DEPT OF PSYCHIATRY
Researcher
: Chan RCK |
List of Research Outputs |
Chan R.C.K., Chen E.Y.H. and Law C.W., Specific executive dysfunction in patients with first-episode medicatino-naive schizophrenia, Schizophrenia Research. 2006, 82: 51-64. |
Ma X.H., Wang Q., Sham P.C., Liu X.H., Rabe-Hesketh S., Sun X.L., Meng H.Q., Chen W., Chen E.Y.H., Deng W., Chan R.C.K., Murray R.M., Collier D.A. and Li T., Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives, American Journal of Medical Genetics. 2006, 141B(7): 775. |
Ma X.H., Wang Q., Sham P.C., Liu X.H., Rabe-Hesketh S., Sun X.L., Meng H.Q., Chen W., Chen E.Y.H., Deng W., Chan R.C.K., Murray R.M., Collier D.A. and Li T., Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives, American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 2006, 141B: 775. |
Wang Q., Chan R.C.K., Sun J.H., Yao J., Deng W., Sun X.L., Liu X.H., Sham P.C., Ma X.H., Meng H.Q., Murray R.M., Collier D.A. and Li T., Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: A study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls, Schizophrenia Research. 2007, 89(1-3): 293-298. |
Researcher
: Chen EYH |
Project Title: |
Outcome of an early intervention programme for psychosis (EASY): a case controlled study |
Investigator(s): |
Chen EYH, Chan RCK |
Department: |
Psychiatry |
Source(s) of Funding: |
Health and Health Services Research Fund - Full Grants |
Start Date: |
09/2005 |
Abstract: |
The study will help identify the
effectiveness of early intervention for psychosis in |
Project Title: |
Duration of maintenance anti-psychotic therapy after first-episode schizophrenia: a double-blind randomized placebo-control relapse prevention study |
Investigator(s): |
Chen EYH, Law CW, Chiu CPY |
Department: |
Psychiatry |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
09/2005 |
Abstract: |
To study the efficacy of relapse prevetion by maintenance antipsychotic therapy in patients who had responded well and remained well for 12 months following a first-episode schizophrenia. |
List of Research Outputs |
Chan R.C.K., Chen E.Y.H. and Law C.W., Specific executive dysfunction in patients with first-episode medicatino-naive schizophrenia, Schizophrenia Research. 2006, 82: 51-64. |
Chen
E.Y.H., A population-based approach to Early
Psychosis in |
Chen
E.Y.H., A population-based approach to early
psychosis in |
Chen
E.Y.H., A population-based early intervention
model: concepts and issues, 30th Annual Meeting of the |
Chen E.Y.H., Hui L.M.C., Chiu C.P.Y. and Law C.W., Cognitive correlates of semantic language disorder in first-episode schizophrenia, Schizophrenia Bulletin. 2007, 33: 214. |
Chen
E.Y.H., Early Psychosis in |
Chen E.Y.H., Editorial Board (2005-present), Chinese Medical Journal. 2006. |
Chen E.Y.H., Editorial Board (2006-present), Early Intervention in Psychiatry. 2006. |
Chen E.Y.H., Editorial Board (from 2003- present), Schizophrenia Research. 2006. |
Chen
E.Y.H., Phase specific intervention for early
psychosis, Toho Asia International Symposium in Psychiatry. |
Chen E.Y.H., Phase-specific intervention for early psychosis, Journal of the Medical Society of Toho University. 2007, 54 (3): 208 (48). |
Chen
E.Y.H., Subjective Experience in the Recovery
Process: Psychopathological Issues, Workshop on Evaluating Experiential
Dimensions of Early Psychosis. Hong Kong, |
Chen
E.Y.H., Uncovering the Mysterious Veil of
Psychotic Disorders, Li Ka Shing Faculty of Medicine, HKU, 120th
Anniversary Public Lecture Series. |
Cheung
V., Chua
S.E., McAlonan
G.M., Chen
E.Y.H. and Khong
P.L., Connectivity along white mater tracts in drug-naive patients of
first-episode psychosis: a diffusion tensor tractography study, |
Chua S.E., Cheung C., Cheung V., Tsang J.T.K., Chen E.Y.H., Wong J.C.H., Cheung J.P.Y., Yip L., Tai K.S., Suckling J. and McAlonan G.M., Cerebral grey, white matter & CSF in never-medicated, first-episode Schizophrenia, Schizophrenia Research. 2006, 89: 12-21. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schisophrenia, 13th Annual
Meeting Human Brain Mapping. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schizophrenia, 2nd International
Congress of Biological Psychiatry 2007. |
Ho H.W., Chen E.Y.H., Chan R.C.K., Wong C.W., Hung S.F., Chung D.W.S., Ng S.M. and Chan C.L.W., Efficacy of a brief intervention for carers of people with first-episode psychosis: a waiting list controlled study, Hong Kong Journal of Psychiatry. 2006, 16: 92-100. |
Hui C.L.M. and Chen E.Y.H., Relapse and medication adherence in first-episode psychosis, Journal of the Medical Society of Toho University. 2007, 54 (3): 208 (48). |
Hui L.M.C., Chen E.Y.H. and Law C.W., Cognitive correlates of the Hayling sentence completion test in first-episode schizophrenia, Schizophrenia Bulletin. 2007, 33: 525. |
Lai C.T., Sutherland S.K., Shan J.J. and Chen
E.Y.H., Remember-fX (HT1001) improved visual working memory in
schziophrenic patients: a double-blind, placebo controlled study, 30th
Annual meeting of the Canadian College of Neuropsychopharmacology. |
Lee T.M.C., Chan M.W.C., Chan C.C.H., Gao J., Wang K. and Chen E.Y.H., Prose memory dificits associated with schizophrenia, Schizophrenia Research. 2006, 81: 199-209. |
Liu
K.Y., Chen
E.Y.H., Chan
C.L.W., Lee
D.T.S., Law
Y.W., Conwell Y. and Yip
P.S.F., Socio-economic and psychological correlates of suicidality among
Hong Kong working-age adults: results from a population-based survey, Psychological
Medicine. |
Ma X.H., Wang Q., Sham P.C., Liu X.H., Rabe-Hesketh S., Sun X.L., Meng H.Q., Chen W., Chen E.Y.H., Deng W., Chan R.C.K., Murray R.M., Collier D.A. and Li T., Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives, American Journal of Medical Genetics. 2006, 141B(7): 775. |
Ma X.H., Wang Q., Sham P.C., Liu X.H., Rabe-Hesketh S., Sun X.L., Meng H.Q., Chen W., Chen E.Y.H., Deng W., Chan R.C.K., Murray R.M., Collier D.A. and Li T., Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives, American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 2006, 141B: 775. |
Ran M., Chen E.Y.H., Conwell Y., Chan C.L.W., Yip P.S.F., Xiang M. and Caine E.D., Mortality in people with schizophrenia in rural China: 10-year cohort study, British Journal of Psychiatry. 2007, 190: 237-242. |
Wong A.W.S., Chiu C.Y., Mok J.W.Y., Wong J.G.W.S. and Chen E.Y.H., The role of knowledge and motivation in symptom identification accuracy among schizophrenic patients: Application of signal detection theory, British Journal of Clinical Psychology. The British Psychological Society, 2006, 45: 427-436. |
Researcher
: Chen RYL |
Project Title: |
Psychological and biological risk factors associated with Pathological Gambling |
Investigator(s): |
Sham PC |
Department: |
Psychiatry |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Abstract: |
To identify psychological risk factors in terms of personality traits as well as genetic risk factors in terms of genetic polymorphisms with respects to certain candidate genes associated with Pathological Gambling (PG) in Hong Kong Chinese; to figure out the patterns in terms of the risk factors mentioned in pathological gamblers engaging in different forms of gambling. |
List of Research Outputs |
Cheng Y.W., Ng M.L., Ko S.N. and Chen R.Y.L., Physical activity and erectile dysfunction: meta-analysis of population-base studies, International Journal of Impotence Research. 2006. |
Cheng Y.W., Ng M.L., Chen R.Y.L. and Ko S.N., Prevalence of erectile dysfunction in Asian populations: a meta-analysis, International Journal of Impotence Research. 2006. |
Iwata Y., Nakajima M., Yamada K., Nakamura K., Sekine Y., Tsuchiya K.J., Sugihara G., Matsuzaki H., Suda S., Suzuki K., Takei N., Mori N., Iwayama Y., Takao H., Yoshikawa T., Riley B., Makoff A., Sham P.C., Chen R.Y.L. and Collier D., Linkage disequilibrium analysis of CHRNA7 gene and its partially duplicated region in schizophrenia, Neuroscience Research. 2007, 57(2): 194-202. |
Researcher
: Cheng YW |
List of Research Outputs |
Cheng Y.W. and Ng M.L., Body mass index, physical activity and erectile dysfunction – U-shaped relationship from population-based study, International Journal of Obesity. 2007. |
Cheng Y.W., Ng M.L., Ko S.N. and Chen R.Y.L., Physical activity and erectile dysfunction: meta-analysis of population-base studies, International Journal of Impotence Research. 2006. |
Cheng Y.W., Ng M.L., Chen R.Y.L. and Ko S.N., Prevalence of erectile dysfunction in Asian populations: a meta-analysis, International Journal of Impotence Research. 2006. |
Researcher
: Cherny SS |
List of Research Outputs |
Andresen J.M., Gayán J., Cherny S.S., Brocklebank D., Alkorta-Aranburu G., Addis E.A., The US-Venezuela Collaborative Research Group , Cardon L.R., Housman D.E. and Wexler N.S., Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds, Journal of Medical Genetics. 2007, 44: 44-50. |
Andresen J.M., Gayán J., Djoussé L., Roberts S., Brocklebank D., Cherny S.S., The US-Venezuela Collaborative Research Group , The HD MAPS Collaborative Research Group , Cardon L.R., Gusella J.F., MacDonald M.E., Myers R.H., Housman D.E. and Wexler N.S., The relationship between CAG repeat length and age of onset differs for Huntington's Disease patients with juvenile onset or adult onset, Annals of Human Genetics. 2007, 71: 295-301. |
Cherny S.S., QTL Methodology in Behavior Genetics: from Linkage to Genomewide Association, 37th Annual Meeting of the Behavior Genetics Association (abstract appears in Behavior Genetics). 2007, 37. |
Gayan J., Brocklebank D., Andresen J.M., Alkorta-Aranburu G., Cader M.Z., Roberts S.A., Cherny S.S., Wexler N.S., Cardon L.R. and Housman D.E., Genomewide linkage analysis of age of onset of Huntington's Disease, 37th Annual Meeting of the Behavior Genetics Association (abstract appears in Behavior Genetics). 2007, 37. |
Hopfer C.J., Lessem J.M., Hartman C.A., Stallings M.C., Cherny S.S., Corley R.P., Hewitt J.K., Krauter K.S., Mikulich-Gilbertson S.K., Rhee S.H., Smolen A., Young S.E. and Crowley T.J., A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9, Drug and Alcohol Dependence. 2007, 89: 34-41. |
Researcher
: Cheung C |
List of Research Outputs |
Chua S.E., Cheung C., Cheung V., Tsang J.T.K., Chen E.Y.H., Wong J.C.H., Cheung J.P.Y., Yip L., Tai K.S., Suckling J. and McAlonan G.M., Cerebral grey, white matter & CSF in never-medicated, first-episode Schizophrenia, Schizophrenia Research. 2006, 89: 12-21. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schisophrenia, 13th Annual
Meeting Human Brain Mapping. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schizophrenia, 2nd International
Congress of Biological Psychiatry 2007. |
Lee
A.M., Wong
J.G.W.S., McAlonan
G.M., Cheung
V., Cheung
C., Sham
P.C., |
McAlonan G.M., Lee A.M., Cheung V., Cheung C., Tsang K.W.T., Sham P.C., Chua S.E. and Wong J.G.W.S., Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers, Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie. 2007, 52(4): 241-247. |
McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research Neuroimaging. Elsevier, 2006, 154: 171-180. |
Researcher
: Cheung V |
List of Research Outputs |
Cheung
V., Chua
S.E., McAlonan
G.M., Chen
E.Y.H. and Khong
P.L., Connectivity along white mater tracts in drug-naive patients of
first-episode psychosis: a diffusion tensor tractography study, |
Cheung V., Connectivity along white matter tracts in drug-naive patients of first-episode psychosis: a diffusion tensor tractography study, Post-graduate symposium 2006, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2006. |
Chua S.E., Cheung C., Cheung V., Tsang J.T.K., Chen E.Y.H., Wong J.C.H., Cheung J.P.Y., Yip L., Tai K.S., Suckling J. and McAlonan G.M., Cerebral grey, white matter & CSF in never-medicated, first-episode Schizophrenia, Schizophrenia Research. 2006, 89: 12-21. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schisophrenia, 13th Annual
Meeting Human Brain Mapping. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schizophrenia, 2nd International
Congress of Biological Psychiatry 2007. |
Lee
A.M., Wong
J.G.W.S., McAlonan
G.M., Cheung
V., Cheung
C., Sham
P.C., |
McAlonan G.M., Lee A.M., Cheung V., Cheung C., Tsang K.W.T., Sham P.C., Chua S.E. and Wong J.G.W.S., Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers, Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie. 2007, 52(4): 241-247. |
McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research Neuroimaging. Elsevier, 2006, 154: 171-180. |
Rudowicz E., Yue X. and Cheung
V., Factor structure of the Style of Creative Behaviour model in Hong
Kong Chinese undergraduates, The 9th Asia-Pacific Conference on Giftedness.
|
Toulopoulou T., Chua S.E., Lam I., Cheung V., Murray R.M. and David A.S., Evidence of normal hearing laterality in familial schizophrenic patients and their relatives, American Journal of Medical Genetics. 2007. |
Researcher
: Chiu CPY |
List of Research Outputs |
Chen E.Y.H., Hui L.M.C., Chiu C.P.Y. and Law C.W., Cognitive correlates of semantic language disorder in first-episode schizophrenia, Schizophrenia Bulletin. 2007, 33: 214. |
Researcher
: Chua SE |
Project Title: |
Brain mapping social impairment in autism |
Investigator(s): |
Chua SE, Fung PCW, Tai KS, McAlonan GM |
Department: |
Psychiatry |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
02/2004 |
Abstract: |
To determine what regions of brain contribute to social impairment in children with autism; the results of the study will help elucidate the causes of autism, and perhaps lead to more effective treatments. |
Project Title: |
Anatomy and connectivity in Attention Deficit-Hyperactivity Disorder (ADHD). A voxel based morphometry and diffusion tensor imaging study. |
Investigator(s): |
Chua SE, McAlonan GM, Khong PL, Tai KS, Cheung V |
Department: |
Psychiatry |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
02/2005 |
Abstract: |
1) To assess the integrity of white matter tracts connecting regions of neuropathology considered important to control of attention and executive processes. With the advent of Diffusion Tensor Imaging (DTI) we are now in a position to do this and in the current project will apply this "cutting-edge" technology to the problem of ADHD 2) This study will rescan the children scanned 4 years ago in our first investigation and examine brain maturational progress in conjunction with symptom rating. |
Project Title: |
Early effects of anti-psychotic drugs on brain growth and gene expression in schizophrenia. A pilot study. |
Investigator(s): |
Chua SE, McAlonan GM, Chen EYH, Wong JGWS, Law CW, Chiu CPY |
Department: |
Psychiatry |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
02/2006 |
Abstract: |
OBJECTIVES : This is a pilot study to
investigate the feasibility of using MRI and microarray to study the early
effects of anti-psychotic drugs on brain growth and gene expression. Since
microarray is expensive, with budget constraints it is fair to adopt a sample
size of n=6. Our project objectives are to determine the feasibility of : (1)
recruitment of subjects with first-onset schizophrenia (n=12) for MRI brain
scan at time 0 and 3 weeks, (2) peripheral blood taking of these subjects at
weeks 0, 3(3) microarray analysis protocol (n=6, see below) at the Genome
Research Centre . SUMMARY : Schizophrenia is a heritable, serious mental
disorder, affecting 1% people worldwide. It usually presents in young adults
with psychosis i.e. hallucinations or delusions. Anti-psychotic drugs
classically block dopamine receptors in the basal ganglia (striatum) in the
brain and take effect after 3 weeks (Johnstone et al 1978). There are a range
of brain morphological abnormalities in schizophrenia including ventricular
enlargement, smaller brain volume, reduced fronto-temporal volume, increased
caudate volume (Wright et al 2000) but these have mainly been studied in
chornic patients who have been treated with neuroleptic medication.
Chronicity and neuroleptic treatment are known to affect interpretation of
brain morphological differences. Thus, in recent years, the research focus in
brain imaging has turned to newly-ill and neuroleptic-naïve patients. In the
first comprehensive voxel-based MRI study of never-medicated patients with first
episode of schizophrenia, we reported significantly smaller volumes of
caudate nuclei of the dopamine-rich basal ganglia (Chua et al, |
List of Research Outputs |
Cheung
V., Chua
S.E., McAlonan
G.M., Chen
E.Y.H. and Khong
P.L., Connectivity along white mater tracts in drug-naive patients of
first-episode psychosis: a diffusion tensor tractography study, |
Chua S.E., Cheung C., Cheung V., Tsang J.T.K., Chen E.Y.H., Wong J.C.H., Cheung J.P.Y., Yip L., Tai K.S., Suckling J. and McAlonan G.M., Cerebral grey, white matter & CSF in never-medicated, first-episode Schizophrenia, Schizophrenia Research. 2006, 89: 12-21. |
Chung K.K. and Chua S.E., Acute Urinary Retention Associated With Selective Serotonin Reuptake Inhibitors and Ziprasidone, Journal of Clinical Psychopharmacology. 2007, 27(5): 1-2. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schisophrenia, 13th Annual
Meeting Human Brain Mapping. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schizophrenia, 2nd International
Congress of Biological Psychiatry 2007. |
Lee
A.M., Wong
J.G.W.S., McAlonan
G.M., Cheung
V., Cheung
C., Sham
P.C., |
McAlonan G.M., Lee A.M., Cheung V., Cheung C., Tsang K.W.T., Sham P.C., Chua S.E. and Wong J.G.W.S., Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers, Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie. 2007, 52(4): 241-247. |
McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research Neuroimaging. Elsevier, 2006, 154: 171-180. |
Toulopoulou T., Chua
S.E., |
Wong
K.W.T., Fung
P.C.W., McAlonan
G.M. and Chua
S.E., An ERP study of the spatiotemporal processing of facial
expressions in children with autism, The 4th Congress of Federation of
Asian-Oceanian Neuroscience Societies. |
Wong K.W.T., Fung P.C.W., McAlonan G.M. and Chua S.E., Event-related potentials to emotional facial expressions in children with autism, Psychophysiology. 2006, 43: S109. |
Wong
K.W.T., Fung
P.C.W., McAlonan
G.M. and Chua
S.E., Multiple Dipole Source Analysis of Event-related Potentials to
Emotional Facial Expressions, Biomedical Engineering Conference 2006. |
Wong T.D.W., Fung P.C.W., McAlonan G.M. and Chua S.E., Multiple dipole source analysis of event-related potentials to facial expression processing, Proceedings of Biomedical Engineering. 2006, 144-148. |
Researcher
: Chung KF |
Project Title: |
Seizure threshold of unilateral electroconvulsive therapy |
Investigator(s): |
Chung KF, Wong SJ |
Department: |
Psychiatry |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
07/2001 |
Abstract: |
To find out the seizure threshold of electroconvulsive therapy and its predictors in Chinese. |
Project Title: |
Influence of a psychiatric clerkship on medical students' attitudes toward psychiatry and mental patients |
Investigator(s): |
Chung KF |
Department: |
Psychiatry |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
01/2002 |
Abstract: |
To compare the effect of a standard clerkship with one augmented with a 1-hour stigma-changing programme on students' attitudes toward mental illness. |
Project Title: |
Response to moderately suprathreshold unilateral (UL) electroconvulsive therapy (ECT): an examination of possible predictors |
Investigator(s): |
Chung KF, Irwin MG |
Department: |
Psychiatry |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
06/2002 |
Abstract: |
To examine factors that associate with response to moderately suprathereshold unilateral ECT. |
List of Research Outputs |
Cheuk D.K.L., Yeung W.F., Chung K.F. and Wong V., Acupuncture for insomnia, Cochrane Database of Systematic Reviews 2007. 2007, Issue 3. |
Chung
K.F., Tso K.C., Cheung E.P. and Wong
M.M.C., Validation of the Chinese version of the Mood Disorder
Questionnaire for the screening of bipolar disorder, 7th International
Conference on Bipolar Disorder. |
Yeung
W.F., Chung
K.F., Zhang
S.P. and Yap T.G., A Randomized Placebo-Controlled Trial of Acupuncture
for Primary Insomnia – Preliminary Data, SLEEP 2007 21st Annual Meeting.
|
Yeung
W.F., Chung
K.F., Zhang
S.P., Yap T.G. and Chan Y.P., A Randomized Placebo-Controlled Trial of
Acupuncture for Primary Insomnia, 2007 Hong Kong – Macau Postgraduate
Symposium on Chinese Medicine. |
Yeung
W.F. and Chung
K.F., A Systematic Review of Acupuncture on Insomnia, 2006 Hong
Kong – |
Yeung
W.F. and Chung
K.F., Acupuncture Treatment for Primary Insomnia: A systematic Review
and Preliminary Local Data, 2006 World Congress on Chinese Medicine:
Charting the Course of Development. Hong Kong, School of Chinese
Medicine, |
Yeung
W.F. and Chung
K.F., Acupuncture Treatment for Primary Insomnia: a Systematic Review
and Preliminary Local Data, 11th Research Postgraduate Symposium. Hong
Kong, Li Ka Shing Faculty of Medicine, The University of |
Yeung W.F., Chung K.F. and Chan T.C.Y., Sleep-wake habits, excessive daytime sleepiness and academic performance among medical students in Hong Kong, Biological Rhythm Research. 2007. |
Researcher
: Deng Y |
List of Research Outputs |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schisophrenia, 13th Annual Meeting
Human Brain Mapping. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schizophrenia, 2nd International
Congress of Biological Psychiatry 2007. |
Researcher
: Fung ASM |
List of Research Outputs |
Lee
P.W.H., Mak-Lieh
F., Mak
K.Y., Fung
A.S.M., Wong
M.M.C. and Lam J., Retrospective Analysis (RA)/Invited Centers: Hong
Kong, In: Kim Hopper, Glynn Harrison, Aleksandar Janca, Norman Sartorius , Recovery
From Schizophrenia An International Perspective A Report from the Who
Collaborative Project, The International Study of Schizophrenia. |
Researcher
: Fung PCW |
Project Title: |
Development of a novel natural antioxidant with strong anti-aging and protective properties for skin |
Investigator(s): |
Fung PCW, Shen J |
Department: |
Medicine |
Source(s) of Funding: |
Seed Funding Programme for Applied Research |
Start Date: |
07/2002 |
Abstract: |
To develop a novel antioxidants from herbal products which can scavenge superoxide, hydroxyl and lipid peroxide free radicals in skin. |
Project Title: |
Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke |
Investigator(s): |
Fung PCW, Shen J |
Department: |
Medicine |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2003 |
Abstract: |
To understand the roles of plasma membrane cholesterol homeostasis in protecting neuronal cells from oxidative damage during ischemic stroke. |
Project Title: |
High level brain activity studies and applications |
Investigator(s): |
Fung PCW |
Department: |
Medicine |
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
Start Date: |
01/2004 |
Abstract: |
To better understand and utilize the functioning of the brain. |
List of Research Outputs |
Wong
K.W.T., Fung
P.C.W., McAlonan
G.M. and Chua
S.E., An ERP study of the spatiotemporal processing of facial expressions
in children with autism, The 4th Congress of Federation of Asian-Oceanian
Neuroscience Societies. |
Wong K.W.T., Fung P.C.W., McAlonan G.M. and Chua S.E., Event-related potentials to emotional facial expressions in children with autism, Psychophysiology. 2006, 43: S109. |
Wong
K.W.T., Fung
P.C.W., McAlonan
G.M. and Chua
S.E., Multiple Dipole Source Analysis of Event-related Potentials to
Emotional Facial Expressions, Biomedical Engineering Conference 2006. |
Wong T.D.W., Fung P.C.W., McAlonan G.M. and Chua S.E., Multiple dipole source analysis of event-related potentials to facial expression processing, Proceedings of Biomedical Engineering. 2006, 144-148. |
Researcher
: Helmeste DM |
List of Research Outputs |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior caused by corticosterone, Thd 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, November 30 - December 2, 2006, Hong Kong. 2006, 120 No. P-C22. |
Qiu G., Helmeste D.M., Samaranayake N.A., Lau W.M., Lee T.M.C., Tang S.W. and So K.F., Modulation by paroxetine of suppressive effect of corticosterone on adult hippocampal cell proliferation, Neuroscience Bulletin. 2007, 23: 131-136. |
Researcher
: Ho TP |
List of Research Outputs |
McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research Neuroimaging. Elsevier, 2006, 154: 171-180. |
Researcher
: Hui CLM |
List of Research Outputs |
Hui C.L.M. and Chen E.Y.H., Relapse and medication adherence in first-episode psychosis, Journal of the Medical Society of Toho University. 2007, 54 (3): 208 (48). |
Researcher
: Hui LMC |
List of Research Outputs |
Chen E.Y.H., Hui L.M.C., Chiu C.P.Y. and Law C.W., Cognitive correlates of semantic language disorder in first-episode schizophrenia, Schizophrenia Bulletin. 2007, 33: 214. |
Hui L.M.C., Chen E.Y.H. and Law C.W., Cognitive correlates of the Hayling sentence completion test in first-episode schizophrenia, Schizophrenia Bulletin. 2007, 33: 525. |
Project Title: |
To establish the use of magnetic resonance imaging for assessing the degree of brain damage following hypoxic ischemic insult with or without neuroprotective therapies |
Investigator(s): |
|
Department: |
Diagnostic Radiology |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
06/2002 |
Abstract: |
To evaluate the neuroprotective effects of one purified component of Traditional Chinese Medicine (TCM), caspase inhibitor (CI) and cyclosporin A (CA), in combination or alone. |
Project Title: |
Whole body magnetic resonance (MR) screening in primary plasmacytomas |
Investigator(s): |
|
Department: |
Diagnostic Radiology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Abstract: |
To evaluate the clinical utility of whole body MR screening to detect occult lesions in the diagnostic work-up of cases with primary plasmacytomas, including primary solitary bone and extramedullary plasmacytomas. |
Project Title: |
Mapping dose distribution on the Fractional Anisotropy Map: Applications in the assessment of treatment-induced white matter injury |
Investigator(s): |
Khong PL, Kwong DLW, Chan GCF |
Department: |
Diagnostic Radiology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
10/2005 |
Abstract: |
Treatment-induced neurotoxicity is
prevalant and impacts significantly on the lives of childhood brain tumour
survivors (Mulhern et al., 2004). Whole brain radiotherapy is considered to
be the major contributory factor that causes these deficits (Johnson et al.,
1994; Mulhern et al., 1998; Silber et al., 1992). It has been shown that
white matter is predisposed to radiation-induced injury and that it may be
the substrate of neurocognitive deterioration. There is emerging evidence
that diffusion tensor MR imaging (DTI), using fractional anisotropy (FA), is
sensitive in detecting and monitoring white matter injury in these patients.
(Khong et al., 2005b; Khong et al., 2003; Khong et al., |
Project Title: |
Whole body MR imaging of bone marrow in children with Acute Lymphoblastic Leukemia (ALL): evaluation of its role in diagnosis, treatment monitoring and response prediction. |
Investigator(s): |
Khong PL, Chan GCF, Kwong DLW |
Department: |
Diagnostic Radiology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
12/2006 |
Abstract: |
We aim to determine the role of whole
body MRI, a relatively new technique in MRI, in the evaluation of the bone
marrow in children with acute lymphoblastic leukaemia (ALL). MRI is the most
sensitive technique for the detection of bone marrow pathologies and has
become the method of choice for bone marrow imaging. However, prior to the
advent of whole body MRI, imaging the marrow has been restricted to selected
areas of the bony skeleton because of long imaging times. Recent advances in
MRI, particularly the development of fast imaging sequences have
significantly reduced imaging times so that the whole body can now be imaged
in 15-30 mins without compromising image quality. These advances have led to
novel clinical applications of whole body MRI, including tumour staging. To
date, there are no reports which have evaluated the role of this new
technique in ALL. ALL is the most common tumour in children accounting for
about 30% of all newly diagnosed childhood cancer patients. In |
Project Title: |
Diffusion tensor MRI imaging (DTI) of radiation-induced white matter injury in a rat model |
Investigator(s): |
|
Department: |
Diagnostic Radiology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2007 |
Abstract: |
To test the following hypotheses: (1) diffusion anisotropy quantitative index, fractional anisotropy (FA) is more sensitive than T2 relaxometry in detecting radiation-induced white matter damage; FA and the diffusion tensor matrix components, radial diffusivity and axial diffusivity, correlate with histological findings of radiation-induced injury, namely demyelination; changes in diffusion anisotropy are dose and time dependent and occur in parallel with histological evidence of demyelination; DTI can accurately detect and monitor the degree of demyelination in-vivo and can be used as a biomarker for the non-invasive evaluation of radiation-induced brain injury. |
Researcher
: Ko SN |
List of Research Outputs |
Cheng Y.W., Ng M.L., Ko S.N. and Chen R.Y.L., Physical activity and erectile dysfunction: meta-analysis of population-base studies, International Journal of Impotence Research. 2006. |
Cheng Y.W., Ng M.L., Chen R.Y.L. and Ko S.N., Prevalence of erectile dysfunction in Asian populations: a meta-analysis, International Journal of Impotence Research. 2006. |
Researcher
: Kwan SH |
List of Research Outputs |
Sham P.C., Ao S.I., Kwan S.H., Kao P., Cheung F., Fong P.Y. and Ng M.K., Combining functional and linkage disequilibrium information in the selection of tag SNPs, Bioinformatics. 2007, 23(1): 129-131. |
Researcher
: Lau WM |
List of Research Outputs |
Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine , Restorative neurology and neuroscience . 2007, 25(1): 17-23. |
Lau
W.M., Yau S.Y., Helmeste D.M., Lee
T.M.C., Tang
S.W. and So
K.F., Differential effect of chronic corticosterone and antidepressant
treatment on amygdale cell proliferation and depression-like behavior , The
|
Lau W.M., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Effect of corticosteroid and selective serotonin reuptake inhibitor on amygdala neurogenesis and depressive behavior , The University of Hong Kong Research postgraduate symposium 2007. 2007. |
Lau
W.M., Yau S.Y., Helmeste D.M., Lee
T.M.C., Tang
S.W. and So
K.F., Effects of corticosteroid and selective serotonin reuptake
inhibitor on masculine copulatory behavior, and c-fos expression in extended
amygdala and preoptic areas, Neuroscience 2007. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Inhibition Of Masculine Sexual Behavior Induced By Corticosterone , Hong Kong Society of Biological Psychiatry Conference 2006. 2006. |
Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Reversal of corticosterone-induced subventricular zone cell proliferation decrease by paroxetine, Restorative Neurology and Neuroscience. 2007, 25: 17-23. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior , The 4th Congress of FAONS. 2006. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior caused by corticosterone, Thd 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, November 30 - December 2, 2006, Hong Kong. 2006, 120 No. P-C22. |
Qiu G., Helmeste D.M., Samaranayake N.A., Lau W.M., Lee T.M.C., Tang S.W. and So K.F., Modulation by paroxetine of suppressive effect of corticosterone on adult hippocampal cell proliferation, The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, November 30 - December 2, 2006, Hong Kong. 2006, 84 No. P-B05. |
Yau S.K., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Protective effect of exercise on corticosterone suppressed hippocampal cell proliferation, Postgraduate seminar 2006, Department of Anatomy, HKU. 2006. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Counteractive effect of voluntary exercise on depression-like behavior of corticoseterone treated rats. , The University of Hong Kong Research postgraduate Symposium. 2007. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of Different Doses of Corticosterone on Hippocampal Cell Proliferation, The Hong Kong Society for Biological Psychiatry . 2007. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of voluntary exercise on corticosterone suppressed hippocampal cell proliferation and impaired spatial memory, Postgraduate Seminar 2007, Department of Anatomy, HKU. 2007. |
Researcher
: Lau WM |
List of Research Outputs |
Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine , Restorative neurology and neuroscience . 2007, 25(1): 17-23. |
Lau
W.M., Yau S.Y., Helmeste D.M., Lee
T.M.C., Tang
S.W. and So
K.F., Differential effect of chronic corticosterone and antidepressant
treatment on amygdale cell proliferation and depression-like behavior , The
|
Lau W.M., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Effect of corticosteroid and selective serotonin reuptake inhibitor on amygdala neurogenesis and depressive behavior , The University of Hong Kong Research postgraduate symposium 2007. 2007. |
Lau
W.M., Yau S.Y., Helmeste D.M., Lee
T.M.C., Tang
S.W. and So
K.F., Effects of corticosteroid and selective serotonin reuptake
inhibitor on masculine copulatory behavior, and c-fos expression in extended
amygdala and preoptic areas, Neuroscience 2007. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Inhibition Of Masculine Sexual Behavior Induced By Corticosterone , Hong Kong Society of Biological Psychiatry Conference 2006. 2006. |
Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Reversal of corticosterone-induced subventricular zone cell proliferation decrease by paroxetine, Restorative Neurology and Neuroscience. 2007, 25: 17-23. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior , The 4th Congress of FAONS. 2006. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior caused by corticosterone, Thd 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, November 30 - December 2, 2006, Hong Kong. 2006, 120 No. P-C22. |
Qiu G., Helmeste D.M., Samaranayake N.A., Lau W.M., Lee T.M.C., Tang S.W. and So K.F., Modulation by paroxetine of suppressive effect of corticosterone on adult hippocampal cell proliferation, The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, November 30 - December 2, 2006, Hong Kong. 2006, 84 No. P-B05. |
Yau S.K., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Protective effect of exercise on corticosterone suppressed hippocampal cell proliferation, Postgraduate seminar 2006, Department of Anatomy, HKU. 2006. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Counteractive effect of voluntary exercise on depression-like behavior of corticoseterone treated rats. , The University of Hong Kong Research postgraduate Symposium. 2007. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of Different Doses of Corticosterone on Hippocampal Cell Proliferation, The Hong Kong Society for Biological Psychiatry . 2007. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of voluntary exercise on corticosterone suppressed hippocampal cell proliferation and impaired spatial memory, Postgraduate Seminar 2007, Department of Anatomy, HKU. 2007. |
Researcher
: Law ACK |
List of Research Outputs |
Law A.C.K., Can we say "NO" to Alzheimer's Disease? Is nitric oxide one of the keys to the answer?, Department of Anatomy, HKU. 2007. |
Researcher
: Law CW |
List of Research Outputs |
Chan R.C.K., Chen E.Y.H. and Law C.W., Specific executive dysfunction in patients with first-episode medicatino-naive schizophrenia, Schizophrenia Research. 2006, 82: 51-64. |
Chen E.Y.H., Hui L.M.C., Chiu C.P.Y. and Law C.W., Cognitive correlates of semantic language disorder in first-episode schizophrenia, Schizophrenia Bulletin. 2007, 33: 214. |
Hui L.M.C., Chen E.Y.H. and Law C.W., Cognitive correlates of the Hayling sentence completion test in first-episode schizophrenia, Schizophrenia Bulletin. 2007, 33: 525. |
Researcher
: Lee AM |
Project Title: |
Psychosocial Group Therapy for Menopausal Women: A model for the non-pharmacological management of menopausal distress |
Investigator(s): |
Lee AM |
Department: |
Psychiatry |
Source(s) of Funding: |
Centre on Behavioral Health Seed Funding Scheme - General Award |
Start Date: |
07/2003 |
Abstract: |
The study aims at developing and evaluating
the efficacy of a psychosocial group therapy approach to the management of
menopausal problems among |
Project Title: |
The efficacy of group psychosocial intervention on psychological distress, quality of life, and post-traumatic growth among patients with gynaecological cancers: a randomized controlled trial |
Investigator(s): |
Lee AM, Ngan HYS, Chan YM, Tam KF, Lee PWH |
Department: |
Psychiatry |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2003 |
Abstract: |
To systematically test the efficacy of group psychosocial intervention in reducing psychological distress, and improving quality of life and adjustment among patients with gynaecological cancers; to examine the usefulness of group psychosocial intervention in bringing about post-traumatic growth among patients with gynaecological cancers; to examine the course of changes in psychological distress, quality of life, and post-traumatic growth over time; to examine the ability of psychological distress in predicting quality of life, adjustment, and post-traumatic growth at post-intervention and three-month follow-up; to identify therapeutic elements of the group psychosocial intervention programme. |
Project Title: |
A prospective
longitudinal study of high-risk behaviors among adolescents in |
Investigator(s): |
Lee AM, Stewart SM, Lam TH, Lee PWH |
Department: |
Psychiatry |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
11/2003 |
Abstract: |
Obtain baseline information on the rates, forms, and patterns of high-risk behaviors among adolescents in Hong Kong; to empirically test the hypothesis that high-risk behaviors (such as smoking, substance abuse, and early sex) represent a single core construct versus the competing hypothesis that they represent multiple constructs or even distinct and isolated behavioral entities; to identify a set of risk and protective factors that may predispose (or protect) adolescents to (from) high-risk behaviors. These risk factors include individual factors as well as measurable vulnerabilities associated with modernization; to understand the developmental trajectories and causative influences of risk factors identified; to examine the longer term consequences (adverse end-points) of high-risk behaviors in terms of a broad range of mental and physical health problems problems as well as functioning. |
Project Title: |
An exploratory study of the male climacteric and its relationship with psychological factors |
Investigator(s): |
Lee AM, Leung SSK, Chen RYL |
Department: |
Psychiatry |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Abstract: |
The document the level of ADAM among
middle- and old-aged males between the ages of 40 and |
Project Title: |
A randomized contolled trial of the efficacy of a model of psychosocial intervention in improving quality of life and psychological well-being of Chinese patients with colorectal cancer |
Investigator(s): |
Lee AM, Chan CLW, Ho JWC |
Department: |
Psychiatry |
Source(s) of Funding: |
Health and Health Services Research Fund - Full Grants |
Start Date: |
02/2005 |
Abstract: |
The study uses a prospective randomized
controlled trial design to systematically assess the efficacy of an Eastern
Body-Mind-Spirit (BMS) approach in improving the quality of life and psychological
well-being among a sample of colorectal cancer patients in |
Project Title: |
Translation of the Depression Anxiety and Stress Scales 21- item version (DASS-21) into Chinese and Validation of the Chinese DASS-21 among Clinical and Non-Clinical Samples in Hong Kong |
Investigator(s): |
Lee AM, Wong JGWS, Lam TP, Tang SW |
Department: |
Psychiatry |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
01/2006 |
Abstract: |
PURPOSE OF PROPOSED STUDY:The Depression
Anxiety Stress Scales (DASS) (1) has been widely evaluated and shown to be a
high quality self-report measure of depression, anxiety, and stress. Its
unique capacity to define and distinguish between these three negative
emotional states renders it a valuable tool in both research and clinical
practice. It is superior to traditional measures of depression, most of which
are less pure measures of depression by containing a mixture of depressive
and anxiety symptoms; the same being true for traditional measures of anxiety
(2,3,4). The DASS-21 is a 21-item short version of the DASS with equally
satisfactory psychometric properties (1). It has been translated into a
number of different languages, and used among diverse populations (5,6). In |
Project Title: |
A multidimensional longitudinal study of disordered eating attitudes and behaviours and its risk factors and outcome among pregnant women |
Investigator(s): |
Lee AM, |
Department: |
Psychiatry |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
04/2007 |
Abstract: |
Primary objectives: (1) To test the
association of pregnancy-related risk factors (ambivalence towards pregnancy,
pregnancy abuse, depression, and anxiety) with disordered eating attitudes
and behaviours during pregnancy. (2) To test the association of pre-pregnancy
related risk factors (pre-pregnant maladaptive eating attitudes and
behaviours, and body dissatisfaction) with disordered eating attitudes and
behaviours during pregnancy. Secondary objectives: (3) To establish the
prevalence of disordered eating attitudes and behaviors among pregnant women
in |
List of Research Outputs |
Chan C.L.W., Lee
A.M., Ho J.W.C. and Tang V.Y.H., Psychosocial Aspects of |
Ho A.H.Y., Lee
A.M., Chan C.L.W., Tang V.Y.H., Wang C.N., Leung P.P.Y., Fu Y.T., Yau
T.K. and Ho J.W.C., Posttraumatic Growth though Meaning Reconstruction: The
Effectiveness of the Body-Mind-Spirit Intervention Model on Improving the
Quality of Life and Psychological Well-being of Chinese patients with
Colorectal Cancer – A preliminary Report, 13th Hong Kong International
Cancer Congress. Hong Kong SAR, |
Ho
A.H.Y., Lee
A.M. and Chan
C.L.W., Posttraumatic Growth Through Meaning Reconstructions: The
Effectiveness of the Body-Mind-Spirit Intervention Model on Improving the
Quality of Life and Psychosocial Wellbeing of Chinese Patients with
Colorectal Cancer: A Preliminary Report, 13th |
Lee A.M., Adjusting to Motherhood, Family Planning Association Education Website (Jan 2007 issue) . 2007. |
Lee
A.M., Menopausal Symptoms and Needs of Asian
Women: Insights from the Asian Menopause Survey, Symposium of the |
Lee A.M., Premenstrual Symptoms, Oriental Daily . 2006, A8. |
Lee A.M., Pressure Brings Menstruation-Related Disorders, Metro Daily (August 18, 2006. Chinese version: page 28, English version: page 43). 2006, 43. |
Lee
A.M., Reviewer for |
Lee
A.M., Wong
J.G.W.S., McAlonan
G.M., Cheung
V., Cheung
C., Sham
P.C., |
Leung K.Y., Ngai C.S.W., Lee A.M., Chan H.Y., Leung W.C., Lee C.P. and Tang M.H.Y., The effects on maternal anxiety of two-dimensional versus two-plus three-four-dimensional ultrasound pregnancies at risk of fetal abnormalities: A randomized study, Ultrasound in Obstetrics & Gynecology. 2006, 28: 249-254. |
McAlonan G.M., Lee A.M., Cheung V., Cheung C., Tsang K.W.T., Sham P.C., Chua S.E. and Wong J.G.W.S., Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers, Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie. 2007, 52(4): 241-247. |
Tang Y.H., Lee A.M., Chan C.L.W., Leung P.P.Y., Sham J.S.T., Ho J.W.C. and Cheng J.Y.Y., Disorientation and reconstruction: The meaning searching pathways of patients with colorectal cancer, Journal of Psychosocial Oncology. 2007, 25: 77-102. |
Researcher
: Lee PWH |
Project Title: |
A study of risk factors for exposure to AIDS in high risk adolescent Chinese females |
Investigator(s): |
Lee PWH |
Department: |
Psychiatry |
Source(s) of Funding: |
Council for the AIDS Trust Fund - General Award |
Start Date: |
04/1997 |
Abstract: |
To study the prevailing pattern of knowledge, practice and attitudes towards sexual intimacy and behaviours in teenage secondary school female students; to study common misconceptions and risks of teenage secondary school students towards developing STDs and AIDs; to study factors associated with increased risk for exposure to STDs and AIDs. |
Project Title: |
Psychological adjustment and stresses of nurses working in acute hospital |
Investigator(s): |
Lee PWH |
Department: |
Psychiatry |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
06/1997 |
Abstract: |
To study the prevalence of psychological malaise in a representative group of registered nurses working in acute general hospital; to identify factors associated with increases stress and strain in registered nurses in acute general hospital. |
Project Title: |
The psychosocial outcomes and well-being of living related donors involved in liver transplantation surgery: a follow-up study of risk factors, resilience, and outcome predictors |
Investigator(s): |
Lee PWH, Fan ST, Fung ASM |
Department: |
Psychiatry |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2003 |
Abstract: |
To trace the natue and course of psycholsocial adjustment of living related donors through a retrospective study on their adjustment in the pre-transplanation, post-transplantation and rehabilitation phases; to identify areas of concerns, difficulties, physical malaise, and psychosocial distress in donors during the different phases of the transplantation procedure and its rehabilitation; to study the relationship between pre-transplantation variables of the living related donors and their levels of post-transplantation functioning and adjustment; to identify predictors of high-risk characteristics and situations likely to be encountered by living related donors and consider ways of reducing such risks; on the basis of data gathered and analyzed, to consider cost-effective avenues, format and focus of psychosocial interventions to enable potential living related donors to achieve an all round better immediate and long-term outcome; to look into the differences in decision making processes and adjustment of living related donors with different relationship with the recipients. |
List of Research Outputs |
Chan
C.L.W., Ho
T.H., Lee
P.W.H., Cheng J.Y.Y., Leung P.P.Y., Foo W., Chow L.W.H., Sham
J.S.T. and Spiegel D., A Randomized Controlled Trial of Psychosocial
Interventions Using the Psychophysiological Framework for Chinese Breast
Cancer Patients, In: James R Zabora, Journal of Psychosocial Oncology.
The |
Lau
K.S., Siong K.H., Cheung P.W., Tang H.Y., Cheung K.S., Chan S.W., Lee
P.W.H. and Wong
J.G.W.S., An innovative web-based student support service: a
student-initiated peer support network, Cotone Congressi (14-18 September
2006). |
Lee P.W.H., Kwan T.T., Kwong D.L., Sham J.S., Pow E.H.N., McMillan A.S. and Au G.K., A prospective study of the impact of nasopharyngeal cancer and radiotherapy on the psychosocial condition of Chinese patients., Cancer. 2007, 109: 1344-54. |
Lee
P.W.H., Psychological Challenges in Diabetes
(Abstract in Fourth International Huaxia Congress of Endocrinology), |
Lee
P.W.H., Psychological Trauma to the Victims
and the Response Team in a Disaster (Abstract), International Symposium on
Disaster Medical Response. The |
Lee
P.W.H., Psychological trauma to the victims
and the response team ni a disaster, The |
Lee
P.W.H., Mak-Lieh
F., Mak
K.Y., Fung
A.S.M., Wong
M.M.C. and Lam J., Retrospective Analysis (RA)/Invited Centers: Hong
Kong, In: Kim Hopper, Glynn Harrison, Aleksandar Janca, Norman Sartorius , Recovery
From Schizophrenia An International Perspective A Report from the Who
Collaborative Project, The International Study of Schizophrenia. |
Lee P.W.H., Targetting knowledge, attitudes and behaviours in Chinese women: the case for prevention of cervical cancer, Biennial General Meeting of the Hong Kong Society for Colposcopy and Cervical Pathology. 2006. |
Lee
P.W.H., The Slimming Movement: Implications
for Clinical Understanding and Interventions, Journal of the |
Lee P.W.H., The slimming movement, Hong Kong College of Cardiology: 1st Asian Preventive Cardiology & Cardiac Rehabilitation Conference. 2006. |
Lee
W., Ho
D.S.Y., Stewart
S.M., Leung
G.M., Lee S., Mak
K.H., Lee
P.W.H., Wong
J.P.S. and Lam
T.H., Eating disorders and smoking among Hong Kong adolescents (abstract
and poster presentation), 5th Annual Conference of the International Society for
the Prevention of Tobacco Induced Disease, 24-26 November 2006, Hong Kong.
|
Lee
W., Lam
T.H., Stewart
S.M., Ho
D.S.Y., Leung
G.M., Lee S., Mak
K.H., Lee
P.W.H., Wong
J.P.S. and Striegel-Moore
R.H., Preliminary findings from "A population-based, longitudinal
study of eating disturbances in Hong Kong Chinese boys and girls"
(abstract), 11th Research Postgraduate Symposium, 7 December 2006, LKS
Faculty of Medicine, University of Hong Kong. Hong Kong, LKS Faculty of
Medicine, University of |
Mak G.K.L., Li
F.W.S. and Lee
P.W.H., A pilot study on psychological interventions with Chinese
young adults with schizophrenia, In: Linda Lam Eric Chen, The Hong Kong
Journal of Psychiatry. |
Zhang J.X., Woo J., Lau W.C.S., Lee P.W.H., Chiu P.K.Y. and Lam D., Effects of use of alternative therapies on quality of life and healthcare spending, The American Journal of Chinese Medicine. 2007, 35: 183-193. |
Researcher
: Lee TMC |
Project Title: |
Memory deficits following unilateral frontal or temporal brain lesion |
Investigator(s): |
Lee TMC, Fan YW |
Department: |
Psychology |
Source(s) of Funding: |
Health Services Research Fund - Full Grants |
Start Date: |
05/2000 |
Abstract: |
To develop an instrument for assessment of confabulation in prose memory. |
Project Title: |
Deception and its detection: brain activities associated with faking memory problems |
Investigator(s): |
Lee TMC, Broadhurst RG, Yang ES |
Department: |
Psychology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
08/2002 |
Abstract: |
The project attempts to investigate the potential application of brain activities to understand the phenomenon of deception and its detection. It will examine the generalizability of forced-choice testing situations, and also different brain activities associated with making genuine errors and feigning memory impairment. |
Project Title: |
The effect of emotional attachment on the brain activities associated with deception: an functional magnetic resonance imaging (fMRI) study |
Investigator(s): |
Lee TMC |
Department: |
Psychology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
06/2005 |
Completion Date: |
11/2006 |
Abstract: |
The study is intended to investigate the role of emotional attachment on the brain activity patterns that are associated with deception. |
Project Title: |
Selective attention biases of people with major depressive disorder, and its relationship with brain damages. |
Investigator(s): |
Lee TMC, Leung KK |
Department: |
Psychology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
09/2005 |
Abstract: |
Attention bias towards mood-congruent information has been postulated to be one of the essential psychological substrates of major depressive disorder. Attention biases could have at least two levels of meanings: a) initial orienting, i.e. attention being captured involuntarily to certain types of information; and b) difficulties in inhibiting or shifting the attention from the current attentional focus once certain types of information has been attended to, either voluntarily or involuntarily. However, research findings are inconsistent in demonstrating these phenomena in people with major depressive disorder. This study aims to investigate whether people with major depressive disorder exhibit these two types of attention biases. In addition, it has been postulated that major depressive disorder is associated with frontal-limbic dysregulation. In particular, various studies suggest that amygdala, prefrontal cortex, anterior cingulate cortex, and hippocampus are involved in depression. This study also attempts to investigate whether people with brain lesions arising from stroke or brain trauma at the above areas also exhibit the attention biases to depression-related information. It also follows that question of whether those who show these attention biases due to brain lesions also exhibit depressive features will also be examined. |
Project Title: |
Brain processes underlying deception |
Investigator(s): |
Lee TMC |
Department: |
Psychology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
03/2007 |
Abstract: |
The purpose of this study is to understand the neuroscientific mechanisms and the pattern of brain activities associated with the faking of memory impairment. In recent years, we have been working on delineating the cognitive processes and on possible neural markers for feigning memory impairment. Our preliminary findings, together with data obtained by other research teams, have suggested possible markers of deceptive behaviors. Nonetheless, simple experimental tasks were adopted in these functional magnetic resonance imaging (fMRI) studies to control for the unwanted confound introduced by task difficulty. One serious limitation of the findings is that the observed different brain activities between honest correct answers to tasks of low level of difficulty and feigned errors (which required mental effort) could be due to the difference in cognitive load of the two conditions. It is therefore informative to compare feigned errors with honest responses, correct or not, caused by a more challenging task to learn if feigning behavior could be identified using functional imaging technology. We therefore proposed this study, with increased task difficulty that encourages the occurrence of errors, to study if errors committed when people attempt to respond honestly can be distinguished from intentionally faked responses. The Key Objectives: 1. To identify the pattern of brain activities that best differentiates accurate honest versus intentionally faked responses. We anticipate activation of the prefrontal-cingulate-parietal areas based on the findings of previous studies. 2. To identify the pattern of brain activities that best differentiates (a) genuine errors versus faked response and (b) false memory (a subset of genuine errors) versus intentionally faked responses. We speculate that different brain activities will be observed in the medial temporal regions known for mediating memory, accurate as well as false memory. |
List of Research Outputs |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior caused by corticosterone, Thd 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, November 30 - December 2, 2006, Hong Kong. 2006, 120 No. P-C22. |
Qiu G., Helmeste D.M., Samaranayake N.A., Lau W.M., Lee T.M.C., Tang S.W. and So K.F., Modulation by paroxetine of suppressive effect of corticosterone on adult hippocampal cell proliferation, The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, November 30 - December 2, 2006, Hong Kong. 2006, 84 No. P-B05. |
Researcher
: Li T |
List of Research Outputs |
Wang Q., Chan R.C.K., Sun J.H., Yao J., Deng W., Sun X.L., Liu X.H., Sham P.C., Ma X.H., Meng H.Q., Murray R.M., Collier D.A. and Li T., Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: A study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls, Schizophrenia Research. 2007, 89(1-3): 293-298. |
Project Title: |
Program enhancement for the mental-ill patients at the S.K. Yee Mental Health Resource and Rehabilitation Centre |
Investigator(s): |
Mak KY, Wong MMC, Mak-Lieh F, Yau EFY |
Department: |
Psychiatry |
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
Start Date: |
09/2000 |
Abstract: |
To facilitate psychiatric patients to return to work and re-integrate into society through widening the present service scope by providing sufficient equipment to meet the increasing demand in work training and offer wider range of therapeutic programs to improve the domestic living skill of patients; to provide professional development and training to psychiatrists and paramedical staff in Hong Kong and China. |
List of Research Outputs |
Lee
P.W.H., Mak-Lieh
F., Mak
K.Y., Fung
A.S.M., Wong
M.M.C. and Lam J., Retrospective Analysis (RA)/Invited Centers: Hong
Kong, In: Kim Hopper, Glynn Harrison, Aleksandar Janca, Norman Sartorius , Recovery
From Schizophrenia An International Perspective A Report from the Who
Collaborative Project, The International Study of Schizophrenia. |
Researcher
: Mak-Lieh F |
List of Research Outputs |
Lee
P.W.H., Mak-Lieh
F., Mak
K.Y., Fung
A.S.M., Wong
M.M.C. and Lam J., Retrospective Analysis (RA)/Invited Centers: Hong
Kong, In: Kim Hopper, Glynn Harrison, Aleksandar Janca, Norman Sartorius , Recovery
From Schizophrenia An International Perspective A Report from the Who
Collaborative Project, The International Study of Schizophrenia. |
Tang
H.N.A., Wong
J.G.W.S., Patil
N.G. and Mak-Lieh
F., Teaching and learning of medical professionalism - medical
students' experience at the University of Hong Kong, Cotone Congressi,
Genoa, Italy (14-18 September 2006). |
Researcher
: McAlonan GM |
List of Research Outputs |
Cheung
V., Chua
S.E., McAlonan
G.M., Chen
E.Y.H. and Khong
P.L., Connectivity along white mater tracts in drug-naive patients of
first-episode psychosis: a diffusion tensor tractography study, |
Chua S.E., Cheung C., Cheung V., Tsang J.T.K., Chen E.Y.H., Wong J.C.H., Cheung J.P.Y., Yip L., Tai K.S., Suckling J. and McAlonan G.M., Cerebral grey, white matter & CSF in never-medicated, first-episode Schizophrenia, Schizophrenia Research. 2006, 89: 12-21. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schisophrenia, 13th Annual
Meeting Human Brain Mapping. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schizophrenia, 2nd International
Congress of Biological Psychiatry 2007. |
Lee
A.M., Wong
J.G.W.S., McAlonan
G.M., Cheung
V., Cheung
C., Sham
P.C., |
McAlonan G.M., Lee A.M., Cheung V., Cheung C., Tsang K.W.T., Sham P.C., Chua S.E. and Wong J.G.W.S., Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers, Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie. 2007, 52(4): 241-247. |
McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research Neuroimaging. Elsevier, 2006, 154: 171-180. |
Page L.A., Daly E., Schmitz N., Simmons A., Toal F., Deeley Q., Ambery F., McAlonan G.M., Murphy K.C. and Murphy D.G.M., In Vivo 1H-Magnetic Resonance Spectroscopy Study of Amygdala-Hippocampal and Parietal Regions in Autism , American Journal of Psychiatry . 2006, 163: 2189-2192. |
Wong
K.W.T., Fung
P.C.W., McAlonan
G.M. and Chua
S.E., An ERP study of the spatiotemporal processing of facial expressions
in children with autism, The 4th Congress of Federation of Asian-Oceanian
Neuroscience Societies. |
Wong K.W.T., Fung P.C.W., McAlonan G.M. and Chua S.E., Event-related potentials to emotional facial expressions in children with autism, Psychophysiology. 2006, 43: S109. |
Wong
K.W.T., Fung
P.C.W., McAlonan
G.M. and Chua
S.E., Multiple Dipole Source Analysis of Event-related Potentials to
Emotional Facial Expressions, Biomedical Engineering Conference 2006. |
Wong T.D.W., Fung P.C.W., McAlonan G.M. and Chua S.E., Multiple dipole source analysis of event-related potentials to facial expression processing, Proceedings of Biomedical Engineering. 2006, 144-148. |
Researcher
: Ng ML |
Project Title: |
Chaos in psychotherapy |
Investigator(s): |
Ng ML |
Department: |
Psychiatry |
Source(s) of Funding: |
Department of Psychiatry - General Award |
Start Date: |
09/1998 |
Abstract: |
To look for chaos patterns in the communication procedures in psychotherapy using mathematical or physical modelling. |
Project Title: |
Violence on male genitalia - a ten year review of cases in Hong Kong |
Investigator(s): |
Ng ML |
Department: |
Psychiatry |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
05/2002 |
Abstract: |
To review and investigate into the
demographic, psychological and social characteristics of the victims and the
offenders involved in cases of violent male genital injury in the last ten
years in |
List of Research Outputs |
Cheng Y.W. and Ng M.L., Body mass index, physical activity and erectile dysfunction – U-shaped relationship from population-based study, International Journal of Obesity. 2007. |
Cheng Y.W., Ng M.L., Ko S.N. and Chen R.Y.L., Physical activity and erectile dysfunction: meta-analysis of population-base studies, International Journal of Impotence Research. 2006. |
Cheng Y.W., Ng M.L., Chen R.Y.L. and Ko S.N., Prevalence of erectile dysfunction in Asian populations: a meta-analysis, International Journal of Impotence Research. 2006. |
Ng
M.L., A meta-analysis on the prevalence of
erectile dysfunction in Asian population, 9th Asia-Oceania Conference of
Sexology (November 1-4, 2006). |
Ng
M.L., Alcohol, exercise and erectile
dysfunction, a meta-analysis, Second Advanced Forum on Sexual Sciences,
organized by |
Ng
M.L., Human Right Implications of Therapy in
Sexual Health, World Health Organization (WHO) Satellite Symposium on
'Sexology and HIV – A Challenge to Win', 18th World Congress of Sexology
(April 15-19, 2007). |
Ng
M.L., Marriage and Sex, Conference on
Strengthening Hong Kong Families – Awareness, Commitment and Action,
organized by Women's Commission, Central Policy Unit, Government of Hong Kong
SAR, and HKU Family Institute (September 5, 2006). |
Ng
M.L., Marriage and Sex, Conference on
Strengthening |
Ng
M.L., Sex and Marital therapy for the Chinese
in Modern Day Hong Kong and China, The AOFS Symposium on Adapting the
Dogmas of Sex & Marital Therapy to Ethnicity and Culture in Asia. 18th
World Congress of Sexology (April 15-19, 2007). |
Ng
M.L., Sex tonics: Facts or Fiction, 9th
Asia-Oceania Conference of Sexology (November 1-4, 2006). |
Ng
M.L. and Ma J.L.C., Sexuality in Hong Kong
Sepcial Administrative Region of the People's Republic of |
Ng M.L., 應把性侵犯兒童者身份上網?, 明報, 2006, 22.8.2006: A28. |
Ng M.L., 健康生命中的性, 澳門天主教美滿家庭協會, 澳門, 2006. |
Pei
Y., Ho
P.S.Y. and Ng
M.L., Studies on Women's Sexuality in |
Researcher
: Ran M |
Project Title: |
A long-term prospective follow-up study of suicide among persons with affective disorders in a chinese rural area |
Investigator(s): |
Ran M, Chan CLW, Yip PSF, Chen EYH |
Department: |
Social Sciences Faculty |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Abstract: |
To explore the characteristics of suicide among 196 individuals with affective disorders in a 10-year prospective follow-up study in a Chinese rural community. |
List of Research Outputs |
Ran M., Chen E.Y.H., Conwell Y., Chan C.L.W., Yip P.S.F., Xiang M. and Caine E.D., Mortality in people with schizophrenia in rural China: 10-year cohort study, British Journal of Psychiatry. 2007, 190: 237-242. |
Researcher
: Sham PC |
Project Title: |
An association screen for schizophrenia susceptibility loci in a high-LD, gene-rich region of chromosome 3p |
Investigator(s): |
Sham PC |
Department: |
Psychiatry |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
07/2004 |
Abstract: |
To identify novel susceptibility loci for schizophrenia, by conducting a high-density SNP screen of a region recently identified by a meta-analysis of 20 genome-wide linkage scans. |
Project Title: |
A systematic screen for schizophrenia susceptibility loci in high-LD, gene-rich chromosomal regions implicated by meta-analysis of whole genome linkage scans |
Investigator(s): |
Sham PC, Chen RYL, Ng KP |
Department: |
Psychiatry |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2006 |
Abstract: |
To identify novel susceptibility loci for
schizophrenia, by conducting a high-density SNP screen of a number of
chromosomal regions that are (a) identified as linkage hotspots by a recent
meta-analysis of 20 genome-wide scans of schizophrenia, (b) gene-rich and (c)
high in the level of linkage disequilibrium (LD). Optimal marker sets that
tag all common variation in these regions will be selected using HapMap data on
the Chinese population. These regions will be screened in 489 cases of DSM-IV
schizophrenia and 520 controls recruited from Hong Kong; significant
associations will be replicated on 500 cases and both parents recruited from |
Project Title: |
Optimal design of genome-wide association studies for multifactorial diseases |
Investigator(s): |
Sham PC, Ng MKP, Tang NLS |
Department: |
Psychiatry |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2007 |
Abstract: |
To focus on the following issues in the design of genome-wide association studies: (1) multi-stage, multi-platform study designs; (2) function-informed selection of tag SNPs and haplotype tagging; to quantitative evaluation of subject informativeness; marker-based derivation of homogeneous sub-populations. |
List of Research Outputs |
Bramon E., Dempster E., Frangou S., McDonald C., Schoenberg P., MacCabe J.H., Walshe M., Sham P.C., Collier D. and Murray R.M., Is there an association between the COMT gene and P300 endophenotypes, European Psychiatry. 2006, 21(1): 70-73. |
Brookes K., Xu X., Chen W., Zhou K., Neale B., Lowe N., Aneey R., Franke B., Gill M., Ebstein R., Buitelaar J., Sham P.C., Campbell D., Knight J., Andreou P., Altink M., Arnold R., Boer F., Buschgens C., Butler L., Christiansen H., Feldman L., Fleischman K., Fliers E., Howe-Forbes R., Goldfarb A., Heise A., Gabriëls I., Korn-Lubetzki I., Marco R., Medad S., Minderaa R., Mulas F., Müller U., Mulligan A., Rabin K., Rommelse N., Sethna V., Sorohan J., Uebel H., Psychogiou L., Weeks A., Barrett R., Craig I., Banaschewski T., Sonuga-Barke E., Eisenberg J., Kuntsi J., Manor I., McGuffin P., Miranda A., Oades R.D., Plomin R., Roeyers H., Rothenberger A., Sergeant J., Steinhausen H.C., Taylor E., Thompson M., Faraone S.V., Asherson P. and Johansson L., The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes , Molecular Psychiatry. 2006, 11(10): 934-953. |
Campbell D.D., Rijsdijk F.V. and Sham P.C., Computation of individual latent variable scores from data with multiple missingness patterns, Behavior Genetics. 2007, 37(2): 408-422. |
Chan D., Song Y., Sham P.C. and Cheung K.M.C., Genetics of disc degeneration, Eur Spine J. 2006, 15 Suppl 15: 317-25. |
Chan Y.K., Tse Y.T., Chan S.Y., Liu W., Garcia-Barcelo M.M., Sham P.C. and Khoo U.S., Estrogen receptors genetic polymorphisms risk association and their functional roles in breast cancer risk: a study on Hong Kong Chinese women, 100th American Association for Cancer Research Annual Meeting, Los Angeles, CA, USA . 2007, Abstract no. 5269. |
Cheung C.L., Huang Q., Ng M.Y.M., Chan V.N.Y., Sham P.C. and Kung A.W.C., Confirmation of linkage to chromosome 1q for spine bone mineral density in Southern Chinese, 11th Research Postgraduate Symposium, HKU, 7 Dec 2006. |
Cheung C.L., Huang Q., Ng M.Y.M., Chan V.N.Y., Sham P.C. and Kung A.W.C., Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese, Human Genetics. 2006, 120: 354-359. |
Cheung C.L., Huang Q., Ng M.Y.M., Chan V.N.Y., Sham P.C. and Kung A.W.C., Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese, Journal of Bone and Mineral Research. 2006, 21(Suppl 1): S146. |
Cheung
C.L., Sham
P.C., Chan
V.N.Y. and Kung
A.W.C., Peak-wide association study on chromosome 3p21 identifies the
CACNA2D2 gene as a novel susceptibility gene for osteoporosis, 8th
International Meeting on Human Genome Variation and Complex Genome Analysis,
14-16 Sep 2006, |
Cheung K.M.C., Chan D., Karppinen J., Chen Y.Q., Jim J.J.T., Yip S.P., Ott J., Wong K.K., Sham P.C., Luk K.D.K., Cheah K.S.E., Leong J.C.Y. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population, Spine. 2006, 31(10): 1143-1148. |
Cheung
K.M.C., Song
Y., Kao
P.Y.P., Ho
D.W.H., Fan
B., Karppinen J., Yip S.P., Cheong J.C.Y., Luk
K.D.K., Ott J., Cheah
K.S.E., Sham
P.C. and Chan
D., Three genes in the aggrecan degradation pathway act synergistically
to predispose to degenerative disc disease., International Society for the
Study of the Lumbar Spine. 34th annual Meeting, June 10-14, 2007 |
Cheung K.M.C., Song Y., Kao P.Y.P., Ho D.W.H., Fan B., Karppinen J., Yip S.P., Leong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Chan D., Three genes in the aggrecan degraduation pathway act synergistically to predispose to degenerative disc disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
Curtis D. and Sham P.C., Journal Letter: Estimated haplotype counts from case-control samples cannot be treated as observed counts, American Journal of Human Genetics. 2006, 78(4): 729-730. |
Curtis D., Knight J. and Sham P.C., Program report: GENECOUNTING support programs, Annals of Human Genetics. 2006, 70: 277-279. |
Dempster E.L., Toulopoulou T., McDonald C., Bramon E., Walshe M., Wickham H., Sham P.C., Murray R.M. and Collier D.A., Episodic memory performance predicated by the 2bp deletion in exon 6 of the “alpha 7-like” nicotinic receptor subunit, American Journal of Psychiatry. 2006, 163(10): 1832-U2. |
Dikeos D.G., Wickham H., McDonald C., Walshe M., Sigmundsson T., Bramon E., Grech A., Toulopoulou T., Murray R. and Sham P.C., Distribution of symptom dimension across Kraepelinian divisions, British Journal of Psychiatry gene. 2006, 189: 346-353. |
Fong P.Y., Garcia-Barcelo M.M., Sham P.C., Ng P.K.M., Lau C.F., So M.T., Mak W.W. and Tam P.K.H., Genetic mapping for RET-dependent modifiers in Hirschsprung disease (HSCR), 56th Annual Meeting of the American Society of Human Genetics, New Orleans, U.S.A., 9-13 October 2006. |
Hall M.H., Schulze K., Bramon E., Murray R.M., Sham P.C. and Rijsdijk F., Genetic overlap between P300, P50 and duration mismatch negativity , American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 2006, 141(B): 336-343. |
Hall M.H., Rijsdijk F., Kalidindi S., Schulze K., Kravariti E., Kane F., Sham P.C., Bramon E. and Murray R.M., Genetic overlap between bipolar illness and event-related potentials, Psychological Medicine. 2007, 37(5): 667-678. |
Hall M.H., Rijsdijk F., Picchioni M.,
Schulze K., |
Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on Familial Early-Onset Degenerative Disc Disease (DDD)., ABS#apbc056 Jan14-17. 2007. |
Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage analysis on familial early onset degenerative disc disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage analysis on familial early-onset degenerative disc disease, Bester Poster Award, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, June 10-14, 2007. 2007. |
Huang Q., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Identification of Two Sex-specific Quantitative Trait Loci in Chromosome 11q for Hip Bone Mineral Density in Chinese , 56th Annual Meeting of The American Society of Human Genetics . 2006. |
Huang Q., Ng M.Y.M., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Identification of two sex-specific quantitative trait loci in chromosome 11q for bone mineral density in southern Chinese, Human Heredity. 2006, 61: 237-243. |
Huang Q., Ng M.Y.M., Cheung C.L., Chan V., Sham P.C. and Kung A.W.C., Identification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in Chinese, Human Heredity. 2006, 61(4): 237-243. |
Huang Q., Cheung C.L., Chan V.N.Y., Sham P.C. and Kung A.W.C., Peak-wide association study on chromosome 3p21 identifies the CACNA2D2 gene as a novel susceptibility gene for osteoporosis , 8th International Meeting on Human Genome Variation and Complex Genome Analysis (HGV2006). 2006. |
Hye A., Lynham S., Thambisetty M., Causevic M., Campbell J., Byers H.L., Hooper C., Rijsdijk F., Tabrizi S.J., Banner S., Shaw C.E., Foy C., Poppe M., Archer N., Hamilton G., Powell J., Brown R.G., Sham P.C., Ward M. and Lovestone S., Proteome-based plasma biomarkers for Alzheimer’s disease , Brain. 2006, 129: 3042-3050. |
Ioannidis J.P.A., Ng M.Y.M., Sham P.C., Zintzaras E., Lewis C.M., Deng H.W., Econs M.J., Karasik D., Devoto M., Kammerer C.M., Spector T., Andrew T., Cupples L.A., Duncan E.L., Foroud T., Kiel D.P., Koller D., Langdahl B., Mitchell B.D., Peacock M., Recker R., Shen H., Sol-Church K., Spotila L.D., Uitterlinden A.G., Wilson S.G., Kung A.W.C. and Ralston S.H., Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass, Journal of Bone and Mineral Research. 2007, 22: 173-83. |
Iwata Y., Nakajima M., Yamada K., Nakamura K., Sekine Y., Tsuchiya K.J., Sugihara G., Matsuzaki H., Suda S., Suzuki K., Takei N., Mori N., Iwayama Y., Takao H., Yoshikawa T., Riley B., Makoff A., Sham P.C., Chen R.Y.L. and Collier D., Linkage disequilibrium analysis of CHRNA7 gene and its partially duplicated region in schizophrenia, Neuroscience Research. 2007, 57(2): 194-202. |
Kao P.Y.P., Chan D., Cheung K.M.C., Cheah K.S.E., Sham P.C. and Song Y., Investigating Epistasis in Degenerative Disc Disease., ABS#apbc101 Jan 14-17, 2007. |
Knight J. and Sham P.C., Design and analysis of association studies using pooled DNA from large twin samples, Behavior Genetics. 2006, 36(5): 665-677. |
Kravariti E., Toulopoulou T., Mapua-Filbey F., Schulze K., Walshe M., Sham P.C., Murray R.M. and McDonald C., Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia, British Journal of Psychiatry. 2006, 188: 186-187. |
Lancefied K., Nosarti C., Rifkin L., Allin M., Sham P.C. and Murray R., Cerebral asymmetry in 14 year olds born very preterm, Brain Research. 2006, 1096: 33-40. |
Lee
A.M., Wong
J.G.W.S., McAlonan
G.M., Cheung
V., Cheung
C., Sham
P.C., |
Li D.W., Sham P.C., Owen M.J. and He L., Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHA), Human Molecular Genetics. 2006, 15(14): 2276-2284. |
Li M., Jiang L., Song Y., Ho S.L. and Sham P.C., Over-Representation Pattern of SNPs in the Genome of Restless Legs Syndrome Samples., ABS# apbc073 . 2007, Jan14-17,2007. |
Ma X.H., Wang Q., Sham P.C., Liu X.H., Rabe-Hesketh S., Sun X.L., Meng H.Q., Chen W., Chen E.Y.H., Deng W., Chan R.C.K., Murray R.M., Collier D.A. and Li T., Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives, American Journal of Medical Genetics. 2006, 141B(7): 775. |
Ma X.H., Wang Q., Sham P.C., Liu X.H., Rabe-Hesketh S., Sun X.L., Meng H.Q., Chen W., Chen E.Y.H., Deng W., Chan R.C.K., Murray R.M., Collier D.A. and Li T., Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives, American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 2006, 141B: 775. |
McAlonan G.M., Lee A.M., Cheung V., Cheung C., Tsang K.W.T., Sham P.C., Chua S.E. and Wong J.G.W.S., Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers, Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie. 2007, 52(4): 241-247. |
McDonald C., Marshall N., Sham P.C., Bullmore E.T., Schulze K., Chapple B., Bramon E., Filbey F., Quraishi S., Walshe M. and Murray R.M., Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives, American Journal of Psychiatry. 2006, 163(3): 478-487. |
Ng
M.Y.M., Sham
P.C., |
North B.V., Sham P.C., Knight J., Martin E.R. and Curtis D., Investigation of the ability of haplotype association and logistic regression to identify associated susceptibility loci, Annals of Human Genetics. 2006, 70: 893-906. |
Purcell S., Daly M.J. and Sham P.C., Haplotype-based association analysis, Bioinformatics. 2007, 23(2): 255-256. |
Sham P.C., Ao S.I., Kwan S.H., Kao P., Cheung F., Fong P.Y. and Ng M.K., Combining functional and linkage disequilibrium information in the selection of tag SNPs, Bioinformatics. 2007, 23(1): 129-131. |
Song Y., Cheung K.M.C., Ho D.W.H., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Yee A.F.Y., Poon S.C.S., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the Asporin D14 allele to lumbar disc degeneration in Chinese and Japanese., Gordon Research Conference on Cartilage Biology and Pathology, March 4-9, 2007, Ventura, CA, USA. 2007. |
Song
Y., Cheung
K.M.C., Fan
B., Karppinen J., Yip S.P., Leong J.C.Y., Luk
K.D.K., Ott J., Cheah
K.S.E., Sham
P.C. and Chan
D., SNP-SNP Interaction in Intervertebral Disc Disease with Genes in the
Aggrecan Degradation Pathway, The 8th International Meeting on Human
Genome Variation and Complex Genome Analysis. Le Meridien Cyberport Hotel and
Convention Centre, Hong Kong SAR, |
Tang
L.F., Chan S.Y., Sham
P.C. and Song
Y., In silico mapping of quantitative trait loci affecting bone mineral
density in mice., 8th International Meeting On HUMAN GENOME VARIATION
& COMPLEX GENOME ANALYSIS (HGV2006) Sept 14-16, 2006. |
Tse
Y.T., Chan
Y.K., Chan
S.Y., Xu
M.S., Sham
P.C. and Khoo
U.S., Estorgen Receptors Genes and Breast cancer Risk in Chinese: A
Haplotype-based Analysis, International Cancer Congress (13th), |
Tso A.W.K., Sham P.C., Wat N.M.S., Xu A., Cheung B.M.Y., Rong R., Fong H.Y., Xu J., Cheng K.Y., Janus E.D. and Lam K.S.L., Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study, Diabetologia. 2006, 49: 1806-15. |
Virtanen I.M., Song Y., Cheung K.M.C., Ala-Kokko L., Karppinen J., Ho D.W.H., Luk K.D.K., Yip S.P., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Chan D., Phenotypic and Population Differences in the Association between CILP and Lumbar Disc Disease., Journal of Medical Genetics. 2007, 44(4): 285-8. |
Wang Q., Chan R.C.K., Sun J.H., Yao J., Deng W., Sun X.L., Liu X.H., Sham P.C., Ma X.H., Meng H.Q., Murray R.M., Collier D.A. and Li T., Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: A study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls, Schizophrenia Research. 2007, 89(1-3): 293-298. |
Xu A., Tso A.W., Cheung B.M.Y., Wang Y., Wat N.M.S., Fong H.Y., Yeung C.Y., Janus E.D., Sham P.C. and Lam K.S.L., Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study, Circulation. 2007, 115: 1537-43. |
Xu
A., Tso A.W.K., Cheung
B.M.Y., Wang
Y., Wat
N.M.S., Fong
H.Y., Yeung
C.Y., Janus E.D., Sham
P.C. and Lam
K.S.L., Circulating levels of adipocyte-fatty acid binding protein
correlate with its adipose tissue expression and predict the development of
the metabolic syndrome. , The Endocrine Society's 89th Annual Meeting, 2-5
June 2007, |
Xu J., Sham P.C., Xu A., Tso A.W.K., Wat N.M.S., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study, Clin Endocrinol (Oxf). 2007, 66: 211-7. |
Yeung M.Y., Smith D.K., Chan S.Y., Wong B.C.W., Cheung K.M.C., Cheah K.S.E., Sham P.C., Chan D. and Song Y., iCartiGD: Integrated Cartilage Gene Database for genetic study of cartilage, BMC Genetics . 2007, 8: 4. |
Yeung M.Y., Smith D.K., Chan M.S.Y., Wong C.B., Wong B.C., Cheung K.M.C., Luk K.D.K., Cheah K.S.E., Sham P.C., Chan D. and Song Y., iCartiGD: the integrated cartilage egne database, BMC Genetics. 2007, 8(1): 4. |
Yeung M.Y., Smith D.K., Chan S.Y., Wong B.C.W., Cheung K.M.C., Cheah K.S.E., Sham P.C., Chan D. and Song Y., iCartiGD:The Integrated Cartilage Gene Database., The Integrated Cartilage Gene Database, The Fifth Asia-Pacific Bioinformatics Conference, APBC2007; 14-17 Jan, 2007; Hong Kong. 2007. |
Researcher
: So KF |
Project Title: |
Neuroprotection in steroid therapy: an animal model |
Investigator(s): |
So KF, Lee TMC, Tang SW |
Department: |
Anatomy |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
01/2005 |
Abstract: |
To investigate the effect of Lithium and paroxetine in arresting hippocampal damages associated with high dosage of steroid through quantitative neuro-anatomical and immunohistochemical methods. |
Project Title: |
The role of KhcU on the development and intracellular transportation of rod bipolar cell of mice retina |
Investigator(s): |
So KF, Huang J |
Department: |
Anatomy |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
10/2005 |
Completion Date: |
09/2006 |
Abstract: |
In this study, we make use of the previously created Pcp2-IRES-Cre mouse line and knock out the ubiquitously expressed kinesin heavy chain (KhcU) specifically in rod bipolar cells. We aim to investigate: 1) the retinal phenotypic and developmental changes after KhcU knockout in rod bipolar; 2) the alterations of intracellular transportation in the absence of KhcU, the MyosinVa-mediated processes will be specially noted. |
Project Title: |
Hemostasis and Hong Kong: The future hub of Nanomedicine |
Investigator(s): |
So KF, Ellis-Behnke RG, Liang Y, |
Department: |
Anatomy |
Source(s) of Funding: |
Innovation and Technology Support Programme |
Start Date: |
09/2006 |
Abstract: |
In order to progress the work to humans we need to perform four additional experiements: 1. Identify the mechanism of action 2. Perform large animal trials in pigs with a liver laceration model 3. Determine the best way to measure the quality of the material during manufacturing 4. Follow up the breakdown of the material by radio labeling the material in the brain and liver |
Project Title: |
Nanobiomedical manufacturing: the workforce of tomorrow |
Investigator(s): |
So KF, Ellis-Behnke RG, |
Department: |
Anatomy |
Source(s) of Funding: |
Innovation and Technology Support Programme |
Start Date: |
09/2006 |
Abstract: |
The goal is to not only understand the variation in the manufacturing process, but to understand how to remove that variation. At the same time the process needs to be optimized for cost, purity and the quantities that will be needed for use in humans. |
Project Title: |
The role of
endothelin |
Investigator(s): |
So KF, Chung SK |
Department: |
Anatomy |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
03/2007 |
Abstract: |
Glaucoma is an ocular degenerative
disease and characterized by progressive damage of optic nerve fibers and
retinal ganglion cells (RGC), resulting in progressive visual field loss and
excavation of the optic nerve head. As a leading cause of blindness
worldwide, glaucoma continues to be a clinical problem. Optic nerve damage in
most forms of glaucoma is commonly associated with increased intraocular
pressure (IOP) caused by impairment in the normal aqueous humor outflow
pathway. Yet, increased IOP may not be the sole risk factor for glaucomatous
disease, and because the eye is a highly perfused organ, the vascular system
may also play a key role in disease progression. Indeed, death of RGC is
thought to be initiated after ischemia resulting from a prolonged
vasoconstriction and/or vasospasms from abnormal auto-regulation of the
retinal microcirculation. Recent experimental evidence suggests that
endothelin-1 (ET-1), a potent vasoconstrictor, may be an important
contributor to glaucoma pathophysiology. Studies indicate that perfusion
instability, resulted from a disturbed auto-regulation in the context of a
general vascular dysregulation, might contribute to glaucoma. Indeed, ET-1
levels in the aqueous humor and plasma are higher in patients with primary
open-angle glaucoma. Both vascular (endothelial) and glial (astrocytic) ET-1
are involved in the regulation of retinal micro-circulation; yet, the
involvement of these two components in pathophysiology of glaucoma
retinopathy is poorly understood. Transient ischemia-related diseases, such
as central retinal artery occlusion, angle-closure glaucoma and carotid
artery disease, also affect vision. Various methods, such as raising the IOP
through cannulation of the eye and ligation of the central retinal artery
together with the optic nerve, have been used to create a model of retinal
ischemia-reperfusion, but they have drawbacks and limitations. In light of
this, we decided to investigate the contribution of vascular and glial ET-1
to the pathogenesis of glaucoma and retinal ischemia-reperfusion using animal
models. As validation and interpretation of the published data on human
studies are difficult, animal systems may provide insights into exploring the
underlying molecular mechanisms of development of glaucoma. Dogs and rats
have provided valuable information on the pathogenesis of experimental
glaucoma in the form of ocular hypertension, but they are poorly suited for
these studies using modern methods of genetic manipulations. Building on our
longstanding expertise in studies using transgenic mice, we propose to use
transgenic mouse models to study the involvement of ET |
List of Research Outputs |
Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine , Restorative neurology and neuroscience . 2007, 25(1): 17-23. |
Lau
W.M., Yau S.Y., Helmeste D.M., Lee
T.M.C., Tang
S.W. and So
K.F., Differential effect of chronic corticosterone and
antidepressant treatment on amygdale cell proliferation and depression-like
behavior , The |
Lau W.M., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Effect of corticosteroid and selective serotonin reuptake inhibitor on amygdala neurogenesis and depressive behavior , The University of Hong Kong Research postgraduate symposium 2007. 2007. |
Lau
W.M., Yau S.Y., Helmeste D.M., Lee
T.M.C., Tang
S.W. and So
K.F., Effects of corticosteroid and selective serotonin reuptake
inhibitor on masculine copulatory behavior, and c-fos expression in extended
amygdala and preoptic areas, Neuroscience 2007. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Inhibition Of Masculine Sexual Behavior Induced By Corticosterone , Hong Kong Society of Biological Psychiatry Conference 2006. 2006. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior , The 4th Congress of FAONS. 2006. |
Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Modulation By Paroxetine Of Suppressive Effect Of Corticosterone On Adult Hippocampal Cell Proliferation , Hong Kong Society of Biologcial Psychiatry Conference 2006. 2006. |
Yau S.K., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Protective effect of exercise on corticosterone suppressed hippocampal cell proliferation, Postgraduate seminar 2006, Department of Anatomy, HKU. 2006. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of Different Doses of Corticosterone on Hippocampal Cell Proliferation, The Hong Kong Society for Biological Psychiatry . 2007. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of voluntary exercise on corticosterone suppressed hippocampal cell proliferation and impaired spatial memory, Postgraduate Seminar 2007, Department of Anatomy, HKU. 2007. |
Researcher
: Song Y |
List of Research Outputs |
Cheung K.M.C., Chan D., Karppinen J., Chen Y.Q., Jim J.J.T., Yip S.P., Ott J., Wong K.K., Sham P.C., Luk K.D.K., Cheah K.S.E., Leong J.C.Y. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population, Spine. 2006, 31(10): 1143-1148. |
Researcher
: Tai KS |
List of Research Outputs |
Chua S.E., Cheung C., Cheung V., Tsang J.T.K., Chen E.Y.H., Wong J.C.H., Cheung J.P.Y., Yip L., Tai K.S., Suckling J. and McAlonan G.M., Cerebral grey, white matter & CSF in never-medicated, first-episode Schizophrenia, Schizophrenia Research. 2006, 89: 12-21. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early
treatment in first-onset, never-medicated schisophrenia, 13th Annual
Meeting Human Brain Mapping. |
Deng
Y., Cheung
V., Cheung
C., Chen
E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai
K.S., Suckling J., Bullmore E., McAlonan
G.M. and Chua
S.E., Early cerebral grey matter excess in basal ganglia after early treatment
in first-onset, never-medicated schizophrenia, 2nd International Congress
of Biological Psychiatry 2007. |
Researcher
: Tang HNA |
List of Research Outputs |
Tang
H.N.A., Wong
J.G.W.S., Patil
N.G. and Mak-Lieh
F., Teaching and learning of medical professionalism - medical students'
experience at the |
Researcher
: Tang SW |
List of Research Outputs |
Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine , Restorative neurology and neuroscience . 2007, 25(1): 17-23. |
Lau
W.M., Yau S.Y., Helmeste D.M., Lee
T.M.C., Tang
S.W. and So
K.F., Differential effect of chronic corticosterone and antidepressant
treatment on amygdale cell proliferation and depression-like behavior , The
|
Lau W.M., Yau S.Y., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Effect of corticosteroid and selective serotonin reuptake inhibitor on amygdala neurogenesis and depressive behavior , The University of Hong Kong Research postgraduate symposium 2007. 2007. |
Lau
W.M., Yau S.Y., Helmeste D.M., Lee
T.M.C., Tang
S.W. and So
K.F., Effects of corticosteroid and selective serotonin reuptake
inhibitor on masculine copulatory behavior, and c-fos expression in extended
amygdala and preoptic areas, Neuroscience 2007. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Inhibition Of Masculine Sexual Behavior Induced By Corticosterone , Hong Kong Society of Biological Psychiatry Conference 2006. 2006. |
Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Reversal of corticosterone-induced subventricular zone cell proliferation decrease by paroxetine, Restorative Neurology and Neuroscience. 2007, 25: 17-23. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior , The 4th Congress of FAONS. 2006. |
Lau W.M., Yau S.Y., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Selective serotonin reuptake inhibitor treatment diminishes inhibition of masculine sexual behavior caused by corticosterone, Thd 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, November 30 - December 2, 2006, Hong Kong. 2006, 120 No. P-C22. |
Lee
A.C.K., Tang
S.W., Yu G.K.K. and Cheung
R.T.F., Depression After Stroke: Incidence and Predictors , In: LI KA
SHING FACULTY OF MEDICINE , THE |
Lee
A.C.K., Tang
S.W., Yu G.K.K. and Cheung
R.T.F., Smiley diagrams: a simple tool to detect depression after stroke,
Evidence-Based Practice in Nursing: Paradigms & Dialogue . |
Lee A.C.K., Tang S.W., Yu G.K.K. and Cheung R.T.F., The Smiley as a Simple Screening Tool for Depression After Stroke: a preliminary study., International Journal of Nursing Studies. 2007, 45: 1081-1089. |
Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Modulation By Paroxetine Of Suppressive Effect Of Corticosterone On Adult Hippocampal Cell Proliferation , Hong Kong Society of Biologcial Psychiatry Conference 2006. 2006. |
Qiu G., Helmeste D.M., Samaranayake N.A., Lau W.M., Lee T.M.C., Tang S.W. and So K.F., Modulation by paroxetine of suppressive effect of corticosterone on adult hippocampal cell proliferation, Neuroscience Bulletin. 2007, 23: 131-136. |
Tang S.W., Using lithium, Hong Kong Medical Journal. 2006, 12 no.4. |
Yau S.K., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Protective effect of exercise on corticosterone suppressed hippocampal cell proliferation, Postgraduate seminar 2006, Department of Anatomy, HKU. 2006. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Counteractive effect of voluntary exercise on depression-like behavior of corticoseterone treated rats. , The University of Hong Kong Research postgraduate Symposium. 2007. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of Different Doses of Corticosterone on Hippocampal Cell Proliferation, The Hong Kong Society for Biological Psychiatry . 2007. |
Yau S.Y., Lau W.M., Tang S.W., Lee T.M.C. and So K.F., Effect of voluntary exercise on corticosterone suppressed hippocampal cell proliferation and impaired spatial memory, Postgraduate Seminar 2007, Department of Anatomy, HKU. 2007. |
Researcher
: Wong AWS |
List of Research Outputs |
Wong A.W.S., Chiu C.Y., Mok J.W.Y., Wong J.G.W.S. and Chen E.Y.H., The role of knowledge and motivation in symptom identification accuracy among schizophrenic patients: Application of signal detection theory, British Journal of Clinical Psychology. The British Psychological Society, 2006, 45: 427-436. |
Researcher
: Wong JGWS |
Project Title: |
What makes a good clinical teacher in the new medical curriculum? A focus group study on student perception |
Investigator(s): |
Wong JGWS, Lam TP, Mak-Lieh F |
Department: |
Psychiatry |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
01/2002 |
Abstract: |
To examine medical student perceptions on what makes a good clinical teacher; to explore the concept of a good role model. |
Project Title: |
A follow-up study on the severity of psychological sequelae in SARS patients |
Investigator(s): |
Wong JGWS, Sham PC, Wong PC, McAlonan GM,
|
Department: |
Psychiatry |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Abstract: |
To assess severity of psychological sequelae in SARS patients (including infected HCWS after recovery from the infection; to assess severity of psychological sequelae in high risk and low risk HCWs after the SARS outbreak; to inform psychological intervention in the event of a future outbreak. |
List of Research Outputs |
Lau
K.S., Siong K.H., Cheung P.W., Tang H.Y., Cheung K.S., Chan S.W., Lee
P.W.H. and Wong
J.G.W.S., An innovative web-based student support service: a
student-initiated peer support network, Cotone Congressi (14-18 September
2006). |
Lee
A.M., Wong
J.G.W.S., McAlonan
G.M., Cheung
V., Cheung
C., Sham
P.C., |
McAlonan G.M., Lee A.M., Cheung V., Cheung C., Tsang K.W.T., Sham P.C., Chua S.E. and Wong J.G.W.S., Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers, Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie. 2007, 52(4): 241-247. |
Tang
H.N.A., Wong
J.G.W.S., Patil
N.G. and Mak-Lieh
F., Teaching and learning of medical professionalism - medical students'
experience at the |
Wong A.W.S., Chiu C.Y., Mok J.W.Y., Wong J.G.W.S. and Chen E.Y.H., The role of knowledge and motivation in symptom identification accuracy among schizophrenic patients: Application of signal detection theory, British Journal of Clinical Psychology. The British Psychological Society, 2006, 45: 427-436. |
Wong
J.G.W.S., Can Guardianship provisions in |
Wong
J.G.W.S., The Assessment of Professionalism, International
Conference of Medical Professionalism and Humanities (9 December 2006). |
Researcher
: Wong KWT |
List of Research Outputs |
Wong
K.W.T., Fung
P.C.W., McAlonan
G.M. and Chua
S.E., An ERP study of the spatiotemporal processing of facial expressions
in children with autism, The 4th Congress of Federation of Asian-Oceanian
Neuroscience Societies. |
Wong K.W.T., Fung P.C.W., McAlonan G.M. and Chua S.E., Event-related potentials to emotional facial expressions in children with autism, Psychophysiology. 2006, 43: S109. |
Wong
K.W.T., Fung
P.C.W., McAlonan
G.M. and Chua
S.E., Multiple Dipole Source Analysis of Event-related Potentials to
Emotional Facial Expressions, Biomedical Engineering Conference 2006. |
Wong K.W.T., Chan F.H.Y., Chan W.L., Kwan T.F. and To C.Y., brain Pathways in Processing Chinese and English by Primary Three Hong Kong Pupils based on Electroencephalography Coherence Analysis, Journal of Bio-education. 2006, 1(1): 34-39. |
Researcher
: Wong MMC |
Project Title: |
Enrichment of collections in the library of the S.K. Yee Mental Health Resources and Rehabilitation Centre |
Investigator(s): |
Wong MMC, Mak KY, Mak-Lieh F, Yau EFY |
Department: |
Psychiatry |
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
Start Date: |
10/2001 |
Abstract: |
Taking care of mentally people in the community is often a great stress to the caregivers (including family members and staff of those agencies which are involved in the rehabilitation of the patients in the community). They often lack the knowledge in mental illness and are not equipped with the skills in taking care of the mentally ill patients. Therefore apart from offering services to the patients, the service should be extended to cover the caregivers. They should have easy access to information (including written and audio-visual material) so that they can have better knowledge on mental illness and can learn the skills in taking care of the mentally ill patients. It is also important to help the public to change their attitude towards the mentally ill through various public education materials which improve their awardness, understanding and acceptance of mental illness in the community. |
List of Research Outputs |
Chung
K.F., Tso K.C., Cheung E.P. and Wong
M.M.C., Validation of the Chinese version of the Mood Disorder
Questionnaire for the screening of bipolar disorder, 7th International
Conference on Bipolar Disorder. |
Lee
P.W.H., Mak-Lieh
F., Mak
K.Y., Fung
A.S.M., Wong
M.M.C. and Lam J., Retrospective Analysis (RA)/Invited Centers: Hong
Kong, In: Kim Hopper, Glynn Harrison, Aleksandar Janca, Norman Sartorius , Recovery
From Schizophrenia An International Perspective A Report from the Who
Collaborative Project, The International Study of Schizophrenia. |
Researcher
: Yeung WF |
List of Research Outputs |
Cheuk D.K.L., Yeung W.F., Chung K.F. and Wong V., Acupuncture for insomnia, Cochrane Database of Systematic Reviews 2007. 2007, Issue 3. |
Yeung
W.F., Chung
K.F., Zhang
S.P. and Yap T.G., A Randomized Placebo-Controlled Trial of Acupuncture
for Primary Insomnia – Preliminary Data, SLEEP 2007 21st Annual Meeting.
|
Yeung
W.F., Chung
K.F., Zhang
S.P., Yap T.G. and Chan Y.P., A Randomized Placebo-Controlled Trial of
Acupuncture for Primary Insomnia, 2007 Hong Kong – Macau Postgraduate
Symposium on Chinese Medicine. |
Yeung
W.F. and Chung
K.F., A Systematic Review of Acupuncture on Insomnia, 2006 Hong Kong –
|
Yeung
W.F. and Chung
K.F., Acupuncture Treatment for Primary Insomnia: A systematic Review and
Preliminary Local Data, 2006 World Congress on Chinese Medicine: Charting
the Course of Development. Hong Kong, School of Chinese Medicine, |
Yeung
W.F. and Chung
K.F., Acupuncture Treatment for Primary Insomnia: a Systematic Review and
Preliminary Local Data, 11th Research Postgraduate Symposium. Hong
Kong, Li Ka Shing Faculty of Medicine, The University of |
Yeung W.F., Chung K.F. and Chan T.C.Y., Sleep-wake habits, excessive daytime sleepiness and academic performance among medical students in Hong Kong, Biological Rhythm Research. 2007. |
Researcher
: Zhang SP |
List of Research Outputs |
Yeung
W.F., Chung
K.F., Zhang
S.P. and Yap T.G., A Randomized Placebo-Controlled Trial of
Acupuncture for Primary Insomnia – Preliminary Data, SLEEP 2007 21st
Annual Meeting. |
Yeung
W.F., Chung
K.F., Zhang
S.P., Yap T.G. and Chan Y.P., A Randomized Placebo-Controlled Trial
of Acupuncture for Primary Insomnia, 2007 Hong Kong – Macau Postgraduate
Symposium on Chinese Medicine. |
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