Prof. Y. GUAN
 
 
Professor, Department of Microbiology
 

 
Email : yguan@hkucc.hku.hk

Research Interests:

Ecology and evolution of influenza A viruses in southern China

Identification of the emergency of animal influenza viruses with pandemic potential

Ecology of SARS

Selected Research Publications
2006 Smith GJD, Fan XH, Wang J, Li KS, Qin K, Zhang JX, Vijaykrishna D, Cheung CL, Huang K, Rayner JM, Wong W, Dyrting KC, Peiris JSM, Chen H, Webster RG and Guan Y (2006) Emergence and predominance of a novel H5N1 influenza virus in China. Proceedings of the National Academy of Science USA (published online).
2006 X. C. Tang, J. X. Zhang, S. Y. Zhang, P. Wang, X. H. Fan, L. F. Li, G. Li, B. Q. Dong, W. Liu, C. L. Cheung, K. M. Xu, W. J. Song, D. Vijaykrishna, L. L. M. Poon, J. S. M. Peiris, G. J. D. Smith, H. Chen and Y. Guan (2006). Prevalence and genetic diversity of coronaviruses in bats from China. J. Virol. 2006 Aug;80(15):7481-90
2006 Smith GJD, Naipospos TSP, Nguyen TD, de Jong MD, Vijaykrishna V, Usman TB, Hassan SS, Nguyen TV, Dao TV, Bui NA, Leung YHC, Cheung CL, Rayner JM, Zhang JX, Zhang LJ, Poon LLM, Li KS, Nguyen VC, Hien TT, Farrar J, Chen H, Webster RG, Peiris JSM, Guan Y (2006) Evolution and Adaptation of H5N1 Influenza Virus in Avian and Human Hosts in Indonesia and Vietnam. Virology 350: 258-268.
2006 Chung-Lam Cheung, Jane M. Rayner, Gavin J. D. Smith, Pui Wang, T. S. P. Naipospos, Jinxia Zhang, Kwok-Yung Yuen, Robert G. Webster, J. S. Malik Peiris, Y Guan, H Chen (2006). Distribution of Amantadine-Resistant H5N1 Avian Influenza Variants in Asia. J Infect Dis. 2006 Jun 15;193(12):1626-9. Epub 2006 May 9
2006 H. Chen, G. J. D. Smith, K. S. Li, J. Wang, X. F. Fan, J. M. Rayner, J Zhang, D. Vijaykrishna, C. T. Guo, C. L. Cheung, K. M. Xu, L. Duan, K Huang, K. Qin, Y. H. C. Leung, W. L. Wu, H. R. Lu, Y. Chen, N. S. Xiao, T. S. P. Naipospos, S. S. Hassan, T. D. Nguyen, L. J. Zhang, K. Y. Yuen, R. G. Webster, J. S. M. Peiris & Y. Guan (2006). Establishment of multiple sub-lineages of H5N1 influenza virus in Asia ¨C implications for pandemic control. Proc. Natl Acad. Sci. USA 103, 2845-2850.
2005 de Jong MD, Thanh TT, Khanh TT, Hien VM, Smith GJD, Chau NV, Cam BV, Qui PV, Ha DQ, Guan Y, Peiris JSM, Hien TT, Farrar J (2005). Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection. New Eng. J. Med. 353: 2667-2672.
2005 KM Butt, Gavin JD Smith, Honglin Chen, LJ Zhang, YH Connie Leung, KM Xu, Wilina Lim, Robert G Webster, KY Yuen, JSM Peiris and Yi Guan (2005). Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003. J Clin. Microbiology 43: 5760-5767.
2005 Guan Y and Chen H (2005). Resistance to anti-influenza agents. Lancet 366, 1139-40.
2005 H. Chen, G. J. D. Smith, S. Y. Zhang, K. Qin, J. Wang, K. S. Li, R. G. Webster, J. S. M. Peiris, Y. Guan (2005). H5N1 virus outbreak in migratory waterfowl. Nature 436, 191-192.
2004 Li KS, Guan Y, Wang J, Smith GJD, Xu KM, Duan L, Rahaedjo AP, Puthavathana P, Buranthai C, Nguyen TD, Estoepangeste ATS, Chaisingh A, Auewarakul P, Long HT, Nahn NTH, Webby RJ, Poon LLM, Chen H, Shortridge KF, Yuen KY, Webster RG, Peiris JSM. (2004) Genesis of a Dominant, Highly Pathogenic, Potentially Pandemic H5N1 Influenza Virus in Eastern Asia. Nature 430, 209-213.
2004 Y. Guan, L.L.M. Poon, C.Y. Cheung, T.M. Ellis, W. Lim, A.S. Lipatov, K.H. Chan, K.M. Sturm-Ramirez, C.L. Cheung, Y.H.C. Leung, K.Y. Yuen, R.G. Webster, J.S.M. Peiris. (2004). H5N1 influenza: a protean pandemic threat. Proc. Natl Acad. Sci. USA 101(21): 8156-61.
2004 Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC. (2004). Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet 363(9403): 99-104.
2004 Peiris JS, Yu WC, Leung CW, Cheung CY, Ng WF, Nicholls JM, Ng TK, Chan KH, Lai ST, Lim WL, Yuen KY, Guan Y. (2004). Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet 363(9409): 617-9.
2003 Guan Y, BJ Zheng, YQ He, XL Liu, ZX Zhuang, CL Cheung, SW Luo, PH Li, LJ Zhang, YJ Guan, KM Butt, KL Wong, KW Chan, W Lim, KF Shortridge, KY Yuen, JSM Peiris, LLM Poon. (2003). Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China. Science. 302(5643): 276-278.
2003 He ML, BJ Zheng, JSM Peiris, MCM Lin, Y Peng, LLM Poon, KY Yuen, HF Kung, Guan Y. (2003). Inhibition of SARS-Associated Coronavirus Infection and Replication by RNA Interference. JAMA. 290(20): 2665-6.
2003 Zhong NS, BJ Zheng, YM Li, LLM Poon, ZH Xie, PH Li, SY Tan, Q Chang, JP Xie, XQ Liu, J Xu, DX Li, KY Yuen, JSM Peiris, Guan Y. (2003). Epidemiological and casue of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. . Lancet 362(9393): 1353-1358.
2003 Li KS, KM Xu, JSM Peiris, LLM Poon, KZ Yu, KY Yuen, KF Shortridge, RG Webster, Guan Y. (2003) Characterization of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans? J. Virol. 77(12): 6988-6994.
2002 Guan Y, M Peiris, KF Kong, KC Dyrting, TM Ellis, T Sit, LJ Zhang, KF Shortridge. (2002) H5N1 influenza viruses isolated from geese in Southeastern China: evidence for genetic reassortment and interspecies transmission to ducks. Virology 292(1): 16-23.
2002 Guan Y, JS Peiris, AS Lipatov, TM Ellis, KC Dyrting, S Krauss, LJ Zhang, RG Webster, KF Shortridge. (2002) Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR. Proc. Natl Acad. Sci. 99(13): 8950-5.
2000 Guan Y, KF Shortridge, S Krauss, PS Chin, KC Dyrting, TM Ellis, RG Webster, M Peiris. (2000) H9N2 influenza viruses possessing H5N1-like internal genomes continue to circulate in poultry in southeastern China. J Virol 74(20): 9372-9380.
2000 Guo YJ, S Krauss, DA Senne, IP Mo, KS Lo, XP Xiong, M Norwood, KF Shortridge, RG Webster, Guan Y. (2000) Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia. Virology 267(2): 279-288. (Corresponding author)
1999 Guan Y, KF Shortridge, S Krauss, RG Webster. (1999) Molecular characterization of H9N2 influenza viruses; were they the donors of the ¡°internal¡± genes of H5N1 viruses in Hong Kong? Proc Natl Acad Sci USA 96(16): 9363-9367.