DEPT OF OBSTETRICS & GYNAECOLOGY
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Researcher
: Chan CCW |
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List of Research Outputs |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., Comparison of 2-Dimensional, 3-Dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles, Journal of Ultrasound In Medicine. 2007, 26(7): 931-939. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., The role of endometrial blood flow measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during in vitro fertilization treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 135: 8-16. |
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Tang G.W.K., Leung K.Y. and Chan C.C.W., Use of hormone therapy: POST-WHI ERA in Hong Kong, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, Tokyo, Japan September 21-25 . 2007. |
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Researcher
: Chan CP |
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List of Research Outputs |
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Chan C.P. and Lao T.T.H., Effect of parity and advanced maternal age on obstetric outcome, International Journal of Gynecology and Obstetrics. Elsevier Ireland Limited, 2008, 102: 237-241. |
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Chan
K.W., Chan G.S.W., Tse K.C. and Chan C.P., Genotypic and phenotypic
divergence: lessons from a family of Fabry’s disease, 24th World Congress
of Pathology and Laboratory Medicine, 20-24 August 2007, |
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Hui P.W., Leung W.C., Au W.Y., Chan C.P. and Lao T.T.H., A rare cause of thrombocytopenia in pregnancy – EDTA-dependent pseudothrombocytopenia, 31st British International Congress of Obstetrics and Gynaecology, 3 – 6 July 2007, London, United Kingdom. 2007. |
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Lao T.T.H., Chan C.P., Leung W.C., Ho L.F. and Tse K.Y., Maternal hepatitis B infection and gestational diabetes mellitus, Journal of Hepatology. 2007, 47(1): 46-50. |
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Researcher
: Chan DW |
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Project Title: |
Characterization of the roles of Dual specificity MAPK phosphatase 3 (MKP-3) in ovarian cancer |
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Investigator(s): |
Chan DW, Ngan HYS |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
11/2006 |
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Abstract: |
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Ovarian cancer is one of the leading
causes of death in women. Although there have been advances in the treatment
of ovarian cancer, the associated mortality rate of this cancer has not
improved significantly over the past decade. Therefore, understanding the
molecular mechanisms in the development of ovarian cancer through
identification and characterization of oncogenes and tumor suppressor genes
will help discovery of novel targets for therapies. To achieve this, we have
previously done cDNA microarray analysis on ovarian cancer cell lines and immortalized
human normal surface epithelial cell lines (HOSEs). We found that a gene
called Dual specificity MAPK phophatase 3 (MKP-3/DUSP6) was downregulated in
ovarian cancer cells. Many studies have documented that MKP-3 possesses
anti-tumorigenic effect on pancreatic cancer through inactivation of ERK
activity (Furukawa et al., 1998; Furukawa et al., 2003). The finding of
underexpression of MKP |
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List of Research Outputs |
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Chan
D.W., Lee
Y.W., Liu V.W.S. and Ngan H.Y.S., Overexpression of AMPKgamma
2 enhances tumorigenicity of Ovarian Cancer Cells, Annual Meetings of
American Association for Cancer Research, April 12-16, 2008, |
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Liu
V.W.S., Chan D.W., To M.Y., Chiu C.N. and Ngan H.Y.S., Forkhead box transcription
factor FoxG1 is over-expressed in ovarian cancer and can inhibit p21 expression,
Annual Meeting of the American Association for Cancer Research, April
12-16, 2008, |
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Yip
C.T., Chan D.W., Liu V.W.S. and Ngan H.Y.S., Zic2 synergistically
enhances Hedgehog signaling pathway in cervical cancer., The 12th Research
Postgraduate Symposium 2007, The |
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Yip
C.T., Chan D.W., Liu V.W.S. and Ngan H.Y.S., Zic2 synergistically
enhances Hedgehog signaling pathway in cervical cancer., The 99th Annual
Meeting of American Association of Cancer Research, 12-16 April 2008, |
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Researcher
: Chan KKL |
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Project Title: |
Relationship between placental ratio and placental function |
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Investigator(s): |
Chan KKL, Lao TTH |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Seed Funding for New Staff |
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Start Date: |
01/2003 |
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Abstract: |
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To examine the relationship between PR and placental function in terms of fetal acid- base balance, haematology and biochemiatry; to determine if there is a cut-off in the PR for the detection of fetal growth restriction (FRG) as reflected by changes in placental function in newborns with birthweigth within the normal range. |
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Project Title: |
The role resistin in gestational diabetes and its relationship with pregnancy outcome |
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Investigator(s): |
Chan KKL, Lam KSL, Lao TTH |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
02/2004 |
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Abstract: |
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To investigate the hypothesis that resistin expression is associated with insulin resistance in pregnancy and has implications on neonatal outcome. |
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Project Title: |
Iron supplement in pregnancy and development of gestational diabetes - a randomized placebo-controlled trial |
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Investigator(s): |
Chan KKL, Lao TTH |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2005 |
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Abstract: |
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To conduct a randomized placebo control trial to establish the relationship between iron store and development of GDM; to explore the mechanism by which a high iron load is related to GDM; to explore the relationship between iron store and liver production of insulin resistance; to explore the relationship between iron store and liver production of IGF which has similar action as insulin on glucose metabolism, whose level has been associated with development of disbetes. |
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Project Title: |
Oestrogen receptor subtypes status in ovarian cancer |
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Investigator(s): |
Chan KKL, Tam KF, Ngan HYS, |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
01/2006 |
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Abstract: |
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Objective : To investigate the
relationship between oestrogen receptors subtypes and clinical parameters in
ovarian cancer Key issues and problem addressed: Ovarian cancer cells, like
breast cancer cells, express oestrogen receptors (Rao 1991) and are oestrogen
sensitive. Oestrogen is a steroid hormone, mainly synthesised in the ovary
but also in peripheral tissues through aromatization of androgen ( |
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Project Title: |
To investigate the relationship between oestrogen receptor subtype status and the effects of oestrogen agonists, antagonists and selective oestrogen receptor modulators ( SERM) on ovarian tumour cell growth |
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Investigator(s): |
Chan KKL, Tam KF, Ngan HYS |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
01/2007 |
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Abstract: |
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Oestrogen regulates the expression of
many genes that are important for cell proliferation, inhibition of
apoptosis, stimulation of invasion and metastasis and promotion of
angiogenesis. Most of the effects of oestrogen are medicated by oestrogen
receptors (ER). ER has at least 2 functions. Apart from being a transcription
factor for oestrogen related genes, it also functions outside the nucleus and
in the plasma membrane to active growth factor signalling. Ovarian cancer
cells express oestrogen receptors and are oestrogen sensitive. Therefore, oestrogen
can potentially affect ovarian cancer cell growth. Hormonal therapy is an
attractive option in the treatment of ovarian cancer because of its better
side effect profile compared to standard chemotherapy regimes. Tamoxifen, a
partial oestrogen agonist which is widely used in the treatment of breast
cancer has also been used in the treatment of ovarian cancer. However,
overall response rate is only about 13% (Perez-Gracia JL et al). Most of the
studies on the use of tamoxifen in ovarian cancer did not fully investigate
the response with respect to the receptor status of their subjects.
Furthermore, a new oestrogen receptor, the ER-β, was discovered after most of
these earlier studies and a number of new selective oestrogen receptors
modulators and pure antagonists have been developed. Second and third
generation SERMs such as raloxifene and arzoxifene had been developed to
produce favourable oestrogen activities , for example, prevention of
osteoporosis ,while minimizing the less desirable effects such as increasing
breast cancer risk. Fulvestrant , a pure oestrogen antagonist, was developed
and already licensed for use in treatment for advanced breast cancer. Again,
the use of these newer agents in ovarian cancer is much less investigated.
While a no. of studies have looked at the effects of oestrogen and tamoxifen
on the ovarian cancer cell growth in vitro and suggested that oestrogen might
stimulate cell proliferation while tamoxifen might inhibit cell growth
(Langdon , Lindgren , Taube ), there is minimal information on the effect of
the newer agents. Moreover, the role of oestrogen receptors on these observed
effects of oestrogen or tamoxifen on ovarian cancer cell growth was not
clear. Although the antiproliferative effect of tamoxifen observed was related
to the cytosolic ER content in 18 ovarian tumours (Lazo), no significant
differences in ER expression was found between the higher and lower survival
groups when cells were cultured in 17 β- oestradiol (Taube ). These previous
studies had not taken into account of the receptor subtypes status. In the
presence of different receptor subtypes, both oestrogen and tamoxifen may
have different actions. In the presence of ER α, both oestradiol and
tamoxifen have agonist action, but in the presence of ER β, oestrogen blocks
the agonist effect of tamoxifen and tamoxifen would give be a pure
antagonistic action ( Barkhem, Hall, Paech, Katzenellenbogen). The
differences in action in the presence of different receptor subtypes may lead
to the discrepancies observed in previous reports. We therefore propose to
study the effects of oestradiol ( the agonist ), different SERMS as well as
the pure antagonist on ovarian cell lines with respect to receptors subtypes
status. References Perez-Gracia JL. Carrasco EM. Tamoxifen therapy for
ovarian cancer in the adjuvant and advanced settings: systematic review of
the literature and implications for future research. Gynecol Oncol. 2002;
84:201-9 Langdon SP. Hawkes MM. Lawrie SS et al. Oestrogen receptor
expression and the effects of oestrogen and tamoxifen on the growth of human
ovarian carcinoma cell lines. Br J Cancer. 1990; 62:213-6 Lindgren P.
Backstrom T. Mahlck CG. et al. Steroid receptors and hormones in relation to
cell proliferation and apoptosis in poorly differentiated epithelial ovarian
tumors. Int J Oncol 2001 ;19:31-8 Taube M. Hockenstrom T. Isaksson M. et al
Effects of sex steroids on survival and receptor expression in ovarian
epithelial tumour cells. Int J Oncol. 2003 ;22:1257-62 Lazo JS. |
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List of Research Outputs |
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Chan K.K.L., Ip P.P.C., Kwong P.W.K., Tam K.F. and Ngan H.Y.S., A combination of chemoirradiation and chemotherapy for treatment of advanced clear cell adenocarcinoma of the cervix (p 559-563) , In: John J. Kavanagh and Uziel Beller, International Journal of Gynecological Cancer. Wiley interscience, 2008, 18: 559-563. |
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Chan K.K.L. and Naik R., Advances on surgical treatment of cervical cancer, Women's Health. Future Medicine, 2008, 4: 245-256. |
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Chan K.K.L., Wei N., Liu S., Liao X., Cheung A.N.Y. and Ngan H.Y.S., Estrogen receptor subtypes in ovarian cancer: a clinical correlation, Obstet Gynecol. 2008, 111: 144-151. |
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Chan K.K.L., Management strategies in keeping with the changing faces of gestational trophoblastic neoplasia in SE Asia, The XXth Asian and Oceanic Congress of Obsterics and Gynaecology. . 2007. |
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Chan K.K.L., Tam K.F., Tse K.Y. and Ngan H.Y.S., The role of physical examination in the routine follow up of patients treated for ovarian carcinoma, British Gynaecological Society Annual Conference 2007. |
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Chan K.K.L., Tam K.F., Tse K.Y. and Ngan H.Y.S., The use of vaginal antimicrobial after large loop excision of transformation zone: a prospective randomised trial, British Journal of Obstetrics and Gynaecology. 2007, 114(8): 970-976. |
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Kwan T.T.C., Chan K.K.L., Yip M.W., Tam K.F., Cheung A.N.Y., Young P.M.C., Lee P.W.H. and Ngan H.Y.S., Barriers and facilitators to human papillomavirus vaccination among Chinese adolescent girls in Hong Kong: a qualitative–quantitative study, Sex Transm Infect. 2008, 84(3): 227-232. |
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Leung C.Y., Liu S., Chan Y.K., Tam K.F., Chan K.K.L., Wong R.L.C. and Ngan H.Y.S., Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer, Oncology Reports. 2008, 19: 1339-1345. |
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Liu S., Tsang P.C.K., Chan Y.K., Cheung A.N.Y., Chan K.K.L., Leung C.Y. and Ngan H.Y.S., Distribution of Six Oncogenic Types of Human Papillomavirus and Type 16 Integration Analysis in Chinese Women with Cervical Precancerous Lesions and Carcinomas, Tumour Biol. 2008, 29(2): 105-113. |
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Ngan
H.Y.S., Tsang P.C.K., Chan Y.K., Liu S., Cheung A.N.Y., Chan K.K.L. and Leung C.Y., Human papillomavirus
genotyping and integration in cervical cancers and precursor lesions, 24th
International Papillomavirus Conference and Clinical Workshop. |
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Ngan H.Y.S., Kwan T.T.C., Tam K.F., Chan K.K.L., Young P.M., Lo S.S., Cheung A.N.Y. and Lee P.W.H., Knowledge and attitute of Chinese women on cervical cancer and human papillomavirus, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, September 21-25, 2007, Tokyo, Japan. 2007. |
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Tse K.Y., Chan K.K.L., Tam K.F. and Ngan H.Y.S., Current concepts in the management of endometrial carcinoma, Journal of Paediatrics, Obstetrics and Gynaecology. 2007, SEP/OCT: 213-220. |
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Researcher
: Chan RWS |
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List of Research Outputs |
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Chan R.W.S., Role of Estrogen On Mouse Endometrial Epithelial Progenitor Proliferation, International Society of Stem Cell Research 2007. |
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Gargett C.E., Chan R.W.S. and Schwab K.E.,
Endometrial stem cells., Current Opinion In Obstetrics and Gynecology.
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Gargett C.E., Chan R.W.S. and Schwab K.E., Hormone
and growth factor signaling in endometrial renewal: Role of stem/progenitor
cells., Molecular and cellular endocrinology. |
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Project Title: |
The signaling pathways of L-SIGN in response to ligand binding |
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Investigator(s): |
Chan YK, Khoo |
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Department: |
Pathology |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
03/2007 |
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Abstract: |
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L-SIGN (liver/lymph node-specific ICAM-3
grabbing non-integrin) serves as a receptor for many of viral pathogens,
including HIV1;2, HCV3, Ebola virus4, and SARS coronavirus (SARS-CoV)5. Its
homologue, DC-SIGN, also serves as a receptor for many of the same viruses
and has been utilized by some of the pathogens to escape immuno-surveillance.
The binding sites of L-SIGN and DC-SIGN appear evolved to serve different
functions. DC-SIGN mediates trafficking as a recycling receptor, releasing
ligand at endosomal pH. In contrast, L-SIGN does not release ligands at
endosomal pH nor does it mediate endocytosis, which indicates that it only
functions as a binding receptor6. L-SIGN on transfected cells has been shown
to internalize HCV virus-like particles and traffic to either lysosomal or
non-lysosomal compartment depending on the cell type7. We speculate that
L-SIGN may have other un-explored functions and signaling events after L-SIGN
engagement with its ligand. Mitogen-activated protein kinases (MAPKs) are
signal transducers that respond to extracellular stimulations, such as
cytokines and viral infection. They in turn regulate cell differentiation,
proliferation, survival and apoptosis8-11. There are three distinct MAPK
cascades, extracellular signal-regulated kinases (ERK1/2), c-JUN N-terminal
kinases (JNK), and p38/MAPK. Phosphatidylinositol 3-kinase (PI3K) signaling
pathway also plays an important role in various cellular processes including
cell growth and survival, vesicular trafficking, etc12. One of the key
signaling molecules in the pathway is AKT which phosphorylates targets
including GSK-3, FKHR-L1 and BAD. SARS-CoV infected permissive Vero E6 cells
(which express the SARS-CoV receptor, ACE213) has been demonstrated to
activate the MAPK and PI3K/Atk signaling pathways14-16. p38/MAPK has been
shown to be activated during SARS-CoV viral replication |
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List of Research Outputs |
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Leung C.Y., Liu S., Chan Y.K., Tam K.F., Chan K.K.L., Wong R.L.C. and Ngan H.Y.S., Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer, Oncology Reports. 2008, 19: 1339-1345. |
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Researcher
: Chan YL |
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List of Research Outputs |
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Lee C.Y.L., Chan Y.L., Chow W.N., Ng E.H.Y., Lee C.K.F., Yeung W.S.B. and Ho P.C., Endocrine gland-derived vascular endothelial growth factor stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the mitogen-activated protein kinase but not through the Akt pathway., Fertility and Sterility. 2008. |
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Researcher
: Chan YM |
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List of Research Outputs |
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Lee A.H.K., Fong D.Y.T. and Chan Y.M., Psychometric Evaluation
of the Hong Kong Chinese Version of Functional Living Index - Cancer in |
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Researcher
: Cheong AWY |
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List of Research Outputs |
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Cheong
A.W.Y., Lee
C.Y.L., Liu W., Yeung W.S.B. and Lee C.K.F., Oviductal microsomal epoxide
hydrolase (Ephx1) enhances preimplantation embryo development by suppressing
reactiveoxygen species (ROS) production, Hong Kong Society of
Endocrinology, Metabolism and Reproduction, November 11, 2007, |
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Researcher
: Cheong KB |
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List of Research Outputs |
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Leung K.Y., Cheong K.B., Tang M.H.Y. and Chan V.N.Y., Prenatal diagnosis of thalassemia, Journal of Paediatrics, Obstetrics & Gynaecology. 2008, 34: 37-42. |
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Researcher
: Cheong WYA |
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List of Research Outputs |
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Cheong W.Y.A., Lee C.Y.L., Liu Y., Yeung W.S.B. and Lee C.K.F., Best poster presentation
award HKSEMR 2007- Oviductal microsomal epoxide hydrolase (Ephx1) enhances
preimplantation embryo development by suppressing reactiveoxygen species
(ROS) production. , The Annual Scientific Meeting of the Hong Kong Society
of Endocrinology, Metabolism and Reproduction, 11 November 2007, |
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Researcher
: Cheung TM |
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List of Research Outputs |
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Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Tang F.O.S. and Ho P.C., Randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, Fertility and Sterility. 2008, 89(5): 1147-1153. |
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Researcher
: Chiu CN |
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Project Title: |
Prevalence of
Y-chromosome AZFd microdeletion in |
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Investigator(s): |
Chiu CN, Ng EHY, Lee CKF, Yeung WSB |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
11/2004 |
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Abstract: |
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To determine the prevalence of AZFd
deletion in a Chinese population in |
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List of Research Outputs |
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Chiu C.N., Wong S.T., Lee C.L., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and Yeung W.S.B., Native human zona pellucida glycoproteins: purification and binding properties, Human Reproduction. 2008, 23: 1385. |
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Chiu
C.N., Wong B.S., Lee C.L., Chung M.K., Lam K.K., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and
Yeung W.S.B., Purification of native
human zona pellucida glycoproteins from eggs: Binding characteristics to
human spermatozoa, hyper-activation, acrosomal exocytosis, and sperm-oocyte
interaction. P.74, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
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Chung
M.K., Chiu C.N., Lam K.W., Lee C.L., Lee C.K.F. and Yeung W.S.B., Cumulus ooporous-associated
glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates
spermatozoa-zona pellucida binding. O.2.05, The 12th Research Postgraduate
Symposium, The |
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Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
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Chung
M.K., Chiu C.N., Lam K., Lee C.L., Pang R., Lee C.K.F. and Yeung W.S.B., Study of the interaction of
cumulus-associated alpha-2-macroglobulin with glycodelin-C from human cumulus
matrix. P. 196, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
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Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
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Lee
C.L., Chiu C.N., Chung M.K., Lam K.K., |
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Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
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Liu
V.W.S., Chan D.W., To M.Y., Chiu C.N. and Ngan H.Y.S., Forkhead box transcription
factor FoxG1 is over-expressed in ovarian cancer and can inhibit p21
expression, Annual Meeting of the American Association for Cancer
Research, April 12-16, 2008, |
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Pang
R.T.K., Liu W., Chiu C.N., Lee C.K.F. and Yeung W.S.B., Microrna regulates notch1
receptor in hela cells, Hong Kong Society of Endocrinology, Metabolism and
Reproduction, November 11, 2007, |
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Tam V.C.G., Chiu C.N., Koistinen R., Koistinen M., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Glycodelin-C receptor on human spermatozoa., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.459. |
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Wong B.S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
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Researcher
: Chow AMK |
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List of Research Outputs |
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Chow A.M.K., Choy M.Y. and Lao T.T.H., Effect of high glucose on cytokine profile in placental explants obtained from normal and gestational diabetic pregnancies, International Federation of Placenta Associations Meetings (13th Meeting) in Kingston, Ontario, Canada, August 16-23, 2007. |
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Chow A.M.K., Choy M.Y. and Lao T.T.H., Effect of lipopolysaccharide on secretory cytokine profile of placental explants from normal and gestational diabetic pregnancies, International Federation of Placenta Associations Meetings (13th Meeting) in Kingston, Ontario, Canada, August 16-23, 2007. |
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Researcher
: Chow WN |
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List of Research Outputs |
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Lee C.Y.L., Chan Y.L., Chow W.N., Ng E.H.Y., Lee C.K.F., Yeung W.S.B. and Ho P.C., Endocrine gland-derived vascular endothelial growth factor stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the mitogen-activated protein kinase but not through the Akt pathway., Fertility and Sterility. 2008. |
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Tse P.K., Lee Y.L., Chow W.N., Luk J.M.C., Lee K.F. and Yeung W.S.B., Preimplantation embryos cooperate with oviductal cells to produce embryotrophic inactivated complement-3b, Endocrinology. 2008, 149(3): 1268-1276. |
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Researcher
: Choy MY |
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Project Title: |
An investigation of human placental insulin degrading enzyme in normal and diabetic pregnancies |
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Investigator(s): |
Choy MY, Lao TTH |
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Department: |
Obstetrics & Gynaecology |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
10/2005 |
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Abstract: |
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Gestational diabetes mellitus (GDM)
affects 12% of pregnant women and is associated with perinatal complications
including macrosomia which is strongly associated with fetal death,
prematurity, birth trauma and respiratory distress syndrome. More
importantly, offspring of GDM have a higher risk of developing obesity,
impaired glucose tolerance, and type 2 diabetes mellitus (DM2).1 As the
interface between mother and fetus, the placenta is the obligatory target of
adverse environmental changes in diabetic pregnancies. Although it is
generally accepted that the hyperinsulinemia in DM2 is a compensatory
response to insulin resistance of target tissues, there is increasing
evidence that, at least in some populations, basal hyperinsulinemia itself
can have a primary role in the pathogenesis of DM2. Insulin resistance has
been reported to occur as a result of excessive insulin degradation.2 IDE
(insulin-degrading enzyme) is a widely expressed zinc-metallopeptidase that
has been shown to regulate both cerebral amyloid beta-peptide and plasma
insulin levels in vivo. In vitro, IDE not only degrades insulin and glucagon,
but also insulin growth factors I and II, the leader peptide of peroxysomal
prethiolase ,transforming growth factor , the ß-amyloid peptide, and other
peptides. |
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List of Research Outputs |
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Chow A.M.K., Choy M.Y. and Lao T.T.H., Effect of high glucose on cytokine profile in placental explants obtained from normal and gestational diabetic pregnancies, International Federation of Placenta Associations Meetings (13th Meeting) in Kingston, Ontario, Canada, August 16-23, 2007. |
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Chow A.M.K., Choy M.Y. and Lao T.T.H., Effect of lipopolysaccharide on secretory cytokine profile of placental explants from normal and gestational diabetic pregnancies, International Federation of Placenta Associations Meetings (13th Meeting) in Kingston, Ontario, Canada, August 16-23, 2007. |
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Choy
M.Y., Kwok
K.L. and Lao T.T.H., Effect of
hyperglycemia on insulin degrading enzyme and insulin receptor substrates 1
& |
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Researcher
: Chung MK |
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List of Research Outputs |
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Chiu
C.N., Wong B.S., Lee C.L., Chung M.K., Lam K.K., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and
Yeung W.S.B., Purification of native
human zona pellucida glycoproteins from eggs: Binding characteristics to
human spermatozoa, hyper-activation, acrosomal exocytosis, and sperm-oocyte
interaction. P.74, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Chung
M.K., Chiu
C.N., Lam K.W., Lee C.L., Lee C.K.F. and Yeung W.S.B., Cumulus ooporous-associated
glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates
spermatozoa-zona pellucida binding. O.2.05, The 12th Research Postgraduate
Symposium, The |
|
Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Chung
M.K., Chiu
C.N., Lam K., Lee C.L., Pang R., Lee C.K.F. and Yeung W.S.B., Study of the interaction of
cumulus-associated alpha-2-macroglobulin with glycodelin-C from human cumulus
matrix. P. 196, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Lee
C.L., Chiu C.N., Chung M.K., Lam K.K., |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Researcher
: Gao J |
|
List of Research Outputs |
|
Ng E.H.Y., So W.Z., Gao J., Wong Y.Y. and Ho P.C., The role of acupuncture in the management of subfertility, Fertility and Sterility. 2008, 90: 1-13. |
|
Researcher
: Ho PC |
|
Project Title: |
Endocrine gland derived vascular endothelial growth factor (EG-VEGF) in human endometrium |
|
Investigator(s): |
Ho PC, Ngan ESW, Ng EHY, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To examine the temporal and spatial expression pattern of EG-VEGF and its receptors in human endometrium; to elucidate the mitogenic and angiogenic properties of EG-VEGF in human endometrial microvascular endothelial cell (hEMVEC); to study the expression of EG-VEGF in patients with endometriosis. |
|
Project Title: |
Will letrozole improve the ovarian response in women with poor ovarian reserve who are undergoing IVF treatment? |
|
Investigator(s): |
Ho PC, Tang OS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
07/2005 |
|
Abstract: |
|
Letrozole is a non-steroidal reversible, competitive aromatase inhibitor that is highly potent and selective. It has a short half-life of around 45 hours (Sioufi et al., 1997). The rapid elimination from the body and the absence of estrogen receptor down-regulation effect as observed in clomiphene citrate treatment allow adequate time for the endometrium to regenerate from the anti-estrogen effect of the drug and therefore enhances implantation. The mechanism of action of letrozole in ovulation induction is proposed to be due to the selective inhibition of the aromatase enzyme that catalyzes the rate-limiting step in the conversion of androstenedione and testosterone to estrone and estradiol respectively. Treatment with an aromatase inhibitor in the early part of the menstrual cycle will decrease estrogen synthesis and hence the negative feedback centrally, resulting in increased gonadotrophin secretion. Moreover, by blocking the conversion of androgens to estrogens in the ovary, the accumulating intra-ovarian androgens may increase follicular sensitivity through amplification of FSH receptor gene expression (Weil et al., 1998; 1999; Vendola et al., 1998; 1999). |
|
Project Title: |
Role of olfactomedin in implantation |
|
Investigator(s): |
Ho PC, Lee CKF, Ng EHY, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To study the expression of olfactomedin in different phases of the reproductive cycle; to determine the site of olfactomedin biosynthesis; to study the role of steroid in the regulation of olfactomedin biosynthesis; to study the role of the molecule in embryo adhesion and trophoblast invasion. |
|
Project Title: |
A pilot study on the use of letrozole and misoprostol for the termination of second trimester pregnancy |
|
Investigator(s): |
Ho PC, Tang FOS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
Objectives: Misoprostol with or without
mifepristone has been used for medical abortion in the second trimester.
Pre-treatment with mifepristone resulted in a shorter induction-to-abortion
interval as compared with regimens without mifepristone (El-Rafaey et al,
1995; Ho et al, 1996; Wong et al, 2000; Ashok et al, 1999). Studies carried
out in early 1980s demonstrate that the efficacy of mifepristone alone in
inducing complete abortion in the first trimester is at most 60-80% in the
human. Dr Garfield R et al. have demonstrated recently that certain compounds
in combination with an antiprogestin can significantly improve abortifacient
efficacy. For example, when low doses of mifepristone (which alone have no
effect on pregnancy) have been combined with low doses iNOS inhibitors or
aromatase inhibitors or progesterone synthesis inhibitors, which again alone
have no effect, a tremendous synergistic effect has been seen in the mouse,
the rat and the guinea pig.(Garfield, unpublished) Abortion rates have been
up to 100%, there has been a complete evacuation of the uterus soon after the
treatment and the duration of bleeding has been surprisingly short. Letrozol
is an aromatase inhibitor used to treat estrogen-dependent breast cancer. It
is a third generation aromatase inhibitor. Aromatase, an enzyme of cytochorme
P450 superfamily and the product of CY195 gene, is highly expressed in the
placenta and granulosa cells of ovarian origin. Aromatase is also present in
several non-glandular tissue including subcutaneous fat, liver, muscle,
brain, normal breast, and breast-cancer tissue. Residual estrogen production
after menopause is solely from nonglandular sources (Miller et al, 1982 &
Nelson et al, 2001). In premenopausal women, the use of aromatase inhibitors
leads to an increase in gonadotropin secretion because of the reduced
feedback of estrogen to the hypothalamus and pituitary. The short-term
application of letrozole has recently been successful for the induction of
ovulation in women with infertility and dosage up to 7.5mg has been used
(Mitwally et al, 2002. Al-Fozan et al., 2004). Third generation aromatase
inhibitors have specific action at clinical doses and they have no effect on
basal levels of cortisol and aldosterone (Plourde et al, 1995; Bajetta et al,
2000 & Bisagni et al, 1996). Estrogen and progesterone are important
hormones for pregnancy. The use of aromatase inhibitor may cause a decrease
in estrogen production by the corpus luteum and the placenta and thus results
in abortion. The use of letrozole may potentiate the effect of prostaglandin
and thus, can shorten the induction to abortion interval and increase the
success rate. We are proposing a pilot study to investigate the effect of the
combination of letrozole and misoprostol in the termination of second
trimester pregnancy: a single dose of 7.5mg letrozol on Day 1 and Day 2
followed by repeated doses of 0.4 mg misoprostol from Day 3. The objective of
the present pilot study is to test whether the aromatase inhibitor,
letrozole, have a synergistic effect when used with misoprostol for the
termination of second trimester pregnancy in women at 12 to 20 weeks of
gestation. This treatment regimen will be studied and the following outcomes
will be assessed: (i) their capability of inducing abortion (ii) the
induction-to-abortion interval; and (iii) the frequency of side effects
Reference: 1. Al-Fozan H, Al-Khadouri M , Tan ST, Tulandi T. A randomized
trial of letrozole versus clomiphene citrate in women undergoing
superovulation. Fert. Steril. 2004, 84, 1561-3. 2. Ashok PW & Templeton
A. (1999) Nonsurgical mid-trimester termination of pregnancy: a review of 500
consecutive cases. Br J Obstet Gynaecol., 106, 706-10. 3. Bajetta E, Zilembo
N, Bischisao E, et al. (2000) Tumour response and estrogen suppression in
breast cancer patients treated with aromatase inhibitors. Ann Onco., 11,
1017-22. 4. Bisagni G, Cocconi G, Scaglione F, Fasichini F, Pfister C, Trunet
PF. Letrozole, a new oral non-steroidal aromatase inhibitor in treating
postmenopausal patients with advanced breast cancer: a pilot study. (1996)
Ann onco., 7, 99-102. 5. El-Rafaey H and Templeton A. (1995) Induction of
abortion in the second trimester by a combination of misoprostol and
mifepristone: a randomized comparison between two misoprostol regimens. Hum.
Reprod., 10, 475-8. 6. Ho PC, Chan YF, Lau W. (1996) Misoprostol is as
effective as gemeprost in termination of second trimester pregnancy when
combined with mifepristone: a randomized comparative trial. Contraception,
53, 281-3. 7. Miller WR, Hawkins RA, Forrest AP. (1982) Significance of
aromatase inhibitors in human breast cancer. Cancer Res., 42 suppl,
3365s-3368s. 8. Nelson LR, Bulun SE. Estrogen production and action. (2001) J
Am Acad Dermatol., 45 suppl: S116-S124. 9. Mitwally MF, Casper RF. (2002)
Aromatase inhibitor for ovarian stimulation: future avenue for infertility
management. Curr Opin Obstet Gynecol., 14, 255-63. 10 Plourde PV, Dyroff M,
Dowsett M. Demers L, Yates R, Webster A. (1995) ARIMIDEX: a new oral,
once-a-day aromatase inhibitor. J Steroid Biochem Mol Biol., 53, 175-9. 11. |
|
Project Title: |
Adrenomedullin and sperm functions |
|
Investigator(s): |
Ho PC, Yeung WSB, Chiu CN, Lee CKF, Tang F |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To determine the effect of adrenomedullin on sperm functions; to study the effect of adrenomedullin on the spermatozoa from patients with mild fertilization problem; to investigate the signaling pathways of adrenomedullin in spermatozoa. |
|
List of Research Outputs |
|
Blum J., Winikoff B., Gemzell-Danielsson K., Ho P.C., Schiavon R. and Weeks A., Treatment of incomplete abortion and miscarriage with misoprostol, International Journal of Gynecology and Obstetrics. 2007, 99 (Supplement 2): S186-S189. |
|
Chan V.N.Y., Ng E.H.Y., Yeung W.S.B., Yam I.Y.L., Chan T.K. and Ho P.C., Preimplantation genetic diagnosis of thalassaemias, 11th Congress of the International Society of Hematology, Asian-Pacific Division (ISH-APD2007) and the 12th Congress of the Asian-Pacific Bone Marrow Transplantation, Beijing, China, September 21-23. 2007. |
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Gemzell-Danielsson K., Ho P.C., Gomez Ponce de Leon R., Weeks A. and Winikoff B., Misoprostol to treat missed abortion in the first trimester, International Journal of Gynecology and Obstetrics. 2007, 99 (Supplement 2): S182-S185. |
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Ho P.C., "New frontiers of assisted reproductive technology", CT Hsu Memorial Lecture, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, AOCOG 2007 Golden Jubilee of Federation, September 21-25, 2007, Tokyo, Japan. 2007. |
|
Ho P.C., Associate Editor, Human Reproduction. 2007. |
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Ho P.C., Director of Editorial Board in Obstetrics and Gynaecology, Journal of Paediatrics, Obstetrics and Gynaecology, 1997 till now. 2007. |
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Ho P.C., Emergency contraception: Does improved access reduce the pregnancy rate?, Gynecological Endocrinology. 2007, 23(9): 497-498. |
|
Ho
P.C., Hong Kong experience with misoprostol
alone, Meeting on Strategies and Guidelines for the Safe Second Trimester
Abortion in |
|
Ho P.C. and Hui P.W., Limitations of first trimester screening for Trisomy 21 after IVF, 2007 Annual Scientific Meeting, The Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Queensland, Australia, October 2-5, 2007. 2007. |
|
Ho
P.C., Management of infertility in PCOS, Scientific
Symposium of "Innovative Approaches to Women's Health", |
|
Ho P.C., Management of subfertility in polycystic ovary syndrome, 41st Annual Scientific Sessions 2008, Sri Lanka College of Obstetricians and Gynaecologists, Sri Lanka, June 27-29, 2008, 30(Suppl):6-7. 2008. |
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Ho P.C., Member of Editorial Board, "Hospital Practice and Infection Control", 1989 till now. 2008. |
|
Ho P.C., Member of Editorial Board, Chinese Journal of Obstetrics and Gynaecology. 2007. |
|
Ho P.C., Member of Editorial Board, Clinical Obstetrics and Gynaecology (Bailliere Tindall). 2007. |
|
Ho P.C., Member of Editorial Board, Journal of Assisted Reproduction and Genetics. 2007. |
|
Ho P.C., Member of Editorial Board, Journal of Practical Obstetrics and Gynaecology. 2007. |
|
Ho
P.C., Member of Editorial Board, Journal
of Reproductive Medicine ( |
|
Ho
P.C., Member of the Advisory Editorial
Board, Asia |
|
Ho P.C., Misoprostol - An essential drug in Obstetrics and Gynaecology, William Meredith Fletcher Shaw Memorial Lecture , 31st The British International Congress of Obstetrics and Gynaecology, July 4-6, 2007, Excel, London, United Kingdom, S.2.5. 2007. |
|
Ho P.C., Blumenthal P.D., Gemzell-Danielsson K., Gomez Ponce de Leon R., Mittal S. and Tang F.O.S., Misoprostol for the termination of pregnancy with a live fetus at 13 to 26 weeks, International Journal of Gynecology and Obstetrics. 2007, 99 (Supplement 2): S178-S181. |
|
Ho P.C., Ovarian stimulation and endometrial receptivity, Abstract in the 2008 Beijing International Congress on Human Reproductive Medicine and the 20th Anniversary Celebration for the Birth of First IVF-baby on China's Mainland, Beijing, China, February 24-26, 2008. |
|
Ho P.C., Recent advances of medical abortion (PS99), Gynecological Endocrinology. 2008, 24 (Supplement No.1): 57. |
|
Ho
P.C., Recent advances of medical abortion, 13th
World Congress of Gynecological Endocrinology, |
|
Ho P.C., Reviewer for "American Journal of Obstetrics and Gynaecology". 2008. |
|
Ho P.C., Reviewer for "Biology of Reproduction". 2008. |
|
Ho P.C., Reviewer for "Obstetrics and Gynaecology". 2008. |
|
Lee C.Y.L., Chan Y.L., Chow W.N., Ng E.H.Y., Lee C.K.F., Yeung W.S.B. and Ho P.C., Endocrine gland-derived vascular endothelial growth factor stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the mitogen-activated protein kinase but not through the Akt pathway., Fertility and Sterility. 2008. |
|
Leung W.C., Lam Y.H., Leung T.W. and Ho P.C., A pilot study on the prevalence of domestic violence against male partners of pregnant women in Hong Kong, The Hong Kong Medical Diary. 2007, 12(7): 25-27. |
|
Liu
Y., Ng E.H.Y., Yeung W.S.B., Ho P.C. and Lee C.K.F., The expression and
functional studies of DKK1 and Wnt signaling molecules in human endometrium
and embryo implantation. O2.16., The 12th Research Postgraduate Symposium,
The University of Hong Kong, December 12-14, 2007, |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., Comparison of 2-Dimensional, 3-Dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles, Journal of Ultrasound In Medicine. 2007, 26(7): 931-939. |
|
Ng E.H.Y. and Ho P.C., Polycystic ovary syndrome in Asian women, Seminar In Reproductive Medicine. 2008, 26: 14-21. |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Tang F.O.S. and Ho P.C., Randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, Fertility and Sterility. 2008, 89(5): 1147-1153. |
|
Ng E.H.Y., So W.Z., Gao J., Wong Y.Y. and Ho P.C., The role of acupuncture in the management of subfertility, Fertility and Sterility. 2008, 90: 1-13. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., The role of endometrial blood flow measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during in vitro fertilization treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 135: 8-16. |
|
Ng P.P.Y., Tang M.H.Y., Lau E.T.K., Ng L.K.L., Ngan E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Chromosome anomalies and Y-microdeletions in subfertile men (Poster), The ACAG-HKSMG International Conference, Hong Kong, 11 June 2008. |
|
Ng P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Differential gene expression of olfactomedin throughout the menstrual cycle is regulated by ovarian hormones., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.508. |
|
Tam V.C.G., Chiu C.N., Koistinen R., Koistinen M., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Glycodelin-C receptor on human spermatozoa., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.459. |
|
Tang F.O.S., Gemzell-Danielsson K. and Ho P.C., Misoprostol: Pharmacokinetic profiles, effects on the uterus and side-effects, International Journal of Gynecology and Obstetrics. 2007, 99, Supplement 2: S160-S167. |
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Tang F.O.S., Vekemans M., Hertzen H. and Ho P.C., Termination of pregnancy in the first trimester with misoprostol alone, International Planned Parenthood Federation Medical Bulletin. 2008, 42(1): 3-4. |
|
Tiwari
A.F.Y., Fong D.Y.T., Chan E.K.L., Leung W.C., Parker B. and Ho P.C., Identifying intimate partner
violence: Comparing the Chinese Abuse Assessment Screen with the Chinese
Revised Conflict Tactics Scales, The 12th International Conference on
Violence Abuse and Trauma. |
|
Tiwari
A.F.Y., Fong D.Y.T., Chan E.K.L., Leung W.C., Parker B. and Ho P.C., Identifying intimate partner
violence: comparing the Chinese abuse assessment screen with the Chinese revised
conflict tactics scales, British Journal of Obstetrics and Gynaecology.
|
|
Tiwari A.F.Y., Wong J.Y.H., Fong D.Y.T., Chan E.K.L., Leung W.C., Brownridge D.A. and Ho P.C., Intimate partner violence in obstetric/gynecology patients: a Chinese perspective, Expert Review of Obstetrics & Gynecology. 2008, 3(3): 317-330. |
|
Tiwari A.F.Y., Chan E.K.L., Fong D.Y.T., Brownridge D.A., Lam H., Wong B., Lam C.M., Chan F., Chan A., Cheung K.B. and Ho P.C., The impact of psychological abuse by an intimate partner on the mental health of pregnant women, BJOG. Blackwell, 2008, 115: 377-384. |
|
Wong B.S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Yao Y.Q., Lee C.K.F., Xu J.S., Ho P.C. and Yeung W.S.B., Effect of human oviductal embryotrophic factors on gene expression of mouse preimplantation embryos, Zhonghua Fu Chan Ke Za Zhi (Chinese). 2007, 42(9): 605-607. |
|
Researcher
: Hui PW |
|
List of Research Outputs |
|
Ho P.C. and Hui P.W., Limitations of first trimester screening for Trisomy 21 after IVF, 2007 Annual Scientific Meeting, The Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Queensland, Australia, October 2-5, 2007. 2007. |
|
Hui P.W., Leung W.C., Au W.Y., Chan C.P. and Lao T.T.H., A rare cause of thrombocytopenia in pregnancy – EDTA-dependent pseudothrombocytopenia, 31st British International Congress of Obstetrics and Gynaecology, 3 – 6 July 2007, London, United Kingdom. 2007. |
|
Hui
P.W. and Ngan
H.Y.S., Discipline-based examination and generic assessment principles, 5th
Asia Pacific Medical Education Conference (APMEC), 24-27 January, 2008, |
|
Hui P.W., Lam T.P.W., Chan K.L. and Lee C.P., Fetus in Fetu - from prenatal ultrasound and MRI diagnosis to postnatal confirmation, Prenatal Diagnosis. 2007, Issue 7, 27: 657 -661. |
|
Researcher
: Kwan TTC |
|
List of Research Outputs |
|
Kwan T.T.C., Chan K.K.L., Yip M.W., Tam K.F., Cheung A.N.Y., Young P.M.C., Lee P.W.H. and Ngan H.Y.S., Barriers and facilitators to human papillomavirus vaccination among Chinese adolescent girls in Hong Kong: a qualitative–quantitative study, Sex Transm Infect. 2008, 84(3): 227-232. |
|
Ngan H.Y.S., Kwan T.T.C., Tam K.F., Chan K.K.L., Young P.M., Lo S.S., Cheung A.N.Y. and Lee P.W.H., Knowledge and attitute of Chinese women on cervical cancer and human papillomavirus, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, September 21-25, 2007, Tokyo, Japan. 2007. |
|
Researcher
: Kwok KL |
|
List of Research Outputs |
|
Choy
M.Y., Kwok K.L. and Lao T.T.H., Effect of hyperglycemia on
insulin degrading enzyme and insulin receptor substrates 1 & |
|
List of Research Outputs |
|
Lee C.K.F., Wong B.P.C., Lai K.Y. and Yeung W.S.B., Cloning and characterization of oviductal demilune cell and parotid protein (Dcpp) gene promoter., The 23rd Annual Meeting of the european Society of Human Reproduction and Embryology. 2007. |
|
Lee C.K.F., Wong B.P.C., Lai K.Y. and Yeung W.S.B., Cloning and characterization of oviductal demilune cell and parotid protein (Dcpp) gene promoter, The 23rd Annual Meeting of the european Society of Human Reproduction and Embryology. 2007. |
|
Researcher
: Lam KW |
|
List of Research Outputs |
|
Chung
M.K., Chiu C.N., Lam K.W., Lee C.L., Lee C.K.F. and Yeung W.S.B., Cumulus ooporous-associated
glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates
spermatozoa-zona pellucida binding. O.2.05, The 12th Research Postgraduate
Symposium, The |
|
Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Ip P.P.C., Lam K.W., Cheung C.L., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid-associated Necrosis and Intralesional Thrombosis of Uterine Leiomyomas: A Clinicopathologic Study of 147 Cases Emphasizing the Importance of Drug-induced Necrosis and Early Infarcts in Leiomyomas , American Journal of Surgical Pathology. 2007, 31(8): 1215-1224. |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Researcher
: Lam KW |
|
List of Research Outputs |
|
Chung
M.K., Chiu C.N., Lam K.W., Lee C.L., Lee C.K.F. and Yeung W.S.B., Cumulus ooporous-associated
glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates
spermatozoa-zona pellucida binding. O.2.05, The 12th Research Postgraduate
Symposium, The |
|
Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Ip P.P.C., Lam K.W., Cheung C.L., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid-associated Necrosis and Intralesional Thrombosis of Uterine Leiomyomas: A Clinicopathologic Study of 147 Cases Emphasizing the Importance of Drug-induced Necrosis and Early Infarcts in Leiomyomas , American Journal of Surgical Pathology. 2007, 31(8): 1215-1224. |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Researcher
: Lao TTH |
|
Project Title: |
Dietary caloric intake and the development of gestational diabetes mellitus in at-risk Chinese women |
|
Investigator(s): |
Lao TTH, Leung WC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To determine the relationship between daily total caloric intake in the third trimester and the development of gestational diabetes mellitus in at-risk pregnant Chinese women; to compare the roles of toal caloric intake versus the carbohydrate: protein: fat ratio in the daily diet and development of gestational diabetes mellitus in the at-risk Chinese women. |
|
Project Title: |
The role of adiponectin in the development of gestational diabetes mellitus and its effect on pregnancy outcome |
|
Investigator(s): |
Lao TTH, Lam KSL, Chan KKL |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To determine if plasma adiponectin concentration is reduced, at the time of the oral glucose tolerance test (OGTT), in women who develop GDM in the latter half of pregnancy versus women with normal OGTT; to determine, following the diagnosis of GDM, whether the subsequent changes in adiponectin concentration is associated with obstetric complications and perinatal morbidity; to correlate circulatory concentration of adiponectin with polymorphisms and mutations in the apM1 gene in high risk women with and without GDM, and with the expression of adiponectin in subcutaneous and omental fat cells obtained from biopsy at the time of caesarean delivery for obstetric indications; to correlate antenatal adiponectin concentration and result of the genetic study with the postnatal glucose tolerance status in the women who have developed GDM. |
|
Project Title: |
A study on the interrelationship among insulin-like growth factors, apoptosis and proliferation of trophoblast, and placental size throughout pregnancy, and their effects on infant outcome, in normal and diabetic pregnancies |
|
Investigator(s): |
Lao TTH, Cheung PT, Cheung ANY, Leung WC, Lam HSW |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2003 |
|
Abstract: |
|
To compare in the normal and diabetic pregnancies the relationship between ultrasound-estimated placenta size and its vasculature, and fetal size, with maternal circulatory levels of IGFs and IGFBPs in the three trimesters; to compare in the normal and diabetic pregnancies the relationship among placental expression of IGFs with placental apoptotic and proliferative indices and placental size at the time of delivery; to determine whether the interactions between IGFs and IGFBPs with placental growth and size in the different trimesters can be predictive of obstetric and perinatal complications; to determine whether the interactions between IGFs and IGFBPs with placental growth and size in the different trimesters can be predictive of fetal growth and size at birth; to examine the relationship between placental and newborn size with the placental expression of IGFs as well as the apoptotic and proliferative indices in normal and diabetic pregnancies. |
|
Project Title: |
Elevated TNF-α in gestational diabetes mellitus-cause or consequence? |
|
Investigator(s): |
Lao TTH, Leung WC, Ngai CSW |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To determine and compare the serial changes in maternal blood level of TNF-α and its receptors, C-reactive protein (CRP) , and ferritin in relation to the development of gestational diabetes mellitus (GDM) in Chinese pregnant women with singleton and twin pregnancies; to determine the relationship between changes in maternal blood level of TNF-α and its receptors, CRP and ferritin with the occurrence of complicantions in Chinese pregnant women with and with and without GDM, and whether there is any difference between singleton and twin pregnancies. To correlate the levels of TNF-α and its receptors between maternal blood with cord blood, and between these two compartments with placental size and the placental expression of TNF-α and its receptors. To correlate maternal and cord blood, and placental TNF-α and its receptors with the infant birthweight and development of perinatal complications, and the determine if there is any difference between singleton and twin pregnancies. |
|
Project Title: |
The relationship between the antioxidant defense system with the development of gestational diabetes mellitus and its complications in the Chinese population. |
|
Investigator(s): |
Lao TTH |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Gestational diabetes mellitus (GDM) has become the leading medical complication in pregnancy in the local Chinese population, and despite satisfactory glycaemic control, maternal and perinatal complications cannot be eliminated. One of the metabolic disturbances now documented with diabetes mellitus in non-pregnant subjects is an increased oxidative stress. The standard approach in the management of GDM is to normalize blood glucose level with dietary and insulin treatment, but this may not be sufficient to counter the increased oxidative stress, and the persistent risk of maternal and perinatal complications could be related to inadequate defense against the increased oxidative stress in GDM. There has been minimal information about the natural antioxidant defense systems, such as the enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and especially thioredoxin reductase (TRx), in pregnancy with and without GDM, and there is no information on these systems in the infant at the time of birth. These enzyme systems are present in the placenta and can also be measured in peripheral blood. The present study is designed to investigate (1) the maternal antioxidant defense systems at the time of diagnosis of GDM, comparing between women with normal and abnormal glucose tolerance; (2) and its subsequent changes in relation to treatment and glycaemic control, (3) the changes in relation to pregnancy complications in women with and without GDM; and (4) the changes in the fetal compartment as reflected in cord blood and placental tissue. |
|
List of Research Outputs |
|
Chan C.P. and Lao T.T.H., Effect of parity and advanced maternal age on obstetric outcome, International Journal of Gynecology and Obstetrics. Elsevier Ireland Limited, 2008, 102: 237-241. |
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Chow A.M.K., Choy M.Y. and Lao T.T.H., Effect of high glucose on cytokine profile in placental explants obtained from normal and gestational diabetic pregnancies, International Federation of Placenta Associations Meetings (13th Meeting) in Kingston, Ontario, Canada, August 16-23, 2007. |
|
Chow A.M.K., Choy M.Y. and Lao T.T.H., Effect of lipopolysaccharide on secretory cytokine profile of placental explants from normal and gestational diabetic pregnancies, International Federation of Placenta Associations Meetings (13th Meeting) in Kingston, Ontario, Canada, August 16-23, 2007. |
|
Choy
M.Y., Kwok K.L. and Lao T.T.H., Effect of hyperglycemia
on insulin degrading enzyme and insulin receptor substrates 1 & |
|
Hui P.W., Leung W.C., Au W.Y., Chan C.P. and Lao T.T.H., A rare cause of thrombocytopenia in pregnancy – EDTA-dependent pseudothrombocytopenia, 31st British International Congress of Obstetrics and Gynaecology, 3 – 6 July 2007, London, United Kingdom. 2007. |
|
Lao T.T.H., Gestational Diabetes Mellitus - An Overview, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, September 21-25, 2007, Tokyo, Japan. 2007. |
|
Lao
T.T.H. and Ho L.F., Impact of
chorioamnionitis on perinatal outcome in gestational diabetic pregnancies, International
Federation of Placenta Associations Meetings (13th Meeting) in |
|
Lao T.T.H., Chan C.P., Leung W.C., Ho L.F. and Tse K.Y., Maternal hepatitis B infection and gestational diabetes mellitus, Journal of Hepatology. 2007, 47(1): 46-50. |
|
Lao T.T.H. and Ho L.F., Relationship between chorioamnionitis and glycemic control in gestational diabetic pregnancies, International Federation of Placenta Associations Meetings (13th Meeting) in Kingston, Ontario, Canada, August 16-23, 2007. |
|
Lee
C.L., Chiu C.N., Chung M.K., Lam K.K., |
|
Leung W.C., Lau E.T.K., Lau W.L., Tang R., Wong S.F., Lau T.K., Tse K.T., Wong S.F., To W.W.K., Ng L.K.L., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?, Hong Kong Medical Journal. 2008, 14(1): 6-13. |
|
Researcher
: Lau ETK |
|
List of Research Outputs |
|
Leung W.C., Lau E.T.K., Lau W.L., Tang R., Wong S.F., Lau T.K., Tse K.T., Wong S.F., To W.W.K., Ng L.K.L., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?, Hong Kong Medical Journal. 2008, 14(1): 6-13. |
|
Ng P.P.Y., Tang M.H.Y., Lau E.T.K., Ng L.K.L., Ngan E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Chromosome anomalies and Y-microdeletions in subfertile men (Poster), The ACAG-HKSMG International Conference, Hong Kong, 11 June 2008. |
|
Researcher
: Lau EYL |
|
List of Research Outputs |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Tang F.O.S. and Ho P.C., Randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, Fertility and Sterility. 2008, 89(5): 1147-1153. |
|
Researcher
: Lau WL |
|
List of Research Outputs |
|
Leung W.C., Lau E.T.K., Lau W.L., Tang R., Wong S.F., Lau T.K., Tse K.T., Wong S.F., To W.W.K., Ng L.K.L., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?, Hong Kong Medical Journal. 2008, 14(1): 6-13. |
|
Researcher
: Lee CKF |
|
Project Title: |
Identification of implantation-related genes in mouse uterus: an genomic approach |
|
Investigator(s): |
Lee CKF, Yeung WSB, Yang ZM |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To identify genes that are more directly related to implantation by using LCM. mRNA from specific endometrial cells around the implantation sites of mouse at Day 5.5 of pregnancy will be compared with endometrial cells at the inter-implantation site of the deciduas. |
|
Project Title: |
The molecular interaction between human oviductal embryotrophic factor-3 and embryo |
|
Investigator(s): |
Lee CKF, Luk JMC, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To compare the fecundity of normal and C3-deficient mice; to determine the role of complement activation in the embryotrophic activity of C3; to determine the machinery for the conversion of C3/C3 to iC3b in the oviduct cell coculture system; to define the fragment of iC3b responsible for the embryotrophic activity of the molecule. |
|
Project Title: |
Cloning and functional characterization of demilune cell and parotid protein (Dcpp) gene promoter |
|
Investigator(s): |
Lee CKF, Yeung WSB |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2006 |
|
Abstract: |
|
The objectives of my proposal are (1) to
isolate the promoter region of the mouse demilune cell and parotid protein
(Dcpp) gene promoter, and (2) to characterise the hormonal regulation of the
isolated promoter regions by transfection studies. Demiline cell and parotid
protein (acc. no.: NM_019910, Dcpp, as named as p20) was first isolated from
both sublingual demilune cells and parotid intercalated duct cells in mouse
salivary glands [1] and shared very high homology (99% aa identity) with the
common salivary gland 1 (acc. no.: S76879, CSP1) protein. The gene coding for
Dcpp was located on chromosome |
|
Project Title: |
Functional characterization of VAD1.3, a novel acrosome-specific protein by conditional tissue-specific gene inactivation |
|
Investigator(s): |
Lee CKF, Cheah KSE, Yeung WSB, Luk JMC, Lee PY |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To generate VAD1.3 knockout targeting construct; to generate VAD1.3 knockout mice; to produce antibodies against mouse VAD1.3; to analysis the VAD1.3 knockout mice. |
|
Project Title: |
Functional characterization of a testis-specific Trs4 gene on spermatogenesis by tissue-specific conditional inactivation |
|
Investigator(s): |
Lee CKF, Yeung WSB, Cheah KSE |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To characterize monoclonal antibodies against TRS4; to determine the interacting partners of TRS4; to generate TRS4 conditional knockout targeting construct; to generate TRS4 conditional knockout mice; to phenotype the TRS4 knockout mice. |
|
List of Research Outputs |
|
Aflatoonian R., Ward J., Lee C.K.F., Yeung W.S.B., Tsao S.W., Elliott S. and
Fazeli A., Sex hormones enhance TLR3 response to its specific ligand in human
fallopian tube epithelial cells. P.608, The Society for the Study of
Reproduction 41st Annual meeting, May 27-30, 2008, |
|
Cheong
A.W.Y., Lee C.Y.L., Liu W., Yeung W.S.B. and Lee C.K.F., Oviductal microsomal
epoxide hydrolase (Ephx1) enhances preimplantation embryo development by
suppressing reactiveoxygen species (ROS) production, Hong Kong Society of
Endocrinology, Metabolism and Reproduction, November 11, 2007, |
|
Cheong
W.Y.A., Lee C.Y.L., Liu Y., Yeung W.S.B. and Lee C.K.F., Best poster presentation
award HKSEMR 2007- Oviductal microsomal epoxide hydrolase (Ephx1) enhances
preimplantation embryo development by suppressing reactiveoxygen species
(ROS) production. , The Annual Scientific Meeting of the Hong Kong Society
of Endocrinology, Metabolism and Reproduction, 11 November 2007, |
|
Chiu C.N., Wong S.T., Lee C.L., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and Yeung W.S.B., Native human zona pellucida glycoproteins: purification and binding properties, Human Reproduction. 2008, 23: 1385. |
|
Chiu
C.N., Wong B.S., Lee C.L., Chung M.K., Lam K.K., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K.
and Yeung W.S.B., Purification of
native human zona pellucida glycoproteins from eggs: Binding characteristics
to human spermatozoa, hyper-activation, acrosomal exocytosis, and sperm-oocyte
interaction. P.74, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Chung
M.K., Chiu C.N., Lam K.W., Lee C.L., Lee C.K.F. and Yeung W.S.B., Cumulus ooporous-associated
glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates
spermatozoa-zona pellucida binding. O.2.05, The 12th Research Postgraduate
Symposium, The |
|
Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Chung
M.K., Chiu C.N., Lam K., Lee C.L., Pang R., Lee C.K.F. and Yeung W.S.B., Study of the interaction of
cumulus-associated alpha-2-macroglobulin with glycodelin-C from human cumulus
matrix. P. 196, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Lee C.K.F., Wong B.P.C., Lai K.Y. and Yeung W.S.B., Cloning and characterization of oviductal demilune cell and parotid protein (Dcpp) gene promoter., The 23rd Annual Meeting of the european Society of Human Reproduction and Embryology. 2007. |
|
Lee C.K.F., Wong B.P.C., Lai K.Y. and Yeung W.S.B., Cloning and characterization of oviductal demilune cell and parotid protein (Dcpp) gene promoter, The 23rd Annual Meeting of the european Society of Human Reproduction and Embryology. 2007. |
|
Lee
C.K.F., Zuo
Y., Tam B.Y., Tang A.Y.B. and Yeung W.S.B., Syntaxin and b-actin
interact with acrosome-expressing protein VAD1.2/AEP |
|
Lee
C.K.F., Zuo
Y., Tam Y.T., Tang A.Y.B. and Yeung W.S.B., The acrosome-expressing
proteins VAD1.3/AEP1 and VAD1.2 interact with syntaxin and b-acting in
vitro., The |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Lee
C.L., Chiu C.N., Chung M.K., Lam K.K., |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Lee C.Y.L., Liu Y., Ng P.Y., Lee C.K.F., Au C.L., Ng E.H.Y. and Yeung W.S.B., Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation, Human Reproduction. 2008, 23: 894-903. |
|
Lee C.Y.L., Chan Y.L., Chow W.N., Ng E.H.Y., Lee C.K.F., Yeung W.S.B. and Ho P.C., Endocrine gland-derived vascular endothelial growth factor stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the mitogen-activated protein kinase but not through the Akt pathway., Fertility and Sterility. 2008. |
|
Lin S.S.W., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Microrna expression profile and their regulatory roles in ovarian folliculogenesis , Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Liu
Y., Ng E.H.Y., Yeung W.S.B., Ho P.C. and Lee C.K.F., The expression and
functional studies of DKK1 and Wnt signaling molecules in human endometrium
and embryo implantation. O2.16., The 12th Research Postgraduate Symposium,
The University of Hong Kong, December 12-14, 2007, |
|
Monkkonen K.S., Aflatoonian R., Lee C.K.F., Yeung W.S.B., Tsao G.S.W., Laitinen J.T. and Fazeli A., Hormonal regulation of G{alpha}i2 and mPR{alpha} in immortalized human oviductal cell line OE-E6/E7., Mol Hum Reprod. 2007, 13: 845-51. |
|
Ng P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Differential gene expression of olfactomedin throughout the menstrual cycle is regulated by ovarian hormones., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.508. |
|
Pang
R.T.K., Liu W., Chiu C.N., Lee C.K.F. and Yeung W.S.B., Microrna regulates notch1
receptor in hela cells, Hong Kong Society of Endocrinology, Metabolism and
Reproduction, November 11, 2007, |
|
Tam V.C.G., Chiu C.N., Koistinen R., Koistinen M., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Glycodelin-C receptor on human spermatozoa., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.459. |
|
Wong B.S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Yan Z., Tam Y.T., Cheah K.S.E., Yeung W.S.B. and Lee C.K.F., Functional characterization of VAD 1.3 /AEP 1 Gene in acrosome-formation and fertility, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Yao Y.Q., Lee C.K.F., Xu J.S., Ho P.C. and Yeung W.S.B., Effect of human oviductal embryotrophic factors on gene expression of mouse preimplantation embryos, Zhonghua Fu Chan Ke Za Zhi (Chinese). 2007, 42(9): 605-607. |
|
Zuo
Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional
characterization of VAD1.3/AEP1 gene in acrosome-formation and fertility.
O2.15., The 12th Research Postgraduate Symposium, The University of Hong
Kong, December 12-14, 2007, |
|
Researcher
: Lee CL |
|
List of Research Outputs |
|
Chiu C.N., Wong S.T., Lee C.L., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and Yeung W.S.B., Native human zona pellucida glycoproteins: purification and binding properties, Human Reproduction. 2008, 23: 1385. |
|
Chiu
C.N., Wong B.S., Lee C.L.,
Chung M.K., Lam K.K., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and
Yeung W.S.B., Purification of native
human zona pellucida glycoproteins from eggs: Binding characteristics to
human spermatozoa, hyper-activation, acrosomal exocytosis, and sperm-oocyte
interaction. P.74, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Chung
M.K., Chiu C.N., Lam K.W., Lee C.L., Lee C.K.F. and Yeung W.S.B., Cumulus ooporous-associated
glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates
spermatozoa-zona pellucida binding. O.2.05, The 12th Research Postgraduate
Symposium, The |
|
Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Chung
M.K., Chiu C.N., Lam K., Lee C.L., Pang R., Lee C.K.F. and Yeung W.S.B., Study of the interaction of
cumulus-associated alpha-2-macroglobulin with glycodelin-C from human cumulus
matrix. P. 196, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Lee
C.L., Chiu
C.N., Lam K.W., Chung M.K., |
|
Lee
C.L., Chiu
C.N., Chung M.K., Lam K.K., |
|
Lee
C.L., Chiu
C.N., Lam K.W., Chung M.K., |
|
Researcher
: Lee CL |
|
List of Research Outputs |
|
Chiu C.N., Wong S.T., Lee C.L., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and Yeung W.S.B., Native human zona pellucida glycoproteins: purification and binding properties, Human Reproduction. 2008, 23: 1385. |
|
Chiu
C.N., Wong B.S., Lee C.L.,
Chung M.K., Lam K.K., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and
Yeung W.S.B., Purification of native
human zona pellucida glycoproteins from eggs: Binding characteristics to
human spermatozoa, hyper-activation, acrosomal exocytosis, and sperm-oocyte
interaction. P.74, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Chung
M.K., Chiu C.N., Lam K.W., Lee C.L., Lee C.K.F. and Yeung W.S.B., Cumulus ooporous-associated
glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates
spermatozoa-zona pellucida binding. O.2.05, The 12th Research Postgraduate
Symposium, The |
|
Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Chung
M.K., Chiu C.N., Lam K., Lee C.L., Pang R., Lee C.K.F. and Yeung W.S.B., Study of the interaction of
cumulus-associated alpha-2-macroglobulin with glycodelin-C from human cumulus
matrix. P. 196, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Lee
C.L., Chiu
C.N., Lam K.W., Chung M.K., |
|
Lee
C.L., Chiu
C.N., Chung M.K., Lam K.K., |
|
Lee
C.L., Chiu
C.N., Lam K.W., Chung M.K., |
|
Researcher
: Lee CP |
|
List of Research Outputs |
|
Hui P.W., Lam T.P.W., Chan K.L. and Lee C.P., Fetus in Fetu - from prenatal ultrasound and MRI diagnosis to postnatal confirmation, Prenatal Diagnosis. 2007, Issue 7, 27: 657 -661. |
|
Researcher
: Lee CYL |
|
Project Title: |
Effects of C3 deficiency on preimplantation embryo development and implantation potential |
|
Investigator(s): |
Lee CYL, Yeung WSB, Lee CKF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2005 |
|
Abstract: |
|
Coculture of embryo with somatic cells is one of the methods to promote embryo development in vitro. We have shown previously that human oviductal epithelial cells secrete embryotrophic glycoproteins that stimulate the growth of mouse preimplantation embryos in vitro (1, 2). Embryotrophic factor-3 (ETF-3) is one of these factors. ETF-3. It enhances the development of mouse blastocysts resulting in blastocysts with more trophectoderm (TE) cells, larger diameter, higher hatching rate and hatched blastocyst with higher attachment potential and larger trophoblast outgrowth (3, 4). It also affects the expression of a number of genes (NKA-beta 1, PAR-2, cullin-1, ezrin, HSP-70, eIF-2 beta) in the treated blastocysts. Our laboratory recently identified ETF-3 to be complement 3. Its derivative, iC3b increases the preimplantation mouse embryo development in terms of higher blastulation rate, higher hatching rate and larger blastocyst size (5). The objective of this project is to study the effect of C3 knockout in the mouse on the development of the embryo. Similar study in human is difficult, if not impossible. 1. L. P. Liu, S. T. Chan, P. C. Ho, W. S. Yeung, Hum. Reprod 10, 2781 (1995). 2. L. P. Liu, S. T. Chan, P. C. Ho, W. S. Yeung, Hum. Reprod 13, 1613 (1998). 3. J. S. Xu, T. M. Cheung, S. T. Chan, P. C. Ho, W. S. Yeung, Biol Reprod 65, 1481 (2001). 4. Y. L. Lee et al., Biol Reprod 68, 375 (2003). 5. Y. L. Lee et al., J. Biol. Chem. (2003). |
|
List of Research Outputs |
|
Cheong
A.W.Y., Lee C.Y.L., Liu W., Yeung W.S.B. and Lee C.K.F., Oviductal microsomal epoxide
hydrolase (Ephx1) enhances preimplantation embryo development by suppressing
reactiveoxygen species (ROS) production, Hong Kong Society of
Endocrinology, Metabolism and Reproduction, November 11, 2007, |
|
Cheong
W.Y.A., Lee C.Y.L., Liu Y., Yeung W.S.B. and Lee C.K.F., Best poster presentation
award HKSEMR 2007- Oviductal microsomal epoxide hydrolase (Ephx1) enhances
preimplantation embryo development by suppressing reactiveoxygen species
(ROS) production. , The Annual Scientific Meeting of the Hong Kong Society
of Endocrinology, Metabolism and Reproduction, 11 November 2007, |
|
Lee C.Y.L., Liu Y., Ng P.Y., Lee C.K.F., Au C.L., Ng E.H.Y. and Yeung W.S.B., Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation, Human Reproduction. 2008, 23: 894-903. |
|
Lee C.Y.L., Chan Y.L., Chow W.N., Ng E.H.Y., Lee C.K.F., Yeung W.S.B. and Ho P.C., Endocrine gland-derived vascular endothelial growth factor stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the mitogen-activated protein kinase but not through the Akt pathway., Fertility and Sterility. 2008. |
|
Researcher
: Lee YL |
|
List of Research Outputs |
|
Tse P.K., Lee Y.L., Chow W.N., Luk J.M.C., Lee K.F. and Yeung W.S.B., Preimplantation embryos cooperate with oviductal cells to produce embryotrophic inactivated complement-3b, Endocrinology. 2008, 149(3): 1268-1276. |
|
Researcher
: Lee YW |
|
List of Research Outputs |
|
Chan
D.W., Lee Y.W., Liu V.W.S. and Ngan H.Y.S., Overexpression of AMPKgamma
2 enhances tumorigenicity of Ovarian Cancer Cells, Annual Meetings of
American Association for Cancer Research, April 12-16, 2008, |
|
Researcher
: Leung CY |
|
List of Research Outputs |
|
Leung C.Y., Liu S., Chan Y.K., Tam K.F., Chan K.K.L., Wong R.L.C. and Ngan H.Y.S., Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer, Oncology Reports. 2008, 19: 1339-1345. |
|
Liu S., Tsang P.C.K., Chan Y.K., Cheung A.N.Y., Chan K.K.L., Leung C.Y. and Ngan H.Y.S., Distribution of Six Oncogenic Types of Human Papillomavirus and Type 16 Integration Analysis in Chinese Women with Cervical Precancerous Lesions and Carcinomas, Tumour Biol. 2008, 29(2): 105-113. |
|
Ngan
H.Y.S., Tsang P.C.K., Chan Y.K., Liu S., Cheung A.N.Y., Chan K.K.L. and Leung C.Y., Human papillomavirus
genotyping and integration in cervical cancers and precursor lesions, 24th
International Papillomavirus Conference and Clinical Workshop. |
|
List of Research Outputs |
|
Leung K.Y., Tang M.H.Y. and Lam Y.H., Prenatal 2D and 3D ultrasound prediction of homozygous alpha thalassemia, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, September 21-25, 2007, Tokyo, Japan. 2007. |
|
Leung K.Y., Cheong K.B., Tang M.H.Y. and Chan V.N.Y., Prenatal diagnosis of thalassemia, Journal of Paediatrics, Obstetrics & Gynaecology. 2008, 34: 37-42. |
|
Tang G.W.K., Leung K.Y. and Chan C.C.W., Use of hormone therapy: POST-WHI ERA in Hong Kong, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, Tokyo, Japan September 21-25 . 2007. |
|
Researcher
: Leung THY |
|
Project Title: |
Functional
characterization of DLC |
|
Investigator(s): |
Leung THY, Ng IOL |
|
Department: |
Pathology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
The purpose of this study is to
characterize the putative tumor suppressor gene, deleted in liver cancer 2,
DLC2, functionally in liver cancer (hepatocellular carcinoma, HCC), which is
a prevalent cancer in Southeast Asia including |
|
List of Research Outputs |
|
Leung T.H.Y., Yam J.W.P. and Ng I.O.L., STARD13 (StAR-related lipid transfer (START) domain containing 13). , Atlas Genet Cytogenet Oncol Haematol.. 2007. |
|
Researcher
: Leung TW |
|
List of Research Outputs |
|
Leung W.C., Lam Y.H., Leung T.W. and Ho P.C., A pilot study on the prevalence of domestic violence against male partners of pregnant women in Hong Kong, The Hong Kong Medical Diary. 2007, 12(7): 25-27. |
|
Ngan
H.Y.S., Liu S., Leung T.W., Cheung A.N.Y. and Chan Y.K., Study of human papillomavirus
status in Southern Chinese women with normal cervix, precancerous cervical
lesions and cervical cancers. , Health Research Symposium 2007: Building
Bridges between research, practice and policy. September, |
|
Researcher
: Leung TW |
|
List of Research Outputs |
|
Leung W.C., Lam Y.H., Leung T.W. and Ho P.C., A pilot study on the prevalence of domestic violence against male partners of pregnant women in Hong Kong, The Hong Kong Medical Diary. 2007, 12(7): 25-27. |
|
Ngan
H.Y.S., Liu S., Leung T.W., Cheung A.N.Y. and Chan Y.K., Study of human papillomavirus
status in Southern Chinese women with normal cervix, precancerous cervical
lesions and cervical cancers. , Health Research Symposium 2007: Building
Bridges between research, practice and policy. September, |
|
Researcher
: Leung WC |
|
List of Research Outputs |
|
Chan
E.K.L., Brownridge D.A., Tiwari A.F.Y., Fong D.Y.T. and Leung W.C., Understanding violence
against Chinese women in |
|
Hui P.W., Leung W.C., Au W.Y., Chan C.P. and Lao T.T.H., A rare cause of thrombocytopenia in pregnancy – EDTA-dependent pseudothrombocytopenia, 31st British International Congress of Obstetrics and Gynaecology, 3 – 6 July 2007, London, United Kingdom. 2007. |
|
Lao T.T.H., Chan C.P., Leung W.C., Ho L.F. and Tse K.Y., Maternal hepatitis B infection and gestational diabetes mellitus, Journal of Hepatology. 2007, 47(1): 46-50. |
|
Leung W.C., Lam Y.H., Leung T.W. and Ho P.C., A pilot study on the prevalence of domestic violence against male partners of pregnant women in Hong Kong, The Hong Kong Medical Diary. 2007, 12(7): 25-27. |
|
Leung W.C., Lau E.T.K., Lau W.L., Tang R., Wong S.F., Lau T.K., Tse K.T., Wong S.F., To W.W.K., Ng L.K.L., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?, Hong Kong Medical Journal. 2008, 14(1): 6-13. |
|
Tiwari
A.F.Y., Fong D.Y.T., Chan E.K.L., Leung W.C., Parker B. and Ho P.C., Identifying intimate partner
violence: Comparing the Chinese Abuse Assessment Screen with the Chinese
Revised Conflict Tactics Scales, The 12th International Conference on
Violence Abuse and Trauma. |
|
Tiwari
A.F.Y., Fong D.Y.T., Chan E.K.L., Leung W.C., Parker B. and Ho P.C., Identifying intimate partner
violence: comparing the Chinese abuse assessment screen with the Chinese
revised conflict tactics scales, British Journal of Obstetrics and
Gynaecology. |
|
Tiwari A.F.Y., Wong J.Y.H., Fong D.Y.T., Chan E.K.L., Leung W.C., Brownridge D.A. and Ho P.C., Intimate partner violence in obstetric/gynecology patients: a Chinese perspective, Expert Review of Obstetrics & Gynecology. 2008, 3(3): 317-330. |
|
Researcher
: Lin SSW |
|
List of Research Outputs |
|
Lin S.S.W., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Microrna expression profile and their regulatory roles in ovarian folliculogenesis , Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Researcher
: Liu S |
|
List of Research Outputs |
|
Chan K.K.L., Wei N., Liu S., Liao X., Cheung A.N.Y. and Ngan H.Y.S., Estrogen receptor subtypes in ovarian cancer: a clinical correlation, Obstet Gynecol. 2008, 111: 144-151. |
|
Leung C.Y., Liu S., Chan Y.K., Tam K.F., Chan K.K.L., Wong R.L.C. and Ngan H.Y.S., Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer, Oncology Reports. 2008, 19: 1339-1345. |
|
Liu S., Tsang P.C.K., Chan Y.K., Cheung A.N.Y., Chan K.K.L., Leung C.Y. and Ngan H.Y.S., Distribution of Six Oncogenic Types of Human Papillomavirus and Type 16 Integration Analysis in Chinese Women with Cervical Precancerous Lesions and Carcinomas, Tumour Biol. 2008, 29(2): 105-113. |
|
Ngan
H.Y.S., Tsang P.C.K., Chan Y.K., Liu S., Cheung A.N.Y., Chan K.K.L. and Leung C.Y., Human papillomavirus
genotyping and integration in cervical cancers and precursor lesions, 24th
International Papillomavirus Conference and Clinical Workshop. |
|
Ngan
H.Y.S., Liu S., Leung T.W., Cheung A.N.Y. and Chan Y.K., Study of human papillomavirus
status in Southern Chinese women with normal cervix, precancerous cervical lesions
and cervical cancers. , Health Research Symposium 2007: Building Bridges
between research, practice and policy. September, |
|
Researcher
: Liu VWS |
|
Project Title: |
Effect of controlled c-myc and p53 expression on mitochondrial biogenesis in ovarian cancer |
|
Investigator(s): |
Liu VWS, Ngan HYS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
PURPOSE OF PROPOSED
INVESTIGATIONRecently, the mitochondrial content changes in tumour have been
found to correlate with the tumour behaviours. C-myc and p53 are demonstrated
to be important in controlling mitochondrial biogenesis. The purpose of this
proposal is to investigate the effect of c-myc and p53 expression on
mitochondrial biogenesis in ovarian cancer.BACKGROUND AND HYPOTHESISIn 1930,
Warburg hypothesized that cancer cells might have impaired mitochondrial
function and sufficient ATP production for cell growth was mainly provided by
an elevated glycolytic pathway. Nowadays, this so called "Warburg
effect" was known to be a common characteristic of most tumours.
Mitochondrial oxidative phosphorylation (OXPHOS) is the bioenergetic pathway
for the synthesis of most ATP for normal cellular activities. The normal
activity of OXPHOS is also required for the execution of cell apoptosis.
Recently, a number of reports demonstrated the down-regulation of
mitochondrial content but the presence of up-regulated glycolytic markers in
several human cancers. Low mitochondrial content in tumor cell has been
related to aggressive behavior of tumour. In addition to the nuclear-encoded
polypeptide subunits of mitochondrial OXPHOS complexes, the mitochondrial
genome encodes for 13 polypeptides that are subunits of complexes I, III, IV
and V, respectively. Interestingly, both increased and decreased
mitochondrial DNA (mtDNA) copy number and mitochondrial gene expression have
been reported in human cancers. MtDNA mutations have also been demonstrated
to cause cancer, increase tumourigenicity and promote cancer growth by
prevention of apoptosis.Although the mechanism leading to the Warburg effect
has not been clear for many years, increasing evidence suggests that abnormal
expression of oncogenes such as c-myc and/or tumour suppressor genes such as
p53 may be the underlying mechanism that drives the Warburg effect and
eventually leads to tumour formation. Under normal circumstances, both c-myc
and p53 have been found to regulate glycolysis and mitochondrial
respiration.I have previously reported the occurrence of high frequency (60%)
of somatic mtDNA mutations in ovarian cancer (1). In addition, it was found
that mtDNA copy numbers in high grade ovarian tumors were significantly lower
than that in low grade tumors (2). In an ongoing study, a few nuclear-encoded
polypeptides of complex I was found to be down-regulated. I hypothesize that
mitochondrial content change may play a significant role in ovarian cancer
development. Furthermore, the c-myc gene has been found to be overexpressed
or amplified in about 30-50% of ovarian cancer. And about 50% of human tumors
lack a functional p53 gene. The most common subtype of ovarian cancer,
high-grade serous carcinoma, is characterized by p53 mutations. I hypothesize
that aberrant expression of c-myc and/or p53 may be responsible for the
mitochondrial content changes in ovarian cancer.PROJECT OBJECTIVES:(1) To
measure the levels of mitochondrial markers in various ovarian cancer cell
lines and determine the potential roles of c-myc and p |
|
List of Research Outputs |
|
Chan
D.W., Lee Y.W., Liu V.W.S. and Ngan H.Y.S., Overexpression of AMPKgamma
2 enhances tumorigenicity of Ovarian Cancer Cells, Annual Meetings of
American Association for Cancer Research, April 12-16, 2008, |
|
Liu
V.W.S., Chan
D.W., To M.Y., Chiu C.N. and Ngan H.Y.S., Forkhead box transcription
factor FoxG1 is over-expressed in ovarian cancer and can inhibit p21
expression, Annual Meeting of the American Association for Cancer
Research, April 12-16, 2008, |
|
Tam C.W., Liu V.W.S., Leung W.Y., Yao K.M. and Shiu S.Y.W., The autocrine sPDZD2 protein is a potential p53 activator, AACR Centennial Conference on Translational Cancer Medicine: Technologies to Treatment. 2007, B40. |
|
Yip
C.T., Chan D.W., Liu V.W.S. and Ngan H.Y.S., Zic2 synergistically
enhances Hedgehog signaling pathway in cervical cancer., The 12th Research
Postgraduate Symposium 2007, The |
|
Yip
C.T., Chan D.W., Liu V.W.S. and Ngan H.Y.S., Zic2 synergistically
enhances Hedgehog signaling pathway in cervical cancer., The 99th Annual
Meeting of American Association of Cancer Research, 12-16 April 2008, |
|
Researcher
: Liu W |
|
Project Title: |
The regulatory effects of miRNA on preimplantation embryo developmen |
|
Investigator(s): |
Liu W, Yeung WSB, Lee CKF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
Purpose:miRNA are small molecules of 18-24 nucleotides in length and they have been demonstrate to regulate differentiation and developmental process. However, their role on pre-implantation embryo development is lacking. In this study, we aimed to study the expression and delineate the roles of miRNA during pre-implantation development, and study the effect of selected miRNA using in vitro functional assays.Objectives:1. To detect miRNA expression profiling of mouse embryo during preimplantation development (including unfertilized oocyte, 1-cell embryo, 2-cell embryo, 4-cell embryo, 8-cell embryo, morula and blastocyst);2. To examine the effects of seletected miRNA on pre-implantation mouse embryo development.Key issues and problems being addressed:1. To use multiplex miRNA assay to study the global expression of miRNA of mouse embryos in different developmental stages;2. Bioinformatics analysis of the qPCR results using statistical analysis tools and miRNA databases for target mRNA identification;3. Functional characterization of the selected genes on embryo development. |
|
List of Research Outputs |
|
Cheong
A.W.Y., Lee C.Y.L., Liu W., Yeung W.S.B. and Lee C.K.F., Oviductal microsomal epoxide
hydrolase (Ephx1) enhances preimplantation embryo development by suppressing
reactiveoxygen species (ROS) production, Hong Kong Society of
Endocrinology, Metabolism and Reproduction, November 11, 2007, |
|
Pang
R.T.K., Liu W., Chiu C.N., Lee C.K.F. and Yeung W.S.B., Microrna regulates notch1
receptor in hela cells, Hong Kong Society of Endocrinology, Metabolism and
Reproduction, November 11, 2007, |
|
Researcher
: Liu Y |
|
List of Research Outputs |
|
Cheong
W.Y.A., Lee C.Y.L., Liu Y., Yeung W.S.B. and Lee C.K.F., Best poster presentation
award HKSEMR 2007- Oviductal microsomal epoxide hydrolase (Ephx1) enhances
preimplantation embryo development by suppressing reactiveoxygen species
(ROS) production. , The Annual Scientific Meeting of the Hong Kong Society
of Endocrinology, Metabolism and Reproduction, 11 November 2007, |
|
Lee C.Y.L., Liu Y., Ng P.Y., Lee C.K.F., Au C.L., Ng E.H.Y. and Yeung W.S.B., Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation, Human Reproduction. 2008, 23: 894-903. |
|
Liu
Y., Ng
E.H.Y., Yeung W.S.B., Ho P.C. and Lee C.K.F., The expression and
functional studies of DKK1 and Wnt signaling molecules in human endometrium
and embryo implantation. O2.16., The 12th Research Postgraduate Symposium,
The University of Hong Kong, December 12-14, 2007, |
|
Ng P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Differential gene expression of olfactomedin throughout the menstrual cycle is regulated by ovarian hormones., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.508. |
|
Researcher
: Liu Y |
|
List of Research Outputs |
|
Cheong
W.Y.A., Lee C.Y.L., Liu Y., Yeung W.S.B. and Lee C.K.F., Best poster presentation
award HKSEMR 2007- Oviductal microsomal epoxide hydrolase (Ephx1) enhances
preimplantation embryo development by suppressing reactiveoxygen species
(ROS) production. , The Annual Scientific Meeting of the Hong Kong Society
of Endocrinology, Metabolism and Reproduction, 11 November 2007, |
|
Lee C.Y.L., Liu Y., Ng P.Y., Lee C.K.F., Au C.L., Ng E.H.Y. and Yeung W.S.B., Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation, Human Reproduction. 2008, 23: 894-903. |
|
Liu
Y., Ng
E.H.Y., Yeung W.S.B., Ho P.C. and Lee C.K.F., The expression and
functional studies of DKK1 and Wnt signaling molecules in human endometrium
and embryo implantation. O2.16., The 12th Research Postgraduate Symposium,
The University of Hong Kong, December 12-14, 2007, |
|
Ng P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Differential gene expression of olfactomedin throughout the menstrual cycle is regulated by ovarian hormones., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.508. |
|
Researcher
: Ng EHY |
|
Project Title: |
Single or multiple biopsies for retrieval of spermatozoa from the testis? |
|
Investigator(s): |
|
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
03/1999 |
|
Abstract: |
|
To compare the recovery rate of testicular spermatozoa after single vs. multiple open testicular biopsies; to compare the testicular function after single vs. multiple open testicular biopsies. |
|
Project Title: |
To study the endometrial receptivity before and after removing intramural fibroids |
|
Investigator(s): |
|
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/2000 |
|
Abstract: |
|
To compare endometrial receptivity in patients having intramural fibroids before and after myomectomy. |
|
Project Title: |
A randomized comparison of side effects of two vaginal progesterone preparations used for luteal support in assisted reproduction cycles using pituitary down regulation |
|
Investigator(s): |
|
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/2000 |
|
Abstract: |
|
To compare the side effects of two vaginal progesterone preparations used for luteal support in assisted reproduction cycles using pituitary down regulation. |
|
Project Title: |
The value of increasing starting dose of gonadotrophin during ovarian stimulation in women with <= 6 antral follicles prior to stimulation |
|
Investigator(s): |
|
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
08/2000 |
|
Abstract: |
|
To determine the value of increasing starting dose of gonadotrophin during ovarian stimulation in women with <= 6 antral follicles prior to stimulation. |
|
Project Title: |
Comparison of the prevalence of polycystic ovary only and polycystic ovary syndrome between two different ethnic populations |
|
Investigator(s): |
Ng EHY, Chan CW |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
The objective of this study is To define the prevalence of polycystic ovary only and polycystic ovary syndrome and its associated hormonal and biochemical profiles in Chinese and Indian populations. |
|
Project Title: |
The role of anti-Müllerian hormone in the prediction of livebirth rate and cumulative livebirth rate during in vitro fertilization treatment |
|
Investigator(s): |
Ng EHY, Yeung WSB, Ho PC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To determine and compare the predictive values of serum FSH, serum AMH and AFC in livebirth and cumulative livebirth rates following in vitro fertilization treatment. This study will provide information on these predictive values and help in counselling patients with regard to the livebirth rate prior to the IVF treatment. |
|
List of Research Outputs |
|
Chan V.N.Y., Ng E.H.Y., Yeung W.S.B., Yam I.Y.L., Chan T.K. and Ho P.C., Preimplantation genetic diagnosis of thalassaemias, 11th Congress of the International Society of Hematology, Asian-Pacific Division (ISH-APD2007) and the 12th Congress of the Asian-Pacific Bone Marrow Transplantation, Beijing, China, September 21-23. 2007. |
|
Lee C.Y.L., Liu Y., Ng P.Y., Lee C.K.F., Au C.L., Ng E.H.Y. and Yeung W.S.B., Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation, Human Reproduction. 2008, 23: 894-903. |
|
Lee C.Y.L., Chan Y.L., Chow W.N., Ng E.H.Y., Lee C.K.F., Yeung W.S.B. and Ho P.C., Endocrine gland-derived vascular endothelial growth factor stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the mitogen-activated protein kinase but not through the Akt pathway., Fertility and Sterility. 2008. |
|
Liu
Y., Ng E.H.Y., Yeung W.S.B., Ho P.C. and Lee C.K.F., The expression and functional
studies of DKK1 and Wnt signaling molecules in human endometrium and embryo
implantation. O2.16., The 12th Research Postgraduate Symposium, The
University of Hong Kong, December 12-14, 2007, |
|
Ng
E.H.Y., Assisted hatching, Asia Pacific
Initiative on Reproduction (ASPIRE) and Pacific Rim Society for Fertility and
Sterility (PRSFS), |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., Comparison of 2-Dimensional, 3-Dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles, Journal of Ultrasound In Medicine. 2007, 26(7): 931-939. |
|
Ng E.H.Y., Controversies in ART, Postgraduate Seminar organized by The Hong Kong College of Obstetricians and Gynaecologists, Hong Kong, November 11, 2007. 2007. |
|
Ng
E.H.Y., How to read a research paper?, HKCOG
Research Course held by |
|
Ng
E.H.Y., New imaging techniques in ART-Road to
success?, The Fourth Asian Fertility Expert Meeting, |
|
Ng E.H.Y. and Ho P.C., Polycystic ovary syndrome in Asian women, Seminar In Reproductive Medicine. 2008, 26: 14-21. |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Tang F.O.S. and Ho P.C., Randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, Fertility and Sterility. 2008, 89(5): 1147-1153. |
|
Ng E.H.Y., Role of ultrasound in determining ovarian reserve, Annual Scientific Meeting 2007 of The Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Gold Coast, Australia, October 2-5, 2007. 2007. |
|
Ng E.H.Y., So W.Z., Gao J., Wong Y.Y. and Ho P.C., The role of acupuncture in the management of subfertility, Fertility and Sterility. 2008, 90: 1-13. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., The role of endometrial blood flow measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during in vitro fertilization treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 135: 8-16. |
|
Ng E.H.Y., Treatment of repeated implantation failure, Symposium on Repeated Implantation Failure, held by 南方医科大學, 廣州, 中國. 2008. |
|
Ng
E.H.Y., Ultrasound in reproductive medicine, CME
Programmes on Reproductive Medicine organized by |
|
Ng
E.H.Y., Use of three-dimensional ultrasound
in assisted reproduction, The XXth Asian and Oceanic Congress of
Obstetrics and Gynaecology organized by Asian and Oceanic Federation of
Obstetrics and Gynaecology, |
|
Ng P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Differential gene expression of olfactomedin throughout the menstrual cycle is regulated by ovarian hormones., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.508. |
|
Researcher
: Ng PPY |
|
List of Research Outputs |
|
Ng P.P.Y., Tang M.H.Y., Lau E.T.K., Ng L.K.L., Ngan E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Chromosome anomalies and Y-microdeletions in subfertile men (Poster), The ACAG-HKSMG International Conference, Hong Kong, 11 June 2008. |
|
Researcher
: Ng PY |
|
List of Research Outputs |
|
Lee C.Y.L., Liu Y., Ng P.Y., Lee C.K.F., Au C.L., Ng E.H.Y. and Yeung W.S.B., Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation, Human Reproduction. 2008, 23: 894-903. |
|
Ng P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Differential gene expression of olfactomedin throughout the menstrual cycle is regulated by ovarian hormones., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.508. |
|
Researcher
: Ng TY |
|
Project Title: |
A propective randomised controlled trial: prevention of lymphedema by omentoplasty after pelvic lymphadenectomy |
|
Investigator(s): |
Ng TY, Ngan HYS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2001 |
|
Abstract: |
|
To see whether these preliminary results are validated in a prospective randomised comparison. |
|
Project Title: |
A prospective randomized controlled trial: prevention of Lymphedema by Omentoplasty after pelvic lymphadenectomy |
|
Investigator(s): |
Ng TY, Ngan HYS, Chan YM, Tam KF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Health and Health Services Research Fund - Full Grants |
|
Start Date: |
04/2004 |
|
Abstract: |
|
Lymphedema is a debilitating condition that occurs in up to 40% of patients after pelvic lymphadenectomy. New surgical techniques have been advocated to reduce this complication. A pilot study using Omentoplasty observed that 8% of patients after this procedure had clinical lymphedema compared with 40% in historical controls. This study aims to see whether these preliminary results are validated in a prospective randomised comparison. |
|
Researcher
: Ngai CSW |
|
Project Title: |
Vaginal misoprostol for first trimester termination of pregnancy prior to 9 weeks of gestation |
|
Investigator(s): |
Ngai CSW, Tang FOS, Chan YM, Ho PC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Health Services Research Fund - Full Grants |
|
Start Date: |
05/1999 |
|
Abstract: |
|
To compare the effectiveness of vaginal misoprostol (water vs no water added) in first trimester termination of pregnancy. |
|
Project Title: |
Cervical assessment in prediction of preterm labour: is three-dimensional ultrasonography a better choice? |
|
Investigator(s): |
Ngai CSW, Lao TTH, Chen M, Leung KY |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To compare the usefulness of 3D versus 2D US in prediction of preterm labour. |
|
Project Title: |
Multiple pregnancy and gestational diabetes: a physiological response or a pathologic condition? |
|
Investigator(s): |
Ngai CSW, Lao TTH, Leung WC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To investigate the incidence of gestational disbetes mellitus in twin pregnancy; to investigate the changes of glucose metabolism throughout pregnancy in multiple pregnancy; to evaluate the diagnostic criteria of gestational diabetes mellitus in twin pregnancy. |
|
Researcher
: Ngan ESW |
|
Project Title: |
Novel Function(s) of Prokineticins in Neural Crest Stem Cells |
|
Investigator(s): |
Ngan ESW, Lui VCH, Tam PKH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
The mammalian enteric nervous system
(ENS) is derived from the neural crest cells (NCC) which enter the foregut
and colonize the entire wall of gastrointestinal tract (1). In mice, NCCs
reach foregut at approximately embryonic day 9.4 (E9.5) and finish the
colonization by ~E14.5. Numerous gut mesenchyme/mucosa-derived factors and
their receptors on NCC are found to be crucial for NCC proliferation,
differentiation and migration. They are glial cell-line derived neurotrophic
factor (GDNF) and its receptors (RET, GFRA1)(2); endothelin 3 (EDN3) and its
receptor (EDNRB)(3); sonic hedgehog (Shh) and its receptor (Ptc)(4). A
delicate balance between these signals is a prerequisite for the proper
regulation of NCCs during ENS development. Failure to completely colonize the
gut results in the absence of enteric ganglia as seen in Hirschsprung’s
disease in human.. Prokineticin –1 and -2 (Prok-1 and Prok-2), also referred
to endocrine gland derived vascular endothelial growth factor (EG-VEGF) and
Bv8, respectively, are structurally related and belong to a newly identified
family of secreted proteins, AVIT protein family. These proteins are
distributed widely in mammalian tissues. Prok-1 mRNA expression has been
described in a variety of tissues, in steroidogenic glands such as the ovary,
testis, adrenal gland and placenta, but also in the brain, colon, skeletal muscle,
small intestine, spleen, thymus liver, bladder, prostate and uterus(5,6) .
Prok-2, on the other hand, shows the highest expression in testis, colon,
brain and peripheral blood leukocytes(7,8). These two prokineticins are known
to bind to two closely related G protein-coupled receptors, PK-R1 and PK-R2.
Receptor activation leads to mobilization of calcium, stimulation of
phosphoinositide turnover, and activation of p44/p42 MAPK signaling pathways.
Within distinct contexts, the receptors are likely differentially regulated
and distinct expression patterns of Prok receptors were observed in various
tissues. In the adrenal gland, only PK-R1 was detected. In the ovary,
follicular cells predominantly express PK-R1, whereas corpus luteum-derived
cells express high levels of both PK-R1 and PK-R2. Similarly, these two
receptors are also co-existing in endometrium, but at different expression
level. Therefore, it is believed that prokineticins may have different
angiogenic as well as non-angiogenic functions in different tissues via
acting on either PK-R1 or PK-R2. However, the exact role(s) of PK-R1 and
PK-R2 remains unclear. A new appreciation for the intricacy of peptidergic
GPCRs is developing, as the ligands for orphan receptors are identified and
as distinct signaling and functional responses for multiple ligands and
oligomerized receptors are demonstrated. Thus, the distinct or overlapping
expression of prokineticins and the possible heteroligomerization of
receptors may increase the functional complexity of this system (8,9). It is
currently known that prokineticins possess diverse biological functions: they
promote angiogenesis in ovary and testis; induce proliferation, migration and
fenestration of endothelial cells derived from adrenal gland ; support neuronal
survival; cause hyperalgesia of skin; promote contraction of gastrointestinal
smooth muscle; and control pain sensation and behavioral circadian
rhythms(8,9). More recently, these two receptors were also found in human and
mouse hematopoietic stem cells and specific mature blood cells, including
lymphocytes. Prokineticins can modulate growth, survival, and function of
cells of the innate and adaptive immune systems, possibly through autocrine
or paracrine signaling mechanisms(7). Given the reported expression patterns
and activities of the mammalian orthologs in brain, reproductive tract, and
cells of the immune system, the molecules seem to have subserved similar
functions across evolution. In addition to being the angiogenic factors,
prokineticins would be the universal survival/mitogenic factors for various
cells including endothelial cells, neuronal cells, lymphocytes as well as the
hematopietic stem cells. Noteworthy, prokineticins and their receptors were
detected in mouse embryo as early at E7, the role(s) of these factors during
embryonic development still remains to be disclosed. Our preliminary data: It
is known that prokineticin-1 is expressed in mouse and human small intestine
and colon. Using antibody specific to Prok-1 to perform the immunohistochemistry
study, we found that Prok-1 protein is expressed in the mucosa and enteric
neuronal plexus of the gut in the adult mouse. The presence of Prok |
|
Project Title: |
Is thyroid transcription factor (TTF-1) the susceptibility gene for familial papillary thyroid carcinoma (PTC) predisposition |
|
Investigator(s): |
Ngan ESW, Garcia-Barcelo MM, Tam PKH, Lo
CY, Khoo |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Papillary thyroid carcinoma (PTC) is the
most common malignant thyroid carcinoma, comprising an estimated 80% of
thyroid cancers. Somatic genetic alterations in PTC, including RET/PTC
rearrangements(1-4) and BRAF(5) and RAS(6) mutations have proved useful as
prognostic markers and may represent the result to a cancer initiation
process governed by the constitutive DNA endowment of the patient.
Nevertheless, these genetic alterations only account for approximately 70% of
PTC and the correlations with clinicopathological features of increase
morbidity are still inconclusive. Importantly, 3.5-6.2% of PTC patients have
one or more first-degree relatives with thyroid carcinoma, suggesting the
presence of heritable genetic determinants for PTC predisposition, but the
genetic basis of familial PTC is yet unknown. Thyroid transcription factor-1
(TTF-1) is a key player implicated in the thyroid development and associated
disorders. TTF-1 knockout mice present with a series of congenital defects
including lack of thyroid(7). Heterozygous "de novo" TTF1 mutations
inherited in an autosomal dominant manner are associated with compensated
congenital hypothyroidism(8-10). Regarding tumorigenesis, it is known to be a
differentiation marker and inversely related to the malignant phenotype of
thyroid neoplasms. More recently, it has been demonstrated that conditional
ablation of TTF |
|
Researcher
: Ngan HYS |
|
Project Title: |
High dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer |
|
Investigator(s): |
Ngan HYS, Wong RLC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/1994 |
|
Abstract: |
|
To study high dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer. |
|
Project Title: |
Rapid identification of tumour-specific gene methylation at multiple loci in gynaecological cancers |
|
Investigator(s): |
Ngan HYS, Liu VWS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To determine and differentiate the methylation status for 30 gene loci among the three gynaecological cancers using a pooled DNA approach. |
|
Project Title: |
Study of human papillomavirus status in Southern Chinese women with normal cervix, precancerous cervical lesions and cervical cancers |
|
Investigator(s): |
Ngan HYS, Cheung ANY, |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
10/2006 |
|
Abstract: |
|
This cross-sectional study will
investigate the current spectrum and prevalence of HPV circulating among
healthy females in |
|
Project Title: |
Potential interaction between Zic2 and Gli proteins in enhancing the oncogenic role of hedgehog signaling in cervical cancer |
|
Investigator(s): |
Ngan HYS, Chan DW, Liu VWS |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
PURPOSE OF PROPOSED INVESTIGATION The
purpose is to investigate the roles of Hedgehog signaling in the development
of cervical cancer, and functionally characterize whether Zic2, one of the
zinc finger proteins, synergistically enhances the oncogenic role of hedgehog
signaling in cervical cancer . HYPOTHESISCervical cancer, a potentially
preventable disease, remains the second most common malignancy in women
worldwide. Human papillomavirus (HPV) is the single most important
etiological agent in cervical cancer, contributing to neoplastic progression
through the action of viral oncoproteins, mainly E6 and E7, which interfere
with critical cell cycle pathways, p53 and retinoblastoma, respectively.
However, evidence suggests that human papillomavirus infection alone is
insufficient to induce malignant changes. Therefore, the transformation from
low-grade lesion to invasive cancer must involve other cellular genetic
changes affecting oncogenes, tumour suppressor genes or signal transduction
pathway. Hedgehog signaling pathway and cervical cancerThe Hedgehog signaling
pathway (HHS) was identified two decades ago in Drosophila as a critical
regulatory mechanism of cell-fate determination during embryogenesis
(Nusslein-Volhard C, Wieschaus E, 1980). In mammals there are three Hh-family
proteins: Sonic (Shh), Indian (Ihh), and Desert (Dhh). Gene-targeting
experiments in mice have demonstrated that the development and patterning of
essentially every major organ requires input from the Hh pathway (Ingham PW
and McMahon AP, 2001). The Hh-signaling pathway comprises three main
components: the Hh ligand; a transmembrane receptor circuit composed of the
negative regulator Patched (PTCH) plus an activator, Smoothened (Smo); and
finally a cytoplasmic complex that regulates the Cubitus interruptus (Ci) or
Gli family of transcriptional effectors which include Gli1, Gli2, and Gli3.
Aberrant activation of the HHS pathway has been documented in promoting cell
poroliferation, tumor growth and metastasis in skin (Couve-Privat et al., 2004;
Cui et al., 2004; Athar et al., 2006), prostate (Fan et al., 2004; Sanchez et
al., 2004; Karhadkar et al., 2004) and hepatocellular carcinomas (Huang et
al., 2006). This indicates the significant role of HHS in cancer development.
However, the roles of HHS in cervial cancer remains unknown. However, a
recent report has shown that the expression levels of Gli1, Gli2 and Gli |
|
List of Research Outputs |
|
Chan
D.W., Lee Y.W., Liu V.W.S. and Ngan H.Y.S., Overexpression of
AMPKgamma 2 enhances tumorigenicity of Ovarian Cancer Cells, Annual
Meetings of American Association for Cancer Research, April 12-16, 2008, |
|
Chan
H.Y., Siu K.Y., Wong E.S.Y., Zhang H., Ngan H.Y.S. and Cheung A.N.Y., Expression of
phospho-Stat |
|
Chan
H.Y., Siu K.Y., Wong E.S.Y., Zhang H., Ngan H.Y.S. and Cheung A.N.Y., Expression of
phospho-Stat |
|
Chan K.K.L., Ip P.P.C., Kwong P.W.K., Tam K.F. and Ngan H.Y.S., A combination of chemoirradiation and chemotherapy for treatment of advanced clear cell adenocarcinoma of the cervix (p 559-563) , In: John J. Kavanagh and Uziel Beller, International Journal of Gynecological Cancer. Wiley interscience, 2008, 18: 559-563. |
|
Chan K.K.L., Wei N., Liu S., Liao X., Cheung A.N.Y. and Ngan H.Y.S., Estrogen receptor subtypes in ovarian cancer: a clinical correlation, Obstet Gynecol. 2008, 111: 144-151. |
|
Chan K.K.L., Tam K.F., Tse K.Y. and Ngan H.Y.S., The role of physical examination in the routine follow up of patients treated for ovarian carcinoma, British Gynaecological Society Annual Conference 2007. |
|
Chan K.K.L., Tam K.F., Tse K.Y. and Ngan H.Y.S., The use of vaginal antimicrobial after large loop excision of transformation zone: a prospective randomised trial, British Journal of Obstetrics and Gynaecology. 2007, 114(8): 970-976. |
|
Chan
Y.K., Ching C.Y.J., Xu M.S., Cheung A.N.Y., Yip S.P., Lam L.Y.C., Lai
S.T., |
|
Cheung A.N.Y., Tsun O.K.L., Szeto E.F., Wong G., Lo S. and Ngan H.Y.S., Application of Novel Markers to Cervial Cytology for enhancing Cervical Cancer Screening, Annual Scientific Meeting of Hong Kong Society of Cytology, Hong Kong, 8-9 December. 2007. |
|
Feng H., Tsao G.S.W., Ngan H.Y.S., Xue W., Kwan H.S., Siu K.Y., Liao X., Wong E.S.Y. and Cheung A.N.Y., Over-expression of Prostatic Stem Cell Antigen (PSCA) is associated with Gestational Trophoblastic neoplasia. , Histopathology. 2007, 52: 167-174. |
|
Feng H., Tsao G.S.W., Ngan H.Y.S., Xue W., Kwan H.S., Siu K.Y., Liao X., Wong E.S.Y. and Cheung A.N.Y., Overexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasia, Histopathology. 2008, 52(2): 167-174. |
|
Hui
P.W. and Ngan H.Y.S.,
Discipline-based examination and generic assessment principles, 5th Asia
Pacific Medical Education Conference (APMEC), 24-27 January, 2008, |
|
Kwan T.T.C., Chan K.K.L., Yip M.W., Tam K.F., Cheung A.N.Y., Young P.M.C., Lee P.W.H. and Ngan H.Y.S., Barriers and facilitators to human papillomavirus vaccination among Chinese adolescent girls in Hong Kong: a qualitative–quantitative study, Sex Transm Infect. 2008, 84(3): 227-232. |
|
Leung C.Y., Liu S., Chan Y.K., Tam K.F., Chan K.K.L., Wong R.L.C. and Ngan H.Y.S., Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer, Oncology Reports. 2008, 19: 1339-1345. |
|
Li A.S.M., Siu K.Y., Wong E.S.Y., Chan Y.K., Ngan H.Y.S. and Cheung A.N.Y., Effect of demethylation and histone deacetylase inhibitors on the expression of stem cell related genes in choriocarcinoma cell lines, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November. 2007. |
|
Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Ngan H.Y.S. and Cheung A.N.Y., Aberrant Activation of Hedgehog Signaling Pathway in Ovarian Cancer, 99th American Association for Cancer Research 2008 Annual Meeting, San Diego, 12-16 April. 2008. |
|
Liu S., Tsang P.C.K., Chan Y.K., Cheung A.N.Y., Chan K.K.L., Leung C.Y. and Ngan H.Y.S., Distribution of Six Oncogenic Types of Human Papillomavirus and Type 16 Integration Analysis in Chinese Women with Cervical Precancerous Lesions and Carcinomas, Tumour Biol. 2008, 29(2): 105-113. |
|
Liu
V.W.S., Chan D.W., To M.Y., Chiu C.N. and Ngan H.Y.S., Forkhead box transcription
factor FoxG1 is over-expressed in ovarian cancer and can inhibit p21
expression, Annual Meeting of the American Association for Cancer
Research, April 12-16, 2008, |
|
Ngan H.Y.S., "Can we reduce anxiety during colposcopy?" and "HPV genotyping meta-analysis", XXth Scientific Meeting, Australian Society for Colposcopy and Cervical Pathology (ASCCP), Gold Coast, Australia, 27-30 September, 2007. 2007. |
|
Ngan
H.Y.S., Cervical cancer vaccine-your
questions answered, |
|
Ngan
H.Y.S., Co-Chairman and Faculty in the MSD
session, 24th International Papillomavirus Conference in |
|
Ngan H.Y.S., Co-eiitor : Staging classification and gynecologic cancers, FIGO Gynecologic Oncology and IGCS Guidelines Committee, Third Edition, November 2006. 2007. |
|
Ngan H.Y.S., Comparison of HPV infection between Hong Kong and Guangzhou, The First China Hybribio HPV Conference, Shenzhen, China, June 14, 2008. 2008. |
|
Ngan H.Y.S., Editorial Boaed Member - Journal of Paediatrics, Gynaecology and Obstetrics 1997. 2007. |
|
Ngan H.Y.S., Editorial Board Member - Gynecologic Oncology 2005. 2007. |
|
Ngan
H.Y.S., Editorial Board Member - |
|
Ngan H.Y.S., Editorial Board Member - International Journal of Gynecologic Cancer 2001. 2007. |
|
Ngan H.Y.S., Editorial Board Member - Journal of Clinical Oncology (Chinese Edition) 2000. 2007. |
|
Ngan H.Y.S., Editorial Board Member - Journal of Obstetrics and Gynaecology Research 1997. 2007. |
|
Ngan
H.Y.S., Editorial Board Member - The |
|
Ngan H.Y.S., Editorial Board Member of 实用婦產科雜誌(編 委) 2008. 2008. |
|
Ngan H.Y.S., Guest Editor of a book "Clinical Obstetrics and Gynaecology (Bailliere's Best Practice and Research) on "Gestational Trophoblastic Diseases" 2003. 2007. |
|
Ngan
H.Y.S., HPV and cervical cancer prevention, |
|
Ngan
H.Y.S., HPV and cervical cancer, 2nd
Reproductive Health Conference, Macau Society of Obstetrics and Gynaecology, |
|
Ngan
H.Y.S., HPV testing - reappraisal, Forum
on HPV testing organized by the |
|
Ngan
H.Y.S., HPV: an evasive pathogen and the need
for broad and sustained protection, Seminars in HPV vaccinology: Jointly
organized by The |
|
Ngan
H.Y.S., Head start on cervical cancer
prevention, CME Session "Asian Perspectives to Clinical
Pediatrics", Macau, July 8, 2007 by Excerpta Medica, |
|
Ngan
H.Y.S., Tsang
P.C.K., Chan Y.K., Liu S., Cheung A.N.Y., Chan K.K.L. and Leung C.Y., Human papillomavirus
genotyping and integration in cervical cancers and precursor lesions, 24th
International Papillomavirus Conference and Clinical Workshop. |
|
Ngan H.Y.S., Kwan T.T.C., Tam K.F., Chan K.K.L., Young P.M., Lo S.S., Cheung A.N.Y. and Lee P.W.H., Knowledge and attitute of Chinese women on cervical cancer and human papillomavirus, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, September 21-25, 2007, Tokyo, Japan. 2007. |
|
Ngan H.Y.S., Psychosocial burden of HPV-related diseases in 3 countries, Health Outcome modeling and HPV vaccines meeting hosted by Family Health International and Chulalongkorn University, Bangkok, Thailand, February 12, 2008 . 2008. |
|
Ngan H.Y.S., Public awareness and psychosocial aspects of HPV vaccination, The Third Biennial Conference of Asia Oceania Research organization on Genital Infections and Neoplasia (AOGIN), Seoul, Korea, May 29-31, 2008. 2008. |
|
Ngan
H.Y.S., Liu
S., Leung T.W., Cheung A.N.Y. and Chan Y.K., Study of human papillomavirus
status in Southern Chinese women with normal cervix, precancerous cervical
lesions and cervical cancers. , Health Research Symposium 2007: Building
Bridges between research, practice and policy. September, |
|
Ngan H.Y.S., Surgical training in Hong Kong, 2007 Annual Scientific Meeting, The Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Queensland, Australia, October 2-5, 2007. 2007. |
|
Ngan H.Y.S., The role of PET scan in Gynaecological oncology, HKCOG Postgraduate Seminar, April 27, 2008. 2008. |
|
Ngan H.Y.S., Updates on HPV prevention and vaccine, Joint Meeting HKSCCP and HKCFP, August 25, 2007, Hong Kong. 2007. |
|
Pon Y.L., Zhou H., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S.T., p70 S6 kinase promotes epithelial to mesenchymal transition through Snail induction in ovarian cancer cells, Cancer Research. 2008, 68(16): 6524-6532. |
|
Siu K.Y., Chan H.Y., Kong S.H., Chan K.Y.Q., Ngan H.Y.S. and Cheung A.N.Y., Differential expression of folate receptor alpha and reduced folate carrier and effect of folate in ovarian cancer, 99th American Association for Cancer Research 2008 Annual Meeting, San Diego, 12-16 April. 2008. |
|
Siu
K.Y., Woo N.W., Wong E.S.Y., Chan H.Y., Chan K.Y.Q., Ngan H.Y.S., Tsao G.S.W. and Cheung A.N.Y., p21-activated kinase |
|
Tse K.Y., Chan K.K.L., Tam K.F. and Ngan H.Y.S., Current concepts in the management of endometrial carcinoma, Journal of Paediatrics, Obstetrics and Gynaecology. 2007, SEP/OCT: 213-220. |
|
Woo N.W.S., Wong E.S.Y., Chan H.Y., Chan K.Y.Q., Ngan H.Y.S., Tsao G.S.W. and Cheung A.N.Y., p21-activated kinase |
|
Yip
C.T., Chan D.W., Liu V.W.S. and Ngan H.Y.S., Zic2 synergistically
enhances Hedgehog signaling pathway in cervical cancer., The 12th Research
Postgraduate Symposium 2007, The |
|
Yip
C.T., Chan D.W., Liu V.W.S. and Ngan H.Y.S., Zic2 synergistically
enhances Hedgehog signaling pathway in cervical cancer., The 99th Annual
Meeting of American Association of Cancer Research, 12-16 April 2008, |
|
Zhang H., Siu K.Y., Li A.S.M., Chan K.Y.Q., Ngan H.Y.S. and Cheung A.N.Y., Oct-4 gene is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease, 14th Hong Kong International Cancer Congress, Hong Kong, 14-16 November. 2007. |
|
Zhang H., Siu K.Y., Wong E.S.Y., Wong K.Y., Li A.S.M., Chan Y.K., Ngan H.Y.S. and Cheung A.N.Y., Oct4 is Epigenetically Regulated by Methylation in Normal Placenta and Gestational Trophoblastic Disease, Placenta. 2008, 29(6): 549-554. |
|
Researcher
: Ong CYT |
|
Project Title: |
To determine the correlation of changes in maternal levels of pregnancy-associated plasma protein A (PAPP-A) and free [beta] human chorionic gonadotrophin (F[beta]-hCG) with placental development and fetal outcomes |
|
Investigator(s): |
Ong CYT, Lao TTH, Leung WC, Leung KY, Lam HSW |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To correlate the serial changes of maternal serum PAPP-A and free [beta]-hCG concentrations with placental volume and vascular indices, swell as fetal size, as assessed by 3-D/4-D ultrasonographic studies throughout pregnancy; to determine whether different patterns in the changes of PAPP-A and free [beta]-hCG in different trimesters will be predictive of different patterns of placental development and fetal growth, and whether this can help to identify specifically the eventual complications through the association with the various growth and developmental patterns. |
|
Project Title: |
First trimester prediction of fetal α-thalassaemia-1 with maternal serum markers, nuchal translucency measurement and three dimentional ultrasound measurement of placental volume |
|
Investigator(s): |
Ong CYT, Chen M, Leung KY, Tang MHY, Lee CP |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To measure 3D ultrasound placental and fetal volume at 10-14 weeks of gestation, and to determine whether different changes in the placental volume is predictive of fetuses affected by α-thalassaemia-1; to measure maternal serum PAPP-A and free β-hCG concentrations in fetuses affected and unaffected by β-thalassaemia-1 at 10-14 weeks of gestation, and determine the predictive value of these markers along with or without NT measurement in diagnosis of fetuses affected by α-thalassaemia-1. |
|
Project Title: |
Maternal serum level of ADAM 12 as an early marker of trisomy 21, trisomy 13 and trisomy 18 |
|
Investigator(s): |
Ong CYT, Lee CP, Lau ETK |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Objectives 1. To investigate the use of
maternal serum ADAM 12 concentration in the first trimeter as a marker of
trisomy 21, trisomy 18 and trisomy 13. 2. To correlate maternal serum with
pregnancy outcomes Brief background and significance The ADAMs (A disintegrin
and metalloprotease) constitute a glycoprotein family with proteolytic and
cell-adhesion activities (Wolfsberg et al., 1995; Primakoff and Myles, 2000;
Seals and Courtneidge, 2003). Human ADAM12 exists in two forms, ADAM12-L
(long) and ADAM12-S (short), the latter being the secreted form of ADAM12.
ADAM12-S differs from ADAM12-L at the C-terminal end in that it does not
contain the transmembrane and cytoplasmatic domains (Gilpin et al., 1998).
ADAM12-S binds to and has proteolytic activity against insulin-like growth
factor binding protein (IGFBP)-3 and, to a lesser extent, IGFBP-5. Insulin
growth factors (IGFs) I and II are proinsulin-like polypeptides that are
produced in nearly all foetal and adult tissues. Lack of IGF I and II causes
foetal growth retardation in mice (Powel-Braxton et al., 1993). The cleavage
of IGFBPs into smaller fragments with reduced affinity for the IGFs reverses
the inhibitory effects of the IGFBPs on the mitogenic and DNA stimulatory
effects of the IGFs (Blat et al., 1994). ADAM12-S is an important indicator
of foetal growth because ADAM12-S is an IGFBP-3 protease and IGFBP-3 is the
most abundant IGFBP in serum. The proteolysis of IGFBP-3 would stimulate
growth by increasing levels of bioavailable IGF I and II. Previous study
(Laigaard et al. 2003) has reported that in 18 first trimester Down syndrome
pregnancies versus 136 healthy controls, maternal serum concentration of ADAM12
was decreased with the median multiple of mean (MoM) value of 0.14
(0.01-0.76). This results in a detection rate of 82% for a false positive
rate of 3.2% (using 1:400 risk as cut-off) for fetal Down syndrome. In
another study (Laigaard et al. 2005), maternal serum ADAM 12-S concentrations
were found to be lower in trisomy 18 pregnancies than in normal pregnancies,
with a median multiple of the median (MoM) of 0.28 (p < 0.001). These
findings suggest that maternal serum ADAM 12-S may be a novel marker for
trisomy 21, trisomy 18 and perhaps trisomy |
|
Researcher
: Pang RTK |
|
List of Research Outputs |
|
Chiu C.N., Wong S.T., Lee C.L., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and Yeung W.S.B., Native human zona pellucida glycoproteins: purification and binding properties, Human Reproduction. 2008, 23: 1385. |
|
Chiu
C.N., Wong B.S., Lee C.L., Chung M.K., Lam K.K., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and
Yeung W.S.B., Purification of native
human zona pellucida glycoproteins from eggs: Binding characteristics to
human spermatozoa, hyper-activation, acrosomal exocytosis, and sperm-oocyte
interaction. P.74, The Society for the Study of Reproduction 41st Annual
meeting, May 27-30, 2008, |
|
Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Lin S.S.W., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Microrna expression profile and their regulatory roles in ovarian folliculogenesis , Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Pang
R.T.K., Liu
W., Chiu C.N., Lee C.K.F. and Yeung W.S.B., Microrna regulates notch1
receptor in hela cells, Hong Kong Society of Endocrinology, Metabolism and
Reproduction, November 11, 2007, |
|
Researcher
: Pun TC |
|
List of Research Outputs |
|
Ip P.P.C., Lam K.W., Cheung C.L., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid-associated Necrosis and Intralesional Thrombosis of Uterine Leiomyomas: A Clinicopathologic Study of 147 Cases Emphasizing the Importance of Drug-induced Necrosis and Early Infarcts in Leiomyomas , American Journal of Surgical Pathology. 2007, 31(8): 1215-1224. |
|
Researcher
: Tam KF |
|
List of Research Outputs |
|
Chan K.K.L., Ip P.P.C., Kwong P.W.K., Tam K.F. and Ngan H.Y.S., A combination of chemoirradiation and chemotherapy for treatment of advanced clear cell adenocarcinoma of the cervix (p 559-563) , In: John J. Kavanagh and Uziel Beller, International Journal of Gynecological Cancer. Wiley interscience, 2008, 18: 559-563. |
|
Chan K.K.L., Tam K.F., Tse K.Y. and Ngan H.Y.S., The role of physical examination in the routine follow up of patients treated for ovarian carcinoma, British Gynaecological Society Annual Conference 2007. |
|
Kwan T.T.C., Chan K.K.L., Yip M.W., Tam K.F., Cheung A.N.Y., Young P.M.C., Lee P.W.H. and Ngan H.Y.S., Barriers and facilitators to human papillomavirus vaccination among Chinese adolescent girls in Hong Kong: a qualitative–quantitative study, Sex Transm Infect. 2008, 84(3): 227-232. |
|
Leung C.Y., Liu S., Chan Y.K., Tam K.F., Chan K.K.L., Wong R.L.C. and Ngan H.Y.S., Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer, Oncology Reports. 2008, 19: 1339-1345. |
|
Ngan H.Y.S., Kwan T.T.C., Tam K.F., Chan K.K.L., Young P.M., Lo S.S., Cheung A.N.Y. and Lee P.W.H., Knowledge and attitute of Chinese women on cervical cancer and human papillomavirus, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, September 21-25, 2007, Tokyo, Japan. 2007. |
|
Tse K.Y., Chan K.K.L., Tam K.F. and Ngan H.Y.S., Current concepts in the management of endometrial carcinoma, Journal of Paediatrics, Obstetrics and Gynaecology. 2007, SEP/OCT: 213-220. |
|
Researcher
: Tam VCG |
|
List of Research Outputs |
|
Tam V.C.G., Chiu C.N., Koistinen R., Koistinen M., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Glycodelin-C receptor on human spermatozoa., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.459. |
|
List of Research Outputs |
|
Lee
C.K.F., Zuo Y., Tam Y.T., Tang A.Y.B. and Yeung W.S.B., The acrosome-expressing
proteins VAD1.3/AEP1 and VAD1.2 interact with syntaxin and b-acting in
vitro., The |
|
Yan Z., Tam Y.T., Cheah K.S.E., Yeung W.S.B. and Lee C.K.F., Functional characterization of VAD 1.3 /AEP 1 Gene in acrosome-formation and fertility, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Zuo
Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional characterization
of VAD1.3/AEP1 gene in acrosome-formation and fertility. O2.15., The 12th
Research Postgraduate Symposium, The University of Hong Kong, December 12-14,
2007, |
|
Researcher
: Tang AWS |
|
List of Research Outputs |
|
Tang A.W.S., Surgical training from the registrars' perspective, 2007 Annual Scientific Meeting, The Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Queensland, Australia, October 2-5, 2007. |
|
Researcher
: Tang AYB |
|
List of Research Outputs |
|
Lee
C.K.F., Zuo Y., Tam B.Y., Tang A.Y.B. and Yeung W.S.B., Syntaxin and b-actin
interact with acrosome-expressing protein VAD1.2/AEP |
|
Lee
C.K.F., Zuo Y., Tam Y.T., Tang A.Y.B. and Yeung W.S.B., The acrosome-expressing
proteins VAD1.3/AEP1 and VAD1.2 interact with syntaxin and b-acting in
vitro., The |
|
Researcher
: Tang FOS |
|
Project Title: |
A prospective randomized comparison of sublingual and vaginal misoprostol in termination of pregnancy in the second trimester |
|
Investigator(s): |
Tang FOS, Ho PC |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
10/2000 |
|
Abstract: |
|
To compare the efficacy of sublingual and vaginal misoprostol in termination of second trimester pregnancy. |
|
List of Research Outputs |
|
Faundes A., Fiala C., Tang F.O.S. and Velasco A., Misoprostol for the termination of pregnancy up to 12 completed weeks of pregnancy, International Journal of Gynecology and Obstetrics. 2007, 99 (Supplement 2): S172-S177. |
|
Fiala C., Gemzell-Danielsson K., Tang F.O.S. and von Hertzen H., Cervical priming with misoprostol prior to transcervical procedures, International Journal of Gynecology and Obstetrics. 2007, 99 (Supplement 2): S168-S171. |
|
Ho P.C., Blumenthal P.D., Gemzell-Danielsson K., Gomez Ponce de Leon R., Mittal S. and Tang F.O.S., Misoprostol for the termination of pregnancy with a live fetus at 13 to 26 weeks, International Journal of Gynecology and Obstetrics. 2007, 99 (Supplement 2): S178-S181. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S. and Ho P.C., Comparison of 2-Dimensional, 3-Dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles, Journal of Ultrasound In Medicine. 2007, 26(7): 931-939. |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Tang F.O.S. and Ho P.C., Randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, Fertility and Sterility. 2008, 89(5): 1147-1153. |
|
Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., The role of endometrial blood flow measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during in vitro fertilization treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 135: 8-16. |
|
Tang F.O.S., Gemzell-Danielsson K. and Ho P.C., Misoprostol: Pharmacokinetic profiles, effects on the uterus and side-effects, International Journal of Gynecology and Obstetrics. 2007, 99, Supplement 2: S160-S167. |
|
Tang F.O.S., Vekemans M., Hertzen H. and Ho P.C., Termination of pregnancy in the first trimester with misoprostol alone, International Planned Parenthood Federation Medical Bulletin. 2008, 42(1): 3-4. |
|
Researcher
: Tang GWK |
|
Project Title: |
A cross sectional health care study of Chinese perimenopausal women in Hong Kong |
|
Investigator(s): |
Tang GWK |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1993 |
|
Abstract: |
|
To study Chinese women in Hong Kong on: 1) their perception and understanding of the menopause; 2) their symptoms expressed and experienced before, during and after the menopause; 3) bone density in various age groups ranging from adolescence to postmenopause and to correlate such values with biophysical parameters and diet; 4) how best health care strategies can be planned based on the findings in the study so that women's needs are met most cost effectively. |
|
Project Title: |
Fracture incidence reduction and safety of TSE-424 (Bazedoxifene Acetate) compared to placebo and Raloxifene in osteoporotic postmenopausal women / Endomentrial Safety Substudy |
|
Investigator(s): |
Tang GWK |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Wyeth Austral PTY Ltd - General Award |
|
Start Date: |
02/2002 |
|
Abstract: |
|
(A) This reduction in the circulating levels of oestrogen during menopause is associated with a number of changes, including osteoporosis. Osteoporosis is characterized by a loss of bone mass and micro architectural deteroration of bones tissue, with a consequent increase in bone fragility and susceptibility to bone fracture. (B) Bazedoxifene acetate is a selective oestrogen receptor modulator (SERM). It has been designed to exhibit the positive effects of an oestrogen agonist on the skeletal and cardiovascular systems, while acting as an antagonist on the uterus and the breast. SERMs have 2 principal indications in the clinic: the prevenetion and treatment of postmenopausal osteoporsis(raloxifene) and the prevention and treatment of breast cancer (tamoxifen), mainly in postmenopausal women. (C) Pre-clinical studies suggest that bazedoxifene acetate protects bone at a lower dose than currently marketed SERMs with no uterine agonist effect, a low potentional to induce flushes, and an improvement in the serum lipid profile. Pre-clinical data has also demonstrated that bazedoxifene acetate effectively suppress the proliferation of breast cancer cell lines, which suggests that it may exhibit antagonist activity on breast cell proliferation. (D) This is a multi-centre, double-blind, randomised, placebo and active comparator controlled phase 3 trial that will involve approximately four thousand patients. There will be about 180 sites participating in the study, which will be conducted globally. Of the four thousand patients recrutied into the study, 1000 patients will be recruited to one of the following four study groups: 1. bazedoxifence acetate 20mg, 2. bazedoxifence acetate 40mg, 3. raloxifece 60mg, 4. placebo. |
|
Project Title: |
Main Study (013-01)- A study to Evaluate the Efficacy of Quadrivalent HPV (Types 6,11,16 and 18) L1 Virus-Like Particle (VLP) Vaccine in Reducing the Incidence of HPV 6/11-, 16- and 18- Related CIN, and HPV 16 and 18-Related AIS and Cervical Cancer, and HPV 6/11-, 16-, and 18-Related External Genital Warts, VIN and VaIN, and HPV 16 and 18-Related Vulvar and Vaginal Cancer in 16- to 23- Year-Old Women -- The F.U.T.U.R.E. I Study (Females United to Unilaterally Reduce Endo/Ectocervical disease). Substudy (012-01)- Immunogenicity and Safety of Quadrivalent HPV (Types 6,11,16,18)L1 Virus-Like Particle (VLP) Vaccine in 16- to 23-Year-Old Women With an Immunogenicity Bridge Between the HPV 16 Component of the Qualdrivalent Vaccine and the Monovalent HPV 16 Vaccine Pilot Manufacturing Material - The F.U.T.U.R.E. I Study (Females United to Unilaterally Reduce Endo/Ectocervical Disease) |
|
Investigator(s): |
Tang GWK |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Merck, Sharp and Dohme ( |
|
Start Date: |
08/2002 |
|
Abstract: |
|
To demonstrate that a 3-dose regimen of quadrivalent HPV (Types 6,11,16,18) L1 VLP vaccine is generally well tolerated; to demonstrate that quadrivalent HPV vaccine is generally well tolerated. |
|
List of Research Outputs |
|
Kung A.W.C., Lee K.K., Ho A.Y.Y., Tang G.W.K. and Luk K.D.K., Ten-Year Risk of Osteoporotic Fractures in Postmenopausal Chinese Women According to Clinical Risk Factors and BMD T Scores: A Prospective Study, Journal of Bone and Mineral Research. 2007, 22: 1080-7. |
|
Tang
G.W.K., Adolescence and Contraception:
Problems in Adolescents, 1st Scientific Meeting of the Asian Pacific
Council on Contraception, |
|
Tang
G.W.K., Graduate Quality Accreditation :
Graduate vs School Accrediation, 4th Congress of Asian Medical Education
Association, |
|
Tang
G.W.K., Health Services Provision from the
Perspective of the Academia, U21 Health Sciences Meeting, |
|
Tang
G.W.K., Medical Education: An uphill battle
or a matter of course?, Distinguished Lecture, Department of Surgery, The |
|
Tang G.W.K., Professionalism - way to service quality, Allied Health (AH) Conference - "Challenges for Modern Allied Health Leaders", Hong Kong, January . 2008. |
|
Tang G.W.K., Treatment of Menopause: From the perspective of Western Medicine, 3rd International Symposium on Healthy Aging, Hong Kong. March . 2008. |
|
Tang G.W.K., Leung K.Y. and Chan C.C.W., Use of hormone therapy: POST-WHI ERA in Hong Kong, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, Tokyo, Japan September 21-25 . 2007. |
|
Tay E.H., Garland S., Tang G.W.K., Nolan T., Huang L.M.,
Orloski L., Lu S. and Barr E., Clinical trial experience with prophylactic
HPV |
|
Researcher
: Tang MHY |
|
List of Research Outputs |
|
Leung K.Y., Tang M.H.Y. and Lam Y.H., Prenatal 2D and 3D ultrasound prediction of homozygous alpha thalassemia, AOCOG 2007 Golden Jubilee of Federation, The XXth Asian and Oceanic Congress of Obstetrics and Gynaecology, September 21-25, 2007, Tokyo, Japan. 2007. |
|
Leung K.Y., Cheong K.B., Tang M.H.Y. and Chan V.N.Y., Prenatal diagnosis of thalassemia, Journal of Paediatrics, Obstetrics & Gynaecology. 2008, 34: 37-42. |
|
Leung W.C., Lau E.T.K., Lau W.L., Tang R., Wong S.F., Lau T.K., Tse K.T., Wong S.F., To W.W.K., Ng L.K.L., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?, Hong Kong Medical Journal. 2008, 14(1): 6-13. |
|
Ng P.P.Y., Tang M.H.Y., Lau E.T.K., Ng L.K.L., Ngan E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Chromosome anomalies and Y-microdeletions in subfertile men (Poster), The ACAG-HKSMG International Conference, Hong Kong, 11 June 2008. |
|
Researcher
: To MY |
|
List of Research Outputs |
|
Liu
V.W.S., Chan D.W., To M.Y., Chiu C.N. and Ngan H.Y.S., Forkhead box transcription
factor FoxG1 is over-expressed in ovarian cancer and can inhibit p21
expression, Annual Meeting of the American Association for Cancer
Research, April 12-16, 2008, |
|
Researcher
: To WWK |
|
List of Research Outputs |
|
Leung W.C., Lau E.T.K., Lau W.L., Tang R., Wong S.F., Lau T.K., Tse K.T., Wong S.F., To W.W.K., Ng L.K.L., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?, Hong Kong Medical Journal. 2008, 14(1): 6-13. |
|
Researcher
: Tsang PCK |
|
List of Research Outputs |
|
Liu S., Tsang P.C.K., Chan Y.K., Cheung A.N.Y., Chan K.K.L., Leung C.Y. and Ngan H.Y.S., Distribution of Six Oncogenic Types of Human Papillomavirus and Type 16 Integration Analysis in Chinese Women with Cervical Precancerous Lesions and Carcinomas, Tumour Biol. 2008, 29(2): 105-113. |
|
Ngan
H.Y.S., Tsang P.C.K., Chan Y.K., Liu S., Cheung A.N.Y., Chan K.K.L. and Leung C.Y., Human papillomavirus
genotyping and integration in cervical cancers and precursor lesions, 24th
International Papillomavirus Conference and Clinical Workshop. |
|
Researcher
: Tse KT |
|
List of Research Outputs |
|
Leung W.C., Lau E.T.K., Lau W.L., Tang R., Wong S.F., Lau T.K., Tse K.T., Wong S.F., To W.W.K., Ng L.K.L., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?, Hong Kong Medical Journal. 2008, 14(1): 6-13. |
|
List of Research Outputs |
|
Chan K.K.L., Tam K.F., Tse K.Y. and Ngan H.Y.S., The role of physical examination in the routine follow up of patients treated for ovarian carcinoma, British Gynaecological Society Annual Conference 2007. |
|
Lao T.T.H., Chan C.P., Leung W.C., Ho L.F. and Tse K.Y., Maternal hepatitis B infection and gestational diabetes mellitus, Journal of Hepatology. 2007, 47(1): 46-50. |
|
Tse K.Y., Chan K.K.L., Tam K.F. and Ngan H.Y.S., Current concepts in the management of endometrial carcinoma, Journal of Paediatrics, Obstetrics and Gynaecology. 2007, SEP/OCT: 213-220. |
|
List of Research Outputs |
|
Tse P.K., Lee Y.L., Chow W.N., Luk J.M.C., Lee K.F. and Yeung W.S.B., Preimplantation embryos cooperate with oviductal cells to produce embryotrophic inactivated complement-3b, Endocrinology. 2008, 149(3): 1268-1276. |
|
Researcher
: Wei N |
|
List of Research Outputs |
|
Chan K.K.L., Wei N., Liu S., Liao X., Cheung A.N.Y. and Ngan H.Y.S., Estrogen receptor subtypes in ovarian cancer: a clinical correlation, Obstet Gynecol. 2008, 111: 144-151. |
|
Researcher
: Wong BPC |
|
List of Research Outputs |
|
Lee C.K.F., Wong B.P.C., Lai K.Y. and Yeung W.S.B., Cloning and characterization of oviductal demilune cell and parotid protein (Dcpp) gene promoter., The 23rd Annual Meeting of the european Society of Human Reproduction and Embryology. 2007. |
|
Lee C.K.F., Wong B.P.C., Lai K.Y. and Yeung W.S.B., Cloning and characterization of oviductal demilune cell and parotid protein (Dcpp) gene promoter, The 23rd Annual Meeting of the european Society of Human Reproduction and Embryology. 2007. |
|
Researcher
: Wong RLC |
|
List of Research Outputs |
|
Leung C.Y., Liu S., Chan Y.K., Tam K.F., Chan K.K.L., Wong R.L.C. and Ngan H.Y.S., Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer, Oncology Reports. 2008, 19: 1339-1345. |
|
Researcher
: Wong SF |
|
List of Research Outputs |
|
Leung W.C., Lau E.T.K., Lau W.L., Tang R., Wong S.F., Lau T.K., Tse K.T., Wong S.F., To W.W.K., Ng L.K.L., Lao T.T.H. and Tang M.H.Y., Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?, Hong Kong Medical Journal. 2008, 14(1): 6-13. |
|
List of Research Outputs |
|
Chiu C.N., Wong S.T., Lee C.L., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and Yeung W.S.B., Native human zona pellucida glycoproteins: purification and binding properties, Human Reproduction. 2008, 23: 1385. |
|
Researcher
: Wong YY |
|
List of Research Outputs |
|
Ng E.H.Y., So W.Z., Gao J., Wong Y.Y. and Ho P.C., The role of acupuncture in the management of subfertility, Fertility and Sterility. 2008, 90: 1-13. |
|
Researcher
: Yeung WSB |
|
Project Title: |
Functional studies of VCY2 and VCY2 interacting protein (VCY2IP-1) |
|
Investigator(s): |
Yeung WSB, Tam PC, Tse JYM, Huang J |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Incentive Award for RGC CERG Fundable But Not Funded Projects |
|
Start Date: |
07/2003 |
|
Abstract: |
|
N/A |
|
Project Title: |
The mechanisms of action of glycodelin-A on zona pellucida induced acrosome reaction |
|
Investigator(s): |
Yeung WSB, Chiu CN, Lee CKF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Glycodelin is a glycoprotein belonging to the lipocalin family. It has 3 reported isoforms; namely amniotic fluid-derived glycodelin-A, seminal plasma-derived glycodelin-S and follicular fluid-derived glycodelin-F (Seppala et al., 2002; Chiu et al., 2003). The isoforms of glycodelin have the same protein core but differ in their glycosylation. Glycodelin-A is the first endogenous glycoprotein found to inhibit spermatozoa-zona pellucida binding (Oehninger et al., 1995). Its absence in the endometrium in the periovulatory period may be related to the presence of a fertilization window (Seppala et al., 1998). Glycodelin-A is produced by the oviduct tissue and is also present in the follicular fluid (Chiu PCN and Yeung WSB, unpublished data). Thus the spermatozoa are likely to come in contact with glycodelin-A in the oviduct before they meet the oocyte. We hypothesize that glycodelin-A has effects on spermatozoa other than its action on spermatozoa-zona pellucida interaction. Indeed, our preliminary data show that glycodelin-A stimulates zona-pellucida-induced acrosome reaction of human spermatozoa, though the molecule does not affect spontaneous acrosome reaction. Acrosome reaction is a critical event in fertilization and is induced by the zona pellucida of oocyte. It allows the spermatozoa to release acrosomal enzymes, and thereby facilitating the penetration of the spermatozoa through the zona pellucida. Our observation suggests that glycodelin-A primes the spermatozoa for this important event of fertilization. The objective of this proposal is to study the intracellular mechanisms in human spermatozoa leading to the priming action of glycodelin-A on zona pellucida-induced acrosome reaction. A priming effect of progesterone on acrosome reaction had been reported in mouse (Roldan et al., 1994) and guinea-pig (Shi et al. 2005) and is regulated by intracellular calcium concentration, phospholipase and/or cAMP/PKA pathway. References Chiu PCN, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WSB (2003) Biol Reprod, 69, 365-72. Oehninger S, Coddington CC, Hodgen GD, Seppala M (1995) Fertil Steril, 63, 377-83. Oehninger S, Franken DR, Sayed E, Barroso G, Kolm P (2000) Hum Reprod Update 6, 160-8. Seppala M, Taylor RN, Koistinen H, Koistinen R, Milgrom E (2002) Endocr Rev 23, 401-430.. Seppala M, Koistinen H, Koistinen R, Mandelin E, Oehninger S, Clark GF, Dell A, Morris HR. (1998) Hum Reprod 13 (suppl 3), 262-70. Roldan ER, Murase T, Shi QX (1994) Science, 266(5190), 1578-81. Shi QX, Chen WY, Yuan YY, Mao LZ, Yu SQ, Chen AJ, Ni Y, Roldan ER (2005) J Cell Physiol.[Epub ahead of print]. |
|
Project Title: |
The mechanism of action of a novel glycodelin isoform from cumulus matrix on stimulating spermatozoa-zona pellucida binding |
|
Investigator(s): |
Yeung WSB, Chiu CN, Lee CKF |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To determine the effect of glycodelin-C treatment on zona pellucida protein binding; to determine the intracellular signalling pathway of glycodelin-C in human spermatozoa; to study the mechanisms of action of glycodelin-C in increasing spermatozoa-zona binding. |
|
Project Title: |
Glycodelin-A binds to and protects human spermatozoa from T-lymphocyte attack |
|
Investigator(s): |
Yeung WSB, Chiu CN |
|
Department: |
Obstetrics & Gynaecology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
The female reproductive tract is fully
capable of cell-mediated and humoral immune responses (Metafora et al.,
1989). Spermatozoa express differentiation and histocompatibility antigens on
their surface (Martin-Villa et al., 1999) and induces leukocytic reaction in
the cervical mucus after insemination leading to massive leukocyte
infiltration comprising of polymorphonuclear cells, lymphocytes and
macrophages (Thompson et al., 1992). However, this immunologic sensitization
of the female to sperm antigens does not lead to immunologic damage of
spermatozoa. The mechanism of sperm immunoprotection within the female
reproductive tract is not well understood (Barratt and Pockley, 1998). One
possible mechanism is the presence of molecules in the female reproductive
tract that inhibit the immune response or mask the sperm antigenic
determinants recognized by the female's immune system. Glycodelin is a
lipocalin glycoprotein with three well-known isoforms, namely glycodelin-A
(amniotic fluid isoform), glycodelin-S (seminal plasma isoform) and
glycodelin-F (follicular fluid isoform) (Seppala et al., 2002; Yeung et al.,
2006). They have the same protein core but with different glycosylation. The
most well accepted biological function of glycodelin-A is on
immunosuppression. Glycodelin-A inhibits T cell proliferation (Rachmilewitz
et al., 1999), induces apoptosis in T cells (Mukhopadhyay et al., 2001) and
decreases synthesis of interleukin (IL)-2 and soluble IL-2 receptor (Pockley
and Bolton, 1989). Glycodelin-A also renders T cells less sensitive to
stimulation (Rachmilewitz et al., 2001) which is mediated by the tyrosine
phosphatase receptor CD45 on T cell surfaces (Rachmilewitz et al., 2003).
Furthermore, glycodelin-S in the seminal plasma exhibited in vitro
immunosuppressive activity, which can be removed by treatment with a
monoclonal anti-PP14 antibody-based immunoadsorbent (Bolton et al., 1987).
The immunosuppressive activities of glycodelin-F is still unknown.
Glycodelin-A, -F and -S binds to the acrosome region of human spermatozoa
(Chiu et al., 2003) and is present in the reproductive tract (Seppala et al.,
2002; Yeung et al., 2006) through which the spermatozoa must pass before
fertilizing the oocyte. We hypothesize that glycodelin-A protects the
spermatozoa from lymphocyte attack by binding on the spermatozoa with their
carbohydrate moieties. There are 3 objectives in this project. They are 1. To
study the effect of glycodelin pretreatment on sperm-mediated stimulation of
T-lymphocyte. 2. To determine the mechanism(s) of immunoprotection of
glycodelin on spermatozoa 3. To study the role of CD |
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List of Research Outputs |
|
Aflatoonian R., Ward J., Lee C.K.F., Yeung W.S.B., Tsao S.W., Elliott S.
and Fazeli A., Sex hormones enhance TLR3 response to its specific ligand in
human fallopian tube epithelial cells. P.608, The Society for the Study of
Reproduction 41st Annual meeting, May 27-30, 2008, |
|
Chan V.N.Y., Ng E.H.Y., Yeung W.S.B., Yam I.Y.L., Chan T.K. and Ho P.C., Preimplantation genetic diagnosis of thalassaemias, 11th Congress of the International Society of Hematology, Asian-Pacific Division (ISH-APD2007) and the 12th Congress of the Asian-Pacific Bone Marrow Transplantation, Beijing, China, September 21-23. 2007. |
|
Cheong
A.W.Y., Lee C.Y.L., Liu W., Yeung W.S.B. and Lee C.K.F., Oviductal microsomal epoxide
hydrolase (Ephx1) enhances preimplantation embryo development by suppressing
reactiveoxygen species (ROS) production, Hong Kong Society of
Endocrinology, Metabolism and Reproduction, November 11, 2007, |
|
Cheong
W.Y.A., Lee C.Y.L., Liu Y., Yeung W.S.B. and Lee C.K.F., Best poster presentation
award HKSEMR 2007- Oviductal microsomal epoxide hydrolase (Ephx1) enhances
preimplantation embryo development by suppressing reactiveoxygen species
(ROS) production. , The Annual Scientific Meeting of the Hong Kong Society
of Endocrinology, Metabolism and Reproduction, 11 November 2007, |
|
Chiu C.N., Wong S.T., Lee C.L., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and Yeung W.S.B., Native human zona pellucida glycoproteins: purification and binding properties, Human Reproduction. 2008, 23: 1385. |
|
Chiu
C.N., Wong B.S., Lee C.L., Chung M.K., Lam K.K., Pang R.T.K., Lee C.K.F., Sumitro S.B., Gupta S.K. and
Yeung W.S.B., Purification of
native human zona pellucida glycoproteins from eggs: Binding characteristics
to human spermatozoa, hyper-activation, acrosomal exocytosis, and
sperm-oocyte interaction. P.74, The Society for the Study of Reproduction
41st Annual meeting, May 27-30, 2008, |
|
Chung
M.K., Chiu C.N., Lam K.W., Lee C.L., Lee C.K.F. and Yeung W.S.B., Cumulus
ooporous-associated glycodelin-C displaces sperm-bound glycodelin-A and -F
and stimulates spermatozoa-zona pellucida binding. O.2.05, The 12th
Research Postgraduate Symposium, The |
|
Chung M.K., Chiu C.N., Lam K.W., Lee C.L., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Purification and identification of a glycodelin-C interacting protein from human cumulus matrix, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Chung
M.K., Chiu C.N., Lam K., Lee C.L., Pang R., Lee C.K.F. and Yeung W.S.B., Study of the
interaction of cumulus-associated alpha-2-macroglobulin with glycodelin-C
from human cumulus matrix. P. 196, The Society for the Study of
Reproduction 41st Annual meeting, May 27-30, 2008, |
|
Lee C.K.F., Wong B.P.C., Lai K.Y. and Yeung W.S.B., Cloning and characterization of oviductal demilune cell and parotid protein (Dcpp) gene promoter., The 23rd Annual Meeting of the european Society of Human Reproduction and Embryology. 2007. |
|
Lee C.K.F., Wong B.P.C., Lai K.Y. and Yeung W.S.B., Cloning and characterization of oviductal demilune cell and parotid protein (Dcpp) gene promoter, The 23rd Annual Meeting of the european Society of Human Reproduction and Embryology. 2007. |
|
Lee
C.K.F., Zuo Y., Tam B.Y., Tang A.Y.B. and Yeung W.S.B., Syntaxin and b-actin
interact with acrosome-expressing protein VAD1.2/AEP |
|
Lee
C.K.F., Zuo Y., Tam Y.T., Tang A.Y.B. and Yeung W.S.B., The acrosome-expressing
proteins VAD1.3/AEP1 and VAD1.2 interact with syntaxin and b-acting in
vitro., The |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Lee
C.L., Chiu C.N., Chung M.K., Lam K.K., |
|
Lee
C.L., Chiu C.N., Lam K.W., Chung M.K., |
|
Lee C.Y.L., Liu Y., Ng P.Y., Lee C.K.F., Au C.L., Ng E.H.Y. and Yeung W.S.B., Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation, Human Reproduction. 2008, 23: 894-903. |
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Lee C.Y.L., Chan Y.L., Chow W.N., Ng E.H.Y., Lee C.K.F., Yeung W.S.B. and Ho P.C., Endocrine gland-derived vascular endothelial growth factor stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the mitogen-activated protein kinase but not through the Akt pathway., Fertility and Sterility. 2008. |
|
Lin S.S.W., Pang R.T.K., Lee C.K.F. and Yeung W.S.B., Microrna expression profile and their regulatory roles in ovarian folliculogenesis , Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Liu
Y., Ng E.H.Y., Yeung W.S.B., Ho P.C. and Lee C.K.F., The expression and
functional studies of DKK1 and Wnt signaling molecules in human endometrium
and embryo implantation. O2.16., The 12th Research Postgraduate Symposium,
The University of Hong Kong, December 12-14, 2007, |
|
Monkkonen K.S., Aflatoonian R., Lee C.K.F., Yeung W.S.B., Tsao G.S.W., Laitinen J.T. and Fazeli A., Hormonal regulation of G{alpha}i2 and mPR{alpha} in immortalized human oviductal cell line OE-E6/E7., Mol Hum Reprod. 2007, 13: 845-51. |
|
Ng E.H.Y., Lau E.Y.L., Yeung W.S.B., Cheung T.M., Tang F.O.S. and Ho P.C., Randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage, Fertility and Sterility. 2008, 89(5): 1147-1153. |
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Ng E.H.Y., Chan C.C.W., Tang F.O.S., Yeung W.S.B. and Ho P.C., The role of endometrial blood flow measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during in vitro fertilization treatment, European Journal of Obstetrics and Gynecology and Reproductive Biology. 2007, 135: 8-16. |
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Ng P.P.Y., Tang M.H.Y., Lau E.T.K., Ng L.K.L., Ngan E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Chromosome anomalies and Y-microdeletions in subfertile men (Poster), The ACAG-HKSMG International Conference, Hong Kong, 11 June 2008. |
|
Ng P.Y., Liu Y., Ng E.H.Y., Ho P.C., Yeung W.S.B. and Lee C.K.F., Differential gene expression of olfactomedin throughout the menstrual cycle is regulated by ovarian hormones., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.508. |
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Pang
R.T.K., Liu W., Chiu C.N., Lee C.K.F. and Yeung W.S.B., Microrna regulates
notch1 receptor in hela cells, Hong Kong Society of Endocrinology,
Metabolism and Reproduction, November 11, 2007, |
|
Sze K.L., Yeung W.S.B. and Fung Y.S., Separation and Determination of Metal Cations in Milk and Dairy Products by CE, Electrophoresis. 2007, 28: 4156-4163. |
|
Tam V.C.G., Chiu C.N., Koistinen R., Koistinen M., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Glycodelin-C receptor on human spermatozoa., The 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 1-4 July, Lyon, France.. 2007, P.459. |
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Tse P.K., Lee Y.L., Chow W.N., Luk J.M.C., Lee K.F. and Yeung W.S.B., Preimplantation embryos cooperate with oviductal cells to produce embryotrophic inactivated complement-3b, Endocrinology. 2008, 149(3): 1268-1276. |
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Wong B.S.T., Chiu C.N., Koistinen R., Koistinen H., Seppala M., Ho P.C., Lee C.K.F. and Yeung W.S.B., Priming effect of glycodelin-A on zona pellucida-induced acrosome reaction in human sperm, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
|
Wu R., Fung Y.S. and Yeung W.S.B., Microfluidic Chip-capillary Electrophoresis for 2-D Separation of Proteins, 7th Asia-Pacific Internationa Symposium on Microscale Separation and Analysis (APCE 2007), Singapore, December 16-19, 2007. Paper 5:49, pp 5:141. |
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Yan Z., Tam Y.T., Cheah K.S.E., Yeung W.S.B. and Lee C.K.F., Functional characterization of VAD 1.3 /AEP 1 Gene in acrosome-formation and fertility, Hong Kong Society of Endocrinology, Metabolism and Reproduction, November 11, 2007, Hong Kong. 2007. |
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Yao Y.Q., Lee C.K.F., Xu J.S., Ho P.C. and Yeung W.S.B., Effect of human oviductal embryotrophic factors on gene expression of mouse preimplantation embryos, Zhonghua Fu Chan Ke Za Zhi (Chinese). 2007, 42(9): 605-607. |
|
Zuo
Y., Tam Y.T., Yeung W.S.B. and Lee C.K.F., Functional characterization
of VAD1.3/AEP1 gene in acrosome-formation and fertility. O2.15., The 12th
Research Postgraduate Symposium, The University of Hong Kong, December 12-14,
2007, |
|
List of Research Outputs |
|
Yip
C.T., Chan
D.W., Liu V.W.S. and Ngan H.Y.S., Zic2 synergistically
enhances Hedgehog signaling pathway in cervical cancer., The 12th Research
Postgraduate Symposium 2007, The |
|
Yip
C.T., Chan
D.W., Liu V.W.S. and Ngan H.Y.S., Zic2 synergistically
enhances Hedgehog signaling pathway in cervical cancer., The 99th Annual
Meeting of American Association of Cancer Research, 12-16 April 2008, |
|
Researcher
: Yip MW |
|
List of Research Outputs |
|
Kwan T.T.C., Chan K.K.L., Yip M.W., Tam K.F., Cheung A.N.Y., Young P.M.C., Lee P.W.H. and Ngan H.Y.S., Barriers and facilitators to human papillomavirus vaccination among Chinese adolescent girls in Hong Kong: a qualitative–quantitative study, Sex Transm Infect. 2008, 84(3): 227-232. |
|
Researcher
: Zuo Y |
|
List of Research Outputs |
|
Lee
C.K.F., Zuo Y., Tam B.Y., Tang A.Y.B. and Yeung W.S.B., Syntaxin and b-actin
interact with acrosome-expressing protein VAD1.2/AEP |
|
Lee
C.K.F., Zuo Y., Tam Y.T., Tang A.Y.B. and Yeung W.S.B., The acrosome-expressing
proteins VAD1.3/AEP1 and VAD1.2 interact with syntaxin and b-acting in
vitro., The |
|
Zuo
Y., Tam
Y.T., Yeung W.S.B. and Lee C.K.F., Functional characterization
of VAD1.3/AEP1 gene in acrosome-formation and fertility. O2.15., The 12th
Research Postgraduate Symposium, The University of Hong Kong, December 12-14,
2007, |
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