Ngan S. W.,  Elly

Ph.D., The University of Hong Kong, Hong Kong,  1997-2000
B.Sc.(Hon), University of Science and Technology, Hong Kong,  1994-1997
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Research interests:

Transcriptional regulation of the human GnRH receptor gene.


Publications:

  1. Ruby LC Hoo, Ngan ESW, Peter CK Leung and Billy KC Chow. Two Inr elements are important for mediating the activity of the proximal promoter of the human gonadoropin-releasing hormone receptor gene. Endocrinology. Feb 2003. (In press)
  2. Ngan ESW, Schillinger K, DeMayo F, Tsai SY. The mifepristone-inducible gene regulatory system in mouse models of disease and gene therapy. Semin Cell Dev Biol. Apr 2002; 13 (2): 143-149.
  3. Ngan ESW, Ma ZQ, Chua SS, DeMayo FJ, Tsai SY. Inducible expression of FGF-3 in mouse mammary gland. P Natl Acad Sci USA. Aug 2002; 99 (17): 11187-11192.
  4. Ma ZQ, Liu Z, Ngan ESW, Tsai SY. Cdc25B functions as a novel coactivator for the steroid receptors. Mol Cell Biol. Dec 2001; 21 (23): 8056-8067.
  5. Ngan ESW, Leung PC, Chow BK. Interplay of pituitary adenylate cyclase-activating polypeptide with a silencer element to regulate the upstream promoter of the human gonadotropin-releasing hormone receptor gene. Mol Cell Endocrinol. May 2001; 176(1-2):135-144.
  6. Cheng KW, Ngan ESW, Kang SK, Chow BK, Leung PC. Transcriptional down-regulation of human gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: role of protein kinase C and activating protein 1. Endocrinology. Oct 2000; 141(10):3611-3622.
  7. Kang SK, Cheng KW, Ngan ESW, Chow BK, Choi KC, Leung PC. Differential expression of human gonadotropin-releasing hormone receptor gene in pituitary and ovarian cells. Mol Cell Endocrinol. Apr 2000; 162(1-2):157-166.
  8. Ngan ESW, Leung PC, Chow BK. Identification of an upstream promoter in the human gonadotropin-releasing hormone receptor gene. Biochem Biophys Res Commun. Apr 2000; 270(3):766-772.
  9. Ngan ESW, Chow LS, Tse DL, Du X, Wei Y, Mojsov S, Chow BK. Functional studies of a glucagon receptor isolated from frog Rana tigrina rugulosa: implications on the molecular evolution of glucagon receptors in vertebrates. FEBS Lett. Sep 1999; 457(3):499-504.
  10. Ho PK, Fong RS, Kai HS, Lau EH, Ngan ESW, Cotton CU, Chow BK. The human secretin receptor gene: genomic organization and promoter characterization. FEBS Lett. Jul 1999; 455(3):209-214.
  11. Ngan ESW, Cheng PK, Leung PC, Chow BK. Steroidogenic factor-1 interacts with a gonadotrope-specific element within the first exon of the human gonadotropin-releasing hormone receptor gene to mediate gonadotrope-specific expression. Endocrinology. Jun 1999; 140(6):2452-2462.