Academic Refereed

Journal articles, book chapters and other published papers

Au, W.N., Gover, S., Naylor, C., Mason, P., Luzzatto, L., Lam, V.M.S. and Adams, M.J. Solution of the structure of tetrameric h-G6PD by molecular replacement. Acta Crystallographica, 1999, D55: 826-834.

Azosdi, A., Chan, D., Hunziker, E.B., Bateman, J.F. and Fassler, R. Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. Journal of Cell Biology, 1998, 143: 1399-1412.

Chan, D. and Jacenko, O. Phenotypic and biochemical consequences of collagen X mutations in mice and humans. Matrix Biology [Review], 1998, 17: 169-184.

Chan, D., Freddi, S., Weng, Y.M. and Bateman, J.F. Interaction of collagen a1(X) containing engineered NC1 mutations with normal alpha1(X) in vitro. Implications for the molecular basis of schmid metaphyseal chondrodysplasia. Journal of Biological Chemistry, 1999, 274: 13091-13097.

Chau, C.H., Shum, D.K.Y., Chan, Y.S. and So, K.F. Heparan sulphates upregulate regeneration of transected sciatic nerves of adult guinea-pigs. European Journal of Neuroscience, 1999, 11: 1914-1926.

Huang, J., Brady, S.T., Richards, B.W., Stenoient, D., Resau, J.H., Copeland, N.G. and Jenkins, N.A. Direct interaction of microtubule- and actin-based transport motors. Nature, 1999, 397: 267-270.

Kamachi, Y., Cheah, K.S.E. and Kondoh, H. Mechanism of regulatory target selection by the SOX high mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Molecular Cell Biology, 1999, 19: 107-120.

Lan, L. and Wong, N.S. Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor. Febs. Letts, 1999, 444(1): 90-96.

Layton, J.E., Shimamoto, G., Osslund, T., Hammacher, A., Smith, D.K., Treutlein, H.R. and Boone, T. Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor: evidence that Glu¹⁹ of G-CSF interacts with Arg²⁸⁸ of the receptor. Journal of Biological Chemistry, 1999, 274: 17445-17451.

Manzanares, M., Trainor, P.A., Nonchev, S., Ariza-Mcnaughton, L., Brodie, J., Gould, A., Marshall, H., Morrison, A., Kwan, C.T., Sham, M.H. and Wilkinson, D.G. The role of kreisler in segmentation during hindbrain devleopment. Development Biology, 1999, 211: 220-237.

Zhang, L.P., Jiang, J.K. and Tam, J.W.O. Effects of matrine on telomerase activity and cell cycle in K562 cell. Chinese Journal of Oncology, 1998, 20: 5.

Zhang, Y., Jiang, J.K., Liu, X.S., Qing, J.P., Zhang, L.P., Liu, B.Z., Xu, X.G., He, Y.J., Dai, B.T., Li, L., Kang, G.F. and Tam, J.W.O. Differentiation and apoptosis in K562 erythroleukemia cells induced by matrine. Nature Medicines, 1998, 52(4): 295-299.

Conference and working papers

Au, D.M.Y., Chan, L.C., Lam, S.T.S. and Lam, V.M.S. Glucose Viangchan/Jammu (nt 871 G -> A): its high frequency provides an insight into G6PD deficiency in Hong Kong. Human Genome Meeting, Australia, 1999.

Au, W.N., Gover, S., Adam, M.J. and Lam, V.M.S. The 3-D X-ray of h-G6PD: the crucial link between the mutations and enzyme deficiency. 30th Annual Meeting of the European Society of Human Genetics, 1998.

Chan, C.H., Shum, D.K.Y. and Ip, M.S.M. TNF-a in bronchial secretions of patients with bronchiectasis stimulates neutrophil-mediated degradation of lung proteoglycans. The keystone Symposium on Type 2 Cytokines in Allergy and Helminth Infections: 56, Nevada, USA, 1999.

Chau, C.H. and Shum, D.K.Y. Bridging of transected sciatic nerves of adult guinea pigs with soluble heparan sulfates speeds up nerve regeneration. XIXth International Carbohydrate Symposium: CP076, San Diego, USA, 1998.

Chau, C.H., Shum, D.K.Y., Chan, Y.S. and So, K.F. Heparan sulfates upregulate regeneration of transected sciatic nerves of adult guinea pigs. Wenner-Gren Foundations Internaitonal Symposium on "Heparan Sulfate proteoglycans", Stockholm, Sweden, 1999.

Cheah, K.S.E., Wai, W.K., Ng, L.J., Watanabe, H., Yamada, Y. and Tam, P.P.L. Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant. 16th FECTS Meetings, Uppsala, 1998.

Cheah, K.S.E., Leung, K.K.H., Poon, W. and Cheslett, D.L. Regulation of development stage- and tissue- specific expression of the human COL2A1 and mouse COL10A1 genes in transgenic mice. ASBMB Fall Symposia, Albuquerque, USA, 1998.

Cheah, K.S.E. Functional Genomics: Lessons learnt from manipulating the mouse genome. International Symposium on Human Genome, Shanghai, China, 1998.

Cheah, K.S.E., Dong, S., Tang, A.S.P., Leung, K.K.H., Heng, H., Tsui, L.C., Kiernan, A. and Steel, K. Inner ear abnormalities in the novel transgenic mouse mutant, yellow submarine (ysb). Human Genome Meeting 1999, Brisbane, Australia.

Cheah, K.S.E., Tang, A.S.P., Dong, S., Leung, K.K.H., Heng, H., Tsui, L.C., Steel, K. and Tam, P.P.L. An insertional mutation causing altered coat colour & vestibular dysfunction in mice. Cold Spring Harbor Meeting on Mouse Molecular Genetics, USA, 1998.

Cheung, K.M.C., Kaluarachchi, T.K.P.K., Lam, S.P., Lu, W.W., Andrew, J.G., Kwan, K.M. and Cheah, K.S.E. The effect of lack of collagen X on fracture healing. Combined British and Irish Orthopaedic Association Meeting, Dublin, Ireland, October 1998.

Cheung, K.M.C., Kaluarachchi, T.K.P.K., Lam, S.P., Lu, W.W., Andrew, J.G., Kwan, K.M. and Cheah, K.S.E. Abnormalities in fracture healing in the absence of collagen type X. 18th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 14-15, 1998.

Diao, T.M., Wong, T.M. and Wong, N.S. Further study on the mechanism responsible for inhibition of cAMP production in CNE-2 and H9c2 cells upon k-opioid receptor stimulation. 29th International Narcotics Research Conference, Germany, 1998.

Gohel, M.D.I., Shum, D.K.Y., Lui, Y.Y. and Wong, W.W.S. Strategy to study urinary glycosaminoglycans by high performance liquid chromatography. Proceedings of the 8th European Symposium on Urolithiasis: 267-270, University of Parma, Italy, 1999.

Ho, L.Y., Lui, Y.Y. and Shum, D.K.Y. Chondroitin sulfate proteoglycans produced by astrocytes modulate neuron adhesion and neurite outgrowth. XIXth International Carbohydrate Symposium: CP075, San Diego, USA, 1998.

Jakt, L.M. and Sham, M.H. Large scale screening of transcription regulatory sequences recognised by Hox homeodomain proteins. The 1st Internaitonal Conference on Bioinformatics of Genome Regulation and Structure, Russia, 1998.

Kaluarachchi, T.K.P.K., Tsang, K.Y., Lau, J., Kwan, K.M., Cheah, K.S.E. and Cheung, K.M.C. Transgenic mouse models of human skeletal disorders. 18th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 14-15, 1998.

Kaluarachchi, T.K.P.K., Cheung, K.M.C., Lam, S.P., Lu, W.W., Andrew, J.G., Kwan, K.M. and Cheah, K.S.E. Fracture healing in collagen type X deficient mice: abnormalities in structure and mechanical properties of the fracture callus. Spring Meeting of the British Orthopaedic Research Society, Liverpool, UK, March 1999.

Leung, T.W.C., Tong, C.S.W., Lin, S.S.W., Tsang, A.C.C. and Yao, K.M. The transcription factor WIN alters cell cycle kinetics through modulation of cyclin expression. ISAC 1999, Samuel A Latt Conference - Signalling for Life and Death: Cytometry in the Analysis and Modelling of Cell Signalling, Hamilton Island, Australia, 1999.

Liao, X.M., Tipoe, G.L. and Shum, D.K.Y. Cytodifferentiation agent-induced changes in production of sulfated proteoglycans in human colon carcinoma cells. 8th Gordon Research Conference on Proteoglycans, Andover, USA, 1998.

Liao, X.M., Tipoe, G.L. and Shum, D.K.Y. Increased release of heparan sulfate proteoglycans from a human colon cancer cell line treated with hexamethylene bisacetamide. XIXth International Carbohydrate Symposium: CP014, San Diego, USA, 1998.

Liong, E.C. and Shum, D.K.Y. Characterization of newly synthesized proteoglycans isolated form renal proximal tubular epithelial cells in culture. 8th Gordon Research Conference on Proteoglycans, Andover, USA, 1998.

Opstelten, D., Niewiadomska, A.K., Kwong, A.Y.H. and Nagasawa, T. Topography of PBSF/SDF-1 mRNA + cells in marrow of long bones during postnatal development of mouse. Proceedings of the 10th International Congress of Immunology, New Delhi, India, November 1-6, 1998. G.P. Talwar, I. Nath, N.K. Ganguly and K.V.S. Rao, eds, Bologna, Italy, Monduzzi Editore, 1998, 63-69.

Opstelten, D., Niewiadomska, A.K., Kwong, A.Y.H. and Nagasawa, T. PBSF/SDF-1 mRNA expression pattern in postnatal bone marrow, liver and spleen. Keystone Symposia Conference "B lymphocyte Biology and Disease ", Taos, New Mexico, USA, 1999.

Shum, D.K.Y., Gohel, M.D.I. and Cheng, H.K.H. Separation and identification of crystal-active urinary glycosaminoglycans. The Second Finlayson Colloqium on Urolithiasis: 38, Florida, USA, 1999.

Thomas, M.K., Yao, K.M., Lee, J.H., Wong, G. and Habener, J.F. Bridge-1 utilizes a PDZ-like domain to coactivate E2A-mediated insulin gene transcription. 81th Annual Meeting of The Endocrine Society, San Diego, CA, USA, 1999.

Thomas, M.K., Yao, K.M., Tenser, M.S., Wong, G.G. and Habener, J.F. Bridge acts as a coactivator of E2A-Mediated regulation of the insulin gene. A Symposium on the 100th Anniversary of the Joslin Diabetes Center, Boston, USA, 1998.

Wong, L.M., Fong, W.F. and Wong, N.S. Latent membrane protein 1 interacts with the proliferation and apoptotic pathways in epithelial cells. 14th Annual Meeting on Oncogenes, San Diego, USA, 1999.

Wong, R.W.C., Kwan, R.W.P., Mak, H.S., Sham, M.H. and Chan, S.Y. Transgenic mice expressing human epidermal growth factor show stunted growth. Nature Biotechnology, 1999, 17(1): 106.

Wong, R.W.C., Kwan, R.W.P., Mak, H.S., Sham, M.H. and Chan, S.Y. Transgenic mice expressing human epidermal growth factor show stunted growth. Miami Nature Biotechnology, Short Reports, 1999, 10: 124.

Xie, W., Tsao, G.S.W. and Wong, N.S. Overexpression of a kallikrein-like protein in ventral prostate secretion at early stage of carcinogenesis in the Noble rat. AACR 90th Ann Meeting, Philadelphia, 1999, 40: 348.

Yao, K.M., Leung, T.W.C., Tong, C.S.W., Lin, S.S.W. and Tsang, A.C.C. Overexpression of the winged helix transcription factor WIN in HeLa cells alters cell-cycle kinetics. Keystone Symposium on The Molecular Basis of Cancer, New Mexico, USA, 1999.

Academic Not Refereed

Journal articles, book chapters and other published papers

Tam, J.W.O. Recent advances in DNA diagnostic technology and current development in Hong Kong. Biotechnology in Hong Kong, USA, USCIPI, 1998, Chapter 8: 128-153.

Conference and working papers

Au, D.M.Y., Xie, J.S., Chan, L.C. and Lam, V.M.S. Common mutation in the glucose-6-phosphate dehydrogenase (G6PD) gene and their frequencies in South China. Eighteenth International Congress of Genetics, Beijing, China, 1998.

Opstelten, D., Niewiadomska, A.K., Kwong, A.Y.H. and Nagasawa, T. PBSF/SDF-1 mRNA expression pattern in posnatal bone marrow, liver and spleen. Annual Scientific Meeting of the Hong Kong Society for Immunology, 1999.

Shum, D.K.Y. and Chau, C.H. Different effects of chondroitin and heparan sulphates on the regenerative efficacy of transected sciatic nerves of adult guinea pigs. The Asia Pacific Symposium on Neural Regeneration: 16, Hong Kong, 1998.

Wong, R.W.C., Sham, M.H. and Chan, S.Y. Transgenic mice expressing human epidermal growth factor show stunted growth. Postgraduate Symposium 1998, The University of Hong Kong, 16 December 1998, 109.