Dr MA Edmond SK | edmond@pathology.hku.hk
Assistant Dean (Education and Student Affairs)
Research Interest
1. Cytogenetics and molecular genetics of haematological malignancies
2. Beta-thalassaemia genotype-phenotype correlations in the Chinese
Recent Publication List:
Wan TSK, Ma SK, Li CK,
Chan LC. Atypical fluorescence in situ hybridisation (FISH) pattern
in chronic myeloid leukaemia (CML) due to cryptic insertion of BCR at 9q34.
Leukemia 18: 161 - 164, 2004.
Wan TSK, Ma SK, Lam CCK, Chan LC, Lee KK, Au WY. Del(9q) as the sole karyotypic
abnormality in myeloid disorders: a new case of myelodysplastic syndrome and
its prognostic implications in acute myeloid leukemia. Cancer Genet Cytogenet145: 184 - 186, 2003.
Wan TSK, Ma SK, Au WY, Chan LC. Derivative chromosome 9 deletion in chronic
myeloid leukaemia: interpretation of atypical D-FISH pattern. J Clin Pathol 56:
471 - 474, 2003.
Wong MP, Fung LF, Wang E, Chow WS, Chiu SW, Lam WK, Ho KK, Ma SK, Wan
TSK, Chung LP. Chromosomal aberrations of primary lung adenocarcinomas in nonsmokers.
Cancer 97: 1263 - 1270, 2003.
Wan TSK, Ma SK, Au WY, Liu HSY, Chan JCW, Chan LC. Trisomy 21 and other
additional chromosomal abnormalities in acute promyelocytic leukemia. Cancer
Genet Cytogenet 140: 170 - 173, 2003.
Au WY, Ma SK, Wan TS, Man C, Kwong YL. Pentasomy 8q in therapy-related
myelodysplastic syndrome due to cyclophosphamide therapy for fibrosing alveolitis.
Cancer Genet Cytogenet 141: 79 - 82, 2003.
Wan TSK, Ma SK, Yip SF, Yeung YM, Chan LC. Two balanced and novel chromosomal
translocations in myeloid malignancies: characterization by multiplex fluorescence in
situ hybridization. Cancer Genet Cytogenet 139: 52 - 56, 2002.
Au WY, Yuen MF, Lai KC, Wan TSK, Ma SK. Clonal marrow abnormalities after
azathioprine and sulfasalazine exposure in Crohn-s disease: a cautionary tale.
Leuk Lymphoma 43: 1679 - 1681, 2002.
Hu YC, Lam KY, Law SY, Wan TSK, Ma SK, Kwong YL, Chan LC, Wong J, Srivastava
G. Establishment, characterization, karyotyping and CGH analysis of HKESC-2 and
HKESC-3, two novel and newly established human esophageal squamous cell carcinoma
cell lines. Cancer Genet Cytogenet 135: 120 - 127, 2002.
Ma SK, Wan TSK, Au WY, Fung LF, So CK, Chan LC. Chromosome 11q deletion
in myeloid malignancies. Leukemia 16: 953 - 955, 2002.
Au WY, Ooi GC, Ma SK,
Wan TSK, Kwong YL. Chronic myeloid leukemia in an adolescent with Ollier-s
disease after intensive X-ray exposure. Leuk Lymphoma 45: 613 - 616, 2004.
Au WY, Lie AKW, Chan EC, Pang A, Ma SK, Choy C, Kwong YL. Treatment of
post-renal transplantation lymphoproliferative disorder manifesting as plasmacytoma
with non-myeloablative hematopoietic stem cell transplantation from the same
kidney donor. Am J Hematol 74: 283 - 286, 2003.
Lee CK, Ma SK, Shek TWH, Lam CCK, Au WY, Wan TSK, Chan LC. Plasmablastic
transformation of multiple myeloma. Hum Pathol 34: 710 - 714, 2003.
Au WY, Fung A, Man C, Ma SK, Wan TSK, Liang R, Kwong YL. Aberrant p15 gene
promoter methylation in therapy related myelodysplastic syndrome and acute myeloid
leukaemia: clinicopathologic and karyotypic association. Br J Haematol 120: 1062
- 1065, 2003.
Au WY, Lie AKW, Chim CS, Liang R, Ma SK, Chan CH, Mak YK, Chen YT, So
JCC, Yeung YM, Yip SF, Wong LG, Chan JC, Liu SY, Kwong YL. Arsenic trioxide is
superior to chemotherapy and bone marrow transplantation for relapsed acute promyelocytic
leukemia: ten years of experience from Hong Kong. Ann Oncol 14: 752 - 757, 2003.
Chan NPH, Ma SK, Wan TSK, Chan LC. The spectrum of acute lymphoblastic
leukemia with mature B-cell phenotype. Leukemia Res 27: 231 - 234, 2003.
Au WY, Ma SK, Liu CL. Essential thrombocytosis and liver transplantation.
Am J Hematol 72: 152 - 153, 2003.
Au WY, Ma SK, Wan TS, Wang EP, Lau TCM, Kwong YL. Concurrent mediastinal
B cell lymphoma and chronic myeloid leukemia with an unusually favorable response
to chemotherapy. Leuk Lymphoma 44: 535 - 538, 2003.
Au WY, Liang R, Lie AKW, Chim CS, Ma SK, Chan CH, Mak YK, Chen YT, So
JCC, Yeung YM, Yip SF, Wong LG, Chan JC, Liu HS, Kwong YL. Arsenic salvage is
superior to chemotherapy and bone marrow transplantation for relapsed acute promyelocytic
leukemia: Tens years of experience from Hong Kong. Prceedings of the 7th Annual
Meeting of the European Haematology Association, Florence, Italy, June 6 - 9,
2002, pp 99 - 102.
Au WY, Ma SK, Chung LP, Chim CS, Kwong YL. Two cases of therapy related
acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational
trophoblastic disease. Ann Hematol 81: 659 - 661, 2002.
Hon C, Au WY, Ma SK, Kwok AKH, Lie AKW, Liang RHS. Isolated orbit relapse
after allogeneic bone marrow transplantation for malignant lymphoma. J Clin Oncol20: 4394 - 4395, 2002.
Au WY, Ma SK, Wan TS, Jim MH, Kwong YL. Pulmonary stenosis, demyelination
and myelodysplasia with monosomy 7. Leuk Lymphoma 43: 1505 - 1507, 2002.
Wan TSK, Yip SF, Yeung YM, Chan LC, Ma SK. Fatal diffuse alveolar damage
complicating acute myeloid leukemia with abnormal eosinophils and trisomy X.
Ann Hematol 81: 167 - 169, 2002.
Au WY, Chan EC, Lie AKW, Liang R, Leung AYH, Ma SK, Kwong YL. Poor engraftment
after allogeneic bone marrow transplantation: role of chimerism analysis in treatment
and outcome. Ann Hematol 82: 410 - 415, 2003.
Au WY, Ma SK, Kwong YL. The occurrence of Philadelphia chromosome (Ph)
negative leukemia after hematopoietic stem cell transplantation for Ph positive
chronic myeloid leukemia: implications for disease monitoring and treatment.
Leuk Lymphoma 44: 1121 - 1129, 2003.
Ma SK, Li YH, Wan TSK, Au WY, Fung LF, Leung AYH, Lie AKW, Chan LC.
Telomere shortening in blood leucocytes after bone marrow transplantation is
mainly contributed by the T-suppressor compartment. Prceedings of the 7th Annual
Meeting of the European Haematology Association, Florence, Italy, June 6 -
9, 2002, pp 1 - 7.
Au WY, Chan EC, Siu LLP, Lau TCM, Lie AKW, Ma SK, Kwong YL. Leukaemic
relapse of donor origin after allogeneic bone marrow transplantation from a donor
who later developed bronchogenic carcinoma. Br J Haematol 119: 777 - 780, 2002.
Li YH, Ma SK, Wan TSK, Au WY, Fung LF, Leung AYH, Lie AKW, Chan LC. Lineage-specific
differences in telomere length after bone marrow transplantation. Bone Marrow
Transplant 30: 475 - 477, 2002.
Au WY, Lie AKW, Ma SK, Wan TS, Liang R, Kwong YL. Tyrosine kinase inhibitor
STI571 in the treatment of Philadelphia chromosome positive leukaemia relapsing
from myeloablative stem cell transplantation. Bone Marrow Transplant 30: 453
- 457, 2002.
Au WY, Ma SK. Hyposplenism after allogeneic bone marrow transplantation.
Br J Haematol images 117: 488, 2002.
Au WY, Lie AKW, Ma SK, Kwong YL, Liang R. Glucose-6-phosphate dehydrogenase
deficiency and hematopoietic stem cell transplantation. Bone Marrow Transplant29: 399 - 402, 2002.
Leung KFS, Ma SK, Chan AYY, Chan LC. Clinical phenotype of Hb Q-H disease.
J Clin Pathol 57: 81 - 82, 2004.
Wang W, Ma SK, Chan AYY, Prior J, Erber W, Chan LC, Chui DHK, Chong SS.
Rapid single tube multiplex-PCR screen for anti-3.7 and anti-4.2 a-globin
gene triplications. Clin Chem 49: 1679 - 1682, 2003.
Ma SK, Lam KKY, Chan AYY, Ha SY, Au WY, Chan LC. Transferrin receptor-2
polymorphisms and iron overload in transfusion independent b-thalassemia
intermedia. Haematologica 88: 345 - 346, 2003.
Wang W, Ma SK, Chan AYY, Chui DHK, Chong SS. Multiplex-minisequencing
screen for common Southeast Asian non-deletional a-thalassemia
mutations. Clin Chem 49: 800 - 803, 2003.
Au WY, Cheung WC, Chan GCF, Ha SY, Khong PL, Ma SK. Risk factors for hyperbilirubinemia
and gallstones in Chinese patients with b-thalassemia syndrome. Haematologica88: 220 - 222, 2003.
Chan AYY, Ma SK, Au WY, Chow EYD, Chan LC. Detection of a small novel
deletion in alpha 1 globin gene and Type II -a3.7 deletion
by heteroduplex formation. Hemoglobin 26: 311 - 316, 2002.
So JCC, Ma SK, Chan AYY, Chan LC, Wong KF. A novel mutation in the b-globin
gene with phenotypic identity to the high oxygen affinity variant Hb Kodaira.
Hemoglobin 26: 205 - 207, 2002.
Ma SK, Ma V, Chan AYY, Chan LC, Chui DHK. Routine screening of (--SEA) a-thalassemia
deletion by an enzyme linked immunosorbent assay for embryonic z-globin
chain. Acta Haematologica 108: 8 - 12, 2002.
Ma SK, Chow EYD, Chan AYY, Chu CM, Lin SY, Chan LC. Low affinity and
unstable hemoglobin variant caused by AAC®ATC (Asn®Ile)
mutation at codon 108 of the b-globin
gene. Haematologica 87: 553 - 554, 2002.
Ma SK, Chan AYY, Ha SY, Chan GCF, Au WY, Chan LC. The (--SEA) a-thalassemia
(SEA) deletion ameliorates the clinical phenotype of b0/b+ but
not necessarily that of b0/b0 thalassemia.
Haematologica 87: 443 - 444, 2002.
Au WY, Tsang J, Cheng TS, Chow WS, Woo YC, Ma SK, Tam S. Cough mixture
abuse related macrocytosis with peripheral neuropathy due to combined folate
and vitamin B12 deficiency. Br J Haematol 123: 956 - 958, 2003.
Leung KFS, Ma SK. Amyloid deposits in the bone marrow. Br J Haematol (images
in haematology) 121: 679, 2003.
Lee ACW, Li CH, Szeto SC, Ma SK. Symptomatic venous thromboembolism in
Hong Kong Chinese children. Hong Kong Med J 9: 259 - 262, 2003.
Lee CK, Ma SK, Tang M, Lam CCK, Lin CK, Chan LC. Prevalence and specificity
of clinically significant red cell alloantibodies in Chinese women during pregnancy
- a review of cases from 1997 - 2001. Transfusion Med 13: 227 - 231, 2003.
Wong AYC, Irwin MG, Hui TWC, Fung SKY, Fan ST, Ma SK. Desmopressin does
not decrease blood loss and transfusion requirements in patients undergoing hepatectomy.
Can J Anesth 50: 14 - 20, 2003.
Chen WH, Lau CP, Lau YK, Ng W, Lee PY, Yu CM, Ma SK. Stable and Optimal
Anticoagulation is Achieved with a Single Dose of Intravenous Enoxaparin in Patients
Undergoing Percutaneous Coronary Intervention. J Invasive Cardiol 14: 439 - 442,
2002.








