. and Koo M.W.L., Partial sleep deprivation compromises gastric mucosal integrity in rats, Life Sciences. 2005, 77 (2005): 220-229. |
| Koo M.W.L. and Cho C.H., Review pharmacological effects of green tea on the gastrointestinal system , European Journal of Pharmacology. 2004, 500: 177-185. |
| Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L., Chu K.M. and Cho C.H., A mechanistic study of cigarette smoke and cyclooxygenase-2 on the proliferation of gastric cancer cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 59. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| Researcher : Ku DD |
| List of Research Outputs |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced diabetes and hyperglycemia: effects on endothelium-dependent responses in rat mesenteric arteries, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 93, No. 4.29. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced effects on endothelium-dependent responses in rat carotid and measenteric arteries, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 92, OC1. |
| Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent contractions occur in arteries of wild type and COX2-/- but not in those of COX1-/- knockout mice, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 94, No. 4.31. |
| Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., The calcium ionophore A23187 causes endothelium-dependent contractions in the aorta of wild type but not COX1 knock-out male mice, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 33. |
| Researcher : Lam KY |
| List of Research Outputs |
| Cho C.H., Wu K.K., Wong P.S.H., Shin V.Y., Lam K.Y. and Tai K.K., NNK from cigarette smoke stimulates colon cancer growth via b-Adrenoceptors , Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis . Seoul Korea, 2005, 14. |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Researcher : Lee YKM |
| List of Research Outputs |
| Lee Y.K.M., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Genistein reduces agonist-induced contractions of porcine coronary arterial smooth muscle in a cyclic AMP-dependent manner, European Journal of Pharmacology. 2004, 503: 165-172. |
| Researcher : Leung GPH |
| Project Title: | Adenosine: signal transduction pathways and role of nucleoside transporter re-uptake in coronary artery |
| Investigator(s): | Leung GPH, Man RYK |
| Department: | Pharmacology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 08/2004 |
| Abstract: |
| To identify the signal transduction pathways of the adenosine-induced hyperpolarization in the coronary arterial smooth muscle cells and endothelial cells. We hypothesize that the adensoine-induced hyperpolarization in vascular smooth muscle cells and endothelial cells is mediated via cAMP-independent pathways and involves more than one K+ channels; to identify the mechanism of regulation of extracellular adenosine level in the coronary arterial smooth muscle cells and endothelial cells. |
| Project Title: | Cloning and characterization of novel equilibrative nucleoside transporter type 4 (ENT4) |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2005 |
| Abstract: |
| Background:The physiological important nucleoside, adenosine, acts through adenosine receptors to exert diverse effects on cellular functions such as inhibition of platelet aggregation, slowing of heart rate and vasodilation. Nucleoside transporters are important in adenosine functions by fine-tuning its concentration in the vicinity of adenosine receptors. There are two classes of nucleoside transporters: Na+-dependent concentrative nucleoside transporters (CNTs) and Na+-independent equilibrative nucleoside transporters (ENTs). So far three equilibrative nucleoside transporters (ENTs) have been cloned and characterized. Both ENT1 and ENT2 are broadly selective, transporting purine and pyrimidine nucleosides. Nevertheless, ENT1 is nitrobenzylmercaptopurine ribonucleoside (NBMPR)-sensitive and has an IC50 of 1nM while ENT2 is relatively NBMPR-insensitive and has an IC50 > 1µM. Unlike ENT1 and ENT2, which are plasma membrane proteins, ENT3 is an intracellular protein. It may be responsible for salvaging nucleosides between the cytoplasm and the lumen of Golgi apparatus.Adenosine transport in endothelial cells is Na+-independent. Interestingly, we found that in physiological levels of adenosine (0.1 to 1µM), high concentrations of NBMPR (> 200µM, a concentration that can completely inhibit both ENT1 and ENT2) only reduce 20% of the adenosine transport. It indicates that another nucleoside transporter, which is characteristically distinct from the ENT1 and ENT2, is present in the endothelial cells. Recently, we have cloned a protein from endothelial cells which has 18% amino acid identity with ENT1. We term it ENT4 and hypothesize that it may be a novel isoform of nucleoside transporter. Objectives:In this grant application, we propose to characterize ENT4. In aim I, we will stably transfect ENT4 into nucleoside transporter-deficient cells. In aim II, we will functionally characterize ENT4. We will determine its affinities to different nucleosides and its sensitivities to different inhibitors such as NBMPR. In aim III, we will study the tissue distribution of ENT4. |
| List of Research Outputs |
| Cheung K.H., Leung G.P.H., Leung M.C.T., Shum W.W.C., Zhou W.L. and Wong P.Y.D., Cell-cell interaction underlies formation of fluid in the male reproductive tract of the rat, The Journal of General Physiology. 2005, 125, May 2005: 443-454. |
| Keung W.Y.W., Leung G.P.H. and Man R.Y.K., Gender difference in the non-genomic effect of 17b-estradiol and the involvement of a novel membrane estrogen receptor in the vascular smooth muscle, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 35. |
| Leung G.P.H. and Man R.Y.K., Adenosine transport in vascular smooth muscle cells and their regulation by high glucose, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 32. |
| Leung G.P.H. and Man R.Y.K., Characterization of nucleoside transporters in vascular smooth muscle cells and their role in cell growth, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004) . 2004, 39. |
| Leung G.P.H., Man R.Y.K. and Tse C.M., D-Glucose upregulates adenosine transport in cultured human aortic smooth muscle cells., American Journal of Physiology Heart Circulation Physiology. 2005, 288: H2576-2762. |
| Leung G.P.H., Tse C.M. and Man R.Y.K., Effect of thiazolidinediones on adenosine transport in vascular smooth muscle cells, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 87. |
| Leung G.P.H., Role of nucleoside transporters in vascular smooth muscle, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 85, IL2. |
| Lin M.J., Leung G.P.H., Zhang W.M., Yang X.R., Yip K.P., Tse C.M. and Sham J.S.K., Chronic Hypoxia-induced Upregulation Of Store-operated And Receptor-operated Ca2+ Channels In Pulmonary Arterial Smooth Muscle Cells, Circulation Research. 2004, 2004;95: 496-505. |
| Yang X.R., Lin M.J., Yip K.P., Jeyakumar L.H., Fleischer S., Leung G.P.H. and Sham J.S.K., Multiple ryanodine receptor subtypes and heterogeneous ryanodine receptor-gated Ca 2+ stores in pulmonary arterial smooth muscle cells, American Journal of Physiology, Lung Cellular and Molecular Physiology. 2005, 289: 338-348. |
| Researcher : Leung SWS |
| Project Title: | The role of calcium calmodulin dependent protein kinase II in the regulation of endothelial-derived hyperpolarizing factor-mediated responses |
| Investigator(s): | Leung SWS, Man RYK |
| Department: | Pharmacology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2005 |
| Abstract: |
| Introduction:The endothelium plays an important role in the regulation of the vascular tone, through the release of many vasoactive substances such as nitric oxide, endothelial-derived hyperpolarizing factor (EDHF), prostaglandins and endothelin-1. Of the endothelial-derived relaxing factors, EDHF is the least characterized. Several putative EDHF candidates are the metabolites of arachidonic acid, including anandamide [1], epoxyeicosatrienoic acids (EET) [2] and hydrogen peroxide (H2O2) [3]. Anandamide is the metabolic product of the action of amidohydrolase on arachidonic acid, whereas both EET and H2O2 are generated by cytochrome P450 epoxygenase. It appears that the release of EDHF, like other vasoactive agents, can be activated by an increase of intracellular concentration of free calcium, which then associates with calmodulin in the endothelial cells [4]. While most research effort has been devoted to identify the chemical entity and the mechanisms of action of EDHF, little is known regarding the regulation of the production of EDHF. Objectives:In view of the involvement of the calcium/calmodulin complex in the stimulation of the production of EDHF, it is hypothesized that calcium/calmodulin dependent protein kinase II (CaMK II) plays a role in regulating the release of EDHF. Therefore, the aim of the present study is to investigate the contributions of CaMK II to the regulation of EDHF-mediated relaxation. References: 1. Randall MD, Alexander SP, Bennett T et al., Biochem Biophys Res Commun 1996; 229: 114-120.2. Campbell WB, Gebremedhin D, Pratt PF et al., Circ Res 1996; 78: 415-423.3. Matoba T, Shimokawa H, Nakashima M et al., J Clin Invest 2000; 106: 1521-1530.4. Illiano S, Nagao T, Vanhoutte PM. Br J Pharmacol 1992; 107: 387-392. |
| List of Research Outputs |
| Lee Y.K.M., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Genistein reduces agonist-induced contractions of porcine coronary arterial smooth muscle in a cyclic AMP-dependent manner, European Journal of Pharmacology. 2004, 503: 165-172. |
| Leung S.W.S. and Man R.Y.K., Cardiovascular effects of danshen extract and its magnesium tanshinoate B enriched form, Journal of Molecular and Cellular Cardiology (Abstracts for the 2004 ISHR World Congress). 2004, 37/1: 280. |
| Leung S.W.S., Quan A., Lao T.T.H. and Man R.Y.K., Characterization of vascular reactivity of human umbilical artery in normal and reduced oxygen conditions, Journal of Molecular and Cellular Cardiology (Abstracts for the 2004 ISHR World Congress) . 2004, 37/1: 241-2. |
| Leung S.W.S., Teoh H., Quan A., Keung W.Y.W. and Man R.Y.K., Non-genomic coronary vascular actions of gonadal hormones: physiological implications , Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 8. |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Flavonoid, kaempferol, a compound isolated from chinese medicine, caused directed and potentiated relaxation on procine coronary arteries via camp pathway, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 106, P22. |
| Xu Y.C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Kaempferol enhances endothelium-independent relaxation: The role of cAMP pathway and K+ channels, Mechanisms of vasodilatation & EDHF 2005. Antwerp Belgium, 97. |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Kaempferol, a compound isolated from chinese medicine, cause direct and potentiated relaxation in porcine coronary arteries via the cAMP pathway, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 40, No. 1.19. |
| Xu Y.C., Leung S.W.S., Yeung K.Y. and Man R.Y.K., The flavonoid, kaempferol, enhances endothelium-independent and dependent relaxation in porcine coronary artery by cAMP pathway, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 32. |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Vascular effect of kaempferol, a flavonoid from traditional chinese medicine, on porcine coronary arteries, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 42. |
| Yeung K.Y., Leung S.W.S., Xu Y.C. and Man R.Y.K., Puerarin, a bioactive isoflavonoid derived from radix puerariae, possesses acute vasomodulatory effects in porcine coronary artery, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 34. |
| Researcher : Liu SLE |
| List of Research Outputs |
| Liu S.L.E., Shin V.Y., Ye Y., Luo J.C., Wu K.K. and Cho C.H., Cyclooxygenase-2 In Cancer Cells And Macrophages Induces Colon Cancer Cell Growth By Cigarette Smoke Extract, European Journal of Pharmacology. 2005, 518: 47-55. |
| Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L., Chu K.M. and Cho C.H., A mechanistic study of cigarette smoke and cyclooxygenase-2 on the proliferation of gastric cancer cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 59. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| So H.L., Shin V.Y., Liu S.L.E., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 60. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking, Toxicology. 2004, 203: 179-188. |
| Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of COX-2 and 5-LOX in the inflammation-associated colonic tumorigenesis promoted by cigarette smoke, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 63. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., The Modulating Role of Nuclear Factor-kB in the Action of a7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, The Journal of Pharmacology and Experimental Therapeutics. 2004, 311, No. 1: 123-130. |
| Researcher : Luo J |
| List of Research Outputs |
| Cho C.H., Luo J., Shin V.Y., Wu K.K., Ye Y., So H.L. and Chang F.Y., Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 21. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| Researcher : Man RYK |
| Project Title: | Defining the bioactive components of Shenmai injection and their mechanisms of action |
| Investigator(s): | Man RYK, O K, Siow YL, Li W.D., Zhu D.Y. |
| Department: | Pharmacology |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 05/2002 |
| Completion Date: | 07/2005 |
| Abstract: |
| To obtain a definitive chemical fingerprint of Shen Mai injection; to isolate, identify, and associate the major bioactive components and their structures to measureable biological activities deemed beneficial to cardiovascular disease. |
| Project Title: | The haemodynamic effects of magnesium tanshinoate B, a bioactive component of danshen, in anaesthetized rats |
| Investigator(s): | Man RYK |
| Department: | Pharmacology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Completion Date: | 10/2004 |
| Abstract: |
| To investigate the cardiovascular effects of MTB70 in an in vivo anaesthetized rat model, the possible mechanisms underlying the cardiovascular actions of MTB70 will be examined. |
| Project Title: | Modulatory effects of 17[beta]-estradiol on the vascular responses of rat isolated mesenteric and pulmonary arteries |
| Investigator(s): | Man RYK |
| Department: | Pharmacology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To study the acute vascular effects of 17[beta]-estradiol in male as well as female rats. In addition, the modulatory actions of long-term treatment of 17[beta]-estradiol on arterial relaxation will be examined in ovariectomized or sham-operated rats. The possible signal transduction pathway underlying the vascular effects of 17[beta]-estradiol will also be investigated. |
| Project Title: | Defining the bioactive components of Shenmai injection and their mechanisms of action |
| Investigator(s): | Man RYK, O K, Siow YL, Li W.D., Zhu D.Y. |
| Department: | Pharmacology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 08/2004 |
| Completion Date: | 12/2004 |
| Abstract: |
| To obtain a definitive chemical fingerprint of Shen Mai injection; to isolate, identify, and associate the major bioactive components and their structures to measureable biological activities deemed beneficial to cardiovascular disease. |
| Project Title: | Vascular function and structure activity relationship of flavonoids |
| Investigator(s): | Man RYK, Leung SWS |
| Department: | Pharmacology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To compare the vascular effect of various flavonoids and to study the structure activity relationship of these flavonoids. |
| List of Research Outputs |
| Keung W.Y.W., Vanhoutte P.M.G.R. and Man R.Y.K., Acute impairment of contractile responses by 17b-estradiol is cAMP and protein kinase G dependent in vascular smooth muscle cells of the porcine coronary arteries , British Journal of Pharmacology. 2004, 144: 71-79. |
| Keung W.Y.W. and Man R.Y.K., Effect of sex hormone levels on the non-genomic action of 17b-estradiol in rat mesenteric arteries, Journal of Molecular and Cellular Cardiology (Abstract for the 2004 ISHR World Congress). 2004, 37/1: 302. |
| Keung W.Y.W., Leung G.P.H. and Man R.Y.K., Gender difference in the non-genomic effect of 17b-estradiol and the involvement of a novel membrane estrogen receptor in the vascular smooth muscle, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 35. |
| Keung W.Y.W. and Man R.Y.K., Modulation of non-genomic effect of 17b-estradiol on vascular contraction by testosterone in female rat mesenteric arteries , Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 109, P33. |
| Keung W.Y.W. and Man R.Y.K., Non-genomic effect of 17b-estradiol in rat arteries is modulated by circulating estrogen and testosterone, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 85, No. 4.14. |
| Keung W.Y.W., Vanhoutte P.M.G.R. and Man R.Y.K., Non-genomic vascular effect of 17b-estradiol involves activation of adenylyl cyclase and protein kinase G in the rat mesenteric artery, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 93. |
| Keung W.Y.W. and Man R.Y.K., The role of gender in the non-genomic effect of 17b-estradiol in rat mesenteric arteries, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 47. |
| Kwok Y., Ng K.F.J., Li C.C.F., Lam C.C.K. and Man R.Y.K., A Prospective, Randomized, Double-Blind, Placebo-Controlled Study of the Platelet and Global Hemostatic Effects of Ganoderma Lucidum (Ling-Zhi) in Healthy Volunteers, Anesth Analg 2005. 2005, 101: 423-6. |
| Lau W.C.S., Chiu P.K.Y., Chu M.Y., Cheng I.Y.W., Tang W.M., Man R.Y.K. and Halpern G.M., Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study, Progress in Nutrition. 2004, 6(1): 17-31. |
| Lee Y.K.M., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Genistein reduces agonist-induced contractions of porcine coronary arterial smooth muscle in a cyclic AMP-dependent manner, European Journal of Pharmacology. 2004, 503: 165-172. |
| Leung G.P.H. and Man R.Y.K., Adenosine transport in vascular smooth muscle cells and their regulation by high glucose, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 32. |
| Leung G.P.H. and Man R.Y.K., Characterization of nucleoside transporters in vascular smooth muscle cells and their role in cell growth, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004) . 2004, 39. |
| Leung G.P.H., Man R.Y.K. and Tse C.M., D-Glucose upregulates adenosine transport in cultured human aortic smooth muscle cells., American Journal of Physiology Heart Circulation Physiology. 2005, 288: H2576-2762. |
| Leung G.P.H., Tse C.M. and Man R.Y.K., Effect of thiazolidinediones on adenosine transport in vascular smooth muscle cells, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 87. |
| Leung S.W.S. and Man R.Y.K., Cardiovascular effects of danshen extract and its magnesium tanshinoate B enriched form, Journal of Molecular and Cellular Cardiology (Abstracts for the 2004 ISHR World Congress). 2004, 37/1: 280. |
| Leung S.W.S., Quan A., Lao T.T.H. and Man R.Y.K., Characterization of vascular reactivity of human umbilical artery in normal and reduced oxygen conditions, Journal of Molecular and Cellular Cardiology (Abstracts for the 2004 ISHR World Congress) . 2004, 37/1: 241-2. |
| Leung S.W.S., Teoh H., Quan A., Keung W.Y.W. and Man R.Y.K., Non-genomic coronary vascular actions of gonadal hormones: physiological implications , Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 8. |
| Man R.Y.K., Hormone and Vascular Function, VIII Chinese Section Congress Conference Meeting of International Society for Heart Research. 2004. |
| Man R.Y.K., Invited Lecture entitled " Vascular Actions of Phytoestrogens" , 2005 National Meeting of Pharmacology and Annual English Symposium of Young Pharmacologists, Xian, China. 2005. |
| Man R.Y.K., Vascular Actions of Phytoestrogens, 2005 national Meeting of Pharmacology and Annual English Symposium of Young Pharmacologists, Xian, China. 2005. |
| Ng J.K.F., Vanhoutte P.M.G.R. and Man R.Y.K., The role of pertussis toxin sensitive pathways in EDHF mediated relaxation in porcine coronary arteries, Mechanisms of vasodilatation & EDHF 2005. Belgium, Antwerp, S20, p17. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent responses of carotid, femoral and mesenteric arteries of streptozotooin-induced diabetic rats, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 22. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced diabetes and hyperglycemia: effects on endothelium-dependent responses in rat mesenteric arteries, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 93, No. 4.29. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced effects on endothelium-dependent responses in rat carotid and measenteric arteries, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 92, OC1. |
| Tang H.C., Feletou M., Huang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Acetylcholine and sodium nitroprusside cause long-term inhibition of EDCF mediated contractions, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 34. |
| Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent contractions occur in arteries of wild type and COX2-/- but not in those of COX1-/- knockout mice, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 94, No. 4.31. |
| Tang H.C., Feletou M., Huang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Nitric oxide causes long-term inhibition of EDCF-mediated contractions, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 95, OC8. |
| Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., The calcium ionophore A23187 causes endothelium-dependent contractions in the aorta of wild type but not COX1 knock-out male mice, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 33. |
| Woo C.W.H., Man R.Y.K., Siow Y.L., Choy P.C., Wan E.W.Y., Lau C.S. and O K.A.R.M.I.N., Ganoderma lucidum inhibits inducible nitric oxide synthase expression in macrophages, Molecular and Cellular Biochemistry. 2005, 275: 165-171, 2005. |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Flavonoid, kaempferol, a compound isolated from chinese medicine, caused directed and potentiated relaxation on procine coronary arteries via camp pathway, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 106, P22. |
| Xu Y.C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Kaempferol enhances endothelium-independent relaxation: The role of cAMP pathway and K+ channels, Mechanisms of vasodilatation & EDHF 2005. Antwerp Belgium, 97. |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Kaempferol, a compound isolated from chinese medicine, cause direct and potentiated relaxation in porcine coronary arteries via the cAMP pathway, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 40, No. 1.19. |
| Xu Y.C., Leung S.W.S., Yeung K.Y. and Man R.Y.K., The flavonoid, kaempferol, enhances endothelium-independent and dependent relaxation in porcine coronary artery by cAMP pathway, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 32. |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Vascular effect of kaempferol, a flavonoid from traditional chinese medicine, on porcine coronary arteries, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 42. |
| Yeung K.Y., Leung S.W.S., Xu Y.C. and Man R.Y.K., Puerarin, a bioactive isoflavonoid derived from radix puerariae, possesses acute vasomodulatory effects in porcine coronary artery, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 34. |
| Researcher : O K |
| Project Title: | Mechanisms of enhanced monocyte binding to vascular endothelium in hyperhomocysteinemia |
| Investigator(s): | O K |
| Department: | Pharmacology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 09/2002 |
| Completion Date: | 08/2005 |
| Abstract: |
| The project aims to investigate the effect of elevated blood homocysteine (Hcy) levels on monocyte binding to aortic endothelium in dietary-induced hyperhomocysteinemic rats as well as the underlying mechanisms. Specifically, efforts will be made to investigate the mechanisms of MCP-1 expression in endothelium and CCR2 expression in peripheral blood moncytes. |
| Researcher : Shi Y |
| List of Research Outputs |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent responses of carotid, femoral and mesenteric arteries of streptozotooin-induced diabetic rats, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 22. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced diabetes and hyperglycemia: effects on endothelium-dependent responses in rat mesenteric arteries, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 93, No. 4.29. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced effects on endothelium-dependent responses in rat carotid and measenteric arteries, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 92, OC1. |
| Researcher : Shi Y |
| List of Research Outputs |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent responses of carotid, femoral and mesenteric arteries of streptozotooin-induced diabetic rats, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 22. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced diabetes and hyperglycemia: effects on endothelium-dependent responses in rat mesenteric arteries, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 93, No. 4.29. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced effects on endothelium-dependent responses in rat carotid and measenteric arteries, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 92, OC1. |
| Researcher : Shin VY |
| List of Research Outputs |
| Cho C.H., Wu K.K., Wong P.S.H., Shin V.Y., Lam K.Y. and Tai K.K., NNK from cigarette smoke stimulates colon cancer growth via b-Adrenoceptors , Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis . Seoul Korea, 2005, 14. |
| Cho C.H., Luo J., Shin V.Y., Wu K.K., Ye Y., So H.L. and Chang F.Y., Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 21. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Liu S.L.E., Shin V.Y., Ye Y., Luo J.C., Wu K.K. and Cho C.H., Cyclooxygenase-2 In Cancer Cells And Macrophages Induces Colon Cancer Cell Growth By Cigarette Smoke Extract, European Journal of Pharmacology. 2005, 518: 47-55. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L., Chu K.M. and Cho C.H., A mechanistic study of cigarette smoke and cyclooxygenase-2 on the proliferation of gastric cancer cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 59. |
| Shin V.Y., So H.L., Liu E.S.L., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, International Journal of Medical Sciences. 2004, 3: 137-145. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Shin V.Y. and Cho C.H., Nicotine and gastric cancer , Alcohol. 2005, 35: 259-264. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| So H.L., Shin V.Y., Liu S.L.E., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 60. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Wu K.K., Shin V.Y., Ye Y., So H.L., Li G.R., Yang Y. and Cho C.H., Multiple expression of voltage-gated potassium ion channels in rat gastric epithelial cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 62. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking, Toxicology. 2004, 203: 179-188. |
| Ye Y., Wu K.K., Shin V.Y., Bruce I.C., Wong B.C.Y. and Cho C.H., Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke, Carcinogenesis. 2005, 26, no. 4: 827-834. |
| Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of COX-2 and 5-LOX in the inflammation-associated colonic tumorigenesis promoted by cigarette smoke, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 63. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., The Modulating Role of Nuclear Factor-kB in the Action of a7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, The Journal of Pharmacology and Experimental Therapeutics. 2004, 311, No. 1: 123-130. |
| Researcher : Shin VY |
| List of Research Outputs |
| Cho C.H., Wu K.K., Wong P.S.H., Shin V.Y., Lam K.Y. and Tai K.K., NNK from cigarette smoke stimulates colon cancer growth via b-Adrenoceptors , Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis . Seoul Korea, 2005, 14. |
| Cho C.H., Luo J., Shin V.Y., Wu K.K., Ye Y., So H.L. and Chang F.Y., Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 21. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Liu S.L.E., Shin V.Y., Ye Y., Luo J.C., Wu K.K. and Cho C.H., Cyclooxygenase-2 In Cancer Cells And Macrophages Induces Colon Cancer Cell Growth By Cigarette Smoke Extract, European Journal of Pharmacology. 2005, 518: 47-55. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L., Chu K.M. and Cho C.H., A mechanistic study of cigarette smoke and cyclooxygenase-2 on the proliferation of gastric cancer cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 59. |
| Shin V.Y., So H.L., Liu E.S.L., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, International Journal of Medical Sciences. 2004, 3: 137-145. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Shin V.Y. and Cho C.H., Nicotine and gastric cancer , Alcohol. 2005, 35: 259-264. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| So H.L., Shin V.Y., Liu S.L.E., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 60. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Wu K.K., Shin V.Y., Ye Y., So H.L., Li G.R., Yang Y. and Cho C.H., Multiple expression of voltage-gated potassium ion channels in rat gastric epithelial cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 62. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking, Toxicology. 2004, 203: 179-188. |
| Ye Y., Wu K.K., Shin V.Y., Bruce I.C., Wong B.C.Y. and Cho C.H., Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke, Carcinogenesis. 2005, 26, no. 4: 827-834. |
| Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of COX-2 and 5-LOX in the inflammation-associated colonic tumorigenesis promoted by cigarette smoke, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 63. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., The Modulating Role of Nuclear Factor-kB in the Action of a7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, The Journal of Pharmacology and Experimental Therapeutics. 2004, 311, No. 1: 123-130. |
| Researcher : Siow YL |
| List of Research Outputs |
| Woo C.W.H., Man R.Y.K., Siow Y.L., Choy P.C., Wan E.W.Y., Lau C.S. and O K.A.R.M.I.N., Ganoderma lucidum inhibits inducible nitric oxide synthase expression in macrophages, Molecular and Cellular Biochemistry. 2005, 275: 165-171, 2005. |
| Researcher : So HL |
| List of Research Outputs |
| Cho C.H., Luo J., Shin V.Y., Wu K.K., Ye Y., So H.L. and Chang F.Y., Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 21. |
| Fong Y.Y.M., Koo M.W.L., Hui K.C., So H.L., Yang Y., Wu K.K. and Cho C.H., Green tea and tea powder solutions attenuate the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 52. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Shin V.Y., So H.L., Liu E.S.L., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, International Journal of Medical Sciences. 2004, 3: 137-145. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| So H.L., Shin V.Y., Liu S.L.E., Wu Y.J., Pang S.F. and Cho C.H., Anti-tumorigenic and pro-apoptotic effects of CKBM on gastric cancer growth in nude mice, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 60. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Wu K.K., Shin V.Y., Ye Y., So H.L., Li G.R., Yang Y. and Cho C.H., Multiple expression of voltage-gated potassium ion channels in rat gastric epithelial cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 62. |
| Researcher : Tai KK |
| List of Research Outputs |
| Cho C.H., Wu K.K., Wong P.S.H., Shin V.Y., Lam K.Y. and Tai K.K., NNK from cigarette smoke stimulates colon cancer growth via b-Adrenoceptors , Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis . Seoul Korea, 2005, 14. |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Researcher : Tang HC |
| List of Research Outputs |
| Tang H.C., Feletou M., Huang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Acetylcholine and sodium nitroprusside cause long-term inhibition of EDCF mediated contractions, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 34. |
| Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent contractions occur in arteries of wild type and COX2-/- but not in those of COX1-/- knockout mice, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 94, No. 4.31. |
| Tang H.C., Feletou M., Huang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Nitric oxide causes long-term inhibition of EDCF-mediated contractions, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 95, OC8. |
| Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., The calcium ionophore A23187 causes endothelium-dependent contractions in the aorta of wild type but not COX1 knock-out male mice, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 33. |
| Researcher : Tom WM |
| List of Research Outputs |
| Chen J.H., Tipoe G.L., Liong E.C., So H.S.H., Leung K.M., Tom W.M., Fung P.C.W. and Nanji A.A., Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants, American Journal of Clinical Nutrition. 2004, 80: 742-751. |
| Lau T.H.Y., Fung M.L., Tom W.M., Nanji A.A. and Tipoe G.L., Mediation of glucose transporters in hepatic adaptation to chronic hypoxia via hypoxia inducible factor, 9th Research Postgraduate Symposium, HKU. 2004. |
| Leung T.M., Fan S.T., Liong E.C., Fung M.L., Lau T.Y.H., Leung K.M., Tom W.M., Nanji A.A. and Tipoe G.L., Nitric oxide and fibrotic factors in chronic liver injury (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005. |
| Leung T.M., Tipoe G.L., Lau T.H.Y., Liong E.C., So H., Leung K.M., Leung W.M., Tom W.M., Fung M.L., Fan S.T. and Nanji A.A., Nitric oxide in an acute liver injury model, Society of Pathology Meeting, 2005 Journal of Pathology, Suppl. . 2005, 205: 11-11. |
| Zhao R., Wong N.S. and Tom W.M., Interferon-genhances nitric oxide synthase expression induced by paclitaxel in alveolar macrophages: The roles of ras/mek/erk and NF-kB in signal transduction, 9th research postgraduate symposium, HKU, December 4, 2004. |
| Zhao R., Wong N.S. and Tom W.M., Synergistically interferon-g enhances paclitaxel-induced nitric oxide production in a murine alveolar macrophage cell line: roles of NF-kB, MEK and PKCd, Free Radical Biology and Medicine. New York, Elsevier, 2004, 37: S102. |
| Researcher : Vanhoutte PMGR |
| Project Title: | Endothelial dysfunction in diabetes: role of endothelium-derived contracting factor |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 08/2003 |
| Abstract: |
| To examine five hypotheses: a) the lack of NO favors endothelium-dependent contractions: b) the endothelium of diabetic arteries releases more vasoconstrictor breakdown products of arachidonic acid: c) endothelium-dependent contractions are due to a diffusible factor (EDCF); d) oxygen-free radicals play a key role in EDCF-mediated responses: and e) high glucose mimicks the impact of diabetes on endothelial function. These studies should yield a better understanding of the mechanisms(s) underlying diabetic endothelial dysfunction, and hence help to improve the prevention and/or therapy of one of the most feared complications of the disease. |
| Project Title: | Endothelial dysfunction in diabetes: role of endothelium-derived contracting factor |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 08/2003 |
| Abstract: |
| To examine five hypotheses: a) the lack of NO favors endothelium-dependent contractions: b) the endothelium of diabetic arteries releases more vasoconstrictor breakdown products of arachidonic acid: c) endothelium-dependent contractions are due to a diffusible factor (EDCF); d) oxygen-free radicals play a key role in EDCF-mediated responses: and e) high glucose mimicks the impact of diabetes on endothelial function. These studies should yield a better understanding of the mechanisms(s) underlying diabetic endothelial dysfunction, and hence help to improve the prevention and/or therapy of one of the most feared complications of the disease. |
| Project Title: | EDCF in spontaneous hypertension |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To explore the exact mechanism(s) underlying, and the importance of, endothelium-dependent contractions in large and small arteries of the spontaneously hypertensive rat, and to study blood vessels of the mouse in order to be able to use genetically modified animals. |
| Project Title: | Endothelium-Dependent Contracting Factor in Hypertension |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology |
| Source(s) of Funding: | Incentive Award for RGC CERG Fundable But Not Funded Projects |
| Start Date: | 07/2004 |
| Abstract: |
| Refer to hard copy |
| Project Title: | Genomic changes underlying the phenotypic alterations of regenerated endothelial cells |
| Investigator(s): | Vanhoutte PMGR, Man RYK |
| Department: | Pharmacology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To define the changes of regenerated endothelial cells at the genomic level which could explain the phenotypic alterations that underlie their dysfunction. |
| List of Research Outputs |
| Chan Y.C., Yao X., Lau C.W., Vanhoutte P.M.G.R. and Huang Y., Raloxifene therapy improves basal nitric oxide release in pulmonary arteries of spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 111, P38. |
| Feletou M. and Vanhoutte P.M.G.R., The obligatory role of endothelial SKCa and IKCa channels in EDHF-mediated responses, Acta Pharmacologica Sinica . 2004, 25, No. 11: 1526. |
| Gluais P., Vanhoutte P.M.G.R. and Feletou M., Endothelium-dependent contractions in the shir aorta: The janus face of prostacyclin, Mechanisms of vasodilatation & EDHF 2005. 31. |
| Gluais P., Edwards G., Weston A.H., Vanhoutte P.M.G.R. and Feletou M., Hydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery, European Journal of Pharmacology. 2005, 513: 219-224. |
| Gluais P., Edwards G., Weston A.H., Falck J.R., Vanhoutte P.M.G.R. and Feletou M., Role of SKCa and IKCa in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery, British Journal of Pharmacology . 2005, 144: 477-485. |
| Ho K.W., Chan Y.C., Wong K.M., Chan F.L., Yao X., Gollasch M., Vanhoutte P.M.G.R. and Huang Y., Regulation of vascular reactivity by periadventitial fat in rat small arteries, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 112, P41. |
| Keung W.Y.W., Vanhoutte P.M.G.R. and Man R.Y.K., Acute impairment of contractile responses by 17b-estradiol is cAMP and protein kinase G dependent in vascular smooth muscle cells of the porcine coronary arteries , British Journal of Pharmacology. 2004, 144: 71-79. |
| Keung W.Y.W., Vanhoutte P.M.G.R. and Man R.Y.K., Non-genomic vascular effect of 17b-estradiol involves activation of adenylyl cyclase and protein kinase G in the rat mesenteric artery, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 93. |
| Lau C.W., Yao X., Chen Z.Y., Vanhoutte P.M.G.R. and Huang Y., Raloxifene treatment modulate pulmonary artery tone in spontaneously hypertensive rats, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 53. |
| Lee Y.K.M., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Genistein reduces agonist-induced contractions of porcine coronary arterial smooth muscle in a cyclic AMP-dependent manner, European Journal of Pharmacology. 2004, 503: 165-172. |
| Leung S.H., Yao X., Vanhoutte P.M.G.R. and Huang Y., Characterization of endothelium-dependent relaxation in rat femoral arteries, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 111, P39. |
| Miao C.Y., Villeneuve N., Brunel-Jacquemin C., Petit C., Guillaumin J.P., Gransagne D., Briant C., Vilaine J.P. and Vanhoutte P.M.G.R., Chronic mild hyperhomocysteinemia induces aortic endothelial dysfunction but does not elevate arterial pressure in rats , Journal of Vascular Research. 2005, 42: 148-156. |
| Ng C.H., Chen Z.Y., Yao X., Au C.L., Yung L., Vanhoutte P.M.G.R. and Huang Y., Raloxifene attenuates endothelial dysfunction induced by oxidized low-density lipoprotein, Mechanisms of vasodilatation & EDHF 2005. 29. |
| Ng C.H., Chen Z.Y., Yao X., Au C.L., Yung L.M., Wong C.M., Vanhoutte P.M.G.R. and Huang Y., Raloxifene improves vasorelaxation in oxidized LDL-treated rat aortas, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 113, P43. |
| Ng J.K.F., Vanhoutte P.M.G.R. and Man R.Y.K., The role of pertussis toxin sensitive pathways in EDHF mediated relaxation in porcine coronary arteries, Mechanisms of vasodilatation & EDHF 2005. Belgium, Antwerp, S20, p17. |
| Rasmussen L.E., Vanhoutte P.M.G.R., Jensen B.L. and Skott O., EDHF-mediated relaxation in rabbit carotid artery is dependent on luminal flow, Mechanisms of vasodilatation & EDHF 2005. Antwerp Belgium, 2005, 94. |
| Rasmussen L.E., Jensen B.L., Vanhoutte P.M.G.R. and Skott O., Flow augments the contractions to phenylephrine in the rabbit carotid artery by reducing the release of endothelium-derived no., Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 12. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent responses of carotid, femoral and mesenteric arteries of streptozotooin-induced diabetic rats, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 22. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced diabetes and hyperglycemia: effects on endothelium-dependent responses in rat mesenteric arteries, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 93, No. 4.29. |
| Shi Y., Ku D.D., Man R.Y.K. and Vanhoutte P.M.G.R., Streptozocin-induced effects on endothelium-dependent responses in rat carotid and measenteric arteries, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 92, OC1. |
| Tang H.C., Feletou M., Huang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Acetylcholine and sodium nitroprusside cause long-term inhibition of EDCF mediated contractions, Mechanisms of vasodilatation & EDHF 2005. Antwerp, Belgium, 34. |
| Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-dependent contractions occur in arteries of wild type and COX2-/- but not in those of COX1-/- knockout mice, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 94, No. 4.31. |
| Tang H.C., Feletou M., Huang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Nitric oxide causes long-term inhibition of EDCF-mediated contractions, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 95, OC8. |
| Tang H.C., Ku D.D., Tipoe G.L., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., The calcium ionophore A23187 causes endothelium-dependent contractions in the aorta of wild type but not COX1 knock-out male mice, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 33. |
| Vanhoutte P.M.G.R., Endothelium-derived contracting factor in health and disease, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 87, IL5. |
| Vanhoutte P.M.G.R., Feletou M. and Taddei S., REVIEW Endothelium-dependent contractions in hypertension, British Journal of Pharmacology. 2005, 144: 449-458. |
| Wong C.M., Yung L.M., Au C.L., Yao X., Leung F.P., Cheng H.K., Vanhoutte P.M.G.R. and Huang Y., Raloxifene ameliorates endothelial dysfunction induced by free radical exposure, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 113, P42. |
| Xu Y.C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Kaempferol enhances endothelium-independent relaxation: The role of cAMP pathway and K+ channels, Mechanisms of vasodilatation & EDHF 2005. Antwerp Belgium, 97. |
| Researcher : Wong HPS |
| List of Research Outputs |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Researcher : Wong PSH |
| List of Research Outputs |
| Cho C.H., Wu K.K., Wong P.S.H., Shin V.Y., Lam K.Y. and Tai K.K., NNK from cigarette smoke stimulates colon cancer growth via b-Adrenoceptors , Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis . Seoul Korea, 2005, 14. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Researcher : Wu KK |
| List of Research Outputs |
| Cho C.H., Wu K.K., Wong P.S.H., Shin V.Y., Lam K.Y. and Tai K.K., NNK from cigarette smoke stimulates colon cancer growth via b-Adrenoceptors , Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis . Seoul Korea, 2005, 14. |
| Cho C.H., Luo J., Shin V.Y., Wu K.K., Ye Y., So H.L. and Chang F.Y., Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 21. |
| Fong Y.Y.M., Koo M.W.L., Hui K.C., So H.L., Yang Y., Wu K.K. and Cho C.H., Green tea and tea powder solutions attenuate the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 52. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Liu S.L.E., Shin V.Y., Ye Y., Luo J.C., Wu K.K. and Cho C.H., Cyclooxygenase-2 In Cancer Cells And Macrophages Induces Colon Cancer Cell Growth By Cigarette Smoke Extract, European Journal of Pharmacology. 2005, 518: 47-55. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Wu K.K., Shin V.Y., Ye Y., So H.L., Li G.R., Yang Y. and Cho C.H., Multiple expression of voltage-gated potassium ion channels in rat gastric epithelial cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 62. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking, Toxicology. 2004, 203: 179-188. |
| Ye Y., Wu K.K., Shin V.Y., Bruce I.C., Wong B.C.Y. and Cho C.H., Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke, Carcinogenesis. 2005, 26, no. 4: 827-834. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., The Modulating Role of Nuclear Factor-kB in the Action of a7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, The Journal of Pharmacology and Experimental Therapeutics. 2004, 311, No. 1: 123-130. |
| Researcher : Wu KK |
| List of Research Outputs |
| Cho C.H., Wu K.K., Wong P.S.H., Shin V.Y., Lam K.Y. and Tai K.K., NNK from cigarette smoke stimulates colon cancer growth via b-Adrenoceptors , Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis . Seoul Korea, 2005, 14. |
| Cho C.H., Luo J., Shin V.Y., Wu K.K., Ye Y., So H.L. and Chang F.Y., Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 21. |
| Fong Y.Y.M., Koo M.W.L., Hui K.C., So H.L., Yang Y., Wu K.K. and Cho C.H., Green tea and tea powder solutions attenuate the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 52. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Lam K.Y., Shin V.Y., Wu K.K., Wong H.P.S., Tai K.K., So H.L. and Cho C.H., Lactobacillus GG Enhances Gastric Ulcer Healing and Promotes Angiogenesis and Cell Proliferation, Symposium on Gastrointestinal Disorders:Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 30. |
| Liu S.L.E., Shin V.Y., Ye Y., Luo J.C., Wu K.K. and Cho C.H., Cyclooxygenase-2 In Cancer Cells And Macrophages Induces Colon Cancer Cell Growth By Cigarette Smoke Extract, European Journal of Pharmacology. 2005, 518: 47-55. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Shin V.Y., Wu K.K., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine Modulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase in the Promotion of Gastric Tumor Growth and Angiogenesis, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 29. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28. |
| Wu K.K., Shin V.Y., Ye Y., So H.L., Li G.R., Yang Y. and Cho C.H., Multiple expression of voltage-gated potassium ion channels in rat gastric epithelial cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 62. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking, Toxicology. 2004, 203: 179-188. |
| Ye Y., Wu K.K., Shin V.Y., Bruce I.C., Wong B.C.Y. and Cho C.H., Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke, Carcinogenesis. 2005, 26, no. 4: 827-834. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., The Modulating Role of Nuclear Factor-kB in the Action of a7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, The Journal of Pharmacology and Experimental Therapeutics. 2004, 311, No. 1: 123-130. |
| Researcher : Xu YC |
| List of Research Outputs |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Flavonoid, kaempferol, a compound isolated from chinese medicine, caused directed and potentiated relaxation on procine coronary arteries via camp pathway, Journal of the Hong Kong College of Cardiology. 2004, 12, No. 3/4: 106, P22. |
| Xu Y.C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Kaempferol enhances endothelium-independent relaxation: The role of cAMP pathway and K+ channels, Mechanisms of vasodilatation & EDHF 2005. Antwerp Belgium, 97. |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Kaempferol, a compound isolated from chinese medicine, cause direct and potentiated relaxation in porcine coronary arteries via the cAMP pathway, The 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 4 December 2004. 40, No. 1.19. |
| Xu Y.C., Leung S.W.S., Yeung K.Y. and Man R.Y.K., The flavonoid, kaempferol, enhances endothelium-independent and dependent relaxation in porcine coronary artery by cAMP pathway, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 32. |
| Xu Y.C., Leung S.W.S. and Man R.Y.K., Vascular effect of kaempferol, a flavonoid from traditional chinese medicine, on porcine coronary arteries, Satellite to the World Congress of International Society for Heart Research, 13-15 August 2004. 42. |
| Yeung K.Y., Leung S.W.S., Xu Y.C. and Man R.Y.K., Puerarin, a bioactive isoflavonoid derived from radix puerariae, possesses acute vasomodulatory effects in porcine coronary artery, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 34. |
| Researcher : Yang Y |
| List of Research Outputs |
| Fong Y.Y.M., Koo M.W.L., Hui K.C., So H.L., Yang Y., Wu K.K. and Cho C.H., Green tea and tea powder solutions attenuate the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 52. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Wu K.K., Shin V.Y., Ye Y., So H.L., Li G.R., Yang Y. and Cho C.H., Multiple expression of voltage-gated potassium ion channels in rat gastric epithelial cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 62. |
| Researcher : Ye Y |
| List of Research Outputs |
| Cho C.H., Luo J., Shin V.Y., Wu K.K., Ye Y., So H.L. and Chang F.Y., Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 21. |
| Hui K.C., So H.L., Ye Y., Shin V.Y., Wu K.K., Fong Y.Y.M., Yang Y. and Cho C.H., Angelica sinensis polysaccharides ameliorate the intestinal toxicity of cyclophosphamide in mice , Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 54. |
| Liu S.L.E., Shin V.Y., Ye Y., Luo J.C., Wu K.K. and Cho C.H., Cyclooxygenase-2 In Cancer Cells And Macrophages Induces Colon Cancer Cell Growth By Cigarette Smoke Extract, European Journal of Pharmacology. 2005, 518: 47-55. |
| Luo J., Shin V.Y., Yang Y., Wu K.K., Ye Y., So H.L., Chang F.Y. and Cho C.H., Tumor necrosis factor-a stimulates gastric epithelial cell proliferation, American Journal of Physiology. 2004, 288: G32-G38. |
| Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L., Chu K.M. and Cho C.H., A mechanistic study of cigarette smoke and cyclooxygenase-2 on the proliferation of gastric cancer cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 59. |
| Shin V.Y., Wu K.K., Ye Y., So H.L., Koo M.W.L., Liu S.L.E., Luo J. and Cho C.H., Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2, Carcinogenesis. 2004, 25, no. 12: 2487-2495. |
| Wu K.K., Wong P.S.H., Luo S.W., Chan K., Huang F.Y., Hui K.C., Lam K.Y., Shin V.Y., Ye Y., Yang Y.H. and Cho C.H., 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via b-Adrenoceptors, Cancer Research 2005. 2005, 65:(12): 5272-7. |
| Wu K.K., Shin V.Y., Ye Y., So H.L., Li G.R., Yang Y. and Cho C.H., Multiple expression of voltage-gated potassium ion channels in rat gastric epithelial cells, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 62. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking, Toxicology. 2004, 203: 179-188. |
| Ye Y. and Cho C.H., Dual Inhibition of 5-LOX and COX-2 Suppresses Colon Cancer Formation Promoted by Cigarette Smoke, 2nd Beijing International Digestive Disease Forum 2005, Beijing, China. 2005, 65-67. |
| Ye Y., Wu K.K., Shin V.Y., Bruce I.C., Wong B.C.Y. and Cho C.H., Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke, Carcinogenesis. 2005, 26, no. 4: 827-834. |
| Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of COX-2 and 5-LOX in the inflammation-associated colonic tumorigenesis promoted by cigarette smoke, Advances in GI Pharmacology, 20-22 November 2004, Shiga, Japan. 2004, 63. |
| Ye Y., Liu S.L.E., Shin V.Y., Wu K.K. and Cho C.H., The Modulating Role of Nuclear Factor-kB in the Action of a7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, The Journal of Pharmacology and Experimental Therapeutics. 2004, 311, No. 1: 123-130. |
| Researcher : Yeung KY |
| List of Research Outputs |
| Xu Y.C., Leung S.W.S., Yeung K.Y. and Man R.Y.K., The flavonoid, kaempferol, enhances endothelium-independent and dependent relaxation in porcine coronary artery by cAMP pathway, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 32. |
| Yeung K.Y., Leung S.W.S., Xu Y.C. and Man R.Y.K., Puerarin, a bioactive isoflavonoid derived from radix puerariae, possesses acute vasomodulatory effects in porcine coronary artery, Hong Kong Pharmacology Society (Abstracts for the 8th Scientific Meeting, 16-17 August 2004). 2004, 34. |
| Researcher : Zhao R |
| List of Research Outputs |
| Zhao R., Wong N.S. and Tom W.M., Interferon-genhances nitric oxide synthase expression induced by paclitaxel in alveolar macrophages: The roles of ras/mek/erk and NF-kB in signal transduction, 9th research postgraduate symposium, HKU, December 4, 2004. |
| Zhao R., Wong N.S. and Tom W.M., Synergistically interferon-g enhances paclitaxel-induced nitric oxide production in a murine alveolar macrophage cell line: roles of NF-kB, MEK and PKCd, Free Radical Biology and Medicine. New York, Elsevier, 2004, 37: S102. |
| Researcher : Zhao R |
| List of Research Outputs |
| Zhao R., Wong N.S. and Tom W.M., Interferon-genhances nitric oxide synthase expression induced by paclitaxel in alveolar macrophages: The roles of ras/mek/erk and NF-kB in signal transduction, 9th research postgraduate symposium, HKU, December 4, 2004. |
| Zhao R., Wong N.S. and Tom W.M., Synergistically interferon-g enhances paclitaxel-induced nitric oxide production in a murine alveolar macrophage cell line: roles of NF-kB, MEK and PKCd, Free Radical Biology and Medicine. New York, Elsevier, 2004, 37: S102. |